PSU Profiles
Last Name

Yongsoo Kim, Ph.D.

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentNeural and Behavioral Sciences
Address500 University Drive Hershey, PA 17033
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    Collapse Biography 
    Collapse awards and honors
    2014 - 2016NARSAD Young Investigator Award, Brain and Behavior Research Foundation
    2008Cold Spring Harbor Summer Course Financial Scholarship, Cold Spring Harbor Laboratory
    2006Children Memorial Research Center Travel Award, Northwestern University
    2004 - 2006Korean Government Overseas Scholarship, South Korea government
    2004International Summer Institute Scholarship, Northwestern University

    Collapse Overview 
    Collapse overview

    Ph.D. Neuroscience (Interdepartmental Neuroscience Program), September 2004 – June 2010
    Northwestern University, Chicago, IL, U.S.A.

    B.S. Pharmacy (College of Pharmacy), March 1996 – February 2000
    Seoul National University, Seoul, South Korea

    Professional Experience

    Assistant Professor September 2015 - Present
    Penn State University, College of Medicine, Department of Neural and Behavioral Sciences

    Postdoctoral Research April 2010 – August 2015
    Cold Spring Harbor Laboratory, U.S.A.

    Doctoral Thesis Research August 2005 – March 2010
    Northwestern University, U.S.A.

    Academic Visitor August 2007 - March 2010
    University of Oxford, U.K.

    Research Interest

    Social neuroscience and whole brain mapping lab

    Social behavior is conserved behavior across different animal species and plays fundamentally important roles in supporting and maintaining life. It is both innate (hard-wired) and acquired (learned) behavior. Impairment of social behavior is one of hallmarks in many neurodevelopmental brain disorders such as autism. My lab focuses on understanding how neural circuitry processing socially relevant information and how such process is impaired in neurodevelopmental disorders using mice as an animal model.

    A brain works as electrical and chemical networks between different cells (neurons and glia). To understand its functions, it is critical to examine the brain at both cellular (microscopic) and network (macroscopic) level. Towards the goal, whole brain mapping method in cellular resolution with automated 3D microscopy system (called “Serial Two-photon tomography”, Ragan et al, 2012, Nature Methods) has been developed (Kim et al., 2015, Cell Reports). The method has been used to study
    1) Functional activity mapping of freely behavior animals during social behavior,
    2) Anatomical axonal projection, and
    3) Quantitative cell type mapping using cell type specific Cre driver lines.
    This method can provide an unprecedented opportunity to examine the entire brain in great details.

    Using the method, I am currently investing how whole brain neural activity during social behavior is affected in a mouse model of autism. I plan to study how neurons implicated in social processing are wired and how they regulate the social behavior in the future. The outcome for the research can provide novel insights of brain mechanism of social behavior and its implication in neurodevelopmental disorders.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Kim Y, Yang GR, Pradhan K, Venkataraju KU, Bota M, García Del Molino LC, Fitzgerald G, Ram K, He M, Levine JM, Mitra P, Huang ZJ, Wang XJ, Osten P. Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism. Cell. 2017 Oct 05; 171(2):456-469.e22. PMID: 28985566.
      View in: PubMed
    2. He M, Tucciarone J, Lee S, Nigro MJ, Kim Y, Levine JM, Kelly SM, Krugikov I, Wu P, Chen Y, Gong L, Hou Y, Osten P, Rudy B, Huang ZJ. Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex. Neuron. 2016 Sep 21; 91(6):1228-1243. PMID: 27618674.
      View in: PubMed
    3. Kim Y, Perova Z, Mirrione MM, Pradhan K, Henn FA, Shea S, Osten P, Li B. Whole-Brain Mapping of Neuronal Activity in the Learned Helplessness Model of Depression. Front Neural Circuits. 2016; 10:3. PMID: 26869888; PMCID: PMC4737884.
    4. Jeong M, Kim Y, Kim J, Ferrante DD, Mitra PP, Osten P, Kim D. Comparative three-dimensional connectome map of motor cortical projections in the mouse brain. Sci Rep. 2016 Feb 02; 6:20072. PMID: 26830143; PMCID: PMC4735720.
    5. Kim Y, Venkataraju KU, Pradhan K, Mende C, Taranda J, Turaga SC, Arganda-Carreras I, Ng L, Hawrylycz MJ, Rockland KS, Seung HS, Osten P. Mapping social behavior-induced brain activation at cellular resolution in the mouse. Cell Rep. 2015 Jan 13; 10(2):292-305. PMID: 25558063; PMCID: PMC4294964.
    6. Ragan T, Kadiri LR, Venkataraju KU, Bahlmann K, Sutin J, Taranda J, Arganda-Carreras I, Kim Y, Seung HS, Osten P. Serial two-photon tomography for automated ex vivo mouse brain imaging. Nat Methods. 2012 Jan 15; 9(3):255-8. PMID: 22245809; PMCID: PMC3297424.
    7. Comte I, Kim Y, Young CC, van der Harg JM, Hockberger P, Bolam PJ, Poirier F, Szele FG. Galectin-3 maintains cell motility from the subventricular zone to the olfactory bulb. J Cell Sci. 2011 Jul 15; 124(Pt 14):2438-47. PMID: 21693585; PMCID: PMC3124373.
    8. James R, Kim Y, Hockberger PE, Szele FG. Subventricular zone cell migration: lessons from quantitative two-photon microscopy. Front Neurosci. 2011; 5:30. PMID: 21472025; PMCID: PMC3064983.
    9. Walker AS, Goings GE, Kim Y, Miller RJ, Chenn A, Szele FG. Nestin reporter transgene labels multiple central nervous system precursor cells. Neural Plast. 2010; 2010:894374. PMID: 21527990; PMCID: PMC3080708.
    10. Martinez-Molina N, Kim Y, Hockberger P, Szele FG. Rostral migratory stream neuroblasts turn and change directions in stereotypic patterns. Cell Adh Migr. 2011 Jan-Feb; 5(1):83-95. PMID: 21045564; PMCID: PMC3038103.
    11. Kim Y, Wang WZ, Comte I, Pastrana E, Tran PB, Brown J, Miller RJ, Doetsch F, Molnár Z, Szele FG. Dopamine stimulation of postnatal murine subventricular zone neurogenesis via the D3 receptor. J Neurochem. 2010 Aug; 114(3):750-60. PMID: 20477937; PMCID: PMC2913229.
    12. Kim Y, Comte I, Szabo G, Hockberger P, Szele FG. Adult mouse subventricular zone stem and progenitor cells are sessile and epidermal growth factor receptor negatively regulates neuroblast migration. PLoS One. 2009 Dec 02; 4(12):e8122. PMID: 19956583; PMCID: PMC2780296.
    13. Nam SC, Kim Y, Dryanovski D, Walker A, Goings G, Woolfrey K, Kang SS, Chu C, Chenn A, Erdelyi F, Szabo G, Hockberger P, Szele FG. Dynamic features of postnatal subventricular zone cell motility: a two-photon time-lapse study. J Comp Neurol. 2007 Nov 10; 505(2):190-208. PMID: 17853439.
      View in: PubMed
    14. Kim Y, Szele FG. Activation of subventricular zone stem cells after neuronal injury. Cell Tissue Res. 2008 Jan; 331(1):337-45. PMID: 17694326.
      View in: PubMed
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