PSU Profiles
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Yuka Imamura

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentPharmacology
Address500 University Drive Hershey, PA 17033
Mailbox: H093
Phone717-531-0003, ext 289250

 Overview 
 overview
TITLE:
Director, Penn State Hershey Genome Sciences Facility
Assistant Professor of Pharmacology, Penn State College of Medicine

OTHER NAME USED:
Yuka Imamura Kawasawa

EDUCATION:
-B.A., The University of Tokyo, 1995
-M.S., The University of Tokyo, 1997
-Ph.D., The University of Tokyo, 2001

EMPLOYMENT:
-2001-2003 Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas (Dallas, TX)
-2003-2005 Yanagisawa Orphan Receptor Project, Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST) (Tokyo, Japan)
-2005-2008 Yale University School of Medicine (New Haven, CT)
-2008-2009 The Rothberg Institute for Childhood Diseases (Guilford, CT)
-2009-2013 Yale University School of Medicine (New Haven, CT)

NARRATIVE:
I am working as Director of Penn State Hershey Genome Sciences Facility (http://www.pennstatehershey.org/web/core/gene-expression-analysis-overview) and Institute for Personalized Medicine (http://www2.med.psu.edu/ipm/) as well as Assistant Professor of Pharmacology at Penn State College of Medicine. The facility provides a range of genetic, epigenetic, and transcriptomic technologies to researchers from throughout the Penn State University. In addition to overseeing day-to-day operation of the facility, I am collaborating with a wide variety of biomedical researchers to aid in successful completion of their research projects. Moreover, there are University-wide efforts in genomics and personalized medicine, and opportunities for collaboration include research activities within various Penn State Institutes, such as the Clinical and Translational Science Institute, Cancer Institute, Heart and Vascular Institute, and Huck Institute of the Life Sciences, and I am playing an essential role to promote application of genomics research in medical science and to stimulate translational and clinical research into personalized health care.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Fertuzinhos S, Li M, Kawasawa YI, Ivic V, Franjic D, Singh D, Crair M, Sestan N. Laminar and Temporal Expression Dynamics of Coding and Noncoding RNAs in the Mouse Neocortex. Cell Rep. 2014 Feb 19.
    View in: PubMed
  2. Pletikos M, Sousa AM, Sedmak G, Meyer KA, Zhu Y, Cheng F, Li M, Kawasawa YI, Sestan N. Temporal specification and bilaterality of human neocortical topographic gene expression. Neuron. 2014 Jan 22; 81(2):321-32.
    View in: PubMed
  3. Kang HJ, Kawasawa YI, Cheng F, Zhu Y, Xu X, Li M, Sousa AM, Pletikos M, Meyer KA, Sedmak G, Guennel T, Shin Y, Johnson MB, Krsnik Z, Mayer S, Fertuzinhos S, Umlauf S, Lisgo SN, Vortmeyer A, Weinberger DR, Mane S, Hyde TM, Huttner A, Reimers M, Kleinman JE, Sestan N. Spatio-temporal transcriptome of the human brain. Nature. 2011 Oct 27; 478(7370):483-9.
    View in: PubMed
  4. Hashimoto-Torii K, Kawasawa YI, Kuhn A, Rakic P. Combined transcriptome analysis of fetal human and mouse cerebral cortex exposed to alcohol. Proc Natl Acad Sci U S A. 2011 Mar 8; 108(10):4212-7.
    View in: PubMed
  5. Johnson MB, Kawasawa YI, Mason CE, Krsnik Z, Coppola G, Bogdanovic D, Geschwind DH, Mane SM, State MW, Sestan N. Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron. 2009 May 28; 62(4):494-509.
    View in: PubMed
  6. Fertuzinhos S, Krsnik Z, Kawasawa YI, Rasin MR, Kwan KY, Chen JG, Judas M, Hayashi M, Sestan N. Selective depletion of molecularly defined cortical interneurons in human holoprosencephaly with severe striatal hypoplasia. Cereb Cortex. 2009 Sep; 19(9):2196-207.
    View in: PubMed
  7. Kwan KY, Lam MM, Krsnik Z, Kawasawa YI, Lefebvre V, Sestan N. SOX5 postmitotically regulates migration, postmigratory differentiation, and projections of subplate and deep-layer neocortical neurons. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):16021-6.
    View in: PubMed
  8. Takayasu S, Sakurai T, Iwasaki S, Teranishi H, Yamanaka A, Williams SC, Iguchi H, Kawasawa YI, Ikeda Y, Sakakibara I, Ohno K, Ioka RX, Murakami S, Dohmae N, Xie J, Suda T, Motoike T, Ohuchi T, Yanagisawa M, Sakai J. A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Proc Natl Acad Sci U S A. 2006 May 9; 103(19):7438-43.
    View in: PubMed
  9. Okamoto N, Saruki N, Mikami H, Yamashita K, Maruyama Y, Yano T, Imamura Y, Kaneko S, Tanaka H. 5-year survival rates for primary cancer sites at cancer-treatment-oriented hospitals in Japan. Asian Pac J Cancer Prev. 2006 Jan-Mar; 7(1):46-50.
    View in: PubMed
  10. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y. The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2; 309(5740):1559-63.
    View in: PubMed
  11. Kawasawa Y, McKenzie LM, Hill DP, Bono H, Yanagisawa M. G protein-coupled receptor genes in the FANTOM2 database. Genome Res. 2003 Jun; 13(6B):1466-77.
    View in: PubMed
  12. Gustincich S, Batalov S, Beisel KW, Bono H, Carninci P, Fletcher CF, Grimmond S, Hirokawa N, Jarvis ED, Jegla T, Kawasawa Y, LeMieux J, Miki H, Raviola E, Teasdale RD, Tominaga N, Yagi K, Zimmer A, Hayashizaki Y, Okazaki Y. Analysis of the mouse transcriptome for genes involved in the function of the nervous system. Genome Res. 2003 Jun; 13(6B):1395-401.
    View in: PubMed
  13. Kawa M, Kayama M, Maeyama E, Iba N, Murata H, Imamura Y, Koyama T, Mizuno M. Distress of inpatients with terminal cancer in Japanese palliative care units: from the viewpoint of spirituality. Support Care Cancer. 2003 Jul; 11(7):481-90.
    View in: PubMed
  14. Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002 Dec 5; 420(6915):563-73.
    View in: PubMed
  15. Kawasawa Y, Kume K, Izumi T, Shimizu T. Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems. Biochem Biophys Res Commun. 2000 Oct 5; 276(3):957-64.
    View in: PubMed
  16. Kawasawa Y, Kume K, Nakade S, Haga H, Izumi T, Shimizu T. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Biochem Biophys Res Commun. 2000 Oct 5; 276(3):952-6.
    View in: PubMed
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