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Song Guo Zheng

TitleDirector of Rheumatology Research
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive Hershey, PA 17033
Phone717-531-0003 ext 289532
Fax717-531-8274
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    Other Positions
    TitleProfessor
    InstitutionCollege of Medicine
    DepartmentMedicine
    DivisionRheumatology


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Xiao ZX, Zheng X, Hu L, Wang J, Olsen N, Zheng SG. Immunosuppressive Effect of B7-H4 Pathway in a Murine Systemic Lupus Erythematosus Model. Front Immunol. 2017; 8:1765. PMID: 29321778.
      View in: PubMed
    2. Zhang W, Zhou L, Dang J, Zhang X, Wang J, Chen Y, Liang J, Li D, Ma J, Yuan J, Chen W, Zadeh HH, Olsen N, Zheng SG. Human Gingiva-Derived Mesenchymal Stem Cells Ameliorate Streptozoticin-induced T1DM in mice via Suppression of T effector cells and Up-regulating Treg Subsets. Sci Rep. 2017 Nov 10; 7(1):15249. PMID: 29127315.
      View in: PubMed
    3. Chen W, Xu Z, Zheng Y, Wang J, Qian W, Olsen N, Brand D, Lin J, Zheng SG. A protocol to develop T helper and Treg cells in vivo. Cell Mol Immunol. 2017 Dec; 14(12):1013-1016. PMID: 29082917.
      View in: PubMed
    4. Liao T, Xue Y, Zhao D, Li S, Liu M, Chen J, Brand DD, Zheng H, Zhang Y, Zheng SG, Sun Q. In Vivo Attenuation of Antibody-Mediated Acute Renal Allograft Rejection by Ex Vivo TGF-ß-Induced CD4+Foxp3+ Regulatory T Cells. Front Immunol. 2017; 8:1334. PMID: 29085374.
      View in: PubMed
    5. Su W, Li Z, Jia Y, Zhu Y, Cai W, Wan P, Zhang Y, Zheng SG, Zhuo Y. microRNA-21a-5p/PDCD4 axis regulates mesenchymal stem cell-induced neuroprotection in acute glaucoma. J Mol Cell Biol. 2017 Aug 01; 9(4):289-301. PMID: 28655163.
      View in: PubMed
    6. Chen X, Su W, Wan T, Yu J, Zhu W, Tang F, Liu G, Olsen N, Liang D, Zheng SG. Sodium butyrate regulates Th17/Treg cell balance to ameliorate uveitis via the Nrf2/HO-1 pathway. Biochem Pharmacol. 2017 10 15; 142:111-119. PMID: 28684304.
      View in: PubMed
    7. Huang W, Solouki S, Koylass N, Zheng SG, August A. ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells. Nat Commun. 2017 Jun 21; 8:15871. PMID: 28635957.
      View in: PubMed
    8. Guan SY, Leng RX, Tao JH, Li XP, Ye DQ, Olsen N, Zheng SG, Pan HF. Hypoxia-inducible factor-1a: a promising therapeutic target for autoimmune diseases. Expert Opin Ther Targets. 2017 07; 21(7):715-723. PMID: 28553732.
      View in: PubMed
    9. Lei F, Haque M, Sandhu P, Ravi S, Song J, Ni B, Zheng S, Fang D, Jia H, Yang JM, Song J. Development and characterization of naive single-type tumor antigen-specific CD8+ T lymphocytes from murine pluripotent stem cells. Oncoimmunology. 2017; 6(7):e1334027. PMID: 28811978.
      View in: PubMed
    10. Wang H, Chen W, Li D, Yin X, Zhang X, Olsen N, Zheng SG. Vitamin D and Chronic Diseases. Aging Dis. 2017 May; 8(3):346-353. PMID: 28580189.
      View in: PubMed
    11. Haque R, Song J, Haque M, Lei F, Sandhu P, Ni B, Zheng S, Fang D, Yang JM, Song J. c-Myc-Induced Survivin Is Essential for Promoting  the Notch-Dependent T Cell Differentiation from  Hematopoietic Stem Cells. Genes (Basel). 2017 Mar 06; 8(3). PMID: 28272325.
      View in: PubMed
    12. Peng WX, Zhu SL, Zhang BY, Shi YM, Feng XX, Liu F, Huang JL, Zheng SG. Smoothened Regulates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Activation of Rho GTPase Signaling. Front Immunol. 2017; 8:159. PMID: 28261216.
      View in: PubMed
    13. Li WX, Qi F, Liu JQ, Li GH, Dai SX, Zhang T, Cheng F, Liu D, Zheng SG. Different impairment of immune and inflammation functions in short and long-term after ischemic stroke. Am J Transl Res. 2017; 9(2):736-745. PMID: 28337302.
      View in: PubMed
    14. Huang F, Chen M, Chen W, Gu J, Yuan J, Xue Y, Dang J, Su W, Wang J, Zadeh HH, He X, Rong L, Olsen N, Zheng SG. Human Gingiva-Derived Mesenchymal Stem Cells Inhibit Xeno-Graft-versus-Host Disease via CD39-CD73-Adenosine and IDO Signals. Front Immunol. 2017; 8:68. PMID: 28210258.
      View in: PubMed
    15. Liu Y, Pan YF, Xue YQ, Fang LK, Guo XH, Guo X, Liu M, Mo BY, Yang MR, Liu F, Wu YT, Olsen N, Zheng SG. uPAR promotes tumor-like biologic behaviors of fibroblast-like synoviocytes through PI3K/Akt signaling pathway in patients with rheumatoid arthritis. Cell Mol Immunol. 2017 Jan 16. PMID: 28090093.
      View in: PubMed
    16. Luo Y, Zheng SG. Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms. Front Immunol. 2016; 7:604. PMID: 28066415.
      View in: PubMed
    17. Li Y, Lu Y, Wang S, Han Z, Zhu F, Ni Y, Liang R, Zhang Y, Leng Q, Wei G, Shi G, Zhu R, Li D, Wang H, Zheng SG, Xu H, Tsun A, Li B. USP21 prevents the generation of T-helper-1-like Treg cells. Nat Commun. 2016 Nov 18; 7:13559. PMID: 27857073.
      View in: PubMed
    18. Sandal I, Karydis A, Luo J, Prislovsky A, Whittington KB, Rosloniec EF, Dong C, Novack DV, Mydel P, Zheng SG, Radic MZ, Brand DD. Bone loss and aggravated autoimmune arthritis in HLA-DRß1-bearing humanized mice following oral challenge with Porphyromonas gingivalis. Arthritis Res Ther. 2016 10 26; 18(1):249. PMID: 27784339.
      View in: PubMed
    19. Zhang X, Huang F, Chen Y, Qian X, Zheng SG. Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis. Am J Transl Res. 2016; 8(10):4017-4024. PMID: 27829989.
      View in: PubMed
    20. Gu J, Ni X, Pan X, Lu H, Lu Y, Zhao J, Guo Zheng S, Hippen KL, Wang X, Lu L. Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions. Cell Mol Immunol. 2017 Jun; 14(6):521-528. PMID: 27374793.
      View in: PubMed
    21. Wang K, Gu J, Ni X, Ding Z, Wang Q, Zhou H, Zheng S, Li B, Lu L. CD25 signaling regulates the function and stability of peripheral Foxp3+ regulatory T cells derived from the spleen and lymph nodes of mice. Mol Immunol. 2016 08; 76:35-40. PMID: 27344615.
      View in: PubMed
    22. Xu A, Liu Y, Chen W, Wang J, Xue Y, Huang F, Rong L, Lin J, Liu D, Yan M, Li QZ, Li B, Song J, Olsen N, Zheng SG. TGF-ß-Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism. J Immunol. 2016 05 01; 196(9):3631-41. PMID: 27001954; PMCID: PMC4868785 [Available on 05/01/17].
    23. Haque M, Song J, Fino K, Sandhu P, Song X, Lei F, Zheng S, Ni B, Fang D, Song J. Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity. Sci Rep. 2016 Feb 05; 6:20588. PMID: 26846186; PMCID: PMC4742827.
    24. Nie J, Li YY, Zheng SG, Tsun A, Li B. FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases. Front Immunol. 2015; 6:493. PMID: 26441996; PMCID: PMC4585344.
    25. Li N, Wei W, Yin F, Chen M, Ma TR, Wu Q, Zhou JR, Zheng SG, Han J. The abnormal expression of CCR4 and CCR6 on Tregs in rheumatoid arthritis. Int J Clin Exp Med. 2015; 8(9):15043-53. PMID: 26628988; PMCID: PMC4658877.
    26. Chen W, Cao H, Lin J, Olsen N, Zheng SG. Biomarkers for Primary Sjögren's Syndrome. Genomics Proteomics Bioinformatics. 2015 Aug; 13(4):219-23. PMID: 26362815; PMCID: PMC4610966.
    27. Li B, Zheng SG. How regulatory T cells sense and adapt to inflammation. Cell Mol Immunol. 2015 Sep; 12(5):519-20. PMID: 26277895; PMCID: PMC4579659.
    28. Chen W, Zhang X, Wang H, Zhang W, Xu Y, Zheng S. The epidemic investigation of serum 25-hydroxy vitamin D levels in the adults in Qujing area of Yunnan province in China. Int J Clin Exp Pathol. 2015; 8(8):9597-601. PMID: 26464725; PMCID: PMC4583957.
    29. Zhu SL, Huang JL, Peng WX, Wu DC, Luo MQ, Li QX, Li ZX, Feng XX, Liu F, Wang MX, Chen WQ, Olsen N, Zheng SG. Inhibition of smoothened decreases proliferation of synoviocytes in rheumatoid arthritis. Cell Mol Immunol. 2017 Feb; 14(2):214-222. PMID: 26189371.
      View in: PubMed
    30. Gao Y, Tang J, Chen W, Li Q, Nie J, Lin F, Wu Q, Chen Z, Gao Z, Fan H, Tsun A, Shen J, Chen G, Liu Z, Lou Z, Olsen NJ, Zheng SG, Li B. Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):E3246-54. PMID: 26060310; PMCID: PMC4485127.
    31. Madouri F, Guillou N, Fauconnier L, Marchiol T, Rouxel N, Chenuet P, Ledru A, Apetoh L, Ghiringhelli F, Chamaillard M, Zheng SG, Trovero F, Quesniaux VF, Ryffel B, Togbe D. Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation. J Mol Cell Biol. 2015 Aug; 7(4):351-65. PMID: 25714839.
      View in: PubMed
    32. Liu ZM, Wang KP, Ma J, Guo Zheng S. The role of all-trans retinoic acid in the biology of Foxp3+ regulatory T cells. Cell Mol Immunol. 2015 Sep; 12(5):553-7. PMID: 25640656; PMCID: PMC4579645.
    33. Su W, Wan Q, Huang J, Han L, Chen X, Chen G, Olsen N, Zheng SG, Liang D. Culture medium from TNF-a-stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms. J Allergy Clin Immunol. 2015 Aug; 136(2):423-32.e8. PMID: 25652765.
      View in: PubMed
    34. Gu J, Lu L, Chen M, Xu L, Lan Q, Li Q, Liu Z, Chen G, Wang P, Wang X, Brand D, Olsen N, Zheng SG. TGF-ß-induced CD4+Foxp3+ T cells attenuate acute graft-versus-host disease by suppressing expansion and killing of effector CD8+ cells. J Immunol. 2014 Oct 01; 193(7):3388-97. PMID: 25156367; PMCID: PMC4247987.
    35. Su W, Wan Q, Han L, Huang J, Chen X, Chen G, Zheng SG, Liang D. Doxycycline exerts multiple anti-allergy effects to attenuate murine allergic conjunctivitis and systemic anaphylaxis. Biochem Pharmacol. 2014 Oct 01; 91(3):359-68. PMID: 25128381.
      View in: PubMed
    36. Lu L, Lan Q, Li Z, Zhou X, Gu J, Li Q, Wang J, Chen M, Liu Y, Shen Y, Brand DD, Ryffel B, Horwitz DA, Quismorio FP, Liu Z, Li B, Olsen NJ, Zheng SG. Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):E3432-40. PMID: 25099355; PMCID: PMC4143025.
    37. Li Z, Lin F, Zhuo C, Deng G, Chen Z, Yin S, Gao Z, Piccioni M, Tsun A, Cai S, Zheng SG, Zhang Y, Li B. PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation. J Biol Chem. 2014 Sep 26; 289(39):26872-81. PMID: 25096571; PMCID: PMC4175328.
    38. Lin S, Yang X, Liang D, Zheng SG. Treg cells: a potential regulator for IL-22 expression? Int J Clin Exp Pathol. 2014; 7(2):474-80. PMID: 24551268; PMCID: PMC3925892.
    39. Yang X, Zheng SG. Interleukin-22: a likely target for treatment of autoimmune diseases. Autoimmun Rev. 2014 Jun; 13(6):615-20. PMID: 24418299; PMCID: PMC3966954.
    40. Chen M, Lin X, Liu Y, Li Q, Deng Y, Liu Z, Brand D, Guo Z, He X, Ryffel B, Zheng SG. The function of BAFF on T helper cells in autoimmunity. Cytokine Growth Factor Rev. 2014 Jun; 25(3):301-5. PMID: 24411564; PMCID: PMC4055514.
    41. Lu L, Feng M, Gu J, Xia Z, Zhang H, Zheng S, Duan Z, Hu R, Wang J, Shi W, Ji C, Shen Y, Chen G, Zheng SG, Han YP. Restoration of intrahepatic regulatory T cells through MMP-9/13-dependent activation of TGF-ß is critical for immune homeostasis following acute liver injury. J Mol Cell Biol. 2013 Dec; 5(6):369-79. PMID: 24280647; PMCID: PMC3841112.
    42. Pan HF, Leng RX, Li XP, Zheng SG, Ye DQ. Targeting T-helper 9 cells and interleukin-9 in autoimmune diseases. Cytokine Growth Factor Rev. 2013 Dec; 24(6):515-22. PMID: 25215394.
      View in: PubMed
    43. Wang P, Zheng SG. Regulatory T cells and B cells: implication on autoimmune diseases. Int J Clin Exp Pathol. 2013; 6(12):2668-74. PMID: 24294353; PMCID: PMC3843247.
    44. Ma J, Liu Y, Li Y, Gu J, Liu J, Tang J, Wang J, Ryffel B, Shen Y, Brand D, Liu Z, Zheng SG. Differential role of all-trans retinoic acid in promoting the development of CD4+ and CD8+ regulatory T cells. J Leukoc Biol. 2014 Feb; 95(2):275-83. PMID: 24082012; PMCID: PMC3896662.
    45. Horwitz DA, Pan S, Ou JN, Wang J, Chen M, Gray JD, Zheng SG. Therapeutic polyclonal human CD8+ CD25+ Fox3+ TNFR2+ PD-L1+ regulatory cells induced ex-vivo. Clin Immunol. 2013 Dec; 149(3):450-63. PMID: 24211847; PMCID: PMC3941976.
    46. Liu Y, Lan Q, Lu L, Chen M, Xia Z, Ma J, Wang J, Fan H, Shen Y, Ryffel B, Brand D, Quismorio F, Liu Z, Horwitz DA, Xu A, Zheng SG. Phenotypic and functional characteristic of a newly identified CD8+ Foxp3- CD103+ regulatory T cells. J Mol Cell Biol. 2014 Feb; 6(1):81-92. PMID: 23861553; PMCID: PMC3927769.
    47. Chen M, Su W, Lin X, Guo Z, Wang J, Zhang Q, Brand D, Ryffel B, Huang J, Liu Z, He X, Le AD, Zheng SG. Adoptive transfer of human gingiva-derived mesenchymal stem cells ameliorates collagen-induced arthritis via suppression of Th1 and Th17 cells and enhancement of regulatory T cell differentiation. Arthritis Rheum. 2013 May; 65(5):1181-93. PMID: 23400582; PMCID: PMC4364405.
    48. Villeret B, Brault L, Couturier-Maillard A, Robinet P, Vasseur V, Secher T, Dimier-Poisson I, Jacobs M, Zheng SG, Quesniaux VF, Ryffel B. Blockade of IL-1R signaling diminishes Paneth cell depletion and Toxoplasma gondii induced ileitis in mice. Am J Clin Exp Immunol. 2013; 2(1):107-16. PMID: 23885328; PMCID: PMC3714202.
    49. Zheng SG. Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are the mutually exclusive? Am J Clin Exp Immunol. 2013; 2(1):94-106. PMID: 23885327; PMCID: PMC3714204.
    50. Tan Z, Jiang R, Wang X, Wang Y, Lu L, Liu Q, Zheng SG, Sun B, Ryffel B. ROR?t+IL-17+ neutrophils play a critical role in hepatic ischemia-reperfusion injury. J Mol Cell Biol. 2013 Apr; 5(2):143-6. PMID: 23362310; PMCID: PMC3934999.
    51. Lin X, Chen M, Liu Y, Guo Z, He X, Brand D, Zheng SG. Advances in distinguishing natural from induced Foxp3(+) regulatory T cells. Int J Clin Exp Pathol. 2013; 6(2):116-23. PMID: 23329997; PMCID: PMC3544233.
    52. Pan HF, Leng RX, Feng CC, Li XP, Chen GM, Li BZ, Xu WD, Zheng SG, Ye DQ. Expression profiles of Th17 pathway related genes in human systemic lupus erythematosus. Mol Biol Rep. 2013 Jan; 40(1):391-9. PMID: 23054011.
      View in: PubMed
    53. Ramalingam R, Larmonier CB, Thurston RD, Midura-Kiela MT, Zheng SG, Ghishan FK, Kiela PR. Dendritic cell-specific disruption of TGF-ß receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity. J Immunol. 2012 Oct 15; 189(8):3878-93. PMID: 22972928; PMCID: PMC3466393.
    54. Li Y, Zheng SG. The secret of FOXP3 downregulation in the inflammation condition. Int J Clin Exp Pathol. 2012; 5(7):624-5. PMID: 22977657; PMCID: PMC3438769.
    55. Pan HF, Li XP, Zheng SG, Ye DQ. Emerging role of interleukin-22 in autoimmune diseases. Cytokine Growth Factor Rev. 2013 Feb; 24(1):51-7. PMID: 22906768; PMCID: PMC4003867.
    56. Kong N, Lan Q, Chen M, Wang J, Shi W, Horwitz DA, Quesniaux V, Ryffel B, Liu Z, Brand D, Zou H, Zheng SG. Antigen-specific transforming growth factor ß-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance. Arthritis Rheum. 2012 Aug; 64(8):2548-58. PMID: 22605463; PMCID: PMC4364395.
    57. Zheng SG. Frontiers in immunology and immune tolerance: new perspectives. J Mol Cell Biol. 2012 Aug; 4(4):266-7. PMID: 22824556.
      View in: PubMed
    58. Xu W, Lan Q, Chen M, Chen H, Zhu N, Zhou X, Wang J, Fan H, Yan CS, Kuang JL, Warburton D, Togbe D, Ryffel B, Zheng SG, Shi W. Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation. PLoS One. 2012; 7(7):e40314. PMID: 22792275; PMCID: PMC3392250.
    59. Lan Q, Zhou X, Fan H, Chen M, Wang J, Ryffel B, Brand D, Ramalingam R, Kiela PR, Horwitz DA, Liu Z, Zheng SG. Polyclonal CD4+Foxp3+ Treg cells induce TGFß-dependent tolerogenic dendritic cells that suppress the murine lupus-like syndrome. J Mol Cell Biol. 2012 Dec; 4(6):409-19. PMID: 22773728; PMCID: PMC3523557.
    60. Su W, Fan H, Chen M, Wang J, Brand D, He X, Quesniaux V, Ryffel B, Zhu L, Liang D, Zheng SG. Induced CD4+ forkhead box protein-positive T cells inhibit mast cell function and established contact hypersensitivity through TGF-ß1. J Allergy Clin Immunol. 2012 Aug; 130(2):444-52.e7. PMID: 22738679.
      View in: PubMed
    61. Chen M, Guo Z, Ju W, Ryffel B, He X, Zheng SG. The development and function of follicular helper T cells in immune responses. Cell Mol Immunol. 2012 Sep; 9(5):375-9. PMID: 22659733; PMCID: PMC4000446.
    62. Xu B, Chen H, Xu W, Zhang W, Buckley S, Zheng SG, Warburton D, Kolb M, Gauldie J, Shi W. Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2012 Jul; 303(2):L89-96. PMID: 22610349; PMCID: PMC3404628.
    63. Besnard AG, Togbe D, Couillin I, Tan Z, Zheng SG, Erard F, Le Bert M, Quesniaux V, Ryffel B. Inflammasome-IL-1-Th17 response in allergic lung inflammation. J Mol Cell Biol. 2012 Feb; 4(1):3-10. PMID: 22147847.
      View in: PubMed
    64. Zheng SG. Emerging topics and new perspectives on regulatory and effector T cells. J Mol Cell Biol. 2012 Feb; 4(1):1-2. PMID: 22140270.
      View in: PubMed
    65. Lan Q, Fan H, Quesniaux V, Ryffel B, Liu Z, Zheng SG. Induced Foxp3(+) regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases? J Mol Cell Biol. 2012 Feb; 4(1):22-8. PMID: 22107826; PMCID: PMC3491614.
    66. Kida Y, Xia Z, Zheng S, Mordwinkin NM, Louie SG, Zheng SG, Feng M, Shi H, Duan Z, Han YP. Interleukin-1 as an injury signal mobilizes retinyl esters in hepatic stellate cells through down regulation of lecithin retinol acyltransferase. PLoS One. 2011; 6(11):e26644. PMID: 22073179; PMCID: PMC3208544.
    67. Lu L, Ma J, Li Z, Lan Q, Chen M, Liu Y, Xia Z, Wang J, Han Y, Shi W, Quesniaux V, Ryffel B, Brand D, Li B, Liu Z, Zheng SG. All-trans retinoic acid promotes TGF-ß-induced Tregs via histone modification but not DNA demethylation on Foxp3 gene locus. PLoS One. 2011; 6(9):e24590. PMID: 21931768; PMCID: PMC3172235.
    68. Zhou X, Xia Z, Lan Q, Wang J, Su W, Han YP, Fan H, Liu Z, Stohl W, Zheng SG. BAFF promotes Th17 cells and aggravates experimental autoimmune encephalomyelitis. PLoS One. 2011; 6(8):e23629. PMID: 21897850; PMCID: PMC3163640.
    69. Shi Q, Cao H, Liu J, Zhou X, Lan Q, Zheng S, Liu Z, Li Q, Fan H. CD4+ Foxp3+ regulatory T cells induced by TGF-ß, IL-2 and all-trans retinoic acid attenuate obliterative bronchiolitis in rat trachea transplantation. Int Immunopharmacol. 2011 Nov; 11(11):1887-94. PMID: 21839859.
      View in: PubMed
    70. Huang Z, Fu B, Zheng SG, Li X, Sun R, Tian Z, Wei H. Involvement of CD226+ NK cells in immunopathogenesis of systemic lupus erythematosus. J Immunol. 2011 Mar 15; 186(6):3421-31. PMID: 21296979; PMCID: PMC3097030.
    71. Xu B, Chen C, Chen H, Zheng SG, Bringas P, Xu M, Zhou X, Chen D, Umans L, Zwijsen A, Shi W. Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development. Development. 2011 Mar; 138(5):925-35. PMID: 21270055; PMCID: PMC3035095.
    72. Lu L, Zhou X, Wang J, Zheng SG, Horwitz DA. Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-ß and retinoic acid. PLoS One. 2010 Dec 17; 5(12):e15150. PMID: 21179414; PMCID: PMC3003689.
    73. Qian X, Wang K, Wang X, Zheng SG, Lu L. Generation of human regulatory T cells de novo with suppressive function prevent xenogeneic graft versus host disease. Int Immunopharmacol. 2011 May; 11(5):630-7. PMID: 21147213; PMCID: PMC3099130.
    74. Zheng SG. Transforming growth factor-beta level: indicator for severity of disease and organ damage in patients with systemic lupus erythematosus. J Rheumatol. 2010 Oct; 37(10):1983-5. PMID: 20889608.
      View in: PubMed
    75. Hu G, Liu Z, Zheng C, Zheng SG. Antigen-non-specific regulation centered on CD25+Foxp3+ Treg cells. Cell Mol Immunol. 2010 Nov; 7(6):414-8. PMID: 20729905; PMCID: PMC3094156.
    76. Fan H, Zheng SG. Frontiers in clinical immunology and immunoregulation 2010: the highlight. J Mol Cell Biol. 2010 Oct; 2(5):240-2. PMID: 20716549.
      View in: PubMed
    77. Zhou X, Kong N, Wang J, Fan H, Zou H, Horwitz D, Brand D, Liu Z, Zheng SG. Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu. J Immunol. 2010 Sep 01; 185(5):2675-9. PMID: 20679534; PMCID: PMC3098624.
    78. Zhou X, Kong N, Zou H, Brand D, Li X, Liu Z, Zheng SG. Therapeutic potential of TGF-ß-induced CD4(+) Foxp3(+) regulatory T cells in autoimmune diseases. Autoimmunity. 2011 Feb; 44(1):43-50. PMID: 20670119; PMCID: PMC4038306.
    79. Ma J, Yu J, Tao X, Cai L, Wang J, Zheng SG. The imbalance between regulatory and IL-17-secreting CD4+ T cells in lupus patients. Clin Rheumatol. 2010 Nov; 29(11):1251-8. PMID: 20563617.
      View in: PubMed
    80. Zhou X, Wang J, Shi W, Brand DD, Liu Z, Fan H, Zheng SG. Isolation of purified and live Foxp3+ regulatory T cells using FACS sorting on scatter plot. J Mol Cell Biol. 2010 Jun; 2(3):164-9. PMID: 20430855; PMCID: PMC2905066.
    81. Lu L, Wang J, Zhang F, Chai Y, Brand D, Wang X, Horwitz DA, Shi W, Zheng SG. Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol. 2010 Apr 15; 184(8):4295-306. PMID: 20304828; PMCID: PMC3087811.
    82. Lu L, Ma J, Wang X, Wang J, Zhang F, Yu J, He G, Xu B, Brand DD, Horwitz DA, Shi W, Zheng SG. Synergistic effect of TGF-beta superfamily members on the induction of Foxp3+ Treg. Eur J Immunol. 2010 Jan; 40(1):142-52. PMID: 19943263; PMCID: PMC2837277.
    83. Fan H, Wang J, Zhou X, Liu Z, Zheng SG. Induction of antigen-specific immune tolerance by TGF-beta-induced CD4+Foxp3+ regulatory T cells. Int J Clin Exp Med. 2009 Aug 25; 2(3):212-20. PMID: 19918314; PMCID: PMC2770184.
    84. Li DM, Li XP, Li XM, Wang GS, Ma Y, Zhao SS, Zheng SG. [Expression of FOXP3 in CD4+ CD39+ T cells of patients with systemic lupus erythematosus and dynamic observation of treatment with glucocorticoid]. Zhonghua Yi Xue Za Zhi. 2009 Jun 16; 89(23):1636-8. PMID: 19957514.
      View in: PubMed
    85. Jacob N, Yang H, Pricop L, Liu Y, Gao X, Zheng SG, Wang J, Gao HX, Putterman C, Koss MN, Stohl W, Jacob CO. Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway. J Immunol. 2009 Feb 15; 182(4):2532-41. PMID: 19201910; PMCID: PMC2790862.
    86. Lu L, Yu Y, Li G, Pu L, Zhang F, Zheng S, Wang X. CD8(+)CD103(+) regulatory T cells in spontaneous tolerance of liver allografts. Int Immunopharmacol. 2009 May; 9(5):546-8. PMID: 19539566.
      View in: PubMed
    87. Horwitz DA, Zheng SG, Gray JD. Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol. 2008 Sep; 29(9):429-35. PMID: 18676178.
      View in: PubMed
    88. Zheng SG. The Critical Role of TGF-beta1 in the Development of Induced Foxp3+ Regulatory T Cells. Int J Clin Exp Med. 2008; 1(3):192-202. PMID: 19079658; PMCID: PMC2592590.
    89. Zheng SG, Wang J, Horwitz DA. Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J Immunol. 2008 Jun 01; 180(11):7112-6. PMID: 18490709.
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    90. Horwitz DA, Zheng SG, Wang J, Gray JD. Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3+CD4+ Treg. Eur J Immunol. 2008 Apr; 38(4):912-5. PMID: 18395858.
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    91. Liu Z, Fan H, Li Y, Zheng SG. Experimental Studies on the Differentiation of Fibroblasts into Myoblasts induced by MyoD Genes in vitro. Int J Biomed Sci. 2008 Mar; 4(1):14-9. PMID: 23675061; PMCID: PMC3614677.
    92. Tao X, Ma J, Zhang Y, Yu J, Cai L, Wang J, Zheng SG. Neutralization of IL-4 and IFN-? Facilitates inducing TGF-ß-induced CD4(+)Foxp3(+) Regulatory Cells. Int J Biomed Sci. 2008 Mar; 4(1):52-7. PMID: 23675066; PMCID: PMC3614670.
    93. Zhao SS, Li XM, Li XP, Zhai ZM, Chen Z, Ma Y, Zhang H, Zheng SG. [Expression of CD4+ CD25+ CD127(low/-) T cells in patients with systemic lupus erythematosus]. Zhonghua Yi Xue Za Zhi. 2008 Feb 19; 88(7):453-6. PMID: 18642784.
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    94. Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J Immunol. 2007 Feb 15; 178(4):2018-27. PMID: 17277105.
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    95. Zheng SG, Wang JH, Stohl W, Kim KS, Gray JD, Horwitz DA. TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J Immunol. 2006 Mar 15; 176(6):3321-9. PMID: 16517699.
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    96. Zheng SG, Meng L, Wang JH, Watanabe M, Barr ML, Cramer DV, Gray JD, Horwitz DA. Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient. Int Immunol. 2006 Feb; 18(2):279-89. PMID: 16415106.
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    97. Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol. 2004 May 01; 172(9):5213-21. PMID: 15100259.
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    98. Horwitz DA, Zheng SG, Gray JD, Wang JH, Ohtsuka K, Yamagiwa S. Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune disease. Semin Immunol. 2004 Apr; 16(2):135-43. PMID: 15036237.
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    99. Zheng SG, Wang JH, Koss MN, Quismorio F, Gray JD, Horwitz DA. CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J Immunol. 2004 Feb 01; 172(3):1531-9. PMID: 14734731.
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    100. Horwitz DA, Zheng SG, Gray JD. The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets. J Leukoc Biol. 2003 Oct; 74(4):471-8. PMID: 14519757.
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    101. Zheng SG, Gray JD, Ohtsuka K, Yamagiwa S, Horwitz DA. Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors. J Immunol. 2002 Oct 15; 169(8):4183-9. PMID: 12370347.
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    102. Horwitz DA, Gray JD, Zheng SG. The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases. Arthritis Res. 2002; 4(4):241-6. PMID: 12106494; PMCID: PMC128930.
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