PSU Profiles
Last Name

Hong Zheng

TitleAssistant Professor
InstitutionCollege of Medicine
Address500 University Drive Hershey, PA 17033
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    Fellowship, Hematology/Oncology, Yale University, 2013
    Residency, Internal Medicine, Penn State Milton S. Hershey Medical Center, 2010
    Ph.D., Immunology, University of Connecticut Health Center, 2003
    M.D., Clinical Medicine, Capital University of Medical Sciences,1995

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jia B, Wang L, Claxton DF, Ehmann WC, Rybka WB, Mineishi S, Rizvi S, Shike H, Bayerl M, Schell TD, Hohl RJ, Zheng H. Bone marrow CD8 T cells express high frequency of PD-1 and exhibit reduced anti-leukemia response in newly diagnosed AML patients. Blood Cancer J. 2018 Mar 21; 8(3):34. PMID: 29563517.
      View in: PubMed
    2. Song Y, Wang B, Song R, Hao Y, Wang D, Li Y, Jiang Y, Xu L, Ma Y, Zheng H, Kong Y, Zeng H. T-cell Immunoglobulin and ITIM Domain Contributes to CD8+ T-cell Immunosenescence. Aging Cell. 2018 Apr; 17(2). PMID: 29349889.
      View in: PubMed
    3. Zhu L, Liu L, Zhang Y, Pu L, Liu J, Li X, Chen Z, Hao Y, Wang B, Han J, Li G, Liang S, Xiong H, Zheng H, Li A, Xu J, Zeng H. High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection. J Infect Dis. 2018 Jan 17; 217(3):428-437. PMID: 29325098.
      View in: PubMed
    4. Zhu L, Kong Y, Zhang J, Claxton DF, Ehmann WC, Rybka WB, Palmisiano ND, Wang M, Jia B, Bayerl M, Schell TD, Hohl RJ, Zeng H, Zheng H. Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia. J Hematol Oncol. 2017 Jun 19; 10(1):124. PMID: 28629373.
      View in: PubMed
    5. Hou P, Wu C, Wang Y, Qi R, Bhavanasi D, Zuo Z, Dos Santos C, Chen S, Chen Y, Zheng H, Wang H, Perl A, Guo D, Huang J. A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220. Cancer Res. 2017 Aug 15; 77(16):4402-4413. PMID: 28625976.
      View in: PubMed
    6. Ballard JO, Wyluda EJ, Zheng H, Creer MH. Unexpected Intravascular Hemolysis and Methemoglobinemia During Treatment for Lymphoma. American Journal of Medical Case Reports. 2016; 4:144-147.
    7. Zheng H, Liu X, Zhang J, Rice SJ, Wagman M, Kong Y, Zhu L, Zhu J, Joshi M, Belani CP. Expression of PD-1 on CD4+ T cells in peripheral blood associates with poor clinical outcome in non-small cell lung cancer. Oncotarget. 2016 Aug 30; 7(35):56233-56240. PMID: 27191652.
      View in: PubMed
    8. Rael E, Rakszawski K, Koller K, Bayerl M, Butte M, Zheng H. Treatment with rituximab and brentuximab vedotin in a patient of common variable immune deficiency-associated classic Hodgkin lymphoma. Biomark Res. 2016; 4:7. PMID: 26966541; PMCID: PMC4785670.
    9. Kong Y, Zhu L, Schell TD, Zhang J, Claxton DF, Ehmann WC, Rybka WB, George MR, Zeng H, Zheng H. T-Cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8+ T-Cell Exhaustion and Poor Clinical Outcome in AML Patients. Clin Cancer Res. 2016 Jun 15; 22(12):3057-66. PMID: 26763253.
      View in: PubMed
    10. Vasekar M, Rizvi S, Liu X, Vrana KE, Zheng H. Novel Immunotherapies for Hematological Malignancies. Curr Mol Pharmacol. 2016; 9(3):264-271. PMID: 26177640.
      View in: PubMed
    11. Kong Y, Zhang J, Claxton DF, Ehmann WC, Rybka WB, Zhu L, Zeng H, Schell TD, Zheng H. PD-1(hi)TIM-3(+) T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation. Blood Cancer J. 2015 Jul 31; 5:e330. PMID: 26230954; PMCID: PMC4526784.
    12. Vasekar M, Liu X, Zheng H, Belani CP. Targeted immunotherapy for non-small cell lung cancer. World J Clin Oncol. 2014 May 10; 5(2):39-47. PMID: 24829850; PMCID: PMC4014795.
    13. Li N, Matte-Martone C, Zheng H, Cui W, Venkatesan S, Tan HS, McNiff J, Demetris AJ, Roopenian D, Kaech S, Shlomchik WD. Memory T cells from minor histocompatibility antigen-vaccinated and virus-immune donors improve GVL and immune reconstitution. Blood. 2011 Nov 24; 118(22):5965-76. PMID: 21917752; PMCID: PMC3228506.
    14. Zheng H, Matte-Martone C, Jain D, McNiff J, Shlomchik WD. Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-leukemia. J Immunol. 2009 May 15; 182(10):5938-48. PMID: 19414745.
      View in: PubMed
    15. Anderson BE, Zheng H, Taylor PA, Matte-Martone C, McNiff JM, Jain D, Demetris AJ, Panoskaltsis-Mortari A, Ager A, Blazar BR, Shlomchik MJ, Shlomchik WD. Memory T cells in GVHD and GVL. Biol Blood Marrow Transplant. 2008 Jan; 14(1 Suppl 1):19-20. PMID: 19418622.
      View in: PubMed
    16. Zheng H, Matte-Martone C, Li H, Anderson BE, Venketesan S, Sheng Tan H, Jain D, McNiff J, Shlomchik WD. Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease. Blood. 2008 Feb 15; 111(4):2476-84. PMID: 18045967; PMCID: PMC2234071.
    17. Zheng H, Li Z. Cutting edge: cross-presentation of cell-associated antigens to MHC class I molecule is regulated by a major transcription factor for heat shock proteins. J Immunol. 2004 Nov 15; 173(10):5929-33. PMID: 15528326.
      View in: PubMed
    18. Liu B, Dai J, Zheng H, Stoilova D, Sun S, Li Z. Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15824-9. PMID: 14668429; PMCID: PMC307652.
    19. Zheng H, Benjamin IJ, Basu S, Li Z. Heat shock factor 1-independent activation of dendritic cells by heat shock: implication for the uncoupling of heat-mediated immunoregulation from the heat shock response. Eur J Immunol. 2003 Jun; 33(6):1754-62. PMID: 12778494.
      View in: PubMed
    20. Dai J, Liu B, Caudill MM, Zheng H, Qiao Y, Podack ER, Li Z. Cell surface expression of heat shock protein gp96 enhances cross-presentation of cellular antigens and the generation of tumor-specific T cell memory. Cancer Immun. 2003 Jan 28; 3:1. PMID: 12747743.
      View in: PubMed
    21. Li Z, Dai J, Zheng H, Liu B, Caudill M. An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response. Front Biosci. 2002 Mar 01; 7:d731-51. PMID: 11861214.
      View in: PubMed
    22. Zheng H, Dai J, Stoilova D, Li Z. Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunity. J Immunol. 2001 Dec 15; 167(12):6731-5. PMID: 11739487.
      View in: PubMed
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