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Amy C. Arnold, PhD

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentNeural and Behavioral Sciences
Address500 University Drive Hershey, PA 17033
Phone717-531-3674
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    Collapse Biography 
    Collapse awards and honors
    2014 - 2019NIH Pathway to Independence Award (K99/R00), National Institutes of Health
    2012 - 2016NIH Loan Repayment Award, Extramural Clinical Research, National Institutes of Health
    2015AHA Fellow, Council on Hypertension, American Heart Association
    2014APS Early Career Research Recognition Award, Neural Control and Autonomic Regulation, American Physiological Society
    2014AAS Penaz-Wesseling Award, American Autonomic Society
    2013ASPET Young Scientist Travel Award, American Society for Pharmacology and Experimental Therapeutics
    2012Hazinski Award, Vanderbilt Masters of Science in Clinical Investigation Program, Vanderbilt University
    2011ASPET Young Scientist Travel Award, American Society for Pharmacology and Experimental Therapeutics
    2010APS Van Harreveld Award, Central Nervous System Section, American Physiological Society
    2010AAS Travel Fellowship Award, American Autonomic Society
    2008AHA Council on Hypertension Merck New Investigator Award, American Heart Association

    Collapse Overview 
    Collapse overview
    My research program is focused on understanding the role of the renin-angiotensin system in the neural control of blood pressure and metabolism. Current studies focus on how angiotensin-(1-7), a beneficial hormone of the renin-angiotensin system, interacts with the autonomic nervous system to improve blood pressure and insulin sensitivity in cardiometabolic diseases including obesity and hypertension. These studies utilize a variety of approaches in mice including in vivo cardiovascular monitoring, pharmacologic and spectral analysis of autonomic function, and measurement of insulin action. We also have translational studies examining the effects of systemic angiotensin-(1-7) infusion on blood pressure and insulin sensitivity in patients with essential hypertension. These studies are currently funded by the National Institutes of Health.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Marinos A, Gamboa A, Celedonio JE, Preheim BA, Okamoto LE, Ramirez CE, Arnold AC, Diedrich A, Biaggioni I, Shibao CA. Hypertension in Obese Black Women is Not Caused by Increased Sympathetic Vascular Tone. J Am Heart Assoc. 2017 Nov 18; 6(11). PMID: 29151035.
      View in: PubMed
    2. Arnold AC, Ng J, Lei L, Raj SR. Autonomic Dysfunction in Cardiology: Pathophysiology, Investigation, and Management. Can J Cardiol. 2017 Dec; 33(12):1524-1534. PMID: 29102451.
      View in: PubMed
    3. Arnold AC, Raj SR. Orthostatic Hypotension: A Practical Approach to Investigation and Management. Can J Cardiol. 2017 Dec; 33(12):1725-1728. PMID: 28807522.
      View in: PubMed
    4. Arnold AC, Garland EM, Celedonio JE, Raj SR, Abumrad NN, Biaggioni I, Robertson D, Luther JM, Shibao CA. Hyperinsulinemia and Insulin Resistance in Dopamine ß-Hydroxylase Deficiency. J Clin Endocrinol Metab. 2017 Jan 01; 102(1):10-14. PMID: 27778639.
      View in: PubMed
    5. Shibao CA, Celedonio JE, Ramirez CE, Love-Gregory L, Arnold AC, Choi L, Okamoto LE, Gamboa A, Biaggioni I, Abumrad NN, Abumrad NA. A Common CD36 Variant Influences Endothelial Function and Response to Treatment with Phosphodiesterase 5 Inhibition. J Clin Endocrinol Metab. 2016 Jul; 101(7):2751-8. PMID: 27144937; PMCID: PMC4929841 [Available on 07/01/17].
    6. Arnold AC. To Sensitize or Not to Sensitize: Leptin Is the Question. Hypertension. 2016 May; 67(5):843-4. PMID: 27021015; PMCID: PMC4833619 [Available on 05/01/17].
    7. Williams IM, Otero YF, Bracy DP, Wasserman DH, Biaggioni I, Arnold AC. Chronic Angiotensin-(1-7) Improves Insulin Sensitivity in High-Fat Fed Mice Independent of Blood Pressure. Hypertension. 2016 May; 67(5):983-91. PMID: 26975707; PMCID: PMC4833535 [Available on 05/01/17].
    8. Arnold AC, Okamoto LE, Gamboa A, Black BK, Raj SR, Elijovich F, Robertson D, Shibao CA, Biaggioni I. Mineralocorticoid Receptor Activation Contributes to the Supine Hypertension of Autonomic Failure. Hypertension. 2016 Feb; 67(2):424-9. PMID: 26644241; PMCID: PMC4748950 [Available on 02/01/17].
    9. Okamoto LE, Raj SR, Gamboa A, Shibao CA, Arnold AC, Garland EM, Black BK, Farley G, Diedrich A, Biaggioni I. Sympathetic activation is associated with increased IL-6, but not CRP in the absence of obesity: lessons from postural tachycardia syndrome and obesity. Am J Physiol Heart Circ Physiol. 2015 Dec 15; 309(12):H2098-107. PMID: 26453329; PMCID: PMC4698423 [Available on 12/15/16].
    10. Arnold AC, Robertson D. Defective Wnt Signaling: A Potential Contributor to Cardiometabolic Disease? Diabetes. 2015 Oct; 64(10):3342-4. PMID: 26405272; PMCID: PMC4587636 [Available on 10/01/16].
    11. Celedonio JE, Arnold AC, Dupont WD, Ramirez CE, Diedrich A, Okamoto LE, Raj SR, Robertson D, Peltier AC, Biaggioni I, Shibao CA. Residual sympathetic tone is associated with reduced insulin sensitivity in patients with autonomic failure. Clin Auton Res. 2015 Oct; 25(5):309-15. PMID: 26359268; PMCID: PMC4785595 [Available on 10/01/16].
    12. Gamboa A, Paranjape SY, Black BK, Arnold AC, Figueroa R, Okamoto LE, Nwazue VC, Diedrich A, Plummer WD, Dupont WD, Robertson D, Raj SR. Inspiratory resistance improves postural tachycardia: a randomized study. Circ Arrhythm Electrophysiol. 2015 Jun; 8(3):651-8. PMID: 25792354; PMCID: PMC4472504.
    13. Arnold AC, Haman K, Garland EM, Raj V, Dupont WD, Biaggioni I, Robertson D, Raj SR. Cognitive dysfunction in postural tachycardia syndrome. Clin Sci (Lond). 2015 Jan; 128(1):39-45. PMID: 25001527; PMCID: PMC4161607.
    14. Kpaeyeh J, Mar PL, Raj V, Black BK, Arnold AC, Biaggioni I, Shibao CA, Paranjape SY, Dupont WD, Robertson D, Raj SR. Hemodynamic profiles and tolerability of modafinil in the treatment of postural tachycardia syndrome: a randomized, placebo-controlled trial. J Clin Psychopharmacol. 2014 Dec; 34(6):738-41. PMID: 25222185; PMCID: PMC4239166.
    15. Okamoto LE, Gamboa A, Shibao CA, Arnold AC, Choi L, Black BK, Raj SR, Robertson D, Biaggioni I. Nebivolol, but not metoprolol, lowers blood pressure in nitric oxide-sensitive human hypertension. Hypertension. 2014 Dec; 64(6):1241-7. PMID: 25267802; PMCID: PMC4230998.
    16. Arnold AC, Diz DI. Endogenous leptin contributes to baroreflex suppression within the solitary tract nucleus of aged rats. Am J Physiol Heart Circ Physiol. 2014 Dec 01; 307(11):H1539-46. PMID: 25260611; PMCID: PMC4255011.
    17. Ramirez CE, Okamoto LE, Arnold AC, Gamboa A, Diedrich A, Choi L, Raj SR, Robertson D, Biaggioni I, Shibao CA. Efficacy of atomoxetine versus midodrine for the treatment of orthostatic hypotension in autonomic failure. Hypertension. 2014 Dec; 64(6):1235-40. PMID: 25185131; PMCID: PMC4231172.
    18. Arnold AC, Ramirez CE, Choi L, Okamoto LE, Gamboa A, Diedrich A, Raj SR, Robertson D, Biaggioni I, Shibao CA. Combination ergotamine and caffeine improves seated blood pressure and presyncopal symptoms in autonomic failure. Front Physiol. 2014; 5:270. PMID: 25104940; PMCID: PMC4109567.
    19. Figueroa RA, Arnold AC, Nwazue VC, Okamoto LE, Paranjape SY, Black BK, Diedrich A, Robertson D, Biaggioni I, Raj SR, Gamboa A. Acute volume loading and exercise capacity in postural tachycardia syndrome. J Appl Physiol (1985). 2014 Sep 15; 117(6):663-8. PMID: 25059240; PMCID: PMC4157162.
    20. Gamboa A, Okamoto LE, Arnold AC, Figueroa RA, Diedrich A, Raj SR, Paranjape SY, Farley G, Abumrad N, Biaggioni I. Autonomic blockade improves insulin sensitivity in obese subjects. Hypertension. 2014 Oct; 64(4):867-74. PMID: 25001269; PMCID: PMC4162826.
    21. Nwazue VC, Arnold AC, Raj V, Black BK, Biaggioni I, Paranjape SY, Orozco C, Dupont WD, Robertson D, Raj SR. Understanding the placebo effect in clinical trials for postural tachycardia syndrome. Clin Exp Pharmacol Physiol. 2014 May; 41(5):325-30. PMID: 24606242; PMCID: PMC4005784.
    22. Arnold AC, Shibao C. Current concepts in orthostatic hypotension management. Curr Hypertens Rep. 2013 Aug; 15(4):304-12. PMID: 23832761; PMCID: PMC3769171.
    23. Arnold AC, Okamoto LE, Diedrich A, Paranjape SY, Raj SR, Biaggioni I, Gamboa A. Low-dose propranolol and exercise capacity in postural tachycardia syndrome: a randomized study. Neurology. 2013 May 21; 80(21):1927-33. PMID: 23616163; PMCID: PMC3716342.
    24. Nautiyal M, Arnold AC, Chappell MC, Diz DI. The brain Renin-Angiotensin system and mitochondrial function: influence on blood pressure and baroreflex in transgenic rat strains. Int J Hypertens. 2013; 2013:136028. PMID: 23401750; PMCID: PMC3564433.
    25. Arnold AC, Okamoto LE, Gamboa A, Shibao C, Raj SR, Robertson D, Biaggioni I. Angiotensin II, independent of plasma renin activity, contributes to the hypertension of autonomic failure. Hypertension. 2013 Mar; 61(3):701-6. PMID: 23266540; PMCID: PMC3573256.
    26. Arnold AC, Gallagher PE, Diz DI. Brain renin-angiotensin system in the nexus of hypertension and aging. Hypertens Res. 2013 Jan; 36(1):5-13. PMID: 23076408; PMCID: PMC3816955.
    27. Arnold AC, Sakima A, Kasper SO, Vinsant S, Garcia-Espinosa MA, Diz DI. The brain renin-angiotensin system and cardiovascular responses to stress: insights from transgenic rats with low brain angiotensinogen. J Appl Physiol (1985). 2012 Dec 15; 113(12):1929-36. PMID: 22984245; PMCID: PMC3544491.
    28. Arnold AC, Biaggioni I. Management approaches to hypertension in autonomic failure. Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):481-5. PMID: 22801444; PMCID: PMC3732047.
    29. Arnold AC, Nautiyal M, Diz DI. Protein phosphatase 1b in the solitary tract nucleus is necessary for normal baroreflex function. J Cardiovasc Pharmacol. 2012 May; 59(5):472-8. PMID: 22569287; PMCID: PMC3349073.
    30. Isa K, Arnold AC, Westwood BM, Chappell MC, Diz DI. Angiotensin-converting enzyme inhibition, but not AT(1) receptor blockade, in the solitary tract nucleus improves baroreflex sensitivity in anesthetized transgenic hypertensive (mRen2)27 rats. Hypertens Res. 2011 Dec; 34(12):1257-62. PMID: 21937997; PMCID: PMC4160904.
    31. Arnold AC, Shaltout HA, Gilliam-Davis S, Kock ND, Diz DI. Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis. Am J Physiol Heart Circ Physiol. 2011 Jun; 300(6):H2206-13. PMID: 21460193; PMCID: PMC3119102.
    32. Diz DI, Arnold AC, Nautiyal M, Isa K, Shaltout HA, Tallant EA. Angiotensin peptides and central autonomic regulation. Curr Opin Pharmacol. 2011 Apr; 11(2):131-7. PMID: 21367658; PMCID: PMC3120135.
    33. Arnold AC, Isa K, Shaltout HA, Nautiyal M, Ferrario CM, Chappell MC, Diz DI. Angiotensin-(1-12) requires angiotensin converting enzyme and AT1 receptors for cardiovascular actions within the solitary tract nucleus. Am J Physiol Heart Circ Physiol. 2010 Sep; 299(3):H763-71. PMID: 20562338; PMCID: PMC2944473.
    34. Arnold AC, Shaltout HA, Gallagher PE, Diz DI. Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus. Hypertension. 2009 Nov; 54(5):1001-8. PMID: 19770402; PMCID: PMC2789663.
    35. Isa K, García-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, Ganten D, Chappell MC, Ferrario CM, Diz DI. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2009 Jul; 297(1):R111-5. PMID: 19403863; PMCID: PMC2711698.
    36. Arnold AC, Sakima A, Ganten D, Ferrario CM, Diz DI. Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen. Hypertension. 2008 May; 51(5):1326-31. PMID: 18347230; PMCID: PMC2483961.
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