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Last Name
Institution

Laura Klein

Title
InstitutionCollege of Health and Human Development
DepartmentBiobehavioral Health
Address311B Health & Human Dev East Bldg
University Park, PA 16802
Phone8148658813
Other Positions
InstitutionHuck Institutes of the Life Sciences


 Overview 
 overview
PREFERRED TITLE/ROLE:

Associate Professor of Biobehavioral Health

GRADUATE PROGRAM AFFILIATIONS:

Neuroscience

EDUCATION:

Ph.D., Uniformed Services University of the Health Sciences, 1997 

NARRATIVE:

Dr. Klein's research focuses on biobehavioral effects of stress on drug abuse in humans and animals, sex differences in neuroendocrine and behavioral stress responses, and nicotine regulation of stress reactivity.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Khairullah A, Klein LC, Ingle SM, May MT, Whetzel CA, Susman EJ, Paus T. Testosterone trajectories and reference ranges in a large longitudinal sample of male adolescents. PLoS One. 2014; 9(9):e108838.
    View in: PubMed
  2. Zarit SH, Whetzel CA, Kim K, Femia EE, Almeida DM, Rovine MJ, Klein LC. Daily stressors and adult day service use by family caregivers: effects on depressive symptoms, positive mood, and dehydroepiandrosterone-sulfate. Am J Geriatr Psychiatry. 2014 Dec; 22(12):1592-602.
    View in: PubMed
  3. Klein LC, Whetzel CA, Bennett JM, Ritter FE, Nater UM, Schoelles M. Caffeine administration does not alter salivary a-amylase activity in young male daily caffeine consumers. BMC Res Notes. 2014; 7(1):30.
    View in: PubMed
  4. Dingman MA, Gyekis JP, Whetzel CA, Klein LC, Vandenbergh DJ. Age-specific locomotor response to nicotine in yellow and mottled yellow Avy/a mice. BMC Res Notes. 2013; 6:497.
    View in: PubMed
  5. Revitsky AR, Klein LC. Role of ghrelin in drug abuse and reward-relevant behaviors: a burgeoning field and gaps in the literature. Curr Drug Abuse Rev. 2013 Sep; 6(3):231-44.
    View in: PubMed
  6. Liu S, Rovine MJ, Klein LC, Almeida DM. Synchrony of diurnal cortisol pattern in couples. J Fam Psychol. 2013 Aug; 27(4):579-88.
    View in: PubMed
  7. Zarit SH, Kim K, Femia EE, Almeida DM, Klein LC. The Effects of Adult Day Services on Family Caregivers' Daily Stress, Affect, and Health: Outcomes From the Daily Stress and Health (DaSH) Study. Gerontologist. 2014 Aug; 54(4):570-9.
    View in: PubMed
  8. Bennett JM, Rodrigues IM, Klein LC. Effects of caffeine and stress on biomarkers of cardiovascular disease in healthy men and women with a family history of hypertension. Stress Health. 2013 Dec; 29(5):401-9.
    View in: PubMed
  9. Walter KN, Corwin EJ, Ulbrecht J, Demers LM, Bennett JM, Whetzel CA, Klein LC. Elevated thyroid stimulating hormone is associated with elevated cortisol in healthy young men and women. Thyroid Res. 2012; 5(1):13.
    View in: PubMed
  10. McHale SM, Blocklin MK, Walter KN, Davis KD, Almeida DM, Klein LC. The role of daily activities in youths' stress physiology. J Adolesc Health. 2012 Dec; 51(6):623-8.
    View in: PubMed
  11. Pennesi CM, Klein LC. Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder: based on parental report. Nutr Neurosci. 2012 Mar; 15(2):85-91.
    View in: PubMed
  12. Cavigelli SA, Michael KC, West SG, Klein LC. Behavioral responses to physical vs. social novelty in male and female laboratory rats. Behav Processes. 2011 Sep; 88(1):56-9.
    View in: PubMed
  13. Guaderrama MM, Corwin EJ, Kapelewski CH, Klein LC. Sex differences in effects of cigarette smoking and 24-hr abstinence on plasma arginine vasopressin. Addict Behav. 2011 Nov; 36(11):1106-9.
    View in: PubMed
  14. Kapelewski CH, Vandenbergh DJ, Klein LC. Effect of the monoamine oxidase inhibition on rewarding effects of nicotine in rodents. Curr Drug Abuse Rev. 2011 Jun; 4(2):110-21.
    View in: PubMed
  15. West SG, Krick AL, Klein LC, Zhao G, Wojtowicz TF, McGuiness M, Bagshaw DM, Wagner P, Ceballos RM, Holub BJ, Kris-Etherton PM. Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function. J Am Coll Nutr. 2010 Dec; 29(6):595-603.
    View in: PubMed
  16. Piazza JR, Almeida DM, Dmitrieva NO, Klein LC. Frontiers in the use of biomarkers of health in research on stress and aging. J Gerontol B Psychol Sci Soc Sci. 2010 Sep; 65(5):513-25.
    View in: PubMed
  17. Whetzel CA, Klein LC. Measuring DHEA-S in saliva: time of day differences and positive correlations between two different types of collection methods. BMC Res Notes. 2010; 3:204.
    View in: PubMed
  18. Klein LC, Bennett JM, Whetzel CA, Granger DA, Ritter FE. Caffeine and stress alter salivary alpha-amylase activity in young men. Hum Psychopharmacol. 2010 Jul; 25(5):359-67.
    View in: PubMed
  19. Kapelewski CH, Bennett JM, Cavigelli SA, Klein LC. Application of a naturalistic psychogenic stressor in periadolescent mice: effect on serum corticosterone levels differs by strain but not sex. BMC Res Notes. 2010; 3:170.
    View in: PubMed
  20. Gyekis J, Anthony K, Foreman JE, Klein LC, Vandenbergh DJ. Perinatal nicotine exposure delays genital development in mice. Reprod Toxicol. 2010 Jun; 29(3):378-80.
    View in: PubMed
  21. Gyekis J, Foreman JE, Anthony K, Klein LC, Vandenbergh DJ. Activity-related behaviors in the hole-board predict nicotine consumption in C57B6 mice perinatally exposed to nicotine. Behav Brain Res. 2010 Jan 5; 206(1):139-42.
    View in: PubMed
  22. Blizard DA, Lionikas A, Vandenbergh DJ, Vasilopoulos T, Gerhard GS, Griffith JW, Klein LC, Stout JT, Mack HA, Lakoski JM, Larsson L, Spicer JM, Vogler GP, McClearn GE. Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences. Physiol Genomics. 2009 Feb 2; 36(3):158-66.
    View in: PubMed
  23. Aronson KR, Almeida DM, Stawski RS, Klein LC, Kozlowski LT. Smoking is associated with worse mood on stressful days: results from a national diary study. Ann Behav Med. 2008 Dec; 36(3):259-69.
    View in: PubMed
  24. Han B, Altman NS, Mong JA, Klein LC, Pfaff DW, Vandenbergh DJ. Comparing quantitative trait Loci and gene expression data. Adv Bioinformatics. 2008; 719818.
    View in: PubMed
  25. Cavigelli SA, Bennett JM, Michael KC, Klein LC. Female temperament, tumor development and life span: relation to glucocorticoid and tumor necrosis factor alpha levels in rats. Brain Behav Immun. 2008 Jul; 22(5):727-35.
    View in: PubMed
  26. Cavigelli SA, Guhad FA, Ceballos RM, Whetzel CA, Nevalainen T, Lang CM, Klein LC. Fecal corticoid metabolites in aged male and female rats after husbandry-related disturbances in the colony room. J Am Assoc Lab Anim Sci. 2006 Nov; 45(6):17-21.
    View in: PubMed
  27. Blizard DA, Weinheimer VK, Klein LC, Petrill SA, Cohen R, McClearn GE. 'Return to home cage' as a reward for maze learning in young and old genetically heterogeneous mice. Comp Med. 2006 Jun; 56(3):196-201.
    View in: PubMed
  28. Whetzel CA, Corwin EJ, Klein LC. Disruption in Th1/Th2 immune response in young adult smokers. Addict Behav. 2007 Jan; 32(1):1-8.
    View in: PubMed
  29. Taylor SE, Gonzaga GC, Klein LC, Hu P, Greendale GA, Seeman TE. Relation of oxytocin to psychological stress responses and hypothalamic-pituitary-adrenocortical axis activity in older women. Psychosom Med. 2006 Mar-Apr; 68(2):238-45.
    View in: PubMed
  30. Corwin EJ, McCoy CS, Whetzel CA, Ceballos RM, Klein LC. Risk indicators of metabolic syndrome in young adults: a preliminary investigation on the influence of tobacco smoke exposure and gender. Heart Lung. 2006 Mar-Apr; 35(2):119-29.
    View in: PubMed
  31. Rodrigues IM, Klein LC. Boiled or filtered coffee? Effects of coffee and caffeine on cholesterol, fibrinogen and C-reactive protein. Toxicol Rev. 2006; 25(1):55-69.
    View in: PubMed
  32. Lando HA, Borrelli B, Klein LC, Waverley LP, Stillman FA, Kassel JD, Warner KE. The landscape in global tobacco control research: a guide to gaining a foothold. Am J Public Health. 2005 Jun; 95(6):939-45.
    View in: PubMed
  33. Drobes D, Klein LC. Research on nicotine and tobacco: a decade of progress. Nicotine Tob Res. 2004 Aug; 6(4):695-741.
    View in: PubMed
  34. Klein LC, Corwin EJ, Ceballos RM. Leptin, hunger, and body weight: Influence of gender, tobacco smoking, and smoking abstinence. Addict Behav. 2004 Jul; 29(5):921-7.
    View in: PubMed
  35. Klein LC, Stine MM, Vandenbergh DJ, Whetzel CA, Kamens HM. Sex differences in voluntary oral nicotine consumption by adolescent mice: a dose-response experiment. Pharmacol Biochem Behav. 2004 May; 78(1):13-25.
    View in: PubMed
  36. Klein LC, Eissenberg T. Recent advances in nicotine and tobacco research. Ninth SRNT annual meeting. New Orleans, Louisiana, USA. 19-22 February 2003. Nicotine Tob Res. 2003 Oct; 5(5):761-94.
    View in: PubMed
  37. Corwin EJ, Klein LC. C-reactive protein and depressed mood in a sub-group of smokers during nicotine abstinence. Hum Psychopharmacol. 2003 Jul; 18(5):329-37.
    View in: PubMed
  38. Blizard DA, Klein LC, Cohen R, McClearn GE. A novel mouse-friendly cognitive task suitable for use in aging studies. Behav Genet. 2003 Mar; 33(2):181-9.
    View in: PubMed
  39. Klein LC, Stine MM, Pfaff DW, Vandenbergh DJ. Laternal nicotine exposure increases nicotine preference in periadolescent male but not female C57B1/6J mice. Nicotine Tob Res. 2003 Feb; 5(1):117-24.
    View in: PubMed
  40. Klein LC, Corwin EJ, Stine MM. Smoking abstinence impairs time estimation accuracy in cigarette smokers. Psychopharmacol Bull. 2003; 37(1):90-5.
    View in: PubMed
  41. Nemeroff CB. Overview of the safety of citalopram. Psychopharmacol Bull. 2003; 37(1):96-121.
    View in: PubMed
  42. Klein LC, Corwin EJ. Seeing the unexpected: how sex differences in stress responses may provide a new perspective on the manifestation of psychiatric disorders. Curr Psychiatry Rep. 2002 Dec; 4(6):441-8.
    View in: PubMed
  43. Stine MM, O'Connor RJ, Yatko BR, Grunberg NE, Klein LC. Evidence for a relationship between daily caffeine consumption and accuracy of time estimation. Hum Psychopharmacol. 2002 Oct; 17(7):361-7.
    View in: PubMed
  44. Corwin EJ, Klein LC, Rickelman K. Predictors of fatigue in healthy young adults: moderating effects of cigarette smoking and gender. Biol Res Nurs. 2002 Apr; 3(4):222-33.
    View in: PubMed
  45. Klein LC. Effects of adolescent nicotine exposure on opioid consumption and neuroendocrine responses in adult male and female rats. Exp Clin Psychopharmacol. 2001 Aug; 9(3):251-61.
    View in: PubMed
  46. Zakowski SG, Hall MH, Klein LC, Baum A. Appraised control, coping, and stress in a community sample: a test of the goodness-of-fit hypothesis. Ann Behav Med. 2001; 23(3):158-65.
    View in: PubMed
  47. Klein LC, Popke EJ, Grunberg NE. Sex differences in effects of opioid blockade on stress-induced freezing behavior. Pharmacol Biochem Behav. 1998 Dec; 61(4):413-7.
    View in: PubMed
  48. Klein LC, Popke EJ, Grunberg NE. Sex differences in effects of predictable and unpredictable footshock on fentanyl self-administration in rats. Exp Clin Psychopharmacol. 1997 May; 5(2):99-106.
    View in: PubMed
  49. Shaham Y, Klein LC, Alvares K, Grunberg NE. Effect of stress on oral fentanyl consumption in rats in an operant self-administration paradigm. Pharmacol Biochem Behav. 1993 Oct; 46(2):315-22.
    View in: PubMed
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