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Katherine Aird, Ph.D.

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentCellular and Molecular Physiology
Address500 University Drive Hershey, PA 17033
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    Collapse Biography 
    Collapse awards and honors
    2014 - 2019Pathway to Independence Award (K99/R00), NIH/NCI
    2012 - 2014The Wistar Institute Training Grant (T32), NIH/NCI
    2008 - 2010Breast Cancer Research Program Predoctoral Award, Department of Defense
    2008Women in Endocrinology Young Investigator Award, The Endocrine Society
    2006 - 2007Duke University Viral Oncology Training Grant (T32), NIH/NCI
    2006Duke Comprehensive Cancer Center Young Investigator Award , Duke University

    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Assistant Professor of Cellular and Molecular Physiology

    SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

    Penn State Hershey Cancer Institute

    EDUCATION:

    Post-doctoral Fellow, The Wistar Institute, 2010-2016
    Ph.D., Duke University, 2010
    B.A., Johns Hopkins University, 2004

    NARRATIVE:

    The Aird lab studies the mechanisms and pathological implications of cellular senescence. Cellular senescence is a stable cell cycle arrest that is a bona vide tumor suppression mechanism and also plays a role in age-related pathologies. In particular, her lab is interested in the intersection between cellular senescence and metabolism. Understanding the mechanisms of how cells undergo and overcome this proliferative arrest may lead to novel therapeutic strategies for both cancer and aging. Currently, Dr. Aird’s lab mainly focuses on ovarian cells as a model system. Her lab aims to: 1) understand the earliest events in ovarian tumorigenesis; and 2) exploit senescence and metabolic pathways as novel therapeutic strategies for ovarian cancer patients.

    Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/50644930/?sort=date&direction=ascending

    Website: https://sites.psu.edu/airdlab/

    Gynecologic Malignancies Group: http://sites.psu.edu/gynecologicmaligancies/


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Dahl ES, Aird KM. Ataxia-Telangiectasia Mutated Modulation of Carbon Metabolism in Cancer. Front Oncol. 2017; 7:291. PMID: 29238697.
      View in: PubMed
    2. Karakashev S, Aird KM. Ovarian cancer: how can resistance to chemotherapy be tackled? Future Oncol. 2017 Dec; 13(30):2737-2739. PMID: 29182383.
      View in: PubMed
    3. Bitler BG, Wu S, Park PH, Hai Y, Aird KM, Wang Y, Zhai Y, Kossenkov AV, Vara-Ailor A, Rauscher FJ, Zou W, Speicher DW, Huntsman DG, Conejo-Garcia JR, Cho KR, Christianson DW, Zhang R. ARID1A-mutated ovarian cancers depend on HDAC6 activity. Nat Cell Biol. 2017 08; 19(8):962-973. PMID: 28737768.
      View in: PubMed
    4. Aird KM, Iwasaki O, Kossenkov AV, Tanizawa H, Fatkhutdinov N, Bitler BG, Le L, Alicea G, Yang TL, Johnson FB, Noma KI, Zhang R. HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci. J Cell Biol. 2016 Nov 07; 215(3):325-334. PMID: 27799366.
      View in: PubMed
    5. Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT. Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. Nature. 2016 Sep 08; 537(7619):254. PMID: 27383789.
      View in: PubMed
    6. Fatkhutdinov N, Sproesser K, Krepler C, Liu Q, Brafford PA, Herlyn M, Aird KM, Zhang R. Targeting RRM2 and Mutant BRAF Is a Novel Combinatorial Strategy for Melanoma. Mol Cancer Res. 2016 Sep; 14(9):767-75. PMID: 27297629; PMCID: PMC5025362 [Available on 09/01/17].
    7. Kaur A, Webster MR, Marchbank K, Behera R, Ndoye A, Kugel CH, Dang VM, Appleton J, O'Connell MP, Cheng P, Valiga AA, Morissette R, McDonnell NB, Ferrucci L, Kossenkov AV, Meeth K, Tang HY, Yin X, Wood WH, Lehrmann E, Becker KG, Flaherty KT, Frederick DT, Wargo JA, Cooper ZA, Tetzlaff MT, Hudgens C, Aird KM, Zhang R, Xu X, Liu Q, Bartlett E, Karakousis G, Eroglu Z, Lo RS, Chan M, Menzies AM, Long GV, Johnson DB, Sosman J, Schilling B, Schadendorf D, Speicher DW, Bosenberg M, Ribas A, Weeraratna AT. sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. Nature. 2016 Apr 14; 532(7598):250-4. PMID: 27042933; PMCID: PMC4833579 [Available on 10/04/16].
    8. Zhu H, Ren S, Bitler BG, Aird KM, Tu Z, Skordalakes E, Zhu Y, Yan J, Sun Y, Zhang R. SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase. Cell Rep. 2015 Nov 10; 13(6):1183-1193. PMID: 26527005; PMCID: PMC4644472.
    9. Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG, Liu XS, Zhang Q. EglN2 associates with the NRF1-PGC1a complex and controls mitochondrial function in breast cancer. EMBO J. 2015 Dec 02; 34(23):2953-70. PMID: 26492917; PMCID: PMC4687683 [Available on 12/02/16].
    10. Caino MC, Ghosh JC, Chae YC, Vaira V, Rivadeneira DB, Faversani A, Rampini P, Kossenkov AV, Aird KM, Zhang R, Webster MR, Weeraratna AT, Bosari S, Languino LR, Altieri DC. PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28):8638-43. PMID: 26124089; PMCID: PMC4507184.
    11. Aird KM, Zhang R. ATM in senescence. Oncotarget. 2015 Jun 20; 6(17):14729-30. PMID: 26143490; PMCID: PMC4558108.
    12. Aird KM, Worth AJ, Snyder NW, Lee JV, Sivanand S, Liu Q, Blair IA, Wellen KE, Zhang R. ATM couples replication stress and metabolic reprogramming during cellular senescence. Cell Rep. 2015 May 12; 11(6):893-901. PMID: 25937285; PMCID: PMC4431925.
    13. Bitler BG, Aird KM, Zhang R. Epigenetic synthetic lethality in ovarian clear cell carcinoma: EZH2 and ARID1A mutations. Mol Cell Oncol. 2016 Jan; 3(1):e1032476. PMID: 27308548; PMCID: PMC4845188.
    14. Bitler BG, Aird KM, Garipov A, Li H, Amatangelo M, Kossenkov AV, Schultz DC, Liu Q, Shih IeM, Conejo-Garcia JR, Speicher DW, Zhang R. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. Nat Med. 2015 Mar; 21(3):231-8. PMID: 25686104; PMCID: PMC4352133.
    15. Aird KM, Zhang R. Metabolic alterations accompanying oncogene-induced senescence. Mol Cell Oncol. 2014 Jul-Sep; 1(3):e963481. PMID: 27308349; PMCID: PMC4904889.
    16. Aird KM, Zhang R. Nucleotide metabolism, oncogene-induced senescence and cancer. Cancer Lett. 2015 Jan 28; 356(2 Pt A):204-10. PMID: 24486217; PMCID: PMC4115046.
    17. Aird KM, Li H, Xin F, Konstantinopoulos PA, Zhang R. Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer. Cell Cycle. 2014; 13(2):199-207. PMID: 24200970; PMCID: PMC3906237.
    18. Tu Z, Aird KM, Zhang R. Chromatin remodeling, BRCA1, SAHF and cellular senescence. Cell Cycle. 2013 Jun 01; 12(11):1653-4. PMID: 23673322; PMCID: PMC3713120.
    19. Aird KM, Zhang G, Li H, Tu Z, Bitler BG, Garipov A, Wu H, Wei Z, Wagner SN, Herlyn M, Zhang R. Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. Cell Rep. 2013 Apr 25; 3(4):1252-65. PMID: 23562156; PMCID: PMC3840499.
    20. Tu Z, Aird KM, Zhang R. RAS, cellular senescence and transformation: the BRCA1 DNA repair pathway at the crossroads. Small GTPases. 2012 Jul-Sep; 3(3):163-7. PMID: 22751483; PMCID: PMC3442802.
    21. Allensworth JL, Aird KM, Aldrich AJ, Batinic-Haberle I, Devi GR. XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells. Mol Cancer Ther. 2012 Jul; 11(7):1518-27. PMID: 22508521.
      View in: PubMed
    22. Tu Z, Aird KM, Bitler BG, Nicodemus JP, Beeharry N, Xia B, Yen TJ, Zhang R. Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence. Dev Cell. 2011 Dec 13; 21(6):1077-91. PMID: 22137763; PMCID: PMC3241855.
    23. Morse MA, Hobeika A, Serra D, Aird K, McKinney M, Aldrich A, Clay T, Mourich D, Lyerly HK, Iversen PL, Devi GR. Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function. Cancer Gene Ther. 2012 Jan; 19(1):30-7. PMID: 21997230.
      View in: PubMed
    24. Aird KM, Allensworth JL, Batinic-Haberle I, Lyerly HK, Dewhirst MW, Devi GR. ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells. Breast Cancer Res Treat. 2012 Feb; 132(1):109-19. PMID: 21559822; PMCID: PMC3734382.
    25. Thomas ZI, Gibson W, Sexton JZ, Aird KM, Ingram SM, Aldrich A, Lyerly HK, Devi GR, Williams KP. Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration. Br J Cancer. 2011 May 10; 104(10):1575-86. PMID: 21505458; PMCID: PMC3101910.
    26. Aird KM, Ghanayem RB, Peplinski S, Lyerly HK, Devi GR. X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor. Mol Cancer Ther. 2010 May; 9(5):1432-42. PMID: 20406946; PMCID: PMC2957814.
    27. Aird KM, Ding X, Baras A, Wei J, Morse MA, Clay T, Lyerly HK, Devi GR. Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression. Mol Cancer Ther. 2008 Jan; 7(1):38-47. PMID: 18202008.
      View in: PubMed
    28. Kesavan AK, Mendez SE, Hatem CL, Lopez-Molina J, Aird K, Pitt ML, Dannenberg AM, Manabe YC. Effects of dexamethasone and transient malnutrition on rabbits infected with aerosolized Mycobacterium tuberculosis CDC1551. Infect Immun. 2005 Oct; 73(10):7056-60. PMID: 16177392; PMCID: PMC1230964.
    29. Dorman SE, Hatem CL, Tyagi S, Aird K, Lopez-Molina J, Pitt ML, Zook BC, Dannenberg AM, Bishai WR, Manabe YC. Susceptibility to tuberculosis: clues from studies with inbred and outbred New Zealand White rabbits. Infect Immun. 2004 Mar; 72(3):1700-5. PMID: 14977978; PMCID: PMC356026.
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