PSU Profiles
Last Name

Bi-Hua Tan

TitleAssistant Professor
InstitutionCollege of Medicine
Address500 University Drive Hershey, PA 17033
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Low ZK, Ng WY, Fook-Chong S, Tan BK, Chong SJ, Hwee J, Tay SM. Comparison of clinical outcomes in diabetic and non-diabetic burns patients in a national burns referral centre in southeast Asia: A 3-year retrospective review. Burns. 2017 Mar; 43(2):436-444. PMID: 28159150.
      View in: PubMed
    2. Wang H, Song C, Ding Y, Pan X, Ge Z, Tan BH, Gowda C, Sachdev M, Muthusami S, Ouyang H, Lai L, Francis OL, Morris CL, Abdel-Azim H, Dorsam G, Xiang M, Payne KJ, Dovat S. Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia. J Biol Chem. 2016 Feb 19; 291(8):4004-18. PMID: 26655717; PMCID: PMC4759178 [Available on 02/19/17].
    3. Tong YQ, Liu B, Zheng HY, Gu J, Liu H, Li F, Tan BH, Hartman M, Song C, Li Y. MiR-215, an activator of the CTNNBIP1/ß-catenin pathway, is a marker of poor prognosis in human glioma. Oncotarget. 2015 Sep 22; 6(28):25024-33. PMID: 26317904; PMCID: PMC4694812.
    4. Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S. Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. Blood. 2015 Oct 08; 126(15):1813-22. PMID: 26219304; PMCID: PMC4600018.
    5. Hu RM, Tan BH, Tester DJ, Song C, He Y, Dovat S, Peterson BZ, Ackerman MJ, Makielski JC. Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis. PLoS One. 2015; 10(4):e0124921. PMID: 25923670; PMCID: PMC4414567.
    6. Vaidyanathan R, Vega AL, Song C, Zhou Q, Tan BH, Tan B, Berger S, Makielski JC, Eckhardt LL. The interaction of caveolin 3 protein with the potassium inward rectifier channel Kir2.1: physiology and pathology related to long qt syndrome 9 (LQT9). J Biol Chem. 2013 Jun 14; 288(24):17472-80. PMID: 23640888; PMCID: PMC3682547.
    7. Hu RM, Tan BH, Orland KM, Valdivia CR, Peterson A, Pu J, Makielski JC. Digenic inheritance novel mutations in SCN5a and SNTA1 increase late I(Na) contributing to LQT syndrome. Am J Physiol Heart Circ Physiol. 2013 Apr 01; 304(7):H994-H1001. PMID: 23376825; PMCID: PMC3625899.
    8. Cheng J, Makielski JC, Yuan P, Shi N, Zhou F, Ye B, Tan BH, Kroboth S. Sudden unexplained nocturnal death syndrome in Southern China: an epidemiological survey and SCN5A gene screening. Am J Forensic Med Pathol. 2011 Dec; 32(4):359-63. PMID: 20110800; PMCID: PMC2930936.
    9. Cheng J, Norstrand DW, Medeiros-Domingo A, Tester DJ, Valdivia CR, Tan BH, Vatta M, Makielski JC, Ackerman MJ. LQTS-associated mutation A257G in a1-syntrophin interacts with the intragenic variant P74L to modify its biophysical phenotype. Cardiogenetics. 2011 Oct 25; 1(1). PMID: 24319568.
      View in: PubMed
    10. Tester DJ, Tan BH, Medeiros-Domingo A, Song C, Makielski JC, Ackerman MJ. Loss-of-function mutations in the KCNJ8-encoded Kir6.1 K(ATP) channel and sudden infant death syndrome. Circ Cardiovasc Genet. 2011 Oct; 4(5):510-5. PMID: 21836131; PMCID: PMC3281577.
    11. Cheng J, Tester DJ, Tan BH, Valdivia CR, Kroboth S, Ye B, January CT, Ackerman MJ, Makielski JC. The common African American polymorphism SCN5A-S1103Y interacts with mutation SCN5A-R680H to increase late Na current. Physiol Genomics. 2011 May 13; 43(9):461-6. PMID: 21385947; PMCID: PMC3110896.
    12. Stoller DA, Fahrenbach JP, Chalupsky K, Tan BH, Aggarwal N, Metcalfe J, Hadhazy M, Shi NQ, Makielski JC, McNally EM. Cardiomyocyte sulfonylurea receptor 2-KATP channel mediates cardioprotection and ST segment elevation. Am J Physiol Heart Circ Physiol. 2010 Oct; 299(4):H1100-8. PMID: 20656890; PMCID: PMC2957346.
    13. Medeiros-Domingo A, Tan BH, Crotti L, Tester DJ, Eckhardt L, Cuoretti A, Kroboth SL, Song C, Zhou Q, Kopp D, Schwartz PJ, Makielski JC, Ackerman MJ. Gain-of-function mutation S422L in the KCNJ8-encoded cardiac K(ATP) channel Kir6.1 as a pathogenic substrate for J-wave syndromes. Heart Rhythm. 2010 Oct; 7(10):1466-71. PMID: 20558321; PMCID: PMC3049900.
    14. Tan BH, Pundi KN, Van Norstrand DW, Valdivia CR, Tester DJ, Medeiros-Domingo A, Makielski JC, Ackerman MJ. Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. Heart Rhythm. 2010 Jun; 7(6):771-8. PMID: 20226894; PMCID: PMC2909680.
    15. Cheng J, Van Norstrand DW, Medeiros-Domingo A, Valdivia C, Tan BH, Ye B, Kroboth S, Vatta M, Tester DJ, January CT, Makielski JC, Ackerman MJ. Alpha1-syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current. Circ Arrhythm Electrophysiol. 2009 Dec; 2(6):667-76. PMID: 20009079; PMCID: PMC2810855.
    16. Wong CH, Ong YS, Chew KY, Tan BK, Song C. The fibula osteoseptocutaneous flap incorporating the hemisoleus muscle for complex head and neck defects: anatomical study and clinical applications. Plast Reconstr Surg. 2009 Dec; 124(6):1956-64. PMID: 19952651.
      View in: PubMed
    17. Medeiros-Domingo A, Tan BH, Iturralde-Torres P, Tester DJ, Tusié-Luna T, Makielski JC, Ackerman MJ. Unique mixed phenotype and unexpected functional effect revealed by novel compound heterozygosity mutations involving SCN5A. Heart Rhythm. 2009 Aug; 6(8):1170-5. PMID: 19632629; PMCID: PMC3073365.
    18. Tan BH, Iturralde-Torres P, Medeiros-Domingo A, Nava S, Tester DJ, Valdivia CR, Tusié-Luna T, Ackerman MJ, Makielski JC. A novel C-terminal truncation SCN5A mutation from a patient with sick sinus syndrome, conduction disorder and ventricular tachycardia. Cardiovasc Res. 2007 Dec 01; 76(3):409-17. PMID: 17897635; PMCID: PMC2100438.
    19. Chen W, Salto-Tellez M, Palanisamy N, Ganesan K, Hou Q, Tan LK, Sii LH, Ito K, Tan B, Wu J, Tay A, Tan KC, Ang E, Tan BK, Tan PH, Ito Y, Tan P. Targets of genome copy number reduction in primary breast cancers identified by integrative genomics. Genes Chromosomes Cancer. 2007 Mar; 46(3):288-301. PMID: 17171680.
      View in: PubMed
    20. Tan BH, Valdivia CR, Song C, Makielski JC. Partial expression defect for the SCN5A missense mutation G1406R depends on splice variant background Q1077 and rescue by mexiletine. Am J Physiol Heart Circ Physiol. 2006 Oct; 291(4):H1822-8. PMID: 16632547.
      View in: PubMed
    21. Tan BH, Valdivia CR, Rok BA, Ye B, Ruwaldt KM, Tester DJ, Ackerman MJ, Makielski JC. Common human SCN5A polymorphisms have altered electrophysiology when expressed in Q1077 splice variants. Heart Rhythm. 2005 Jul; 2(7):741-7. PMID: 15992732.
      View in: PubMed
    22. Tan BH, Shimizu H, Furukawa Y, Kanemori T, Ohyanagi M. Sinus slowing caused by adenosine-5'-triphosphate in patients with and without sick sinus syndrome under various autonomic states. J Electrocardiol. 2004 Oct; 37(4):305-9. PMID: 15484159.
      View in: PubMed
    23. Tan BH, Shimizu H, Hiromoto K, Furukawa Y, Ohyanagi M, Iwasaki T. Wavelet transform analysis of heart rate variability to assess the autonomic changes associated with spontaneous coronary spasm of variant angina. J Electrocardiol. 2003 Apr; 36(2):117-24. PMID: 12764694.
      View in: PubMed
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