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Mary Truckenmiller

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentMicrobiology and Immunology
Address500 University Drive Hershey PA 17033
Mailbox: H107
Phone7175318147
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    Collapse Overview 
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    PREFERRED TITLE/ROLE:

    Assistant Professor of Microbiology

    GRADUATE PROGRAM AFFILIATIONS:

    Integrative Biosciences, Microbiology and Immunology

    EDUCATION:

    Ph.D.

    NARRATIVE:

    Dendritic cells (DCs) are the primary antigen presenting cells that are responsible for initiating and directing T and B lymphocyte-mediated immune responses against pathogens or tumors. DCs are a heterogeneous population with subpopulations potentially exhibiting different functions. Some DCs, in an immature state, can serve as sentinels in tissues and organs where their main function is to capture antigen at the site of infection. During the course of an infection, DCs recognize pathogen-associated molecules and are signaled to undergo maturation. This maturation process involves their migration to lymph nodes, increased antigen presentation on MHC class I and class II, and upregulation of co-stimulatory molecules. These processes are required for effective T cell-mediated immunity. However, it has long been recognized that many aspects of immune function are modulated by neurological and/or endocrine interactions. In particular, exposure to stress can lead to increased susceptibility to many pathogens, including viruses. Our focus is the influence of neuro-endocrine interactions upon DCs that can affect their maturation state and function at the cellular and molecular levels. In particular, we examine the acquisition of antigen (via uptake or direct viral infection), antigen processing, and antigen presentation in the context of the initiation of antiviral immunity.


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sei JJ, Haskett S, Kaminsky LW, Lin E, Truckenmiller ME, Bellone CJ, Buller RM, Norbury CC. Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation. PLoS Pathog. 2015 Jun; 11(6):e1004941. PMID: 26107264; PMCID: PMC4479883.
    2. Rubio D, Xu RH, Remakus S, Krouse TE, Truckenmiller ME, Thapa RJ, Balachandran S, Alcamí A, Norbury CC, Sigal LJ. Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection. Cell Host Microbe. 2013 Jun 12; 13(6):701-10. PMID: 23768494; PMCID: PMC3688842.
    3. Xu RH, Rubio D, Roscoe F, Krouse TE, Truckenmiller ME, Norbury CC, Hudson PN, Damon IK, Alcamí A, Sigal LJ. Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver. PLoS Pathog. 2012 Jan; 8(1):e1002475. PMID: 22241999; PMCID: PMC3252373.
    4. Hunzeker JT, Elftman MD, Mellinger JC, Princiotta MF, Bonneau RH, Truckenmiller ME, Norbury CC. A marked reduction in priming of cytotoxic CD8+ T cells mediated by stress-induced glucocorticoids involves multiple deficiencies in cross-presentation by dendritic cells. J Immunol. 2011 Jan 01; 186(1):183-94. PMID: 21098225; PMCID: PMC3701459.
    5. Elftman MD, Hunzeker JT, Mellinger JC, Bonneau RH, Norbury CC, Truckenmiller ME. Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function. J Immunol. 2010 Feb 15; 184(4):1867-75. PMID: 20089700; PMCID: PMC3701455.
    6. Elftman MD, Norbury CC, Bonneau RH, Truckenmiller ME. Corticosterone impairs dendritic cell maturation and function. Immunology. 2007 Oct; 122(2):279-90. PMID: 17848165; PMCID: PMC2265998.
    7. Fischer MA, Tscharke DC, Donohue KB, Truckenmiller ME, Norbury CC. Reduction of vector gene expression increases foreign antigen-specific CD8+ T-cell priming. J Gen Virol. 2007 Sep; 88(Pt 9):2378-86. PMID: 17698646.
      View in: PubMed
    8. Truckenmiller ME, Bonneau RH, Norbury CC. Stress presents a problem for dendritic cells: corticosterone and the fate of MHC class I antigen processing and presentation. Brain Behav Immun. 2006 May; 20(3):210-8. PMID: 16504465.
      View in: PubMed
    9. Sanchez JF, Crooks DR, Lee CT, Schoen CJ, Amable R, Zeng X, Florival-Victor T, Morales N, Truckenmiller ME, Smith DR, Freed WJ. GABAergic lineage differentiation of AF5 neural progenitor cells in vitro. Cell Tissue Res. 2006 Apr; 324(1):1-8. PMID: 16408195.
      View in: PubMed
    10. Freed WJ, Zhang P, Sanchez JF, Dillon-Carter O, Coggiano M, Errico SL, Lewis BD, Truckenmiller ME. Truncated N-terminal mutants of SV40 large T antigen as minimal immortalizing agents for CNS cells. Exp Neurol. 2005 Feb; 191 Suppl 1:S45-59. PMID: 15629761; PMCID: PMC1925051.
    11. Truckenmiller ME, Princiotta MF, Norbury CC, Bonneau RH. Corticosterone impairs MHC class I antigen presentation by dendritic cells via reduction of peptide generation. J Neuroimmunol. 2005 Mar; 160(1-2):48-60. PMID: 15710457.
      View in: PubMed
    12. Truckenmiller ME, Norbury CC. Viral vectors for inducing CD8+ T cell responses. Expert Opin Biol Ther. 2004 Jun; 4(6):861-8. PMID: 15174968.
      View in: PubMed
    13. Anglen CS, Truckenmiller ME, Schell TD, Bonneau RH. The dual role of CD8+ T lymphocytes in the development of stress-induced herpes simplex encephalitis. J Neuroimmunol. 2003 Jul; 140(1-2):13-27. PMID: 12864968.
      View in: PubMed
    14. Phillips AW, Zhang P, Truckenmiller ME, Keir SD, Bouvier M, Tornatore C, Freed WJ. Platelet-derived growth factor-producing cells immortalized from rat mesencephalon with SV40 large T antigen transduced by an AAV vector. Restor Neurol Neurosci. 2003; 21(1-2):1-10. PMID: 12808197.
      View in: PubMed
    15. Truckenmiller ME, Vawter MP, Zhang P, Conejero-Goldberg C, Dillon-Carter O, Morales N, Cheadle C, Becker KG, Freed WJ. AF5, a CNS cell line immortalized with an N-terminal fragment of SV40 large T: growth, differentiation, genetic stability, and gene expression. Exp Neurol. 2002 Jun; 175(2):318-37. PMID: 12061863.
      View in: PubMed
    16. Dillon-Carter O, Johnston RE, Borlongan CV, Truckenmiller ME, Coggiano M, Freed WJ. T155g-immortalized kidney cells produce growth factors and reduce sequelae of cerebral ischemia. Cell Transplant. 2002; 11(3):251-9. PMID: 12075990.
      View in: PubMed
    17. Truckenmiller ME, Vawter MP, Cheadle C, Coggiano M, Donovan DM, Freed WJ, Becker KG. Gene expression profile in early stage of retinoic acid-induced differentiation of human SH-SY5Y neuroblastoma cells. Restor Neurol Neurosci. 2001; 18(2-3):67-80. PMID: 11847429.
      View in: PubMed
    18. Truckenmiller ME, Tornatore C, Wright RD, Dillon-Carter O, Meiners S, Geller HM, Freed WJ. A truncated SV40 large T antigen lacking the p53 binding domain overcomes p53-induced growth arrest and immortalizes primary mesencephalic cells. Cell Tissue Res. 1998 Feb; 291(2):175-89. PMID: 9426306.
      View in: PubMed
    19. Truckenmiller ME, Dillon-Carter O, Tornatore C, Kulaga H, Takashima H, Freed WJ. Growth properties of neural cell lines immortalized with the tsA58 allele of SV40 large T antigen. Cell Transplant. 1997 May-Jun; 6(3):231-8. PMID: 9171156.
      View in: PubMed
    20. Truckenmiller ME, Kulaga H, Coggiano M, Wyatt R, Snyder SH, Sweetnam PM. Human cortical neuronal cell line: a model for HIV-1 infection in an immature neuronal system. AIDS Res Hum Retroviruses. 1993 May; 9(5):445-53. PMID: 8318271.
      View in: PubMed
    21. Gordon MR, Truckenmiller ME, Recker DP, Dickerson DR, Kuta E, Kulaga H, Kindt TJ. Evidence for HIV-1 infection in rabbits. A possible model for AIDS. Ann N Y Acad Sci. 1990; 616:270-80. PMID: 2078023.
      View in: PubMed
    22. Truckenmiller ME, Kulaga H, Gugel E, Dickerson D, Kindt TJ. Evidence for dual infection of rabbits with the human retroviruses HTLV-I and HIV-1. Res Immunol. 1989 Jun-Aug; 140(5-6):527-44. PMID: 2781136.
      View in: PubMed
    23. Kulaga H, Folks T, Rutledge R, Truckenmiller ME, Gugel E, Kindt TJ. Infection of rabbits with human immunodeficiency virus 1. A small animal model for acquired immunodeficiency syndrome. J Exp Med. 1989 Jan 01; 169(1):321-6. PMID: 2462611; PMCID: PMC2189195.
    24. Truckenmiller ME, Namboodiri MA, Brownstein MJ, Neale JH. N-Acetylation of L-aspartate in the nervous system: differential distribution of a specific enzyme. J Neurochem. 1985 Nov; 45(5):1658-62. PMID: 4045470.
      View in: PubMed
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