PSU Profiles
Last Name

Yandong Zhou, Ph.D.

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentCellular and Molecular Physiology
Address500 University Drive Hershey, PA 17033
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhou Y, Nwokonko RM, Cai X, Loktionova NA, Abdulqadir R, Xin P, Niemeyer BA, Wang Y, Trebak M, Gill DL. Cross-linking of Orai1 channels by STIM proteins. Proc Natl Acad Sci U S A. 2018 Mar 26. PMID: 29581306.
      View in: PubMed
    2. Lee S, Zhou Y, Gill DL, Kelleher SL. A genetic variant in SLC30A2 causes breast dysfunction during lactation by inducing ER stress, oxidative stress and epithelial barrier defects. Sci Rep. 2018 Feb 23; 8(1):3542. PMID: 29476070.
      View in: PubMed
    3. Zhou Y, Cai X, Nwokonko RM, Loktionova NA, Wang Y, Gill DL. The STIM-Orai coupling interface and gating of the Orai1 channel. Cell Calcium. 2017 May; 63:8-13. PMID: 28087079.
      View in: PubMed
    4. Nwokonko RM, Cai X, Loktionova NA, Wang Y, Zhou Y, Gill DL. The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry. Adv Exp Med Biol. 2017; 993:83-98. PMID: 28900910.
      View in: PubMed
    5. Zhou Y, Cai X, Loktionova NA, Wang X, Nwokonko RM, Wang X, Wang Y, Rothberg BS, Trebak M, Gill DL. The STIM1-binding site nexus remotely controls Orai1 channel gating. Nat Commun. 2016 Dec 08; 7:13725. PMID: 27929067.
      View in: PubMed
    6. Cai X, Zhou Y, Nwokonko RM, Loktionova NA, Wang X, Xin P, Trebak M, Wang Y, Gill DL. The Orai1 Store-operated Calcium Channel Functions as a Hexamer. J Biol Chem. 2016 Dec 09; 291(50):25764-25775. PMID: 27780862.
      View in: PubMed
    7. Zhou Y, Wang X, Wang X, Loktionova NA, Cai X, Nwokonko RM, Vrana E, Wang Y, Rothberg BS, Gill DL. STIM1 dimers undergo unimolecular coupling to activate Orai1 channels. Nat Commun. 2015 Sep 24; 6:8395. PMID: 26399906; PMCID: PMC4598629.
    8. Zhou Y, Trebak M, Gill DL. Calcium signals tune the fidelity of transcriptional responses. Mol Cell. 2015 Apr 16; 58(2):197-9. PMID: 25884365; PMCID: PMC4743736.
    9. Shanmughapriya S, Rajan S, Hoffman NE, Zhang X, Guo S, Kolesar JE, Hines KJ, Ragheb J, Jog NR, Caricchio R, Baba Y, Zhou Y, Kaufman BA, Cheung JY, Kurosaki T, Gill DL, Madesh M. Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU. Sci Signal. 2015 Mar 03; 8(366):ra23. PMID: 25737585; PMCID: PMC4722812.
    10. Hendron E, Wang X, Zhou Y, Cai X, Goto J, Mikoshiba K, Baba Y, Kurosaki T, Wang Y, Gill DL. Potent functional uncoupling between STIM1 and Orai1 by dimeric 2-aminodiphenyl borinate analogs. Cell Calcium. 2014 Dec; 56(6):482-92. PMID: 25459299; PMCID: PMC4314399.
    11. Wang X, Wang Y, Zhou Y, Hendron E, Mancarella S, Andrake MD, Rothberg BS, Soboloff J, Gill DL. Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site. Nat Commun. 2014; 5:3183. PMID: 24492416; PMCID: PMC3995141.
    12. Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell. 2013 Feb 14; 152(4):778-790. PMID: 23394946; PMCID: PMC3908667.
    13. Xiang Wang, Xiaoli Zhang, Xian-ping Dong, Mohammad Samie1, Xinran Li, Xiping Cheng, Andrew Goschka, Dongbiao Shen, Yandong Zhou, Janice Harlow, Michael X. Zhu, David E. Clapham, Dejian Ren, Haoxing Xu. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 2012; 2(151):372-383.
    14. Ritchie MF, Zhou Y, Soboloff J. WT1/EGR1-mediated control of STIM1 expression and function in cancer cells. Front Biosci (Landmark Ed). 2011; (16):24012415.
    15. Zhou Y, Lewis TL, Robinson LJ, Brundage KM, Schafer R, Martin KH, Blair HC, Soboloff J, Barnett JB. The role of calcium release activated calcium channels in osteoclast differentiation. J Cell Physiol. 2011 Apr; 226(4):1082-1089. PMID: 20839232; PMCID: PMC4020518.
    16. Ritchie MF, Zhou Y, Soboloff J. Transcriptional mechanisms regulating Ca(2+) homeostasis. Cell Calcium. 2011 May; 49(5):314-21. PMID: 21074851; PMCID: PMC3225030.
    17. Ritchie MF, Yue C, Zhou Y, Houghton PJ, Soboloff J. Wilms tumor suppressor 1 (WT1) and early growth response 1 (EGR1) are regulators of STIM1 expression. J Biol Chem. 2010 Apr 02; 285(14):10591-6. PMID: 20123987; PMCID: PMC2856267.
    18. Zhou Y, Mancarella S, Wang Y, Yue C, Ritchie M, Gill DL, Soboloff J. The short N-terminal domains of STIM1 and STIM2 control the activation kinetics of Orai1 channels. J Biol Chem. 2009 Jul 17; 284(29):19164-8. PMID: 19487696; PMCID: PMC2740537.
    19. Deng X, Wang Y, Zhou Y, Soboloff J, Gill DL. STIM and Orai: dynamic intermembrane coupling to control cellular calcium signals. J Biol Chem. 2009 Aug 21; 284(34):22501-5. PMID: 19473984; PMCID: PMC2755655.
    20. Wang Y, Deng X, Zhou Y, Hendron E, Mancarella S, Ritchie MF, Tang XD, Baba Y, Kurosaki T, Mori Y, Soboloff J, Gill DL. STIM protein coupling in the activation of Orai channels. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7391-6. PMID: 19376967; PMCID: PMC2678612.
    21. Zhou YD, Fang XF, Cui ZJ. UVA-induced calcium oscillations in rat mast cells. Cell Calcium. 2009 Jan; 45(1):18-28. PMID: 18602157.
      View in: PubMed
    22. Su L, Ma CY, Zhou YD, Jia YH, Cui ZJ. Cytosolic calcium oscillations in submandibular gland cells. Acta Pharmacol Sin. 2006 Jul; 27(7):843-7. PMID: 16787567.
      View in: PubMed
    23. Cui ZJ, Zhou YD, Satoh Y, Habara Y. A physiological role for protoporphyrin IX photodynamic action in the rat Harderian gland? Acta Physiol Scand. 2003 Oct; 179(2):149-54. PMID: 14510778.
      View in: PubMed
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