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Last Name
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Lawrence Sinoway

TitleProfessor
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive Hershey PA 17033
Mailcode: MC H047
Phone7175316853

 Overview 
 overview
PREFERRED TITLE/ROLE:

Distinguished Professor of Medicine, Physician
Director, Penn State Heart and Vascular Institute
Director, Clinical and Translational Science Institute

EDUCATION:

Fellowship, Cardiovascular Disease, Bronx Municipal Hospital Center-Jacobi Hospital (1984)
Residency, Internal Medicine, Bronx Municipal Hospital Center-Jacobi Hospital (1982)
M.D., UMDNJ - New Jersey Medical School - Newark, NJ (1978)


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Li S, Kiehne J, Sinoway LI, Cameron CE, Huang TJ. Microfluidic opportunities in the field of nutrition. Lab Chip. 2013 Oct 21; 13(20):3993-4003.
    View in: PubMed
  2. Spilk S, Herr MD, Sinoway LI, Leuenberger UA. Endothelium-derived hyperpolarizing factor contributes to hypoxia-induced skeletal muscle vasodilation in humans. Am J Physiol Heart Circ Physiol. 2013 Dec; 305(11):H1639-45.
    View in: PubMed
  3. Drew RC, Muller MD, Blaha CA, Mast JL, Herr MD, Stocker SD, Sinoway LI. Aspirin augments carotid-cardiac baroreflex sensitivity during muscle mechanoreflex and metaboreflex activation in humans. J Appl Physiol (1985). 2013 Oct 15; 115(8):1183-90.
    View in: PubMed
  4. Muller MD, Reed AB, Leuenberger UA, Sinoway LI. Physiology in Medicine: Peripheral arterial disease. J Appl Physiol (1985). 2013 Nov; 115(9):1219-26.
    View in: PubMed
  5. Cui J, Gao Z, Blaha C, Herr MD, Mast J, Sinoway LI. Distension of central great vein decreases sympathetic outflow in humans. Am J Physiol Heart Circ Physiol. 2013 Aug 1; 305(3):H378-85.
    View in: PubMed
  6. Patel HM, Mast JL, Sinoway LI, Muller MD. Effect of healthy aging on renal vascular responses to local cooling and apnea. J Appl Physiol (1985). 2013 Jul 1; 115(1):90-6.
    View in: PubMed
  7. Muller MD, Mast JL, Cui J, Heffernan MJ, McQuillan PM, Sinoway LI. Tactile stimulation of the oropharynx elicits sympathoexcitation in conscious humans. J Appl Physiol (1985). 2013 Jul 1; 115(1):71-7.
    View in: PubMed
  8. Liu G, Chen G, Sinoway LI, Berg A. Assessing the impact of the NIH CTSA program on institutionally sponsored clinical trials. Clin Transl Sci. 2013 Jun; 6(3):196-200.
    View in: PubMed
  9. Monahan KD, Feehan RP, Sinoway LI, Gao Z. Contribution of sympathetic activation to coronary vasodilatation during the cold pressor test in healthy men: effect of ageing. J Physiol. 2013 Jun 1; 591(Pt 11):2937-47.
    View in: PubMed
  10. Cui J, Boehmer JP, Blaha C, Lucking R, Kunselman AR, Sinoway LI. Chronic heart failure does not attenuate the total activity of sympathetic outflow to skin during whole-body heating. Circ Heart Fail. 2013 Mar; 6(2):271-8.
    View in: PubMed
  11. Stocker SD, Monahan KD, Sinoway LI. The hypothalamic paraventricular nucleus may not be at the heart of sympathetic outflow. J Physiol. 2013 Jan 1; 591(Pt 1):1.
    View in: PubMed
  12. Muller MD, Mast JL, Patel H, Sinoway LI. Cardiac mechanics are impaired during fatiguing exercise and cold pressor test in healthy older adults. J Appl Physiol (1985). 2013 Jan 15; 114(2):186-94.
    View in: PubMed
  13. Muller MD, Drew RC, Blaha CA, Mast JL, Cui J, Reed AB, Sinoway LI. Oxidative stress contributes to the augmented exercise pressor reflex in peripheral arterial disease patients. J Physiol. 2012 Dec 1; 590(Pt 23):6237-46.
    View in: PubMed
  14. Gao Z, Novick M, Muller MD, Williams RJ, Spilk S, Leuenberger UA, Sinoway LI. Exercise and diet-induced weight loss attenuates oxidative stress related-coronary vasoconstriction in obese adolescents. Eur J Appl Physiol. 2013 Feb; 113(2):519-28.
    View in: PubMed
  15. Cui J, McQuillan PM, Blaha C, Kunselman AR, Sinoway LI. Limb venous distension evokes sympathetic activation via stimulation of the limb afferents in humans. Am J Physiol Heart Circ Physiol. 2012 Aug 15; 303(4):H457-63.
    View in: PubMed
  16. Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS). Clin Transl Sci. 2012 Apr; 5(2):121-9.
    View in: PubMed
  17. Muller MD, Gao Z, Mast JL, Blaha CA, Drew RC, Leuenberger UA, Sinoway LI. Aging attenuates the coronary blood flow response to cold air breathing and isometric handgrip in healthy humans. Am J Physiol Heart Circ Physiol. 2012 Apr 15; 302(8):H1737-46.
    View in: PubMed
  18. Muller MD, Gao Z, Drew RC, Herr MD, Leuenberger UA, Sinoway LI. Effect of cold air inhalation and isometric exercise on coronary blood flow and myocardial function in humans. J Appl Physiol (1985). 2011 Dec; 111(6):1694-702.
    View in: PubMed
  19. Cui J, Leuenberger UA, Gao Z, Sinoway LI. Sympathetic and cardiovascular responses to venous distension in an occluded limb. Am J Physiol Regul Integr Comp Physiol. 2011 Dec; 301(6):R1831-7.
    View in: PubMed
  20. Gao Z, Spilk S, Momen A, Muller MD, Leuenberger UA, Sinoway LI. Vitamin C prevents hyperoxia-mediated coronary vasoconstriction and impairment of myocardial function in healthy subjects. Eur J Appl Physiol. 2012 Feb; 112(2):483-92.
    View in: PubMed
  21. Drew RC, Sinoway LI, White MJ. The two-hour marathon: running economy and lower body flexibility. J Appl Physiol (1985). 2011 Jan; 110(1):284-5; discussion 294.
    View in: PubMed
  22. Cui J, Leuenberger UA, Blaha C, King NC, Sinoway LI. Effect of P2 receptor blockade with pyridoxine on sympathetic response to exercise pressor reflex in humans. J Physiol. 2011 Feb 1; 589(Pt 3):685-95.
    View in: PubMed
  23. Koba S, Hayes SG, Sinoway LI. Transient receptor potential A1 channel contributes to activation of the muscle reflex. Am J Physiol Heart Circ Physiol. 2011 Jan; 300(1):H201-13.
    View in: PubMed
  24. Momen A, Gao Z, Cohen A, Khan T, Leuenberger UA, Sinoway LI. Coronary vasoconstrictor responses are attenuated in young women as compared with age-matched men. J Physiol. 2010 Oct 15; 588(Pt 20):4007-16.
    View in: PubMed
  25. Moradkhan R, Sinoway LI. Revisiting the role of oxygen therapy in cardiac patients. J Am Coll Cardiol. 2010 Sep 21; 56(13):1013-6.
    View in: PubMed
  26. Cui J, Leuenberger UA, Blaha C, Yoder J, Gao Z, Sinoway LI. Local adenosine receptor blockade accentuates the sympathetic responses to fatiguing exercise. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H2130-7.
    View in: PubMed
  27. Koba S, Xing J, Sinoway LI, Li J. Bradykinin receptor blockade reduces sympathetic nerve response to muscle contraction in rats with ischemic heart failure. Am J Physiol Heart Circ Physiol. 2010 May; 298(5):H1438-44.
    View in: PubMed
  28. Momen A, Kozak M, Leuenberger UA, Ettinger S, Blaha C, Mascarenhas V, Lendel V, Herr MD, Sinoway LI. Transthoracic Doppler echocardiography to noninvasively assess coronary vasoconstrictor and dilator responses in humans. Am J Physiol Heart Circ Physiol. 2010 Feb; 298(2):H524-9.
    View in: PubMed
  29. Koba S, Gao Z, Sinoway LI. Oxidative stress and the muscle reflex in heart failure. J Physiol. 2009 Nov 1; 587(Pt 21):5227-37.
    View in: PubMed
  30. Cui J, McQuillan P, Moradkhan R, Pagana C, Sinoway LI. Sympathetic responses during saline infusion into the veins of an occluded limb. J Physiol. 2009 Jul 15; 587(Pt 14):3619-28.
    View in: PubMed
  31. Momen A, Mascarenhas V, Gahremanpour A, Gao Z, Moradkhan R, Kunselman A, Boehmer JP, Sinoway LI, Leuenberger UA. Coronary blood flow responses to physiological stress in humans. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H854-61.
    View in: PubMed
  32. Li J, Lu J, Gao Z, Koba S, Xing J, King N, Sinoway L. Spinal P2X receptor modulates muscle pressor reflex via glutamate. J Appl Physiol (1985). 2009 Mar; 106(3):865-70.
    View in: PubMed
  33. Lott ME, Hogeman C, Herr M, Bhagat M, Sinoway LI. Sex differences in limb vasoconstriction responses to increases in transmural pressures. Am J Physiol Heart Circ Physiol. 2009 Jan; 296(1):H186-94.
    View in: PubMed
  34. Lott ME, Hogeman C, Herr M, Bhagat M, Kunselman A, Sinoway LI. Vasoconstrictor responses in the upper and lower limbs to increases in transmural pressure. J Appl Physiol (1985). 2009 Jan; 106(1):302-10.
    View in: PubMed
  35. McNulty PH, Scott S, Kehoe V, Kozak M, Sinoway LI, Li J. Nitrite consumption in ischemic rat heart catalyzed by distinct blood-borne and tissue factors. Am J Physiol Heart Circ Physiol. 2008 Nov; 295(5):H2143-8.
    View in: PubMed
  36. Li J, Gao Z, Kehoe V, Xing J, King N, Sinoway L. Interstitial adenosine triphosphate modulates muscle afferent nerve-mediated pressor reflex. Muscle Nerve. 2008 Aug; 38(2):972-7.
    View in: PubMed
  37. Xing J, Gao Z, Lu J, Sinoway LI, Li J. Femoral artery occlusion augments TRPV1-mediated sympathetic responsiveness. Am J Physiol Heart Circ Physiol. 2008 Sep; 295(3):H1262-H1269.
    View in: PubMed
  38. Xing J, Sinoway L, Li J. Differential responses of sensory neurones innervating glycolytic and oxidative muscle to protons and capsaicin. J Physiol. 2008 Jul 1; 586(13):3245-52.
    View in: PubMed
  39. Cui J, Moradkhan R, Mascarenhas V, Momen A, Sinoway LI. Cyclooxygenase inhibition attenuates sympathetic responses to muscle stretch in humans. Am J Physiol Heart Circ Physiol. 2008 Jun; 294(6):H2693-700.
    View in: PubMed
  40. Gao Z, Koba S, Sinoway L, Li J. 20-HETE increases renal sympathetic nerve activity via activation of chemically and mechanically sensitive muscle afferents. J Physiol. 2008 May 15; 586(10):2581-91.
    View in: PubMed
  41. Momen A, Cui J, McQuillan P, Sinoway LI. Local prostaglandin blockade attenuates muscle mechanoreflex-mediated renal vasoconstriction during muscle stretch in humans. Am J Physiol Heart Circ Physiol. 2008 May; 294(5):H2184-90.
    View in: PubMed
  42. Lydakis C, Momen A, Blaha C, Gugoff S, Gray K, Herr M, Leuenberger UA, Sinoway LI. Changes of central haemodynamic parameters during mental stress and acute bouts of static and dynamic exercise. J Hum Hypertens. 2008 May; 22(5):320-8.
    View in: PubMed
  43. Lydakis C, Momen A, Blaha C, Herr M, Leuenberger UA, Sinoway LI. Changes of elastic properties of central arteries during acute static exercise and lower body negative pressure. Eur J Appl Physiol. 2008 Apr; 102(6):633-41.
    View in: PubMed
  44. Cui J, Mascarenhas V, Moradkhan R, Blaha C, Sinoway LI. Effects of muscle metabolites on responses of muscle sympathetic nerve activity to mechanoreceptor(s) stimulation in healthy humans. Am J Physiol Regul Integr Comp Physiol. 2008 Feb; 294(2):R458-66.
    View in: PubMed
  45. Koba S, Xing J, Sinoway LI, Li J. Sympathetic nerve responses to muscle contraction and stretch in ischemic heart failure. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H311-21.
    View in: PubMed
  46. Cui J, McQuillan P, Momen A, Blaha C, Moradkhan R, Mascarenhas V, Hogeman C, Krishnan A, Sinoway LI. The role of the cyclooxygenase products in evoking sympathetic activation in exercise. Am J Physiol Heart Circ Physiol. 2007 Sep; 293(3):H1861-8.
    View in: PubMed
  47. Koba S, Xing J, Sinoway LI, Li J. Differential sympathetic outflow elicited by active muscle in rats. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2335-43.
    View in: PubMed
  48. Xing J, Koba S, Kehoe V, Gao Z, Rice K, King N, Sinoway L, Li J. Interstitial norepinephrine concentrations in skeletal muscle of ischemic heart failure. Am J Physiol Heart Circ Physiol. 2007 Aug; 293(2):H1190-5.
    View in: PubMed
  49. Gao Z, Li JD, Sinoway LI, Li J. Effect of muscle interstitial pH on P2X and TRPV1 receptor-mediated pressor response. J Appl Physiol (1985). 2007 Jun; 102(6):2288-93.
    View in: PubMed
  50. McNulty PH, Robertson BJ, Tulli MA, Hess J, Harach LA, Scott S, Sinoway LI. Effect of hyperoxia and vitamin C on coronary blood flow in patients with ischemic heart disease. J Appl Physiol (1985). 2007 May; 102(5):2040-5.
    View in: PubMed
  51. Momen A, Gahremanpour A, Mansoor A, Kunselman A, Blaha C, Pae W, Leuenberger UA, Sinoway LI. Vasoconstriction seen in coronary bypass grafts during handgrip in humans. J Appl Physiol (1985). 2007 Feb; 102(2):735-9.
    View in: PubMed
  52. Gao Z, Xing J, Sinoway L, Li J. P2X receptor-mediated muscle pressor reflex in myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H939-45.
    View in: PubMed
  53. Li J, Gao Z, Kehoe V, Sinoway LI. Interstitial K+ concentration in active muscle after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H808-13.
    View in: PubMed
  54. Middlekauff HR, Sinoway LI. Increased mechanoreceptor stimulation explains the exaggerated exercise pressor reflex seen in heart failure. J Appl Physiol (1985). 2007 Jan; 102(1):492-4; discussion 496.
    View in: PubMed
  55. Lott ME, Hogeman C, Herr M, Gabbay R, Sinoway LI. Effects of an oral glucose tolerance test on the myogenic response in healthy individuals. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H304-10.
    View in: PubMed
  56. Cui J, Blaha C, Moradkhan R, Gray KS, Sinoway LI. Muscle sympathetic nerve activity responses to dynamic passive muscle stretch in humans. J Physiol. 2006 Oct 15; 576(Pt 2):625-34.
    View in: PubMed
  57. Koba S, Gao Z, Xing J, Sinoway LI, Li J. Sympathetic responses to exercise in myocardial infarction rats: a role of central command. Am J Physiol Heart Circ Physiol. 2006 Dec; 291(6):H2735-42.
    View in: PubMed
  58. Momen A, Thomas K, Blaha C, Gahremanpour A, Mansoor A, Leuenberger UA, Sinoway LI. Renal vasoconstrictor responses to static exercise during orthostatic stress in humans: effects of the muscle mechano- and the baroreflexes. J Physiol. 2006 Jun 15; 573(Pt 3):819-25.
    View in: PubMed
  59. Gao Z, Kehoe V, Xing J, Sinoway L, Li J. Temperature modulates P2X receptor-mediated cardiovascular responses to muscle afferent activation. Am J Physiol Heart Circ Physiol. 2006 Sep; 291(3):H1255-61.
    View in: PubMed
  60. Momen A, Handly B, Kunselman A, Leuenberger UA, Sinoway LI. Influence of sex and active muscle mass on renal vascular responses during static exercise. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H121-6.
    View in: PubMed
  61. Li J, Sinoway LI, Ng YC. Aging augments interstitial K+ concentrations in active muscle of rats. J Appl Physiol (1985). 2006 Apr; 100(4):1158-63.
    View in: PubMed
  62. Gao Z, Henig O, Kehoe V, Sinoway LI, Li J. Vanilloid type 1 receptor and the acid-sensing ion channel mediate acid phosphate activation of muscle afferent nerves in rats. J Appl Physiol (1985). 2006 Feb; 100(2):421-6.
    View in: PubMed
  63. Sinoway LI, Li J. A perspective on the muscle reflex: implications for congestive heart failure. J Appl Physiol (1985). 2005 Jul; 99(1):5-22.
    View in: PubMed
  64. Momen A, Bower D, Leuenberger UA, Boehmer J, Lerner S, Alfrey EJ, Handly B, Sinoway LI. Renal vascular response to static handgrip exercise: sympathetic vs. autoregulatory control. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1770-6.
    View in: PubMed
  65. Gao Z, Li J, Kehoe V, Davidson WR, Sinoway L, Pu M. An initial application of transesophageal Doppler echocardiography in experimental small animal models. J Am Soc Echocardiogr. 2005 Jun; 18(6):626-31.
    View in: PubMed
  66. Li J, King NC, Sinoway LI. Interstitial ATP and norepinephrine concentrations in active muscle. Circulation. 2005 May 31; 111(21):2748-51.
    View in: PubMed
  67. Pu M, Gao Z, Li J, Sinoway L, Davidson WR. Development of a new animal model of chronic mitral regurgitation in rats under transesophageal echocardiographic guidance. J Am Soc Echocardiogr. 2005 May; 18(5):468-74.
    View in: PubMed
  68. McNulty PH, King N, Scott S, Hartman G, McCann J, Kozak M, Chambers CE, Demers LM, Sinoway LI. Effects of supplemental oxygen administration on coronary blood flow in patients undergoing cardiac catheterization. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1057-62.
    View in: PubMed
  69. Gao Z, Kehoe V, Sinoway LI, Li J. Spinal P2X receptor modulates reflex pressor response to activation of muscle afferents. Am J Physiol Heart Circ Physiol. 2005 May; 288(5):H2238-43.
    View in: PubMed
  70. Li J, Sinoway AN, Gao Z, Maile MD, Pu M, Sinoway LI. Muscle mechanoreflex and metaboreflex responses after myocardial infarction in rats. Circulation. 2004 Nov 9; 110(19):3049-54.
    View in: PubMed
  71. Momen A, Bower D, Boehmer J, Kunselman AR, Leuenberger UA, Sinoway LI. Renal blood flow in heart failure patients during exercise. Am J Physiol Heart Circ Physiol. 2004 Dec; 287(6):H2834-9.
    View in: PubMed
  72. Li J, Maile MD, Sinoway AN, Sinoway LI. Muscle pressor reflex: potential role of vanilloid type 1 receptor and acid-sensing ion channel. J Appl Physiol (1985). 2004 Nov; 97(5):1709-14.
    View in: PubMed
  73. Imadojemu VA, Mooney K, Hogeman C, Lott ME, Kunselman A, Sinoway LI. Extracellular calcium and vascular responses after forearm ischemia. Circulation. 2004 Jul 6; 110(1):79-83.
    View in: PubMed
  74. Lott ME, Herr MD, Sinoway LI. Effects of age on brachial artery myogenic responses in humans. Am J Physiol Regul Integr Comp Physiol. 2004 Sep; 287(3):R586-91.
    View in: PubMed
  75. Lott ME, Sinoway LI. What has microdialysis shown us about the metabolic milieu within exercising skeletal muscle? Exerc Sport Sci Rev. 2004 Apr; 32(2):69-74.
    View in: PubMed
  76. Momen A, Leuenberger UA, Handly B, Sinoway LI. Effect of aging on renal blood flow velocity during static exercise. Am J Physiol Heart Circ Physiol. 2004 Aug; 287(2):H735-40.
    View in: PubMed
  77. Imadojemu VA, Sinoway LI, Leuenberger UA. Vascular dysfunction in sleep apnea: a reversible link to cardiovascular disease? Am J Respir Crit Care Med. 2004 Feb 1; 169(3):328-9.
    View in: PubMed
  78. Samii S, Khan MH, MacLean DA, King N, Herr MD, Sinoway LI. Muscle interstitial calcium during head-up tilt in humans. Circulation. 2004 Jan 20; 109(2):215-9.
    View in: PubMed
  79. Leuenberger UA, Mostoufi-Moab S, Herr M, Gray K, Kunselman A, Sinoway LI. Control of skin sympathetic nerve activity during intermittent static handgrip exercise. Circulation. 2003 Nov 11; 108(19):2329-35.
    View in: PubMed
  80. Daley JC, Khan MH, Hogeman CS, Sinoway LI. Autonomic and vascular responses to reduced limb perfusion. J Appl Physiol (1985). 2003 Oct; 95(4):1493-8.
    View in: PubMed
  81. Shoemaker JK, Hogeman CS, Sinoway LI. Sympathetic responses to Valsalva's manoeuvre following bed rest. Can J Appl Physiol. 2003 Jun; 28(3):342-55.
    View in: PubMed
  82. Momen A, Leuenberger UA, Ray CA, Cha S, Handly B, Sinoway LI. Renal vascular responses to static handgrip: role of muscle mechanoreflex. Am J Physiol Heart Circ Physiol. 2003 Sep; 285(3):H1247-53.
    View in: PubMed
  83. Li J, King NC, Sinoway LI. ATP concentrations and muscle tension increase linearly with muscle contraction. J Appl Physiol (1985). 2003 Aug; 95(2):577-83.
    View in: PubMed
  84. Markel TA, Daley JC, Hogeman CS, Herr MD, Khan MH, Gray KS, Kunselman AR, Sinoway LI. Aging and the exercise pressor reflex in humans. Circulation. 2003 Feb 11; 107(5):675-8.
    View in: PubMed
  85. Li J, Sinoway LI. ATP stimulates chemically sensitive and sensitizes mechanically sensitive afferents. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2636-43.
    View in: PubMed
  86. Khan MH, Sinoway LI, MacLean DA. Effects of graded LBNP on MSNA and interstitial norepinephrine. Am J Physiol Heart Circ Physiol. 2002 Nov; 283(5):H2038-44.
    View in: PubMed
  87. Lott ME, Herr MD, Sinoway LI. Effects of transmural pressure on brachial artery mean blood velocity dynamics in humans. J Appl Physiol (1985). 2002 Dec; 93(6):2137-46.
    View in: PubMed
  88. Shoemaker JK, Hughson RL, Sinoway LI. Gender affects sympathetic neurovascular control during postural stress. J Gravit Physiol. 2002 Jul; 9(1):P83-4.
    View in: PubMed
  89. Daley JC, Hogeman CS, Sinoway LI. Venous plasma potassium is not associated with maintenance of the exercise pressor reflex in humans. Am J Physiol Regul Integr Comp Physiol. 2002 Jun; 282(6):R1608-12.
    View in: PubMed
  90. Khan MH, Kunselman AR, Leuenberger UA, Davidson WR, Ray CA, Gray KS, Hogeman CS, Sinoway LI. Attenuated sympathetic nerve responses after 24 hours of bed rest. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2210-5.
    View in: PubMed
  91. Imadojemu VA, Gleeson K, Quraishi SA, Kunselman AR, Sinoway LI, Leuenberger UA. Impaired vasodilator responses in obstructive sleep apnea are improved with continuous positive airway pressure therapy. Am J Respir Crit Care Med. 2002 Apr 1; 165(7):950-3.
    View in: PubMed
  92. Imadojemu VA, Gleeson K, Gray KS, Sinoway LI, Leuenberger UA. Obstructive apnea during sleep is associated with peripheral vasoconstriction. Am J Respir Crit Care Med. 2002 Jan 1; 165(1):61-6.
    View in: PubMed
  93. Shoemaker JK, Hogeman CS, Khan M, Kimmerly DS, Sinoway LI. Gender affects sympathetic and hemodynamic response to postural stress. Am J Physiol Heart Circ Physiol. 2001 Nov; 281(5):H2028-35.
    View in: PubMed
  94. Lott ME, Hogeman CS, Vickery L, Kunselman AR, Sinoway LI, MacLean DA. Effects of dynamic exercise on mean blood velocity and muscle interstitial metabolite responses in humans. Am J Physiol Heart Circ Physiol. 2001 Oct; 281(4):H1734-41.
    View in: PubMed
  95. Imadojemu VA, Lott ME, Gleeson K, Hogeman CS, Ray CA, Sinoway LI. Contribution of perfusion pressure to vascular resistance response during head-up tilt. Am J Physiol Heart Circ Physiol. 2001 Jul; 281(1):H371-5.
    View in: PubMed
  96. Leuenberger UA, Hardy JC, Herr MD, Gray KS, Sinoway LI. Hypoxia augments apnea-induced peripheral vasoconstriction in humans. J Appl Physiol (1985). 2001 Apr; 90(4):1516-22.
    View in: PubMed
  97. MacLean DA, Vickery LM, Sinoway LI. Elevated interstitial adenosine concentrations do not activate the muscle reflex. Am J Physiol Heart Circ Physiol. 2001 Feb; 280(2):H546-53.
    View in: PubMed
  98. MacLean DA, Ettinger SM, Sinoway LI, Lanoue KF. Determination of muscle-specific glucose flux using radioactive stereoisomers and microdialysis. Am J Physiol Endocrinol Metab. 2001 Jan; 280(1):E187-92.
    View in: PubMed
  99. Cornett JA, Herr MD, Gray KS, Smith MB, Yang QX, Sinoway LI. Ischemic exercise and the muscle metaboreflex. J Appl Physiol (1985). 2000 Oct; 89(4):1432-6.
    View in: PubMed
  100. Shoemaker JK, Herr MD, Sinoway LI. Dissociation of muscle sympathetic nerve activity and leg vascular resistance in humans. Am J Physiol Heart Circ Physiol. 2000 Sep; 279(3):H1215-9.
    View in: PubMed
  101. Lee F, Shoemaker JK, McQuillan PM, Kunselman AR, Smith MB, Yang QX, Smith H, Gray K, Sinoway LI. Effects of forearm bier block with bretylium on the hemodynamic and metabolic responses to handgrip. Am J Physiol Heart Circ Physiol. 2000 Aug; 279(2):H586-93.
    View in: PubMed
  102. Mostoufi-Moab S, Herr MD, Silber DH, Gray KS, Leuenberger UA, Sinoway LI. Limb congestion enhances the synchronization of sympathetic outflow with muscle contraction. Am J Physiol Regul Integr Comp Physiol. 2000 Aug; 279(2):R478-83.
    View in: PubMed
  103. Khan MH, Sinoway LI. Muscle reflex control of sympathetic nerve activity in heart failure: the role of exercise conditioning. Heart Fail Rev. 2000 Mar; 5(1):87-100.
    View in: PubMed
  104. MacLean DA, Imadojemu VA, Sinoway LI. Interstitial pH, K(+), lactate, and phosphate determined with MSNA during exercise in humans. Am J Physiol Regul Integr Comp Physiol. 2000 Mar; 278(3):R563-71.
    View in: PubMed
  105. Silber DH, Sinoway LI, Leuenberger UA, Amassian VE. Magnetic stimulation of the human motor cortex evokes skin sympathetic nerve activity. J Appl Physiol (1985). 2000 Jan; 88(1):126-34.
    View in: PubMed
  106. Shoemaker JK, Hogeman CS, Sinoway LI. Contributions of MSNA and stroke volume to orthostatic intolerance following bed rest. Am J Physiol. 1999 Oct; 277(4 Pt 2):R1084-90.
    View in: PubMed
  107. Shoemaker JK, Naylor HL, Hogeman CS, Sinoway LI. Blood flow dynamics in heart failure. Circulation. 1999 Jun 15; 99(23):3002-8.
    View in: PubMed
  108. Shoemaker JK, McQuillan PM, Sinoway LI. Upright posture reduces forearm blood flow early in exercise. Am J Physiol. 1999 May; 276(5 Pt 2):R1434-42.
    View in: PubMed
  109. Herr MD, Imadojemu V, Kunselman AR, Sinoway LI. Characteristics of the muscle mechanoreflex during quadriceps contractions in humans. J Appl Physiol (1985). 1999 Feb; 86(2):767-72.
    View in: PubMed
  110. Ettinger SM, Silber DH, Gray KS, Smith MB, Yang QX, Kunselman AR, Sinoway LI. Effects of the ovarian cycle on sympathetic neural outflow during static exercise. J Appl Physiol (1985). 1998 Dec; 85(6):2075-81.
    View in: PubMed
  111. MacLean DA, Sinoway LI, Leuenberger U. Systemic hypoxia elevates skeletal muscle interstitial adenosine levels in humans. Circulation. 1998 Nov 10; 98(19):1990-2.
    View in: PubMed
  112. Shoemaker JK, Kunselman AR, Silber DH, Sinoway LI. Maintained exercise pressor response in heart failure. J Appl Physiol (1985). 1998 Nov; 85(5):1793-9.
    View in: PubMed
  113. MacLean DA, LaNoue KF, Gray KS, Sinoway LI. Effects of hindlimb contraction on pressor and muscle interstitial metabolite responses in the cat. J Appl Physiol (1985). 1998 Oct; 85(4):1583-92.
    View in: PubMed
  114. Shoemaker JK, Hogeman CS, Silber DH, Gray K, Herr M, Sinoway LI. Head-down-tilt bed rest alters forearm vasodilator and vasoconstrictor responses. J Appl Physiol (1985). 1998 May; 84(5):1756-62.
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  115. Silber DH, Sutliff G, Yang QX, Smith MB, Sinoway LI, Leuenberger UA. Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart failure. J Appl Physiol (1985). 1998 May; 84(5):1551-9.
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  116. Lloyd T, Chinchilli VM, Rollings N, Kieselhorst K, Tregea DF, Henderson NA, Sinoway LI. Fruit consumption, fitness, and cardiovascular health in female adolescents: the Penn State Young Women's Health Study. Am J Clin Nutr. 1998 Apr; 67(4):624-30.
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  117. Shoemaker JK, Hogeman CS, Leuenberger UA, Herr MD, Gray K, Silber DH, Sinoway LI. Sympathetic discharge and vascular resistance after bed rest. J Appl Physiol (1985). 1998 Feb; 84(2):612-7.
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  118. Mostoufi-Moab S, Widmaier EJ, Cornett JA, Gray K, Sinoway LI. Forearm training reduces the exercise pressor reflex during ischemic rhythmic handgrip. J Appl Physiol (1985). 1998 Jan; 84(1):277-83.
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  119. Maclean DA, Saltin B, Râdegran G, Sinoway L. Femoral arterial injection of adenosine in humans elevates MSNA via central but not peripheral mechanisms. J Appl Physiol (1985). 1997 Oct; 83(4):1045-53.
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  120. Shoemaker JK, Pandey P, Herr MD, Silber DH, Yang QX, Smith MB, Gray K, Sinoway LI. Augmented sympathetic tone alters muscle metabolism with exercise: lack of evidence for functional sympatholysis. J Appl Physiol (1985). 1997 Jun; 82(6):1932-8.
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  121. Crawford P, Good PA, Gutierrez E, Feinberg JH, Boehmer JP, Silber DH, Sinoway LI. Effects of supplemental oxygen on forearm vasodilation in humans. J Appl Physiol (1985). 1997 May; 82(5):1601-6.
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  122. Sinoway L, Shenberger J, Leaman G, Zelis R, Gray K, Baily R, Leuenberger U. Forearm training attenuates sympathetic responses to prolonged rhythmic forearm exercise. J Appl Physiol (1985). 1996 Oct; 81(4):1778-84.
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  123. Sinoway LI. Neural responses to exercise in humans: implications for congestive heart failure. Clin Exp Pharmacol Physiol. 1996 Aug; 23(8):693-9.
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  124. Luck JC, Hoover RJ, Biederman RW, Ettinger SM, Sinoway LI, Leuenberger UA. Observations on carotid sinus hypersensitivity from direct intraneural recordings of sympathetic nerve traffic. Am J Cardiol. 1996 Jun 15; 77(15):1362-5.
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  125. Hartz AJ, Ratner ER, Sinoway LI, Bartholomew MJ. Smoking and idiopathic congestive cardiomyopathy. Jpn Heart J. 1996 May; 37(3):401-7.
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  126. Waradekar NV, Sinoway LI, Zwillich CW, Leuenberger UA. Influence of treatment on muscle sympathetic nerve activity in sleep apnea. Am J Respir Crit Care Med. 1996 Apr; 153(4 Pt 1):1333-8.
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  127. Haque WA, Boehmer J, Clemson BS, Leuenberger UA, Silber DH, Sinoway LI. Hemodynamic effects of supplemental oxygen administration in congestive heart failure. J Am Coll Cardiol. 1996 Feb; 27(2):353-7.
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  128. Ettinger SM, Silber DH, Collins BG, Gray KS, Sutliff G, Whisler SK, McClain JM, Smith MB, Yang QX, Sinoway LI. Influences of gender on sympathetic nerve responses to static exercise. J Appl Physiol (1985). 1996 Jan; 80(1):245-51.
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  129. Leuenberger U, Jacob E, Sweer L, Waravdekar N, Zwillich C, Sinoway L. Surges of muscle sympathetic nerve activity during obstructive apnea are linked to hypoxemia. J Appl Physiol (1985). 1995 Aug; 79(2):581-8.
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  130. McClain J, Hardy JC, Sinoway LI. Forearm compression during exercise increases sympathetic nerve traffic. J Appl Physiol (1985). 1994 Dec; 77(6):2612-7.
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  131. Sinoway LI, Smith MB, Enders B, Leuenberger U, Dzwonczyk T, Gray K, Whisler S, Moore RL. Role of diprotonated phosphate in evoking muscle reflex responses in cats and humans. Am J Physiol. 1994 Aug; 267(2 Pt 2):H770-8.
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  132. Batman BA, Hardy JC, Leuenberger UA, Smith MB, Yang QX, Sinoway LI. Sympathetic nerve activity during prolonged rhythmic forearm exercise. J Appl Physiol (1985). 1994 Mar; 76(3):1077-81.
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  133. McClain J, Hardy C, Enders B, Smith M, Sinoway L. Limb congestion and sympathoexcitation during exercise. Implications for congestive heart failure. J Clin Invest. 1993 Nov; 92(5):2353-9.
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  134. Leuenberger U, Sinoway L, Gubin S, Gaul L, Davis D, Zelis R. Effects of exercise intensity and duration on norepinephrine spillover and clearance in humans. J Appl Physiol (1985). 1993 Aug; 75(2):668-74.
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  135. Sinoway LI, Hill JM, Pickar JG, Kaufman MP. Effects of contraction and lactic acid on the discharge of group III muscle afferents in cats. J Neurophysiol. 1993 Apr; 69(4):1053-9.
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  136. Sinoway LI, Wroblewski KJ, Prophet SA, Ettinger SM, Gray KS, Whisler SK, Miller G, Moore RL. Glycogen depletion-induced lactate reductions attenuate reflex responses in exercising humans. Am J Physiol. 1992 Nov; 263(5 Pt 2):H1499-505.
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  137. Sinoway LI, Rea RF, Mosher TJ, Smith MB, Mark AL. Hydrogen ion concentration is not the sole determinant of muscle metaboreceptor responses in humans. J Clin Invest. 1992 Jun; 89(6):1875-84.
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  138. Ettinger S, Gray K, Whisler S, Sinoway L. Dichloroacetate reduces sympathetic nerve responses to static exercise. Am J Physiol. 1991 Nov; 261(5 Pt 2):H1653-8.
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  139. Sterns DA, Ettinger SM, Gray KS, Whisler SK, Mosher TJ, Smith MB, Sinoway LI. Skeletal muscle metaboreceptor exercise responses are attenuated in heart failure. Circulation. 1991 Nov; 84(5):2034-9.
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  140. Leuenberger U, Gleeson K, Wroblewski K, Prophet S, Zelis R, Zwillich C, Sinoway L. Norepinephrine clearance is increased during acute hypoxemia in humans. Am J Physiol. 1991 Nov; 261(5 Pt 2):H1659-64.
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  141. Silber D, McLaughlin D, Sinoway L. Leg exercise conditioning increases peak forearm blood flow. J Appl Physiol (1985). 1991 Oct; 71(4):1568-73.
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  142. Zelis R, Sinoway LI, Leuenberger U, Clemson BS, Davis D. Time-constant adaptations in heart failure. Eur Heart J. 1991 Aug; 12 Suppl C:2-7.
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  143. Baily RG, Leuenberger U, Leaman G, Silber D, Sinoway LI. Norepinephrine kinetics and cardiac output during nonhypotensive lower body negative pressure. Am J Physiol. 1991 May; 260(5 Pt 2):H1708-12.
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  144. Baily RG, Prophet SA, Shenberger JS, Zelis R, Sinoway LI. Direct neurohumoral evidence for isolated sympathetic nervous system activation to skeletal muscle in response to cardiopulmonary baroreceptor unloading. Circ Res. 1990 Jun; 66(6):1720-8.
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  145. Sinoway L, Prophet S. Skeletal muscle metaboreceptor stimulation opposes peak metabolic vasodilation in humans. Circ Res. 1990 Jun; 66(6):1576-84.
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  146. Silber DH, Sinoway LI. Reversible impairment of forearm vasodilation after forearm casting. J Appl Physiol (1985). 1990 May; 68(5):1945-9.
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  147. Shenberger JS, Leaman GJ, Neumyer MM, Musch TI, Sinoway LI. Physiologic and structural indices of vascular function in paraplegics. Med Sci Sports Exerc. 1990 Feb; 22(1):96-101.
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  148. Zelis R, Musch TI, Sinoway LI. The maximal stress test: does it have any value in heart failure? J Am Coll Cardiol. 1990 Jan; 15(1):62-3.
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  149. Baily RG, Sinoway LI. Insight into human baroreceptor function using multiple indices of neural activity. Heart Fail. 1990 Jan-Feb; 6(1):33-41.
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  150. Shenberger JS, Prophet SA, Waldhausen JA, Davidson WR, Sinoway LI. Left subclavian flap aortoplasty for coarctation of the aorta: effects on forearm vascular function and growth. J Am Coll Cardiol. 1989 Oct; 14(4):953-9.
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  151. Sinoway LI, Zelis R. The peripheral circulation. Cardiol Clin. 1989 Feb; 7(1):63-71.
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  152. Sinoway LI, Hendrickson C, Davidson WR, Prophet S, Zelis R. Characteristics of flow-mediated brachial artery vasodilation in human subjects. Circ Res. 1989 Jan; 64(1):32-42.
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  153. Sinoway L, Prophet S, Gorman I, Mosher T, Shenberger J, Dolecki M, Briggs R, Zelis R. Muscle acidosis during static exercise is associated with calf vasoconstriction. J Appl Physiol (1985). 1989 Jan; 66(1):429-36.
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  154. Sinoway LI, Wilson JS, Zelis R, Shenberger J, McLaughlin DP, Morris DL, Day FP. Sympathetic tone affects human limb vascular resistance during a maximal metabolic stimulus. Am J Physiol. 1988 Oct; 255(4 Pt 2):H937-46.
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  155. Zelis R, Sinoway LI, Musch TI, Davis D, Just H. Regional blood flow in congestive heart failure: concept of compensatory mechanisms with short and long time constants. Am J Cardiol. 1988 Sep 9; 62(8):2E-8E.
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  156. Sinoway LI. Effect of conditioning and deconditioning stimuli on metabolically determined blood flow in humans and implications for congestive heart failure. Am J Cardiol. 1988 Sep 9; 62(8):45E-48E.
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  157. Zelis R, Sinoway LI, Musch TI. Why do patients with congestive heart failure stop exercising? J Am Coll Cardiol. 1988 Aug; 12(2):359-61.
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  158. Sinoway LI, Minotti JR, Davis D, Pennock JL, Burg JE, Musch TI, Zelis R. Delayed reversal of impaired vasodilation in congestive heart failure after heart transplantation. Am J Cardiol. 1988 May 1; 61(13):1076-9.
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  159. Bier AJ, Eichacker PQ, Sinoway LI, Terribile SM, Strom JA, Keefe DL. Acute cardiogenic pulmonary edema: clinical and noninvasive evaluation. Angiology. 1988 Mar; 39(3 Pt 1):211-8.
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  160. Zelis R, Sinoway L, Musch T, Davis D. The peripheral distribution of cardiac output in heart failure. Z Kardiol. 1988; 77 Suppl 5:61-5.
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  161. Moore RL, Thacker EM, Kelley GA, Musch TI, Sinoway LI, Foster VL, Dickinson AL. Effect of training/detraining on submaximal exercise responses in humans. J Appl Physiol (1985). 1987 Nov; 63(5):1719-24.
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  162. Davis D, Sinoway LI, Robison J, Minotti JR, Day FP, Baily R, Zelis R. Norepinephrine kinetics during orthostatic stress in congestive heart failure. Circ Res. 1987 Oct; 61(4 Pt 2):I87-90.
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  163. Sinoway L, Minotti J, Musch T, Goldner D, Davis D, Leaman D, Zelis R. Enhanced metabolic vasodilation secondary to diuretic therapy in decompensated congestive heart failure secondary to coronary artery disease. Am J Cardiol. 1987 Jul 1; 60(1):107-11.
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  164. Sinoway LI, Shenberger J, Wilson J, McLaughlin D, Musch T, Zelis R. A 30-day forearm work protocol increases maximal forearm blood flow. J Appl Physiol (1985). 1987 Mar; 62(3):1063-7.
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  165. Sinoway LI, Musch TI, Minotti JR, Zelis R. Enhanced maximal metabolic vasodilatation in the dominant forearms of tennis players. J Appl Physiol (1985). 1986 Aug; 61(2):673-8.
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  166. LeJemtel TH, Maskin CS, Mancini D, Sinoway L, Feld H, Chadwick B. Systemic and regional hemodynamic effects of captopril and milrinone administered alone and concomitantly in patients with heart failure. Circulation. 1985 Aug; 72(2):364-9.
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  167. Maskin CS, Sinoway L, Chadwick B, Sonnenblick EH, Le Jemtel TH. Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203, in patients with severe congestive heart failure. Circulation. 1983 May; 67(5):1065-70.
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  168. Boyle J, Englestein ES, Sinoway LI. Mean air space diameter, lung surface area and alveolar surface tension. Respiration. 1977; 34(5):241-9.
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