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Mohamed Trebak

TitleProfessor
InstitutionCollege of Medicine
DepartmentCellular and Molecular Physiology
Address500 University Drive Hershey, PA 17033
Phone717-531-8152
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    Collapse Overview 
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    PREFERRED TITLE/ROLE:

    Professor of Cellular and Molecular Physiology


    EDUCATION:

    Ph.D., University of Liege, Belgium, 1998
    Postdoctoral Training, The Wistar Institute, Philadelphia PA, 2000
    Postdoctoral Training, The National Institutes of Health (NIEHS) NC, 2006

    NARRATIVE:

    The overall goal of my laboratory is to investigate the activation mechanisms of ion channels and their contribution to pathophysiology using animal models of disease. Our work is centered on the role of STIM/Orai Ca2+ channels and Transient Receptor Potential (TRP) cation channels in the processes of survival, proliferation and migration in cancer and pathological remodeling of airways and vessels. Our in vivo studies are complemented by the use of a variety of molecular, biochemical, biophysical and imaging techniques to gain mechanistic insights into regulation of these ion channels by various signaling pathways under native conditions of expression and the effector proteins and transcription factors that are activated downstream of these calcium entry channels.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Verkhratsky A, Trebak M, Perocchi F, Khananshvili D, Sekler I. Crosslink between calcium and sodium signalling. Exp Physiol. 2017 Dec 06. PMID: 29210126.
      View in: PubMed
    2. Trebak M, Putney JW. ORAI Calcium Channels. Physiology (Bethesda). 2017 Jul; 32(4):332-342. PMID: 28615316.
      View in: PubMed
    3. Hanes CM, D'Amico AE, Ueyama T, Wong AC, Zhang X, Hynes WF, Barroso MM, Cady NC, Trebak M, Saito N, Lennartz MR. Golgi-Associated Protein Kinase C-e Is Delivered to Phagocytic Cups: Role of Phosphatidylinositol 4-Phosphate. J Immunol. 2017 Jul 01; 199(1):271-277. PMID: 28539432.
      View in: PubMed
    4. Ben-Kasus Nissim T, Zhang X, Elazar A, Roy S, Stolwijk JA, Zhou Y, Motiani RK, Gueguinou M, Hempel N, Hershfinkel M, Gill DL, Trebak M, Sekler I. Mitochondria control store-operated Ca2+ entry through Na+ and redox signals. EMBO J. 2017 03 15; 36(6):797-815. PMID: 28219928.
      View in: PubMed
    5. Hempel N, Trebak M. Crosstalk between calcium and reactive oxygen species signaling in cancer. Cell Calcium. 2017 May; 63:70-96. PMID: 28143649.
      View in: PubMed
    6. Tanwar J, Trebak M, Motiani RK. Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders. Adv Exp Med Biol. 2017; 993:425-452. PMID: 28900927.
      View in: PubMed
    7. Zhou Y, Cai X, Loktionova NA, Wang X, Nwokonko RM, Wang X, Wang Y, Rothberg BS, Trebak M, Gill DL. The STIM1-binding site nexus remotely controls Orai1 channel gating. Nat Commun. 2016 Dec 08; 7:13725. PMID: 27929067.
      View in: PubMed
    8. Cai X, Zhou Y, Nwokonko RM, Loktionova NA, Wang X, Xin P, Trebak M, Wang Y, Gill DL. The Orai1 Store-operated Calcium Channel Functions as a Hexamer. J Biol Chem. 2016 Dec 09; 291(50):25764-25775. PMID: 27780862.
      View in: PubMed
    9. Stolwijk JA, Zhang X, Gueguinou M, Zhang W, Matrougui K, Renken C, Trebak M. Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function. J Biol Chem. 2016 10 28; 291(44):22894-22912. PMID: 27624938.
      View in: PubMed
    10. Kassan M, Ait-Aissa K, Radwan E, Mali V, Haddox S, Gabani M, Zhang W, Belmadani S, Irani K, Trebak M, Matrougui K. Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1900-9. PMID: 27470514.
      View in: PubMed
    11. Wang H, Zhang X, Xue L, Xing J, Jouvin MH, Putney JW, Anderson MP, Trebak M, Kinet JP. Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles. Immunity. 2016 Apr 19; 44(4):782-94. PMID: 27037192.
      View in: PubMed
    12. Zhang X, Spinelli AM, Masiello T, Trebak M. Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca(2+)) Permeable Non-selective Cation Channel. Adv Exp Med Biol. 2016; 898:251-64. PMID: 27161232.
      View in: PubMed
    13. Spinelli AM, Trebak M. Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle. Am J Physiol Cell Physiol. 2016 Mar 15; 310(6):C402-13. PMID: 26718630; PMCID: PMC4796280 [Available on 03/15/17].
    14. Shakerley NL, Chandrasekaran A, Trebak M, Miller BA, Melendez JA. Francisella tularensis Catalase Restricts Immune Function by Impairing TRPM2 Channel Activity. J Biol Chem. 2016 Feb 19; 291(8):3871-81. PMID: 26679996; PMCID: PMC4759167 [Available on 02/19/17].
    15. Hooper R, Zhang X, Webster M, Go C, Kedra J, Marchbank K, Gill DL, Weeraratna AT, Trebak M, Soboloff J. Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma. Mol Cell Biol. 2015 Aug; 35(16):2790-8. PMID: 26055321; PMCID: PMC4508319.
    16. Desai PN, Zhang X, Wu S, Janoshazi A, Bolimuntha S, Putney JW, Trebak M. Multiple types of calcium channels arising from alternative translation initiation of the Orai1 message. Sci Signal. 2015 Jul 28; 8(387):ra74. PMID: 26221052; PMCID: PMC4583604.
    17. Spinelli AM, Liu Y, Sun LY, González-Cobos JC, Backs J, Trebak M, Singer HA. Smooth muscle CaMKIId promotes allergen-induced airway hyperresponsiveness and inflammation. Pflugers Arch. 2015 Dec; 467(12):2541-54. PMID: 26089028; PMCID: PMC4651734 [Available on 12/01/16].
    18. Beardslee LA, Stolwijk J, Khaladj DA, Trebak M, Halman J, Torrejon KY, Niamsiri N, Bergkvist M. A sacrificial process for fabrication of biodegradable polymer membranes with submicron thickness. J Biomed Mater Res B Appl Biomater. 2016 08; 104(6):1192-201. PMID: 26079689.
      View in: PubMed
    19. Kassan M, Ait-Aissa K, Ali M, Trebak M, Matrougui K. Augmented EGF receptor tyrosine kinase activity impairs vascular function by NADPH oxidase-dependent mechanism in type 2 diabetic mouse. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt A):2404-10. PMID: 26036345; PMCID: PMC4855834 [Available on 10/01/16].
    20. Vashisht A, Trebak M, Motiani RK. STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis. Am J Physiol Cell Physiol. 2015 Oct 01; 309(7):C457-69. PMID: 26017146; PMCID: PMC4593768 [Available on 10/01/16].
    21. Zhou Y, Trebak M, Gill DL. Calcium signals tune the fidelity of transcriptional responses. Mol Cell. 2015 Apr 16; 58(2):197-9. PMID: 25884365; PMCID: PMC4743736.
    22. Kassan M, Choi SK, Galán M, Trebak M, Belmadani S, Matrougui K. Nuclear factor kappa B inhibition improves conductance artery function in type 2 diabetic mice. Diabetes Metab Res Rev. 2015 Jan; 31(1):39-49. PMID: 24652705; PMCID: PMC4829069.
    23. Stolwijk JA, Matrougui K, Renken CW, Trebak M. Impedance analysis of GPCR-mediated changes in endothelial barrier function: overview and fundamental considerations for stable and reproducible measurements. Pflugers Arch. 2015 Oct; 467(10):2193-218. PMID: 25537398; PMCID: PMC4480219 [Available on 10/01/16].
    24. Zhang W, Zhang X, González-Cobos JC, Stolwijk JA, Matrougui K, Trebak M. Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia. J Biol Chem. 2015 Feb 20; 290(8):5015-27. PMID: 25540197; PMCID: PMC4335238.
    25. Zhang W, Trebak M. Vascular balloon injury and intraluminal administration in rat carotid artery. J Vis Exp. 2014 Dec 23; (94). PMID: 25548998; PMCID: PMC4354472.
    26. Saliba Y, Keck M, Marchand A, Atassi F, Ouillé A, Cazorla O, Trebak M, Pavoine C, Lacampagne A, Hulot JS, Farès N, Fauconnier J, Lompré AM. Emergence of Orai3 activity during cardiac hypertrophy. Cardiovasc Res. 2015 Mar 01; 105(3):248-59. PMID: 25213556; PMCID: PMC4351368.
    27. Kassan M, Zhang W, Aissa KA, Stolwijk J, Trebak M, Matrougui K. Differential role for stromal interacting molecule 1 in the regulation of vascular function. Pflugers Arch. 2015 Jun; 467(6):1195-202. PMID: 24965067; PMCID: PMC4843990.
    28. Zhang X, Zhang W, González-Cobos JC, Jardin I, Romanin C, Matrougui K, Trebak M. Complex role of STIM1 in the activation of store-independent Orai1/3 channels. J Gen Physiol. 2014 Mar; 143(3):345-59. PMID: 24567509; PMCID: PMC3933941.
    29. Galán M, Kassan M, Kadowitz PJ, Trebak M, Belmadani S, Matrougui K. Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction. Biochim Biophys Acta. 2014 Jun; 1843(6):1063-75. PMID: 24576409; PMCID: PMC4086191.
    30. Kassan M, Choi SK, Galán M, Lee YH, Trebak M, Matrougui K. Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 2014 Apr 01; 306(7):H972-80. PMID: 24486509; PMCID: PMC3962637.
    31. Zhang X, Trebak M. Transient receptor potential canonical 7: a diacylglycerol-activated non-selective cation channel. Handb Exp Pharmacol. 2014; 222:189-204. PMID: 24756707; PMCID: PMC4838195.
    32. Kassan M, Wecker A, Kadowitz P, Trebak M, Matrougui K. CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension. J Hypertens. 2013 Oct; 31(10):1939-43. PMID: 23881298; PMCID: PMC3915504.
    33. McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA. Redox control of the senescence regulator interleukin-1a and the secretory phenotype. J Biol Chem. 2013 Nov 08; 288(45):32149-59. PMID: 24062309; PMCID: PMC3820855.
    34. Rodríguez-Moyano M, Díaz I, Dionisio N, Zhang X, Avila-Medina J, Calderón-Sánchez E, Trebak M, Rosado JA, Ordóñez A, Smani T. Urotensin-II promotes vascular smooth muscle cell proliferation through store-operated calcium entry and EGFR transactivation. Cardiovasc Res. 2013 Nov 01; 100(2):297-306. PMID: 23933581; PMCID: PMC3797630.
    35. Zhang X, González-Cobos JC, Schindl R, Muik M, Ruhle B, Motiani RK, Bisaillon JM, Zhang W, Fahrner M, Barroso M, Matrougui K, Romanin C, Trebak M. Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels. Mol Cell Biol. 2013 Sep; 33(18):3715-23. PMID: 23878392; PMCID: PMC3753864.
    36. Motiani RK, Stolwijk JA, Newton RL, Zhang X, Trebak M. Emerging roles of Orai3 in pathophysiology. Channels (Austin). 2013 Sep-Oct; 7(5):392-401. PMID: 23695829; PMCID: PMC3913762.
    37. Wood TR, Chow RY, Hanes CM, Zhang X, Kashiwagi K, Shirai Y, Trebak M, Loegering DJ, Saito N, Lennartz MR. PKC-e pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis. J Leukoc Biol. 2013 Jul; 94(1):109-22. PMID: 23670290; PMCID: PMC3685018.
    38. Trebak M, Zhang W, Ruhle B, Henkel MM, González-Cobos JC, Motiani RK, Stolwijk JA, Newton RL, Zhang X. What role for store-operated Ca²? entry in muscle? Microcirculation. 2013 May; 20(4):330-6. PMID: 23312019; PMCID: PMC3646967.
    39. McCarthy DA, Ranganathan A, Subbaram S, Flaherty NL, Patel N, Trebak M, Hempel N, Melendez JA. Redox-control of the alarmin, Interleukin-1a. Redox Biol. 2013; 1:218-25. PMID: 24024155; PMCID: PMC3757693.
    40. Motiani RK, Hyzinski-García MC, Zhang X, Henkel MM, Abdullaev IF, Kuo YH, Matrougui K, Mongin AA, Trebak M. STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion. Pflugers Arch. 2013 Sep; 465(9):1249-60. PMID: 23515871; PMCID: PMC3748246.
    41. Shinde AV, Motiani RK, Zhang X, Abdullaev IF, Adam AP, González-Cobos JC, Zhang W, Matrougui K, Vincent PA, Trebak M. STIM1 controls endothelial barrier function independently of Orai1 and Ca2+ entry. Sci Signal. 2013 Mar 19; 6(267):ra18. PMID: 23512989; PMCID: PMC4030669.
    42. Merlet E, Atassi F, Motiani RK, Mougenot N, Jacquet A, Nadaud S, Capiod T, Trebak M, Lompré AM, Marchand A. miR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat. Cardiovasc Res. 2013 Jun 01; 98(3):458-68. PMID: 23447642; PMCID: PMC3656613.
    43. González-Cobos JC, Zhang X, Zhang W, Ruhle B, Motiani RK, Schindl R, Muik M, Spinelli AM, Bisaillon JM, Shinde AV, Fahrner M, Singer HA, Matrougui K, Barroso M, Romanin C, Trebak M. Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia. Circ Res. 2013 Mar 29; 112(7):1013-25. PMID: 23349245; PMCID: PMC3658112.
    44. Kassan M, Choi SK, Galán M, Bishop A, Umezawa K, Trebak M, Belmadani S, Matrougui K. Enhanced NF-?B activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes. Diabetes. 2013 Jun; 62(6):2078-87. PMID: 23349490; PMCID: PMC3661639.
    45. Ruhle B, Trebak M. Emerging roles for native Orai Ca2+ channels in cardiovascular disease. Curr Top Membr. 2013; 71:209-35. PMID: 23890117.
      View in: PubMed
    46. Amin A, Choi SK, Osman-Elazeik Y, Badr El-Din NK, Kevil CG, Navar LG, Kadowitz P, Trebak M, Matrougui K. Sodium nitrite therapy rescues ischemia-induced neovascularization and blood flow recovery in hypertension. Pflugers Arch. 2012 Dec; 464(6):583-92. PMID: 23053479; PMCID: PMC3514594.
    47. Spinelli AM, González-Cobos JC, Zhang X, Motiani RK, Rowan S, Zhang W, Garrett J, Vincent PA, Matrougui K, Singer HA, Trebak M. Airway smooth muscle STIM1 and Orai1 are upregulated in asthmatic mice and mediate PDGF-activated SOCE, CRAC currents, proliferation, and migration. Pflugers Arch. 2012 Nov; 464(5):481-92. PMID: 23014880; PMCID: PMC3489062.
    48. Motiani RK, Zhang X, Harmon KE, Keller RS, Matrougui K, Bennett JA, Trebak M. Orai3 is an estrogen receptor a-regulated Ca²? channel that promotes tumorigenesis. FASEB J. 2013 Jan; 27(1):63-75. PMID: 22993197; PMCID: PMC3528310.
    49. Wang X, Hu G, Gao X, Wang Y, Zhang W, Harmon EY, Zhi X, Xu Z, Lennartz MR, Barroso M, Trebak M, Chen C, Zhou J. The induction of yes-associated protein expression after arterial injury is crucial for smooth muscle phenotypic modulation and neointima formation. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2662-9. PMID: 22922963; PMCID: PMC3475752.
    50. Oulès B, Del Prete D, Greco B, Zhang X, Lauritzen I, Sevalle J, Moreno S, Paterlini-Bréchot P, Trebak M, Checler F, Benfenati F, Chami M. Ryanodine receptor blockade reduces amyloid-ß load and memory impairments in Tg2576 mouse model of Alzheimer disease. J Neurosci. 2012 Aug 22; 32(34):11820-34. PMID: 22915123; PMCID: PMC3458216.
    51. Galán M, Kassan M, Choi SK, Partyka M, Trebak M, Henrion D, Matrougui K. A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus. Hypertension. 2012 Jul; 60(1):71-80. PMID: 22665120; PMCID: PMC3915519.
    52. Trebak M. STIM/Orai signalling complexes in vascular smooth muscle. J Physiol. 2012 Sep 01; 590(17):4201-8. PMID: 22641780; PMCID: PMC3473279.
    53. Kassan M, Galán M, Partyka M, Saifudeen Z, Henrion D, Trebak M, Matrougui K. Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice. Arterioscler Thromb Vasc Biol. 2012 Jul; 32(7):1652-61. PMID: 22539597.
      View in: PubMed
    54. Choi SK, Galán M, Kassan M, Partyka M, Trebak M, Matrougui K. Poly(ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus. Hypertension. 2012 May; 59(5):1060-8. PMID: 22454481; PMCID: PMC3331962.
    55. Trebak M, Parekh AB. Ion channels in patho-physiology. J Physiol. 2012 Mar 15; 590(6):1347. PMID: 22422116; PMCID: PMC3382325.
    56. Amin A, Choi SK, Galan M, Kassan M, Partyka M, Kadowitz P, Henrion D, Trebak M, Belmadani S, Matrougui K. Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice. J Pathol. 2012 Jun; 227(2):165-74. PMID: 22081301; PMCID: PMC3915506.
    57. Trebak M. PLC: Johnny-come-lately to ORAI and the ups and downs of calcium signalling. J Physiol. 2011 Nov 15; 589(Pt 22):5337-8. PMID: 22086246; PMCID: PMC3240871.
    58. Choi SK, Galán M, Partyka M, Trebak M, Belmadani S, Matrougui K. Chronic inhibition of epidermal growth factor receptor tyrosine kinase and extracellular signal-regulated kinases 1 and 2 (ERK1/2) augments vascular response to limb ischemia in type 2 diabetic mice. Am J Pathol. 2012 Jan; 180(1):410-8. PMID: 22067908; PMCID: PMC3338339.
    59. Kassan M, Galan M, Partyka M, Trebak M, Matrougui K. Interleukin-10 released by CD4(+)CD25(+) natural regulatory T cells improves microvascular endothelial function through inhibition of NADPH oxidase activity in hypertensive mice. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2534-42. PMID: 21817097; PMCID: PMC3571694.
    60. Balghi H, Robert R, Rappaz B, Zhang X, Wohlhuter-Haddad A, Evagelidis A, Luo Y, Goepp J, Ferraro P, Roméo P, Trebak M, Wiseman PW, Thomas DY, Hanrahan JW. Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways. FASEB J. 2011 Dec; 25(12):4274-91. PMID: 21873556; PMCID: PMC3236623.
    61. Zhang W, Trebak M. STIM1 and Orai1: novel targets for vascular diseases? Sci China Life Sci. 2011 Aug; 54(8):780-5. PMID: 21786201; PMCID: PMC3164553.
    62. Zhang W, Halligan KE, Zhang X, Bisaillon JM, Gonzalez-Cobos JC, Motiani RK, Hu G, Vincent PA, Zhou J, Barroso M, Singer HA, Matrougui K, Trebak M. Orai1-mediated I (CRAC) is essential for neointima formation after vascular injury. Circ Res. 2011 Aug 19; 109(5):534-42. PMID: 21737791; PMCID: PMC3164514.
    63. Gonzalez-Cobos JC, Trebak M. TRPC channels in smooth muscle cells. Front Biosci (Landmark Ed). 2010 Jun 01; 15:1023-39. PMID: 20515740; PMCID: PMC3164555.
    64. Wang Z, Ginnan R, Abdullaev IF, Trebak M, Vincent PA, Singer HA. Calcium/Calmodulin-dependent protein kinase II delta 6 (CaMKIIdelta6) and RhoA involvement in thrombin-induced endothelial barrier dysfunction. J Biol Chem. 2010 Jul 09; 285(28):21303-12. PMID: 20442409; PMCID: PMC2898399.
    65. Motiani RK, Abdullaev IF, Trebak M. A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells. J Biol Chem. 2010 Jun 18; 285(25):19173-83. PMID: 20395295; PMCID: PMC2885196.
    66. Trebak M, Ginnan R, Singer HA, Jourd'heuil D. Interplay between calcium and reactive oxygen/nitrogen species: an essential paradigm for vascular smooth muscle signaling. Antioxid Redox Signal. 2010 Mar 01; 12(5):657-74. PMID: 19719386; PMCID: PMC2861541.
    67. Bisaillon JM, Motiani RK, Gonzalez-Cobos JC, Potier M, Halligan KE, Alzawahra WF, Barroso M, Singer HA, Jourd'heuil D, Trebak M. Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration. Am J Physiol Cell Physiol. 2010 May; 298(5):C993-1005. PMID: 20107038; PMCID: PMC2867390.
    68. Trebak M. The puzzling role of TRPC3 channels in motor coordination. Pflugers Arch. 2010 Feb; 459(3):369-75. PMID: 19823866; PMCID: PMC3164554.
    69. Trebak M. STIM1/Orai1, ICRAC, and endothelial SOC. Circ Res. 2009 May 08; 104(9):e56-7. PMID: 19423858; PMCID: PMC3164852.
    70. Potier M, Gonzalez JC, Motiani RK, Abdullaev IF, Bisaillon JM, Singer HA, Trebak M. Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration. FASEB J. 2009 Aug; 23(8):2425-37. PMID: 19364762; PMCID: PMC2717784.
    71. Zayed N, Afif H, Chabane N, Mfuna-Endam L, Benderdour M, Martel-Pelletier J, Pelletier JP, Motiani RK, Trebak M, Duval N, Fahmi H. Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2. Arthritis Rheum. 2008 Nov; 58(11):3530-40. PMID: 18975308; PMCID: PMC2657141.
    72. Abdullaev IF, Bisaillon JM, Potier M, Gonzalez JC, Motiani RK, Trebak M. Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation. Circ Res. 2008 Nov 21; 103(11):1289-99. PMID: 18845811; PMCID: PMC2682347.
    73. Trebak M, Lemonnier L, DeHaven WI, Wedel BJ, Bird GS, Putney JW. Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels. Pflugers Arch. 2009 Feb; 457(4):757-69. PMID: 18665391.
      View in: PubMed
    74. Potier M, Trebak M. New developments in the signaling mechanisms of the store-operated calcium entry pathway. Pflugers Arch. 2008 Nov; 457(2):405-15. PMID: 18536932; PMCID: PMC2585609.
    75. House SJ, Potier M, Bisaillon J, Singer HA, Trebak M. The non-excitable smooth muscle: calcium signaling and phenotypic switching during vascular disease. Pflugers Arch. 2008 Aug; 456(5):769-85. PMID: 18365243; PMCID: PMC2531252.
    76. Lemonnier L, Trebak M, Putney JW. Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate. Cell Calcium. 2008 May; 43(5):506-14. PMID: 17942152.
      View in: PubMed
    77. Trebak M, Lemonnier L, Smyth JT, Vazquez G, Putney JW. Phospholipase C-coupled receptors and activation of TRPC channels. Handb Exp Pharmacol. 2007; (179):593-614. PMID: 17217081.
      View in: PubMed
    78. Trebak M. Canonical transient receptor potential channels in disease: targets for novel drug therapy? Drug Discov Today. 2006 Oct; 11(19-20):924-30. PMID: 16997143.
      View in: PubMed
    79. Smyth JT, Dehaven WI, Jones BF, Mercer JC, Trebak M, Vazquez G, Putney JW. Emerging perspectives in store-operated Ca2+ entry: roles of Orai, Stim and TRP. Biochim Biophys Acta. 2006 Nov; 1763(11):1147-60. PMID: 17034882.
      View in: PubMed
    80. Lemonnier L, Trebak M, Lievremont JP, Bird GS, Putney JW. Protection of TRPC7 cation channels from calcium inhibition by closely associated SERCA pumps. FASEB J. 2006 Mar; 20(3):503-5. PMID: 16401641.
      View in: PubMed
    81. Lievremont JP, Numaga T, Vazquez G, Lemonnier L, Hara Y, Mori E, Trebak M, Moss SE, Bird GS, Mori Y, Putney JW. The role of canonical transient receptor potential 7 in B-cell receptor-activated channels. J Biol Chem. 2005 Oct 21; 280(42):35346-51. PMID: 16123040.
      View in: PubMed
    82. Vazquez G, Wedel BJ, Aziz O, Trebak M, Putney JW. The mammalian TRPC cation channels. Biochim Biophys Acta. 2004 Dec 06; 1742(1-3):21-36. PMID: 15590053.
      View in: PubMed
    83. Trebak M, Hempel N, Wedel BJ, Smyth JT, Bird GS, Putney JW. Negative regulation of TRPC3 channels by protein kinase C-mediated phosphorylation of serine 712. Mol Pharmacol. 2005 Feb; 67(2):558-63. PMID: 15533987.
      View in: PubMed
    84. Bird GS, Aziz O, Lievremont JP, Wedel BJ, Trebak M, Vazquez G, Putney JW. Mechanisms of phospholipase C-regulated calcium entry. Curr Mol Med. 2004 May; 4(3):291-301. PMID: 15101686.
      View in: PubMed
    85. Putney JW, Trebak M, Vazquez G, Wedel B, Bird GS. Signalling mechanisms for TRPC3 channels. Novartis Found Symp. 2004; 258:123-33; discussion 133-9, 155-9, 263-6. PMID: 15104179.
      View in: PubMed
    86. Trebak M, Vazquez G, Bird GS, Putney JW. The TRPC3/6/7 subfamily of cation channels. Cell Calcium. 2003 May-Jun; 33(5-6):451-61. PMID: 12765690.
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    87. Vazquez G, Wedel BJ, Trebak M, St John Bird G, Putney JW. Expression level of the canonical transient receptor potential 3 (TRPC3) channel determines its mechanism of activation. J Biol Chem. 2003 Jun 13; 278(24):21649-54. PMID: 12686562.
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    88. Trebak M, St J Bird G, McKay RR, Birnbaumer L, Putney JW. Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels. J Biol Chem. 2003 May 02; 278(18):16244-52. PMID: 12606542.
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    89. Trebak M, Bird GS, McKay RR, Putney JW. Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel composition. J Biol Chem. 2002 Jun 14; 277(24):21617-23. PMID: 11943785.
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    90. Rahmouni S, Aandahl EM, Trebak M, Boniver J, Taskén K, Moutschen M. Increased cAMP levels and protein kinase (PKA) type I activation in CD4+ T cells and B cells contribute to retrovirus-induced immunodeficiency of mice (MAIDS): a useful in vivo model for drug testing. FASEB J. 2001 Jun; 15(8):1466-8. PMID: 11387259.
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    91. Trebak M, Begg GE, Chong JM, Kanazireva EV, Herlyn D, Speicher DW. Oligomeric state of the colon carcinoma-associated glycoprotein GA733-2 (Ep-CAM/EGP40) and its role in GA733-mediated homotypic cell-cell adhesion. J Biol Chem. 2001 Jan 19; 276(3):2299-309. PMID: 11058587.
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    92. Trebak M, Chong JM, Herlyn D, Speicher DW. Efficient laboratory-scale production of monoclonal antibodies using membrane-based high-density cell culture technology. J Immunol Methods. 1999 Nov 19; 230(1-2):59-70. PMID: 10594354.
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    93. Trebak M, Lambert CA, Rahmouni S, Greimers R, Boniver J, Moutschen M. Reciprocal regulation of protein tyrosine kinases p56lck and p59fyn, and altered tyrosine phosphorylation in murine AIDS. Int Immunol. 1998 Oct; 10(10):1473-80. PMID: 9796914.
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    94. Trebak M, Lambert CA, Rahmouni S, Debrus S, Defresne MP, Regnier D, Boniver J, Moutschen M. Decreased protein levels of the c-Cbl protooncogene in murine AIDS. Cell Immunol. 1998 Sep 15; 188(2):151-7. PMID: 9756645.
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    95. Colombi S, Moutschen M, de Leval L, Demoitié MA, Trebak M, Martin MT, Boniver J. Peyer's patches in murine AIDS: dissociation between lymphoproliferation and anergy. Scand J Immunol. 1997 Feb; 45(2):175-81. PMID: 9042430.
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    96. Moutschen M, Trebak M, Greimers R, Colombi S, Boniver J. Subset-specific analysis of calcium fluxes in murine AIDS. Int Immunol. 1996 Nov; 8(11):1715-27. PMID: 8943566.
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    97. Jacobs N, Greimers R, Mazzoni A, Trebak M, Schaaf-Lafontaine N, Boniver J, Moutschen MP. Further characterization of cytotoxic T cells generated by short-term culture of human peripheral blood lymphocytes with interleukin-2 and anti-CD3 mAb. Cancer Immunol Immunother. 1996 Jul; 42(6):369-75. PMID: 8830741.
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    98. Greimers R, Trebak M, Moutschen M, Jacobs N, Boniver J. Improved four-color flow cytometry method using fluo-3 and triple immunofluorescence for analysis of intracellular calcium ion ([Ca2+]i) fluxes among mouse lymph node B- and T-lymphocyte subsets. Cytometry. 1996 Mar 01; 23(3):205-17. PMID: 8974866.
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