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Last Name
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Andrea Manni

TitleProfessor
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive Hershey PA 17033
Phone7175318395

 Overview 
 overview
PREFERRED TITLE/ROLE:

Physician, Professor of Medicine

EDUCATION:

Fellowship, Endocrinology, Case Western Reserve University School of Medicine (1977)
Residency, Medicine, Case Western Reserve University School of Medicine (1975)
Internship, Medicine, Saint John Hospital & Medical Center - Detroit, MI (1973)
M.D., University of Florence (1970)


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Skibinski CG, Thompson HJ, Das A, Manni A, Bortner JD, Stanley A, Stanley BA, El-Bayoumy K. Proteomic changes induced by effective chemopreventive ratios of n-3:n-6 fatty acids and tamoxifen against MNU-induced mammary cancer in the rat. Cancer Prev Res (Phila). 2013 Sep; 6(9):979-88.
    View in: PubMed
  2. Sun D, Jones NR, Manni A, Lazarus P. Characterization of raloxifene glucuronidation: potential role of UGT1A8 genotype on raloxifene metabolism in vivo. Cancer Prev Res (Phila). 2013 Jul; 6(7):719-30.
    View in: PubMed
  3. Ghiani G, Guerriero E, Manni A, Manni E, Potenza A. Simultaneous personnel and vehicle shift scheduling in the waste management sector. Waste Manag. 2013 Jul; 33(7):1589-94.
    View in: PubMed
  4. Signori C, DuBrock C, Richie JP, Prokopczyk B, Demers LM, Hamilton C, Hartman TJ, Liao J, El-Bayoumy K, Manni A. Administration of omega-3 fatty acids and Raloxifene to women at high risk of breast cancer: interim feasibility and biomarkers analysis from a clinical trial. Eur J Clin Nutr. 2012 Aug; 66(8):878-84.
    View in: PubMed
  5. Jiang W, Zhu Z, McGinley JN, El Bayoumy K, Manni A, Thompson HJ. Identification of a molecular signature underlying inhibition of mammary carcinoma growth by dietary N-3 fatty acids. Cancer Res. 2012 Aug 1; 72(15):3795-806.
    View in: PubMed
  6. Kaul S, Tulchinsky M, Campbell DB, Crist HS, Manni A. Isolated cardiac metastasis from papillary thyroid cancer: prolonged survival with late diagnosis related to inadequate positron emission tomography preparation. Thyroid. 2012 Apr; 22(4):443-4.
    View in: PubMed
  7. Bidinotto LT, de Cicco RL, Vanegas JE, Santucci-Pereira J, Vanden Heuvel JP, Washington S, Aliaga C, Xu H, Russo IH, Manni A, El-Bayoumy K, Russo J. Fish oil alters tamoxifen-modulated expression of mRNAs that encode genes related to differentiation, proliferation, metastasis, and immune response in rat mammary tumors. Nutr Cancer. 2012; 64(7):991-9.
    View in: PubMed
  8. Signori C, El-Bayoumy K, Russo J, Thompson HJ, Richie JP, Hartman TJ, Manni A. Chemoprevention of breast cancer by fish oil in preclinical models: trials and tribulations. Cancer Res. 2011 Oct 1; 71(19):6091-6.
    View in: PubMed
  9. Zhu Z, Jiang W, McGinley JN, Prokopczyk B, Richie JP, El Bayoumy K, Manni A, Thompson HJ. Mammary gland density predicts the cancer inhibitory activity of the N-3 to N-6 ratio of dietary fat. Cancer Prev Res (Phila). 2011 Oct; 4(10):1675-85.
    View in: PubMed
  10. Manni A, Xu H, Washington S, Aliaga C, Das A, Cooper T, Richie JP, Prokopczyk B, Calcagnotto A, Trushin N, Van den Heuvel JP, Hamilton C, Demers LM, Liao J, Verderame MF, El-Bayoumy K. The effects of Tamoxifen and fish oil on mammary carcinogenesis in polyoma middle T transgenic mice. Horm Cancer. 2011 Aug; 2(4):249-59.
    View in: PubMed
  11. Manni A, Richie JP, Xu H, Washington S, Aliaga C, Cooper TK, Bruggeman R, Das A, Prokopczyk B, Calcagnotto A, Trushin N, Dickinson R, Liao J, Verderame MF, El-Bayoumy K. Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Int J Oncol. 2011 Nov; 39(5):1153-64.
    View in: PubMed
  12. Pichardo-Lowden AR, Manni A, Saunders BD, Baker MJ. Familial hyperparathyroidism due to a germline mutation of the CDC73 gene: implications for management and age-appropriate testing of relatives at risk. Endocr Pract. 2011 Jul-Aug; 17(4):602-9.
    View in: PubMed
  13. Pichardo-Lowden A, Manni A. Cushing syndrome related to gingival application of a dexamethasone-containing preparation. Endocr Pract. 2010 Mar-Apr; 16(2):336.
    View in: PubMed
  14. Manni A, Xu H, Washington S, Aliaga C, Cooper T, Richie JP, Bruggeman R, Prokopczyk B, Calcagnotto A, Trushin N, Mauger D, Verderame MF, El-Bayoumy K. The impact of fish oil on the chemopreventive efficacy of tamoxifen against development of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Cancer Prev Res (Phila). 2010 Mar; 3(3):322-30.
    View in: PubMed
  15. Jun JY, Manni A. Medical management of persistent or recurrent differentiated thyroid carcinoma. Otolaryngol Clin North Am. 2008 Dec; 41(6):1241-60, xi-xii.
    View in: PubMed
  16. Fanali C, Inzitari R, Cabras T, Pisano E, Castagnola M, Celletti R, Manni A, Messana I. alpha-Defensin levels in whole saliva of totally edentulous subjects. Int J Immunopathol Pharmacol. 2008 Oct-Dec; 21(4):845-9.
    View in: PubMed
  17. Xu H, Washington S, Verderame MF, Manni A. Role of non-receptor and receptor tyrosine kinases (TKs) in the antitumor action of alpha-difluoromethylornithine (DFMO) in breast cancer cells. Breast Cancer Res Treat. 2008 Nov; 112(2):255-61.
    View in: PubMed
  18. Manni A, Rager T, Kimball SR, Jefferson LS, Washington S, Hu X, Verderame MF. Effects of alpha-difluoromethylornithine on thrombospondin-1 production by human breast cancer cells. Int J Oncol. 2007 Nov; 31(5):1187-91.
    View in: PubMed
  19. Lendel I, Manni A, Ruggiero FM. Novel association of duodenal gastrinoma and atrophic gastritis: case report and literature review. Endocr Pract. 2007 Nov-Dec; 13(7):770-5.
    View in: PubMed
  20. Jun JY, Griffith JW, Bruggeman R, Washington S, Demers LM, Verderame MF, Manni A. Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. Breast Cancer Res Treat. 2008 Jan; 107(1):33-40.
    View in: PubMed
  21. Xu H, Washington S, Verderame MF, Manni A. Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells. Breast Cancer Res Treat. 2008 Jan; 107(1):63-70.
    View in: PubMed
  22. Jun JY, Griffith JW, Bruggeman R, Washington S, Demers LM, Verderame MF, Manni A. Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. Breast Cancer Res Treat. 2007 Sep; 105(1):29-36.
    View in: PubMed
  23. Hu X, Washington S, Verderame MF, Manni A. Interaction between Polyamines and the Mitogen-Activated Protein Kinase Pathway in the Regulation of Cell Cycle Variables in Breast Cancer Cells. Cancer Res. 2005 Dec 1; 65(23):11026-33.
    View in: PubMed
  24. Richert MM, Phadke PA, Matters G, DiGirolamo DJ, Washington S, Demers LM, Bond JS, Manni A, Welch DR. Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment. Breast Cancer Res. 2005; 7(5):R819-27.
    View in: PubMed
  25. Matters GL, Manni A, Bond JS. Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells. Clin Exp Metastasis. 2005; 22(4):331-9.
    View in: PubMed
  26. Manni A, Washington S, Hu X, Griffith JW, Bruggeman R, Demers LM, Mauger D, Verderame MF. Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells. Clin Exp Metastasis. 2005; 22(3):255-63.
    View in: PubMed
  27. Hu X, Washington S, Verderame MF, Demers LM, Mauger D, Manni A. Biological activity of the S-adenosylmethionine decarboxylase inhibitor SAM486A in human breast cancer cells in vitro and in vivo. Int J Oncol. 2004 Dec; 25(6):1831-8.
    View in: PubMed
  28. Cantore M, Rabbi C, Fiorentini G, Oliani C, Zamagni D, Iacono C, Mambrini A, Del Freo A, Manni A. Combined irinotecan and oxaliplatin in patients with advanced pre-treated pancreatic cancer. Oncology. 2004; 67(2):93-7.
    View in: PubMed
  29. Manni A, Washington S, Mauger D, Hackett DA, Verderame MF. Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor alpha-difluoromethylornithine (DFMO) in human breast cancer cells. Clin Exp Metastasis. 2004; 21(5):461-7.
    View in: PubMed
  30. Cantore M, Fiorentini G, Mambrini A, Rabbi C, Zamagni D, Carlone N, Manni A, Caudana R, Torri T. Regional combined with systemic chemotherapy in unresectable biliary tract cancers: a phase II study. J Exp Clin Cancer Res. 2003 Dec; 22(4 Suppl):59-64.
    View in: PubMed
  31. Manni A, Washington S, Craig L, Cloud M, Griffith JW, Verderame MF, Texter LJ, Mauger D, Demers LM, Harms JF, Welch DR. Effects of alpha-difluoromethylornithine on local recurrence and pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice. Clin Exp Metastasis. 2003; 20(4):321-5.
    View in: PubMed
  32. Manni A. Polyamine involvement in breast cancer phenotype. In Vivo. 2002 Nov-Dec; 16(6):493-500.
    View in: PubMed
  33. Manni A, Brunori P, Ursini R, Deli R. [Neuromuscular occlusion in the orthodontic treatment of craniomandibular disorders. A clinical case]. Minerva Stomatol. 2002 Mar; 51(3):95-101.
    View in: PubMed
  34. Manni A, Washington S, Griffith JW, Verderame MF, Mauger D, Demers LM, Samant RS, Welch DR. Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells. Clin Exp Metastasis. 2002; 19(2):95-105.
    View in: PubMed
  35. Manni A, Fischer S, Franks M, Washington S, De Arment R, Griffith J, Demers L, Verderame M, Leiby B, Mauger D. S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in nude mice of MCF-7 breast cancer cells. Int J Oncol. 2001 Aug; 19(2):317-23.
    View in: PubMed
  36. Manni A, Trout D, Verderame MF, Washington S, Mauger D, Demers L. Effect of alpha-difluoromethyl-ornithine on the expression and function of the epidermal growth factor receptor in human breast epithelial cells in culture. Breast Cancer Res Treat. 2001 Jul; 68(2):139-46.
    View in: PubMed
  37. Manni A, Astrow SH, Gammon S, Thompson J, Mauger D, Washington S. Immunohistochemical detection of ornithine-decarboxylase in primary and metastatic human breast cancer specimens. Breast Cancer Res Treat. 2001 May; 67(2):147-56.
    View in: PubMed
  38. Manni A. Hormonal approaches to the chemoprevention of endocrine-dependent tumors. Endocr Relat Cancer. 1999 Dec; 6(4):483-5.
    View in: PubMed
  39. O'Shaughnessy JA, Demers LM, Jones SE, Arseneau J, Khandelwal P, George T, Gersh R, Mauger D, Manni A. Alpha-difluoromethylornithine as treatment for metastatic breast cancer patients. Clin Cancer Res. 1999 Nov; 5(11):3438-44.
    View in: PubMed
  40. Manni A, Wechter R, Verderame MF, Mauger D. Cooperativity between the polyamine pathway and HER-2neu in transformation of human mammary epithelial cells in culture: role of the MAPK pathway. Int J Cancer. 1998 May 18; 76(4):563-70.
    View in: PubMed
  41. Manni A, Wechter R, Gilmour S, Verderame MF, Mauger D, Demers LM. Ornithine decarboxylase over-expression stimulates mitogen-activated protein kinase and anchorage-independent growth of human breast epithelial cells. Int J Cancer. 1997 Jan 17; 70(2):175-82.
    View in: PubMed
  42. Manni A, Mauger D, Gimotty P, Badger B. Prognostic influence on survival of increased ornithine decarboxylase activity in human breast cancer. Clin Cancer Res. 1996 Nov; 2(11):1901-6.
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  43. Manni A, Buckwalter E, Etindi R, Kunselman S, Rossini A, Mauger D, Dabbs D, Demers L. Induction of a less aggressive breast cancer phenotype by protein kinase C-alpha and -beta overexpression. Cell Growth Differ. 1996 Sep; 7(9):1187-98.
    View in: PubMed
  44. Manni A, Kleimberg J, Ackerman V, Bellini A, Patalano F, Mattoli S. Inducibility of RANTES mRNA by IL-1beta in human bronchial epithelial cells is associated with increased NF-kappaB DNA binding activity. Biochem Biophys Res Commun. 1996 Mar 7; 220(1):120-4.
    View in: PubMed
  45. Grimes RW, Manni A, Hammond JM. Postsynthetic regulation of insulin-like growth factor-binding protein-3 by MCF-7 human breast cancer cells in culture. Breast Cancer Res Treat. 1996; 39(2):187-96.
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  46. Manni A, Badger B, Grove R, Kunselman S, Demers L. Isolation and characterization of human breast cancer cells overexpressing S-adenosylmethionine decarboxylase. Cancer Lett. 1995 Aug 16; 95(1-2):23-8.
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  47. Manni A, Badger B, Wechter R, Kunselman S, Rossini A, Demers L. Biochemical and growth-modulatory effects of the new S-adenosylmethionine decarboxylase inhibitor CGP 48664 in malignant and immortalized normal human breast epithelial cells in culture. Int J Cancer. 1995 Aug 9; 62(4):485-91.
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  48. Manni A, Grove R, Kunselman S, Aldaz CM. Involvement of the polyamine pathway in breast cancer progression. Cancer Lett. 1995 May 25; 92(1):49-57.
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  49. Manni A, Wechter R, Wei L, Heitjan D, Demers L. Phenotypic features of breast cancer cells overexpressing ornithine-decarboxylase. J Cell Physiol. 1995 Apr; 163(1):129-36.
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  50. Manni A, Wechter R, Grove R, Wei L, Martel J, Demers L. Polyamine profiles and growth properties of ornithine decarboxylase overexpressing MCF-7 breast cancer cells in culture. Breast Cancer Res Treat. 1995 Apr; 34(1):45-53.
    View in: PubMed
  51. Manni A, Badger B, Wei L, Zaenglein A, Grove R, Khin S, Heitjan D, Shimasaki S, Ling N. Hormonal regulation of insulin-like growth factor II and insulin-like growth factor binding protein expression by breast cancer cells in vivo: evidence for stromal epithelial interactions. Cancer Res. 1994 Jun 1; 54(11):2934-42.
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  52. Manni A. The role of polyamines in the hormonal control of breast cancer cell proliferation. Cancer Treat Res. 1994; 71:209-25.
    View in: PubMed
  53. Heitjan DF, Manni A, Santen RJ. Statistical analysis of in vivo tumor growth experiments. Cancer Res. 1993 Dec 15; 53(24):6042-50.
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  54. Joshi R, Manni A. Pheochromocytoma manifested as noncardiogenic pulmonary edema. South Med J. 1993 Jul; 86(7):826-8.
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  55. Manni A. Clinical use of aromatase inhibitors in the treatment of breast cancers. J Cell Biochem Suppl. 1993; 17G:242-6.
    View in: PubMed
  56. Manni A, Khin S, Biser N, English H, Badger B, Martel J, Demers L. Synchronization of breast cancer cell proliferation in vivo by combined hormonal and polyamine manipulation. Cancer Res. 1992 Oct 15; 52(20):5720-4.
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  57. Etindi R, Manni A. TGF-alpha and IGF-I effects on calcium ion transients in human breast cancer cells. Cancer Lett. 1992 Sep 30; 66(2):131-7.
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  58. Manni A, Badger B, Martel J, Demers L. Role of polyamines in the growth of hormone-responsive and -resistant human breast cancer cells in nude mice. Cancer Lett. 1992 Sep 14; 66(1):1-9.
    View in: PubMed
  59. Manni A, Wei L, Badger B, Zaenglein A, Leighton J, Shimasaki S, Ling N. Expression of messenger RNA for insulin-like growth factors and insulin-like growth factor binding proteins by experimental breast cancer and normal breast tissue in vivo. Endocrinology. 1992 Mar; 130(3):1744-6.
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  60. Etindi RN, Manni A, Martel J. The effects of TGF-alpha and 17 beta-estradiol on polyphosphoinositide metabolism in MCF-7 breast cancer cells. Breast Cancer Res Treat. 1992; 24(1):61-70.
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  61. Manni A. Somatostatin and growth hormone regulation in cancer. Biotherapy. 1992; 4(1):31-6.
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  62. Manni A. Pharmacologic manipulation of steroid hormones. Adjunctive therapies in cancer of the breast. Endocrinol Metab Clin North Am. 1991 Dec; 20(4):825-44.
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  63. Manni A, Wright C, Buck H. Growth factor involvement in the multihormonal regulation of MCF-7 breast cancer cell growth in soft agar. Breast Cancer Res Treat. 1991 Dec; 20(1):43-52.
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  64. Ahmed SR, Badger B, Wright C, Manni A. Role of transforming growth factor-alpha (TGF-alpha) in basal and hormone-stimulated growth by estradiol, prolactin and progesterone in human and rat mammary tumor cells: studies using TGF-alpha and EGF receptor antibodies. J Steroid Biochem Mol Biol. 1991 Jun; 38(6):687-93.
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  65. Kim I, Manni A, Lynch J, Hammond JM. Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines. Mol Cell Endocrinol. 1991 Jun; 78(1-2):71-8.
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  66. Kim I, Manni A, Lynch J, Demers L. Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture. Breast Cancer Res Treat. 1991 May; 18(2):83-91.
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  67. Manni A, Lancaster S, English H, Badger B, Lynch J, Demers L. Kinetic and morphometric responses of heterogeneous populations of NMU-induced rat mammary tumor cells to hormone and antipolyamine therapy in vivo. Breast Cancer Res Treat. 1991 Jan-Feb; 17(3):179-86.
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  68. Manni A, Badger B, Lynch J, Demers L. Selectivity of polyamine involvement in hormone action on normal and neoplastic target tissues of the rat. Breast Cancer Res Treat. 1991 Jan-Feb; 17(3):187-96.
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  69. Manni A, Boucher AE, Demers LM, Harvey HA, Lipton A, Simmonds MA, Bartholomew M. Somatostatin analogues in the treatment of breast and prostate cancer. J Steroid Biochem Mol Biol. 1990 Dec 20; 37(6):1083-7.
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  70. Santen RJ, Manni A, English HF, Heitjan D. Androgen-primed chemotherapy-experimental confirmation of efficacy. J Steroid Biochem Mol Biol. 1990 Dec 20; 37(6):1115-20.
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  71. Manni A, Wright C, Badger B, Lynch J, Demers L. Role of insulin-like growth factor-related peptides in the estradiol-, prolactin-, and progesterone-stimulated growth of N-nitrosomethylurea-induced rat mammary tumors in soft agar. Cancer Res. 1990 Nov 15; 50(22):7179-83.
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  72. Ahmed SR, Manni A, Gray G, Hammond JM. Characterization and hormonal regulation of radioimmunoassayable IGF-I (insulin-like growth factor I) like activity and IGF-binding proteins secreted by human breast cancer cells. Anticancer Res. 1990 Sep-Oct; 10(5A):1217-23.
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  73. Glikman PL, Manni A, Bartholomew M, Demers L. Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture. J Steroid Biochem Mol Biol. 1990 Sep; 37(1):1-10.
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  74. Simons RJ, Manni A, Fang SL, Braverman L. Free triiodothyronine toxicosis in a patient with multinodular goiter. Am J Med. 1990 Jun; 88(6):689-92.
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  75. Santen RJ, Manni A, Harvey H, Redmond C. Endocrine treatment of breast cancer in women. Endocr Rev. 1990 May; 11(2):221-65.
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  76. Manni A, Wright C, Badger B, Bartholomew M, Herlyn M, Mendelsohn J, Masui H, Demers L. Role of transforming growth factor-alpha-related peptides in the autocrine/paracrine control of experimental breast cancer growth in vitro by estradiol, prolactin, and progesterone. Breast Cancer Res Treat. 1990 Feb; 15(2):73-83.
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  77. Aiello DP, Manni A. Thyroglobulin measurement vs iodine 131 total-body scan for follow-up of well-differentiated thyroid cancer. Arch Intern Med. 1990 Feb; 150(2):437-9.
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  78. Cohen FJ, Manni A, Glikman P, Bartholomew M, Demers L. Interactions between growth factor secretion and polyamines in MCF-7 breast cancer cells. Eur J Cancer. 1990; 26(5):603-8.
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  79. Manni A, Boucher AE, Demers LM, Harvey HA, Lipton A, Simmonds MA, Bartholomew M. Endocrine effects of combined somatostatin analog and bromocriptine therapy in women with advanced breast cancer. Breast Cancer Res Treat. 1989 Dec; 14(3):289-98.
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  80. Manni A, Badger B, Lynch J, Glikman P, Demers L. Hormonal control of polyamine pools in experimental breast cancer in vivo: correlation with estrogen and progesterone receptor levels. Breast Cancer Res Treat. 1989 Nov; 14(2):227-34.
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  81. Manni A, Badger B, Glikman P, Bartholomew M, Santner S, Demers L. Individual and combined effects of alpha-difluoromethylornithine and ovariectomy on the growth and polyamine milieu of experimental breast cancer in rats. Cancer Res. 1989 Jul 1; 49(13):3529-34.
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  82. Manni A. Endocrine therapy of breast and prostate cancer. Endocrinol Metab Clin North Am. 1989 Jun; 18(2):569-92.
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  83. Manni A. Endocrine therapy of metastatic breast cancer. J Endocrinol Invest. 1989 May; 12(5):357-72.
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  84. Glikman P, Manni A, Demers L, Bartholomew M. Polyamine involvement in the growth of hormone-responsive and -resistant human breast cancer cells in culture. Cancer Res. 1989 Mar 15; 49(6):1371-6.
    View in: PubMed
  85. Manni A. Polyamines and hormonal control of breast cancer growth. Crit Rev Oncog. 1989; 1(2):163-74.
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  86. Cohen FJ, Manni A, Glikman P, Bartholomew M, Demers L. Involvement of the polyamine pathway in antiestrogen-induced growth inhibition of human breast cancer. Cancer Res. 1988 Dec 1; 48(23):6819-25.
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  87. Manni A, Bartholomew M, Caplan R, Boucher A, Santen R, Lipton A, Harvey H, Simmonds M, White-Hershey D, Gordon R, et al. Androgen priming and chemotherapy in advanced prostate cancer: evaluation of determinants of clinical outcome. J Clin Oncol. 1988 Sep; 6(9):1456-66.
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  88. Manni A, Badger B, Wright C, Glenn J, Ahmed SR, Demers LM. Species-specificity of estradiol regulated growth factors in breast cancer. Eur J Cancer Clin Oncol. 1988 Aug; 24(8):1349-54.
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  89. Manni A, Badger B, Luk G, Wright C, Caplan R, Rockette H, Bartholomew M, Ahmed SR. Role of polyamines in the growth of hormone-responsive experimental breast cancer in vivo. Breast Cancer Res Treat. 1988 Jul; 11(3):231-40.
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  90. Al-Mondhiry H, Manni A, Owen J, Gordon R. Hemostatic effects of hormonal stimulation in patients with metastatic prostate cancer. Am J Hematol. 1988 Jul; 28(3):141-5.
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  91. Lancaster S, English HF, Demers LM, Manni A. Kinetic and morphometric responses of heterogeneous populations of experimental breast cancer cells in vivo. Cancer Res. 1988 Jun 1; 48(11):3276-81.
    View in: PubMed
  92. Manni A, Wright C, Badger B, Demers L, Bartholomew M. Polyamines and autocrine control of N-nitrosomethylurea-induced rat mammary tumor growth in vitro by progesterone. Cancer Res. 1988 Jun 1; 48(11):3058-61.
    View in: PubMed
  93. Ahmed SR, Boucher AE, Manni A, Santen RJ, Bartholomew M, Demers LM. Transdermal testosterone therapy in the treatment of male hypogonadism. J Clin Endocrinol Metab. 1988 Mar; 66(3):546-51.
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  94. Manni A, Santen RJ. Clinical use of aromatase inhibitors in the treatment of breast cancer. Cancer Treat Res. 1988; 39:67-81.
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  95. Manni A, Badger B, Wright C, Ahmed SR, Santner SJ, Luk G. Role of polyamines in the synthesis of prolactin-regulated growth factors by experimental breast cancer in culture. Breast Cancer Res Treat. 1987 Nov; 10(2):191-6.
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  96. Manni A, Badger B, Wright C, Ahmed SR, Demers LM. Effects of progestins on growth of experimental breast cancer in culture: interaction with estradiol and prolactin and involvement of the polyamine pathway. Cancer Res. 1987 Jun 15; 47(12):3066-71.
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  97. Manni A. Tamoxifen therapy of metastatic breast cancer. J Lab Clin Med. 1987 Mar; 109(3):290-9.
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  98. Lipton A, Santen RJ, Harvey HA, Manni A, Simmonds MA, White-Hershey D, Bartholomew MJ, Walker BK, Dixon RH, Valdevia DE, et al. A randomized trial of aminoglutethimide +/- estrogen before chemotherapy in advanced breast cancer. Am J Clin Oncol. 1987 Feb; 10(1):65-70.
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  99. Manni A, Wright C, Luk GD, Davis G, Demers LM. Polyamines and the synthesis of estradiol-regulated growth factors in rat mammary cancer in culture. Breast Cancer Res Treat. 1987; 9(1):45-51.
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  100. Manni A, Santen RJ, Boucher AE, Lipton A, Harvey H, Simmonds M, Gordon R, Rohner T, Drago J, Wettlaufer J. Androgen depletion and repletion as a means of potentiating the effect of cytotoxic chemotherapy in advanced prostate cancer. J Steroid Biochem. 1987; 27(1-3):551-6.
    View in: PubMed
  101. Manni A, Santen RJ, Boucher AE, Lipton A, Harvey H, Simmonds M, White-Hershey D, Gordon RA, Rohner TJ, Drago J, et al. Androgen priming and response to chemotherapy in advanced prostatic cancer. J Urol. 1986 Dec; 136(6):1242-6.
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  102. Manni A, Wright C, Hsu CJ, Hammond JM. Polyamines and autocrine control of tumor growth by prolactin in experimental breast cancer in culture. Endocrinology. 1986 Nov; 119(5):2033-7.
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  103. Manni A, Wright C, Demers L, Luk G. Polyamines and hormonal regulation of N-nitrosomethylurea-induced rat mammary tumor growth in vivo. Cancer Res. 1986 Oct; 46(10):4938-41.
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  104. Manni A, Basarab RM, Plourde PV, Koivunen D, Harrison TS, Santen RJ. Thallium-technetium parathyroid scan. A useful noninvasive technique for localization of abnormal parathyroid tissue. Arch Intern Med. 1986 Jun; 146(6):1077-80.
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  105. Manni A, Wright C, Feil P, Baranao L, Demers L, Garcia M, Rochefort H. Autocrine stimulation by estradiol-regulated growth factors of rat hormone-responsive mammary cancer: interaction with the polyamine pathway. Cancer Res. 1986 Apr; 46(4 Pt 1):1594-8.
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  106. Manni A, Wright C, Davis G, Glenn J, Joehl R, Feil P. Promotion by prolactin of the growth of human breast neoplasms cultured in vitro in the soft agar clonogenic assay. Cancer Res. 1986 Apr; 46(4 Pt 1):1669-72.
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  107. Manni A, Santen RJ, Boucher AE, Lipton A, Harvey H, Simmonds M, White-Hershey D, Gordon RA, Rohner T, Drago J, et al. Hormone stimulation and chemotherapy in advanced prostate cancer: interim analysis of an ongoing randomized trial. Anticancer Res. 1986 Mar-Apr; 6(2):309-14.
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  108. Manni A, Santen R, Harvey H, Lipton A, Max D. Treatment of breast cancer with gonadotropin-releasing hormone. Endocr Rev. 1986 Feb; 7(1):89-94.
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  109. Santen RJ, Manni A, Harvey H. Gonadotropin releasing hormone (GnRH) analogs for the treatment of breast and prostatic carcinoma. Breast Cancer Res Treat. 1986; 7(3):129-45.
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  110. Santner SJ, Leszczynski D, Wright C, Manni A, Feil PD, Santen RJ. Estrone sulfate: a potential source of estradiol in human breast cancer tissues. Breast Cancer Res Treat. 1986; 7(1):35-44.
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  111. Santen RJ, Leszczynski D, Tilson-Mallet N, Feil PD, Wright C, Manni A, Santner SJ. Enzymatic control of estrogen production in human breast cancer: relative significance of aromatase versus sulfatase pathways. Ann N Y Acad Sci. 1986; 464:126-37.
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  112. Hubay CA, Pearson OH, Manni A, Gordon NH, McGuire WL. Adjuvant endocrine therapy, cytotoxic chemotherapy and immunotherapy in stage II breast cancer: 6-year result. J Steroid Biochem. 1985 Dec; 23(6B):1147-50.
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  113. Manni A, Pontari M, Wright C. Autocrine stimulation by prolactin of hormone-responsive breast cancer growth in culture. Endocrinology. 1985 Nov; 117(5):2040-3.
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  114. Manni A, Pardridge WM, Cefalu W, Nisula BC, Bardin CW, Santner SJ, Santen RJ. Bioavailability of albumin-bound testosterone. J Clin Endocrinol Metab. 1985 Oct; 61(4):705-10.
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  115. Manni A, Wright C, Pontari M, Feil P, Joehl R. Hormone dependency of human breast neoplasms cultured in vitro in the stem cell assay. J Natl Cancer Inst. 1985 Apr; 74(4):767-70.
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  116. Manni A, Wright C. Polyamines as mediators of the effect of prolactin and growth hormone on the growth of N-nitroso-N-methylurea-induced rat mammary tumor cultured in vitro in soft agar. J Natl Cancer Inst. 1985 Apr; 74(4):941-4.
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  117. Manni A, Santen RJ, Boucher A, Lipton A, Harvey H, Simmonds M, White D, Gordon R, Ronher T, Drago J, et al. Hormone stimulation and chemotherapy in advanced prostate cancer: preliminary results of a prospective controlled clinical trial. Anticancer Res. 1985 Mar-Apr; 5(2):161-5.
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  118. Drago JR, Rohner T, Santen R, Manni A, Lipton A, Harvey H, English H. Leuprolide: a review of its effects in animals and man. Br J Clin Pract Suppl. 1985 Mar; 37:4-7, 16-9.
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  119. Drago JR, Rohner T, Santen R, Manni A, English H, Lipton A, Harvey H. Leuprolide: a review of its effects in animals and man. Br J Clin Pract. 1985 Feb; 39(2):77-9.
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  120. Manni A, Wright C, Pontari M. Polyamines and estrogen control of growth of the NMU-induced rat mammary tumor. Breast Cancer Res Treat. 1985; 5(2):129-36.
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  121. Goodnough LT, Saito H, Manni A, Jones PK, Pearson OH. Increased incidence of thromboembolism in stage IV breast cancer patients treated with a five-drug chemotherapy regimen. A study of 159 patients. Cancer. 1984 Oct 1; 54(7):1264-8.
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  122. Manni A, Wright C. Polyamines as mediators of estrogen action on the growth of experimental breast cancer in rats. J Natl Cancer Inst. 1984 Aug; 73(2):511-4.
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  123. Manni A, Santen RJ, Boucher AE, Lipton A, Harvey H, Drago J, Rohner T, Haagensen D, Glode M, Santner SJ. Evaluation of CEA and GCDFP-15 plasma level during hormonally induced cancer stimulation. Anticancer Res. 1984 May-Jun; 4(3):141-4.
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  124. Drago JR, Santen RJ, Lipton A, Worgul TJ, Harvey HA, Boucher A, Manni A, Rohner TJ. Clinical effect of aminoglutethimide, medical adrenalectomy, in treatment of 43 patients with advanced prostatic carcinoma. Cancer. 1984 Apr 1; 53(7):1447-50.
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  125. Manni A, Wright C. Reversal of the antiproliferative effect of the antiestrogen tamoxifen by polyamines in breast cancer cells. Endocrinology. 1984 Mar; 114(3):836-9.
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  126. Manni A. Hormone receptors and breast cancer. N Engl J Med. 1983 Dec 1; 309(22):1383-5.
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  127. Manni A, Latshaw RF, Page R, Santen RJ. Simultaneous bilateral venous sampling for adrenocorticotropin in pituitary-dependent cushing's disease: evidence for lateralization of pituitary venous drainage. J Clin Endocrinol Metab. 1983 Nov; 57(5):1070-3.
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  128. Manni A, Wright C. Effect of tamoxifen and alpha-difluoromethylornithine on clones of nitrosomethylurea-induced rat mammary tumor cells grown in soft agar culture. Cancer Res. 1983 Mar; 43(3):1084-6.
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  129. Manni A, Wright C. Assessment of mitogenesis of the hormone-responsive NMU rat mammary tumor grown in culture in soft agar, using 3H-thymidine incorporation into DNA. Breast Cancer Res Treat. 1983; 3(3):287-92.
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  130. Arafah BM, Brodkey JS, Manni A, Velasco ME, Kaufman B, Pearson OH. Recovery of pituitary function following surgical removal of large nonfunctioning pituitary adenomas. Clin Endocrinol (Oxf). 1982 Sep; 17(3):213-22.
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  131. Manni A, Rainieri J, Arafah BM, Finegan HM, Pearson OH. Role of estrogen and prolactin in the growth and receptor levels of N-nitrosomethylurea-induced rat mammary tumors. Cancer Res. 1982 Sep; 42(9):3492-5.
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  132. Pearson OH, Manni A, Arafah BM. Antiestrogen treatment of breast cancer: an overview. Cancer Res. 1982 Aug; 42(8 Suppl):3424s-3429s.
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  133. Arafah BM, Finegan HM, Roe J, Manni A, Pearson OH. Hormone dependency in N-nitrosomethylurea-induced rat mammary tumors. Endocrinology. 1982 Aug; 111(2):584-8.
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  134. Rosner IA, Manni A, Malemud CJ, Boja B, Moskowitz RW. Estradiol receptors in articular chondrocytes. Biochem Biophys Res Commun. 1982 Jun 30; 106(4):1378-82.
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  135. Manni A, Rainieri J, Arafah BM, Pearson OH. Effect of high-dose oestrogen administration on the growth and prolactin receptor content of N-nitrosomethylurea-induced mammary tumours in the rat. J Endocrinol. 1982 Apr; 93(1):11-6.
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  136. Manni A, Arafah BM, Pearson OH. Androgen-induced remissions after antiestrogen and hypophysectomy in stage IV breast cancer. Cancer. 1981 Dec 1; 48(11):2507-9.
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  137. Manni A, Baker R, Arafah BM, Pearson OH. Uterine oestrogen and progesterone receptors in the ovariectomized rat. J Endocrinol. 1981 Nov; 91(2):281-7.
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  138. Manni A, Arafah BM. Tamoxifen-induced remission in breast cancer by escalating the dose to 40 mg daily after progression on 20 mg daily: a case report and review of the literature. Cancer. 1981 Aug 15; 48(4):873-5.
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  139. Manni A, Pearson OH, Marshall JS, Arafah BM. Sequential endocrine therapy and chemotherapy in metastatic breast cancer: effects on survival. Breast Cancer Res Treat. 1981; 1(2):97-103.
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  140. Arafah BM, Manni A, Brodkey JS, Kaufman B, Velasco M, Pearson OH. Cure of hypogonadism after removal of prolactin-secreting adenomas in men. J Clin Endocrinol Metab. 1981 Jan; 52(1):91-4.
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  141. Manni A, Arafah B, Pearson OH. Estrogen and progesterone receptors in the prediction of response of breast cancer to endocrine therapy. Cancer. 1980 Dec 15; 46(12 Suppl):2838-41.
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  142. Arafah BM, Gullino PM, Manni A, Pearson OH. Effect of ovariectomy on hormone receptors and growth of N-nitrosomethylurea-induced mammary tumors in the rat. Cancer Res. 1980 Dec; 40(12):4628-30.
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  143. Arafah BM, Manni A, Pearson OH. Effect of hypophysectomy and hormone replacement of hormone receptor levels and the growth of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in the rat. Endocrinology. 1980 Nov; 107(5):1364-9.
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  144. Manni A, Pearson OH. Antiestrogen-induced remissions in premenopausal women with stage IV breast cancer: effects on ovarian function. Cancer Treat Rep. 1980 Jun-Jul; 64(6-7):779-85.
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  145. Arafah BU, Brodkey JS, Kaufman B, Velasco M, Manni A, Pearson OH. Transsphenoidal microsurgery in the treatment of acromegaly and gigantism. J Clin Endocrinol Metab. 1980 Mar; 50(3):578-85.
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  146. Arafah B, Manni A, Pearson OH. Trioxifene mesylate (LY 133314): a new antiestrogen which inhibits growth hormone secretion in the rat. Eur J Cancer. 1980; Suppl 1:281-5.
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  147. Manni A, Trujillo JE, Pearson OH. Sequential use of endocrine therapy and chemotherapy for metastatic breast cancer: effects on survival. Cancer Treat Rep. 1980 Jan; 64(1):111-6.
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  148. Manni A, Pearson OH, Brodkey J, Marshall JS. Transsphenoidal hypophysectomy in breast cancer: evidence for an individual role of pituitary and gonadal hormones in supporting tumor growth. Cancer. 1979 Dec; 44(6):2330-7.
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  149. Manni A, Trujillo JE, Marshall JS, Brodkey J, Pearson OH. Antihormone treatment of stage IV breast cancer. Cancer. 1979 Feb; 43(2):444-50.
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  150. Manni A, Chambers MJ, Pearson OH. Prolactin induces its own receptors in rat liver. Endocrinology. 1978 Dec; 103(6):2168-71.
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  151. Brodkey JS, Pearson OH, Manni A. Hypophysectomy for relief of bone pain in breast cancer. N Engl J Med. 1978 Nov 2; 299(18):1016.
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  152. Pearson OH, Manni A, Chambers M, Brodkey J, Marshall JS. Role of pituitary hormones in the growth of human breast cancer. Cancer Res. 1978 Nov; 38(11 Pt 2):4323-6.
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  153. Pearson OH, Brodkey JS, Manni A. Hypophysectomy for stage IV breast cancer. Surg Clin North Am. 1978 Aug; 58(4):809-17.
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  154. Pearson OH, Manni A. Hormonal control of breast cancer growth in women and rats. Curr Top Exp Endocrinol. 1978; 3:75-92.
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  155. Manni A, Trujillo JE, Pearson OH. Predominant role of prolactin in stimulating the growth of 7, 12-dimethylbenz(a)anthracene-induced rat mammary tumor. Cancer Res. 1977 Apr; 37(4):1216-9.
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  156. Manni A, Trujillo J, Brodkey J, Marshall JS, Pearson OH. Treatment of breast cancer with antiestrogen: approach to medical hypophysectomy? Trans Assoc Am Physicians. 1977; 90:342-52.
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  157. Manni A, Trujillo J, Marshall JS, Pearson OH. Antiestrogen-induced remissions in stage IV breast cancer. Cancer Treat Rep. 1976 Oct; 60(10):1445-50.
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