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Judie Howrylak

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive Hershey, PA 17033
Phone717-531-4950
Fax717 531-4870
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    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Assistant Professor of Medicine, Public Health Sciences, and Biochemistry and Molecular Biology

    EDUCATION:

    Ph.D., Computational Biology, University of Pittsburgh/Carnegie Mellon University (2013)
    Fellowship, Pulmonary and Critical Care Medicine, Penn State Hershey Medical Center (2012)
    Residency, Internal Medicine, University of Pittsburgh Medical Center (2006)
    M.D., University of Michigan Medical School (2003)

    NARRATIVE:

    Dr. Howrylak’s research is focused on using integrative genomics approaches to refine the diagnosis and prognosis of inflammatory lung diseases, with a focus on Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS). Current projects involve combining gene expression analysis and genetic associations to identify genes and regulatory regions that contribute to the susceptibility and severity of ARDS.

    Dr. Howrylak is the primary investigator (PI) for the Penn State Hershey Medical Center Registry of Critical Illness (PSHMC RoCI), a research registry and bio-repository for the study of genetic and genomic risk factors for critical illness. She oversees the collection of biologic specimens from critically ill patients in the Intensive Care Unit (ICU), and the development of a clinical database of detailed phenotypes from several hundred critically ill patients.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lee S, Nakahira K, Dalli J, Siempos II, Norris PC, Colas RA, Moon JS, Shinohara M, Hisata S, Howrylak JA, Suh GY, Ryter SW, Serhan CN, Choi AMK. NLRP3 Inflammasome Deficiency Protects against Microbial Sepsis via Increased Lipoxin B4 Synthesis. Am J Respir Crit Care Med. 2017 09 15; 196(6):713-726. PMID: 28245134.
      View in: PubMed
    2. Howrylak JA, Nakahira K. Inflammasomes: Key Mediators of Lung Immunity. Annu Rev Physiol. 2017 Feb 10; 79:471-494. PMID: 28192059.
      View in: PubMed
    3. Marchetti-Bowick M, Yin J, Howrylak JA, Xing EP. A time-varying group sparse additive model for genome-wide association studies of dynamic complex traits. Bioinformatics. 2016 Oct 01; 32(19):2903-10. PMID: 27296983.
      View in: PubMed
    4. Van Scoy LJ, Reading JM, Howrylak JA, Tamhane A, Sherman MS. Low quality of dying and death in patients with septic shock as perceived by nurses and resident physicians. Death Stud. 2016 Sep; 40(8):486-493. PMID: 27192058.
      View in: PubMed
    5. Panganiban RP, Wang Y, Howrylak J, Chinchilli VM, Craig TJ, August A, Ishmael FT. Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma. J Allergy Clin Immunol. 2016 May; 137(5):1423-32. PMID: 27025347.
      View in: PubMed
    6. Howrylak JA, Moll M, Weiss ST, Raby BA, Wu W, Xing EP. Gene expression profiling of asthma phenotypes demonstrates molecular signatures of atopy and asthma control. J Allergy Clin Immunol. 2016 May; 137(5):1390-1397.e6. PMID: 26792209; PMCID: PMC4860055 [Available on 05/01/17].
    7. Moon JS, Lee S, Park MA, Siempos II, Haslip M, Lee PJ, Yun M, Kim CK, Howrylak J, Ryter SW, Nakahira K, Choi AM. UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J Clin Invest. 2015 Feb; 125(2):665-80. PMID: 25574840; PMCID: PMC4319445.
    8. Silveyra P, Chroneos ZC, DiAngelo SL, Thomas NJ, Noutsios GT, Tsotakos N, Howrylak JA, Umstead TM, Floros J. Knockdown of Drosha in human alveolar type II cells alters expression of SP-A in culture: a pilot study. Exp Lung Res. 2014 Sep; 40(7):354-66. PMID: 25058539; PMCID: PMC4197128.
    9. Van Scoy LJ, Howrylak J, Nguyen A, Chen M, Sherman M. Family structure, experiences with end-of-life decision making, and who asked about advance directives impacts advance directive completion rates. J Palliat Med. 2014 Oct; 17(10):1099-106. PMID: 25000276.
      View in: PubMed
    10. Howrylak JA, Fuhlbrigge AL, Strunk RC, Zeiger RS, Weiss ST, Raby BA. Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications. J Allergy Clin Immunol. 2014 May; 133(5):1289-300, 1300.e1-12. PMID: 24892144; PMCID: PMC4047642.
    11. Howrylak JA, Spanier AJ, Huang B, Peake RW, Kellogg MD, Sauers H, Kahn RS. Cotinine in children admitted for asthma and readmission. Pediatrics. 2014 Feb; 133(2):e355-62. PMID: 24446438; PMCID: PMC3904280.
    12. Forno E, Lasky-Su J, Himes B, Howrylak J, Ramsey C, Brehm J, Klanderman B, Ziniti J, Melén E, Pershagen G, Wickman M, Martinez F, Mauger D, Sorkness C, Tantisira K, Raby BA, Weiss ST, Celedón JC. Genome-wide association study of the age of onset of childhood asthma. J Allergy Clin Immunol. 2012 Jul; 130(1):83-90.e4. PMID: 22560479; PMCID: PMC3387331.
    13. Dolinay T, Kim YS, Howrylak J, Hunninghake GM, An CH, Fredenburgh L, Massaro AF, Rogers A, Gazourian L, Nakahira K, Haspel JA, Landazury R, Eppanapally S, Christie JD, Meyer NJ, Ware LB, Christiani DC, Ryter SW, Baron RM, Choi AM. Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med. 2012 Jun 01; 185(11):1225-34. PMID: 22461369; PMCID: PMC3373064.
    14. Sharma S, Murphy A, Howrylak J, Himes B, Cho MH, Chu JH, Hunninghake GM, Fuhlbrigge A, Klanderman B, Ziniti J, Senter-Sylvia J, Liu A, Szefler SJ, Strunk R, Castro M, Hansel NN, Diette GB, Vonakis BM, Adkinson NF, Carey VJ, Raby BA. The impact of self-identified race on epidemiologic studies of gene expression. Genet Epidemiol. 2011 Feb; 35(2):93-101. PMID: 21254216; PMCID: PMC3718033.
    15. Howrylak JA, Dolinay T, Lucht L, Wang Z, Christiani DC, Sethi JM, Xing EP, Donahoe MP, Choi AM. Discovery of the gene signature for acute lung injury in patients with sepsis. Physiol Genomics. 2009 Apr 10; 37(2):133-9. PMID: 19174476; PMCID: PMC3774580.
    16. Howrylak J, Choi AM. Gene expression profiling in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008 Feb 15; 177(4):364-5. PMID: 18250352.
      View in: PubMed
    17. Dubreuil RR, Frankel J, Wang P, Howrylak J, Kappil M, Grushko TA. Mutations of alpha spectrin and labial block cuprophilic cell differentiation and acid secretion in the middle midgut of Drosophila larvae. Dev Biol. 1998 Feb 01; 194(1):1-11. PMID: 9473327.
      View in: PubMed
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