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Chandrika Shivappa Gowda, M.D.

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentPediatric
Address500 University Drive, Hershey, PA 17033
Phone717-531-6012
Fax717-531-4789
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    Collapse Biography 
    Collapse awards and honors
    2015 - 2016Association of Faculty and Friends, Penn State University
    2012 - 2015St.Baldrick's Fellowship Grant , St. Baldrick's Foundation
    2012 - 2014Hyundai Hope on Wheels Fellow, Hyundai Hope on Wheels Foundation
    2016 - 2017Young Investigator Award, American Society of Pediatric Hematology-Oncology
    2017 - 2018Young Investigator Award, Rally Foundation
    2017 - 2019Hyundai Scholar Award - Young Investigator, Hyundai Hope on Wheels foundation
    2017 - 2020Scholar Award, St.Baldrick's Foundation

    Collapse Overview 
    Collapse overview
    Dr.Gowda is a board certified Hematologist/Oncologist since 2013 who has strong commitment to research in childhood cancer including leukemia and neuroblastoma. Her major research project is to study Role of Ikaros tumor suppressor and pro-oncogenic casein Kinase II(CK2) in leukemogenesis and drug resistance. Dr.Gowda's current work is focused on targeting CK2 for treatment of hematological malignancies. Her most notable work published in 'Blood' in 2015 established for the first time,novel approach of using specific CK2 inhibitors for treatment of high risk B cell lineage leukemia using PDX models. She has presented her work at various national and international scientific forums and gained national recognition as outstanding 'Young Investigator'. Dr.Gowda’s research is currently supported by several extramural grants. She has also authored several chapters and review articles related to leukemia, CK2 and Ikaros. Her other projects are focused on designing novel therapeutic strategies for treatment of high risk neuroblastoma, which is the most common abdominal solid tumor in young children with poor prognosis.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gowda C, Soliman M, Kapadia M, Ding Y, Payne K, Dovat S. Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia. Adv Biol Regul. 2017 08; 65:16-25. PMID: 28623166.
      View in: PubMed
    2. Gowda C, Song C, Kapadia M, Payne JL, Hu T, Ding Y, Dovat S. Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros. Adv Biol Regul. 2017 Jan; 63:71-80. PMID: 27666503.
      View in: PubMed
    3. Gowda CS, Song C, Ding Y, Kapadia M, Dovat S. Protein signaling and regulation of gene transcription in leukemia: role of the Casein Kinase II-Ikaros axis. J Investig Med. 2016 Mar; 64(3):735-9. PMID: 26912004.
      View in: PubMed
    4. Wang H, Song C, Ding Y, Pan X, Ge Z, Tan BH, Gowda C, Sachdev M, Muthusami S, Ouyang H, Lai L, Francis OL, Morris CL, Abdel-Azim H, Dorsam G, Xiang M, Payne KJ, Dovat S. Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia. J Biol Chem. 2016 Feb 19; 291(8):4004-18. PMID: 26655717; PMCID: PMC4759178 [Available on 02/19/17].
    5. Song C, Pan X, Ge Z, Gowda C, Ding Y, Li H, Li Z, Yochum G, Muschen M, Li Q, Payne KJ, Dovat S. Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia. Leukemia. 2016 Jun; 30(6):1436-40. PMID: 26639180; PMCID: PMC4889471.
    6. Chandrika Gowda · Olivia L. Francis · Yali Ding · Parveen Shiraz · Kimberly J. Payne · Sinisa Dovat. Leukemias- Updates and New Insights, Edited by Margarita Guenova and Gueorgui Balatzenko(Ed.), ISBN: 978-953-51-2202-9, InTech, DOI: 10.5772/61247. Chapter: Pediatric High Risk Leukemia - Molecular Insights. 2015.
    7. Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S. Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. Blood. 2015 Oct 08; 126(15):1813-22. PMID: 26219304; PMCID: PMC4600018.
    8. Gowda C, Dovat S. Genetic targets in pediatric acute lymphoblastic leukemia. Adv Exp Med Biol. 2013; 779:327-40. PMID: 23288647.
      View in: PubMed
    9. Noone ML, Sinha S, Taly AB, Chandrika S. Periodic lateralized epileptiform discharges in neurosyphilis. Epilepsia. 2007 Feb; 48(2):390-3. PMID: 17295636.
      View in: PubMed
    10. Sinisa Dovat, Chandrika Gowda, Chunhua Song, Mansi Sachdev. Medical Reviews. MD-Medical Data 2013;5(1): 043-048 UDK: 616.155.392:577.2. Signal Transduction and Gene expression in Leukemia.
    11. Gowda, C., Song, C., Ding, Y., Muthusami, S., Pan, X., Desai, D., ... & Dovat, S. Cancer Research,75(15 Supplement), 2159-2159. Ikaros and Casein kinase II (CK2) regulate PI3K pathway in pediatric leukemia.
    12. Gowda, Chandrika, Sunil Muthusami, Dhimant Desai, Shantu Amin, Kimberly Payne, and Sinisa Dovat. "REGULATION OF PI3K PATHWAY BY IKAROS AND CASEIN KINASE II (CK2) IN PEDIATRIC LEUKEMIA." PEDIATRIC BLOOD & CANCER 62 (2015): 85-86.
    13. Gowda, Chandrika S., Chunhua Song, Sunil Muthusami, Yali Ding, Mansi Sachdev, Kimberly Payne, and Sinisa Dovat. "Restoring Ikaros Function in Leukemia: Casein Kinase II (CK2) Inhibition Restores Ikaros Tumor Supressor Function and Shows Theraputic Efficacy in Preclinical Models of High Risk Pediatric Leukemia." Blood 124, no. 21 (2014): 3712-3712.
    14. Gowda, Chandrika, Chunhua Song, Mansi Sachdev, Xiaokang Pan, Yali Ding, Kimberley Payne, and Sinisa Dovat. "Casein kinase II inhibitors regulate cell cycle progression in leukemia." Cancer Research 74, no. 19 Supplement (2014): 2632-2632.
    15. Gowda, Chandrika, Chunhua Song, Mansi Sachdev, Kimberly Payne, and Sinisa Dovat. "THERAPEUTIC EFFICACY OF CK2 INHIBITION IS MEDIATED VIA ENHANCED IKAROS FUNCTION IN A PRECLINICAL LEUKEMIA MODEL." PEDIATRIC BLOOD & CANCER 60 (2013): S1-S1.
    16. Gowda, Chandrika, Chunhua Song, Xiaokang Pan, Mansi Sachdev, Kimberly Payne, and Sinisa Dovat. "REGULATION OF CELL CYCLE PROGRESSION BY CASEIN KINASE II (CKII) VIA IKAROS AND ROLE OF CKII INHIBITORS IN LEUKEMIA." PEDIATRIC BLOOD & CANCER 61 (2014): S25-S25.
    17. Gowda, Chandrika, Chunhua Song, Kimberly Payne, and Sinisa Dovat. "INHIBITION OF PROTEIN KINASE CK2 SENSITIZES LEUKEMIA CELLS TO CHEMOTHERAPY BY INCREASING THE TUMOR SUPPRESSOR ACTIVITY OF IKAROS." PEDIATRIC BLOOD & CANCER 58, no. 7 (2012): 1014-1014.
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