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Allan Lipton

TitleProfessor
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive Hershey PA 17033
Mailbox: H046
Phone7175318677
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    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Physician, Professor of Medicine

    EDUCATION:

    Fellowship, Medical Oncology/Hematology, Memorial Sloan Kettering Cancer Center (1969)
    Residency, Internal Medicine, Bellevue Hospital Center (New York University) (1965)
    M.D., New York University, School of Medicine (1963)


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hortobagyi GN, Van Poznak C, Harker WG, Gradishar WJ, Chew H, Dakhil SR, Haley BB, Sauter N, Mohanlal R, Zheng M, Lipton A. Continued Treatment Effect of Zoledronic Acid Dosing Every 12 vs 4 Weeks in Women With Breast Cancer Metastatic to Bone: The OPTIMIZE-2 Randomized Clinical Trial. JAMA Oncol. 2017 Jul 01; 3(7):906-912. PMID: 28125763.
      View in: PubMed
    2. Ho D, Huang J, Chapman JW, Leitzel K, Ali SM, Shepherd L, Parulekar WR, Ellis CE, Crescnzo RJ, Zhu L, Virk S, Nomikos D, Aparicio S, Gelmon KA, Carney WP, Lipton A. Impact of serum HER2, TIMP-1, and CAIX on outcome for HER2+ metastatic breast cancer patients: CCTG MA.31 (lapatinib vs. trastuzumab). Breast Cancer Res Treat. 2017 Aug; 164(3):571-580. PMID: 28484925.
      View in: PubMed
    3. Lipton A, Chapman JW, Leitzel K, Garg A, Pritchard KI, Ingle JN, Budd GT, Ellis MJ, Sledge GW, Rabaglio M, Han L, Elliott CR, Shepherd LE, Goss PE, Ali SM. Osteoporosis therapy and outcomes for postmenopausal patients with hormone receptor-positive breast cancer: NCIC CTG MA.27. Cancer. 2017 Jul 01; 123(13):2444-2451. PMID: 28464211.
      View in: PubMed
    4. Kamalakar A, Washam CL, Akel NS, Allen BJ, Williams DK, Swain FL, Leitzel K, Lipton A, Gaddy D, Suva LJ. PTHrP(12-48) Modulates the Bone Marrow Microenvironment and Suppresses Human Osteoclast Differentiation and Lifespan. J Bone Miner Res. 2017 Jul; 32(7):1421-1431. PMID: 28370412.
      View in: PubMed
    5. Ferreira AR, Alho I, Shan N, Matias M, Faria M, Casimiro S, Leitzel K, Ali S, Lipton A, Costa L. N-Telopeptide of Type I Collagen Long-Term Dynamics in Breast Cancer Patients With Bone Metastases: Clinical Outcomes and Influence of Extraskeletal Metastases. Oncologist. 2016 Dec; 21(12):1418-1426. PMID: 27534575.
      View in: PubMed
    6. Lipton A, Smith MR, Fizazi K, Stopeck AT, Henry D, Brown JE, Shore ND, Saad F, Spencer A, Zhu L, Warner DJ. Changes in Bone Turnover Marker Levels and Clinical Outcomes in Patients with Advanced Cancer and Bone Metastases Treated with Bone Antiresorptive Agents. Clin Cancer Res. 2016 Dec 01; 22(23):5713-5721. PMID: 27140926.
      View in: PubMed
    7. Body JJ, Bone HG, de Boer RH, Stopeck A, Van Poznak C, Damião R, Fizazi K, Henry DH, Ibrahim T, Lipton A, Saad F, Shore N, Takano T, Shaywitz AJ, Wang H, Bracco OL, Braun A, Kostenuik PJ. Hypocalcaemia in patients with metastatic bone disease treated with denosumab. Eur J Cancer. 2015 Sep; 51(13):1812-21. PMID: 26093811.
      View in: PubMed
    8. Garg A, Leitzel K, Ali S, Lipton A. Antiresorptive therapy in the management of cancer treatment-induced bone loss. Curr Osteoporos Rep. 2015 Apr; 13(2):73-7. PMID: 25575469.
      View in: PubMed
    9. Lipton A, Goodman L, Leitzel K, Cook J, Sperinde J, Haddad M, Köstler WJ, Huang W, Weidler JM, Ali S, Newton A, Fuchs EM, Paquet A, Singer CF, Horvat R, Jin X, Banerjee J, Mukherjee A, Tan Y, Shi Y, Chenna A, Larson J, Lie Y, Sherwood T, Petropoulos CJ, Williams S, Winslow J, Parry G, Bates M. HER3, p95HER2, and HER2 protein expression levels define multiple subtypes of HER2-positive metastatic breast cancer. Breast Cancer Res Treat. 2013 Aug; 141(1):43-53. PMID: 23959396; PMCID: PMC3758835.
    10. Lipton A, Fizazi K, Stopeck AT, Henry DH, Braun AH. Reply to Araki et al. Eur J Cancer. 2013 Jun; 49(9):2266-8. PMID: 23578571.
      View in: PubMed
    11. Washam CL, Byrum SD, Leitzel K, Ali SM, Tackett AJ, Gaddy D, Sundermann SE, Lipton A, Suva LJ. Identification of PTHrP(12-48) as a plasma biomarker associated with breast cancer bone metastasis. Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):972-83. PMID: 23462923; PMCID: PMC3651837.
    12. Coleman RE, Lipton A, Costa L, Cook RJ, Lee KA, Saad F, Brown JE, Terpos E, Major PP, Kohno N, Smith M, Body JJ. Possible survival benefits from zoledronic acid treatment in patients with bone metastases from solid tumours and poor prognostic features-An exploratory analysis of placebo-controlled trials. J Bone Oncol. 2013 Jun; 2(2):70-6. PMID: 26909273; PMCID: PMC4723367.
    13. Alkhateeb AA, Leitzel K, Ali SM, Campbell-Baird C, Evans M, Fuchs EM, Köstler WJ, Lipton A, Connor J. Elevation in inflammatory serum biomarkers predicts response to trastuzumab-containing therapy. PLoS One. 2012; 7(12):e51379. PMID: 23300545; PMCID: PMC3530544.
    14. Lipton A, Fizazi K, Stopeck AT, Henry DH, Brown JE, Yardley DA, Richardson GE, Siena S, Maroto P, Clemens M, Bilynskyy B, Charu V, Beuzeboc P, Rader M, Viniegra M, Saad F, Ke C, Braun A, Jun S. Superiority of denosumab to zoledronic acid for prevention of skeletal-related events: a combined analysis of 3 pivotal, randomised, phase 3 trials. Eur J Cancer. 2012 Nov; 48(16):3082-92. PMID: 22975218.
      View in: PubMed
    15. Cleeland CS, Body JJ, Stopeck A, von Moos R, Fallowfield L, Mathias SD, Patrick DL, Clemons M, Tonkin K, Masuda N, Lipton A, de Boer R, Salvagni S, Oliveira CT, Qian Y, Jiang Q, Dansey R, Braun A, Chung K. Pain outcomes in patients with advanced breast cancer and bone metastases: results from a randomized, double-blind study of denosumab and zoledronic acid. Cancer. 2013 Feb 15; 119(4):832-8. PMID: 22951813.
      View in: PubMed
    16. Brown JE, Cook RJ, Lipton A, Coleman RE. Serum lactate dehydrogenase is prognostic for survival in patients with bone metastases from breast cancer: a retrospective analysis in bisphosphonate-treated patients. Clin Cancer Res. 2012 Nov 15; 18(22):6348-55. PMID: 22952345.
      View in: PubMed
    17. Lipton A, Smith MR, Ellis GK, Goessl C. Treatment-induced bone loss and fractures in cancer patients undergoing hormone ablation therapy: efficacy and safety of denosumab. Clin Med Insights Oncol. 2012; 6:287-303. PMID: 22933844; PMCID: PMC3427033.
    18. Lipton A, Balakumaran A. Denosumab for the treatment of cancer therapy-induced bone loss and prevention of skeletal-related events in patients with solid tumors. Expert Rev Clin Pharmacol. 2012 Jul; 5(4):359-71. PMID: 22943116.
      View in: PubMed
    19. Costa L, Lipton A, Hadji P, Chen YM, Kosmidis P. Treatment of bone metastases before the onset of pain. Int J Clin Oncol. 2013 Jun; 18(3):531-8. PMID: 22572805.
      View in: PubMed
    20. Berruti A, Cook R, Saad F, Buttigliero C, Lipton A, Tampellini M, Lee KA, Coleman RE, Smith MR. Prognostic role of serum parathyroid hormone levels in advanced prostate cancer patients undergoing zoledronic acid administration. Oncologist. 2012; 17(5):645-52. PMID: 22523198; PMCID: PMC3360904.
    21. Ha NH, Nair VS, Reddy DN, Mudvari P, Ohshiro K, Ghanta KS, Pakala SB, Li DQ, Costa L, Lipton A, Badwe RA, Fuqua S, Wallon M, Prendergast GC, Kumar R. Lactoferrin-endothelin-1 axis contributes to the development and invasiveness of triple-negative breast cancer phenotypes. Cancer Res. 2011 Dec 01; 71(23):7259-69. PMID: 22006997; PMCID: PMC3617573.
    22. Lipton A, Jacobs I. Denosumab: benefits of RANK ligand inhibition in cancer patients. Curr Opin Support Palliat Care. 2011 Sep; 5(3):258-64. PMID: 21826000.
      View in: PubMed
    23. Lipton A, Chapman JA, Demers L, Shepherd LE, Han L, Wilson CF, Pritchard KI, Leitzel KE, Ali SM, Pollak M. Elevated bone turnover predicts for bone metastasis in postmenopausal breast cancer: results of NCIC CTG MA.14. J Clin Oncol. 2011 Sep 20; 29(27):3605-10. PMID: 21859992.
      View in: PubMed
    24. Gralow JR, Lipton A, Stopeck AT. How do we define efficacy in comparing osteoclast-targeted agents in metastatic breast cancer? J Clin Oncol. 2011 Sep 10; 29(26):3591-2; author reply 3592-3. PMID: 21844502.
      View in: PubMed
    25. Lipton A. Zoledronic acid: multiplicity of use across the cancer continuum. Expert Rev Anticancer Ther. 2011 Jul; 11(7):999-1012. PMID: 21806323.
      View in: PubMed
    26. Gervais R, Hainsworth JD, Blais N, Besse B, Laskin J, Hamm JT, Lipton A, Albain KS, Masters GA, Natale RB, Selaru P, Kim ST, Chao RC, Page RD. Phase II study of sunitinib as maintenance therapy in patients with locally advanced or metastatic non-small cell lung cancer. Lung Cancer. 2011 Dec; 74(3):474-80. PMID: 21680048.
      View in: PubMed
    27. Hatoum HT, Lin SJ, Smith MR, Guo A, Lipton A. Treatment persistence with monthly zoledronic acid is associated with lower risk and frequency of skeletal complications in patients with breast cancer and bone metastasis. Clin Breast Cancer. 2011 Jun; 11(3):177-83. PMID: 21665138.
      View in: PubMed
    28. Sivendran S, Harvey H, Lipton A, Drabick J. Treatment of Langerhans cell histiocytosis bone lesions with zoledronic acid: a case series. Int J Hematol. 2011 Jun; 93(6):782-786. PMID: 21519845.
      View in: PubMed
    29. Lipton A, Leitzel K, Ali SM, Carney W, Platek G, Steplewski K, Westlund R, Gagnon R, Martin AM, Maltzman J. Human epidermal growth factor receptor 2 (HER2) extracellular domain levels are associated with progression-free survival in patients with HER2-positive metastatic breast cancer receiving lapatinib monotherapy. Cancer. 2011 Nov 01; 117(21):5013-20. PMID: 21456017.
      View in: PubMed
    30. Lipton A. Bones, breasts, and bisphosphonates: rationale for the use of zoledronic acid in advanced and early breast cancer. Breast Cancer (Dove Med Press). 2011 Mar 15; 3:1-7. PMID: 24367171; PMCID: PMC3846369.
    31. Ghosh R, Narasanna A, Wang SE, Liu S, Chakrabarty A, Balko JM, González-Angulo AM, Mills GB, Penuel E, Winslow J, Sperinde J, Dua R, Pidaparthi S, Mukherjee A, Leitzel K, Kostler WJ, Lipton A, Bates M, Arteaga CL. Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers. Cancer Res. 2011 Mar 01; 71(5):1871-82. PMID: 21324925; PMCID: PMC3221734.
    32. Lipton A. Denosumab in breast cancer. Curr Oncol Rep. 2011 Feb; 13(1):1-4. PMID: 21053109.
      View in: PubMed
    33. Costa L, Harper P, Coleman RE, Lipton A. Anticancer evidence for zoledronic acid across the cancer continuum. Crit Rev Oncol Hematol. 2011 Feb; 77 Suppl 1:S31-7. PMID: 21353179.
      View in: PubMed
    34. Lipton A. Improving progression-free and overall survival in patients with cancer: a potential role for bisphosphonates. Expert Opin Pharmacother. 2011 Apr; 12(5):749-62. PMID: 21247359.
      View in: PubMed
    35. Lipton A. New strategies to prevent and manage bone complications in cancer. Clin Adv Hematol Oncol. 2011 Jan; 9(1):42-4. PMID: 21326145.
      View in: PubMed
    36. Coleman R, Cook R, Hirsh V, Major P, Lipton A. Zoledronic acid use in cancer patients: more than just supportive care? Cancer. 2011 Jan 01; 117(1):11-23. PMID: 21235033.
      View in: PubMed
    37. Lipton A, Costa L, Coleman RE. Bone turnover markers: tools for prognosis and monitoring response to bisphosphonates? Breast Dis. 2011; 33(2):59-69. PMID: 22142664.
      View in: PubMed
    38. Albain KS, Carey L, Gradishar WJ, Gralow JR, Lipton A, Rugo H, Tripathy D, Peck S, Abair T, Pegram M. Proceedings of the First Global Workshop on Breast Cancer: pathways to the evaluation and clinical development of novel agents for breast cancer. Clin Breast Cancer. 2010 Dec 01; 10(6):421-39. PMID: 21147685.
      View in: PubMed
    39. Hatoum HT, Lin SJ, Guo A, Lipton A, Smith MR. Zoledronic acid therapy impacts risk and frequency of skeletal complications and follow-up duration in prostate cancer patients with bone metastasis. Curr Med Res Opin. 2011 Jan; 27(1):55-62. PMID: 21083514; PMCID: PMC3047395.
    40. Lipton A, Köstler WJ, Leitzel K, Ali SM, Sperinde J, Weidler J, Paquet A, Sherwood T, Huang W, Bates M. Quantitative HER2 protein levels predict outcome in fluorescence in situ hybridization-positive patients with metastatic breast cancer treated with trastuzumab. Cancer. 2010 Nov 15; 116(22):5168-78. PMID: 20661914.
      View in: PubMed
    41. Stopeck AT, Lipton A, Body JJ, Steger GG, Tonkin K, de Boer RH, Lichinitser M, Fujiwara Y, Yardley DA, Viniegra M, Fan M, Jiang Q, Dansey R, Jun S, Braun A. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol. 2010 Dec 10; 28(35):5132-9. PMID: 21060033.
      View in: PubMed
    42. Green J, Lipton A. Anticancer properties of zoledronic acid. Cancer Invest. 2010 Nov; 28(9):944-57. PMID: 20879838.
      View in: PubMed
    43. Lipton A, Goessl C. Clinical development of anti-RANKL therapies for treatment and prevention of bone metastasis. Bone. 2011 Jan; 48(1):96-9. PMID: 20950721.
      View in: PubMed
    44. Lipton A. Implications of bone metastases and the benefits of bone-targeted therapy. Semin Oncol. 2010 Oct; 37 Suppl 2:S15-29. PMID: 21111244.
      View in: PubMed
    45. Morgan G, Lipton A. Antitumor effects and anticancer applications of bisphosphonates. Semin Oncol. 2010 Oct; 37 Suppl 2:S30-40. PMID: 21111246.
      View in: PubMed
    46. Oh WK, Vargas R, Jacobus S, Leitzel K, Regan MM, Hamer P, Pierce K, Brown-Shimer S, Carney W, Ali SM, Kantoff PW, Lipton A. Elevated plasma tissue inhibitor of metalloproteinase-1 levels predict decreased survival in castration-resistant prostate cancer patients. Cancer. 2011 Feb 01; 117(3):517-25. PMID: 20862742.
      View in: PubMed
    47. Hadji P, Gnant M, Aapro M, Lipton A, Coleman R. Dosing of zoledronic acid throughout the treatment continuum in breast cancer. Crit Rev Oncol Hematol. 2011 Aug; 79(2):175-88. PMID: 20846875.
      View in: PubMed
    48. Lipton A. New approaches to treating and preventing bone metastases. Curr Opin Support Palliat Care. 2010 Sep; 4(3):178-81. PMID: 20703154.
      View in: PubMed
    49. Saad F, Lipton A. Bone-marker levels in patients with prostate cancer: potential correlations with outcomes. Curr Opin Support Palliat Care. 2010 Sep; 4(3):127-34. PMID: 20489645.
      View in: PubMed
    50. Sperinde J, Jin X, Banerjee J, Penuel E, Saha A, Diedrich G, Huang W, Leitzel K, Weidler J, Ali SM, Fuchs EM, Singer CF, Köstler WJ, Bates M, Parry G, Winslow J, Lipton A. Quantitation of p95HER2 in paraffin sections by using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients. Clin Cancer Res. 2010 Aug 15; 16(16):4226-35. PMID: 20664024.
      View in: PubMed
    51. Brown JE, Cook RJ, Lipton A, Costa L, Coleman RE. Prognostic factors for skeletal complications from metastatic bone disease in breast cancer. Breast Cancer Res Treat. 2010 Oct; 123(3):767-79. PMID: 20574672.
      View in: PubMed
    52. Lipton A. Bone loss prevention in cancer: new developments and perspectives. Semin Oncol. 2010 Jun; 37 Suppl 1:S1-2. PMID: 20682366.
      View in: PubMed
    53. Lipton A. Bone continuum of cancer. Am J Clin Oncol. 2010 Jun; 33(3 Suppl):S1-7. PMID: 20526089.
      View in: PubMed
    54. Lipton A. Should bisphosphonates be utilized in the adjuvant setting for breast cancer? Breast Cancer Res Treat. 2010 Aug; 122(3):627-36. PMID: 20490653.
      View in: PubMed
    55. Coleman RE, Lipton A, Roodman GD, Guise TA, Boyce BF, Brufsky AM, Clézardin P, Croucher PI, Gralow JR, Hadji P, Holen I, Mundy GR, Smith MR, Suva LJ. Metastasis and bone loss: advancing treatment and prevention. Cancer Treat Rev. 2010 Dec; 36(8):615-20. PMID: 20478658; PMCID: PMC3047387.
    56. Lipton A, Campbell-Baird C, Witters L, Harvey H, Ali S. Phase II trial of gemcitabine, irinotecan, and celecoxib in patients with advanced pancreatic cancer. J Clin Gastroenterol. 2010 Apr; 44(4):286-8. PMID: 20216081.
      View in: PubMed
    57. Body JJ, Lipton A, Gralow J, Steger GG, Gao G, Yeh H, Fizazi K. Effects of denosumab in patients with bone metastases with and without previous bisphosphonate exposure. J Bone Miner Res. 2010 Mar; 25(3):440-6. PMID: 19653815.
      View in: PubMed
    58. Lipton A, Campbell-Baird C, Harvey H, Kim C, Demers L, Costa L. Phase I trial of zoledronic acid + imatinib mesylate (Gleevec) in patients with bone metastases. Am J Clin Oncol. 2010 Feb; 33(1):75-8. PMID: 19652577.
      View in: PubMed
    59. Saad F, Lipton A. SRC kinase inhibition: targeting bone metastases and tumor growth in prostate and breast cancer. Cancer Treat Rev. 2010 Apr; 36(2):177-84. PMID: 20015594.
      View in: PubMed
    60. Ali SM, Leitzel K, Lipton A, Carney WP, Köstler WJ. Value of serum human epidermal growth factor receptor 2 (HER2)/neu testing for early prediction of response to HER2/neu-directed therapies is still an open one and deserves further study in large prospective trials. J Clin Oncol. 2009 Dec 20; 27(36):e273; author reply e274-5. PMID: 19917836.
      View in: PubMed
    61. Karp DD, Pollak MN, Cohen RB, Eisenberg PD, Haluska P, Yin D, Lipton A, Demers L, Leitzel K, Hixon ML, Terstappen LW, Garland L, Paz-Ares LG, Cardenal F, Langer CJ, Gualberto A. Safety, pharmacokinetics, and pharmacodynamics of the insulin-like growth factor type 1 receptor inhibitor figitumumab (CP-751,871) in combination with paclitaxel and carboplatin. J Thorac Oncol. 2009 Nov; 4(11):1397-403. PMID: 19745765; PMCID: PMC2941876.
    62. Lipton A, Uzzo R, Amato RJ, Ellis GK, Hakimian B, Roodman GD, Smith MR. The science and practice of bone health in oncology: managing bone loss and metastasis in patients with solid tumors. J Natl Compr Canc Netw. 2009 Oct; 7 Suppl 7:S1-29; quiz S30. PMID: 19878635; PMCID: PMC3047391.
    63. Terpos E, Dimopoulos MA, Shrivastava V, Leitzel K, Christoulas D, Migkou M, Gavriatopoulou M, Anargyrou K, Hamer P, Kastritis E, Carney W, Lipton A. High levels of serum TIMP-1 correlate with advanced disease and predict for poor survival in patients with multiple myeloma treated with novel agents. Leuk Res. 2010 Mar; 34(3):399-402. PMID: 19781774.
      View in: PubMed
    64. Major PP, Cook RJ, Lipton A, Smith MR, Terpos E, Coleman RE. Natural history of malignant bone disease in breast cancer and the use of cumulative mean functions to measure skeletal morbidity. BMC Cancer. 2009 Aug 06; 9:272. PMID: 19660124; PMCID: PMC2739221.
    65. Lipton A, Brown GA, Mundy GR, Roodman GD, Smith MR. New opportunities for the management of cancer-related bone complications. Clin Adv Hematol Oncol. 2009 May; 7(5 Suppl 11):1-30; quiz 31. PMID: 19741583.
      View in: PubMed
    66. Fizazi K, Lipton A, Mariette X, Body JJ, Rahim Y, Gralow JR, Gao G, Wu L, Sohn W, Jun S. Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. J Clin Oncol. 2009 Apr 01; 27(10):1564-71. PMID: 19237632.
      View in: PubMed
    67. Coleman RE, Guise TA, Lipton A, Roodman GD, Berenson JR, Body JJ, Boyce BF, Calvi LM, Hadji P, McCloskey EV, Saad F, Smith MR, Suva LJ, Taichman RS, Vessella RL, Weilbaecher KN. Advancing treatment for metastatic bone cancer: consensus recommendations from the Second Cambridge Conference. Clin Cancer Res. 2008 Oct 15; 14(20):6387-95. PMID: 18927277; PMCID: PMC2763638.
    68. Lipton A, Steger GG, Figueroa J, Alvarado C, Solal-Celigny P, Body JJ, de Boer R, Berardi R, Gascon P, Tonkin KS, Coleman RE, Paterson AH, Gao GM, Kinsey AC, Peterson MC, Jun S. Extended efficacy and safety of denosumab in breast cancer patients with bone metastases not receiving prior bisphosphonate therapy. Clin Cancer Res. 2008 Oct 15; 14(20):6690-6. PMID: 18927312.
      View in: PubMed
    69. Hatoum HT, Lin SJ, Smith MR, Barghout V, Lipton A. Zoledronic acid and skeletal complications in patients with solid tumors and bone metastases: analysis of a national medical claims database. Cancer. 2008 Sep 15; 113(6):1438-45. PMID: 18720527; PMCID: PMC2900766.
    70. Ali SM, Carney WP, Esteva FJ, Fornier M, Harris L, Köstler WJ, Lotz JP, Luftner D, Pichon MF, Lipton A. Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer. Cancer. 2008 Sep 15; 113(6):1294-301. PMID: 18661530.
      View in: PubMed
    71. Lipton A, Jun S. RANKL inhibition in the treatment of bone metastases. Curr Opin Support Palliat Care. 2008 Sep; 2(3):197-203. PMID: 18685421.
      View in: PubMed
    72. Witters L, Scherle P, Friedman S, Fridman J, Caulder E, Newton R, Lipton A. Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor. Cancer Res. 2008 Sep 01; 68(17):7083-9. PMID: 18757423.
      View in: PubMed
    73. Lipton A, Cook R, Saad F, Major P, Garnero P, Terpos E, Brown JE, Coleman RE. Normalization of bone markers is associated with improved survival in patients with bone metastases from solid tumors and elevated bone resorption receiving zoledronic acid. Cancer. 2008 Jul 01; 113(1):193-201. PMID: 18459173.
      View in: PubMed
    74. Coleman R, Brown J, Terpos E, Lipton A, Smith MR, Cook R, Major P. Bone markers and their prognostic value in metastatic bone disease: clinical evidence and future directions. Cancer Treat Rev. 2008 Nov; 34(7):629-39. PMID: 18579314; PMCID: PMC3090688.
    75. Lipton A. Emerging role of bisphosphonates in the clinic--antitumor activity and prevention of metastasis to bone. Cancer Treat Rev. 2008; 34 Suppl 1:S25-30. PMID: 18486347.
      View in: PubMed
    76. Coleman RE, Body JJ, Gralow JR, Lipton A. Bone loss in patients with breast cancer receiving aromatase inhibitors and associated treatment strategies. Cancer Treat Rev. 2008; 34 Suppl 1:S31-42. PMID: 18486346.
      View in: PubMed
    77. Lipton A, Leitzel K, Chaudri-Ross HA, Evans DB, Ali SM, Demers L, Hamer P, Brown-Shimer S, Pierce K, Gaur V, Carney W. Serum TIMP-1 and response to the aromatase inhibitor letrozole versus tamoxifen in metastatic breast cancer. J Clin Oncol. 2008 Jun 01; 26(16):2653-8. PMID: 18443351.
      View in: PubMed
    78. Costa L, Badia X, Chow E, Lipton A, Wardley A. Impact of skeletal complications on patients' quality of life, mobility, and functional independence. Support Care Cancer. 2008 Aug; 16(8):879-89. PMID: 18392862.
      View in: PubMed
    79. Hirsh V, Major PP, Lipton A, Cook RJ, Langer CJ, Smith MR, Brown JE, Coleman RE. Zoledronic acid and survival in patients with metastatic bone disease from lung cancer and elevated markers of osteoclast activity. J Thorac Oncol. 2008 Mar; 3(3):228-36. PMID: 18317064.
      View in: PubMed
    80. Saad F, Lipton A. Clinical benefits and considerations of bisphosphonate treatment in metastatic bone disease. Semin Oncol. 2007 Dec; 34(6 Suppl 4):S17-23. PMID: 18068486.
      View in: PubMed
    81. Saad F, Lipton A, Cook R, Chen YM, Smith M, Coleman R. Pathologic fractures correlate with reduced survival in patients with malignant bone disease. Cancer. 2007 Oct 15; 110(8):1860-7. PMID: 17763372.
      View in: PubMed
    82. Lipton A, Steger GG, Figueroa J, Alvarado C, Solal-Celigny P, Body JJ, de Boer R, Berardi R, Gascon P, Tonkin KS, Coleman R, Paterson AH, Peterson MC, Fan M, Kinsey A, Jun S. Randomized active-controlled phase II study of denosumab efficacy and safety in patients with breast cancer-related bone metastases. J Clin Oncol. 2007 Oct 01; 25(28):4431-7. PMID: 17785705.
      View in: PubMed
    83. Lipton A, Cook RJ, Major P, Smith MR, Coleman RE. Zoledronic acid and survival in breast cancer patients with bone metastases and elevated markers of osteoclast activity. Oncologist. 2007 Sep; 12(9):1035-43. PMID: 17914073.
      View in: PubMed
    84. Smith MR, Cook RJ, Coleman R, Brown J, Lipton A, Major P, Hei YJ, Saad F. Predictors of skeletal complications in men with hormone-refractory metastatic prostate cancer. Urology. 2007 Aug; 70(2):315-9. PMID: 17826496; PMCID: PMC3047396.
    85. Lipton A. Efficacy and safety of intravenous bisphosphonates in patients with bone metastases caused by metastatic breast cancer. Clin Breast Cancer. 2007 Jul; 7 Suppl 1:S14-20. PMID: 17683649.
      View in: PubMed
    86. Lipton A, Gnant M, Aapro M. Managing aromatase inhibitor-associated bone loss in breast cancer. Womens Health (Lond). 2007 Jul; 3(4):441-8. PMID: 19804020.
      View in: PubMed
    87. Fury MG, Lipton A, Smith KM, Winston CB, Pfister DG. A phase-I trial of the epidermal growth factor receptor directed bispecific antibody MDX-447 without and with recombinant human granulocyte-colony stimulating factor in patients with advanced solid tumors. Cancer Immunol Immunother. 2008 Feb; 57(2):155-63. PMID: 17602224.
      View in: PubMed
    88. Lipton A, Ali SM, Leitzel K, Demers L, Evans DB, Hamer P, Brown-Shimer S, Pierce K, Carney W. Elevated plasma tissue inhibitor of metalloproteinase-1 level predicts decreased response and survival in metastatic breast cancer. Cancer. 2007 May 15; 109(10):1933-9. PMID: 17407159.
      View in: PubMed
    89. Lipton A. The safety of zoledronic acid. Expert Opin Drug Saf. 2007 May; 6(3):305-13. PMID: 17480179.
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    90. Lipton A, Cook RJ, Coleman RE, Smith MR, Major P, Terpos E, Berenson JR. Clinical utility of biochemical markers of bone metabolism for improving the management of patients with advanced multiple myeloma. Clin Lymphoma Myeloma. 2007 Mar; 7(5):346-53. PMID: 17562244.
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    91. Witters LM, Witkoski A, Planas-Silva MD, Berger M, Viallet J, Lipton A. Synergistic inhibition of breast cancer cell lines with a dual inhibitor of EGFR-HER-2/neu and a Bcl-2 inhibitor. Oncol Rep. 2007 Feb; 17(2):465-9. PMID: 17203189.
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    92. Lipton A. Treatment of bone metastases and bone pain with bisphosphonates. Support Cancer Ther. 2007 Jan 01; 4(2):92-100. PMID: 18632473.
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    93. Carney WP, Leitzel K, Ali S, Neumann R, Lipton A. HER-2/neu diagnostics in breast cancer. Breast Cancer Res. 2007; 9(3):207. PMID: 17561991; PMCID: PMC1929087.
    94. Souder C, Leitzel K, Ali SM, Demers L, Evans DB, Chaudri-Ross HA, Hackl W, Hamer P, Carney W, Lipton A. Serum epidermal growth factor receptor/HER-2 predicts poor survival in patients with metastatic breast cancer. Cancer. 2006 Nov 15; 107(10):2337-45. PMID: 17048231.
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    95. Lipton A, Berenson JR, Body JJ, Boyce BF, Bruland OS, Carducci MA, Cleeland CS, Clohisy DR, Coleman RE, Cook RJ, Guise TA, Pearse RN, Powles TJ, Rogers MJ, Roodman GD, Smith MR, Suva LJ, Vessella RL, Weilbaecher KN, King L. Advances in treating metastatic bone cancer: summary statement for the First Cambridge Conference. Clin Cancer Res. 2006 Oct 15; 12(20 Pt 2):6209s-6212s. PMID: 17062702; PMCID: PMC2705325.
    96. Lipton A. Future treatment of bone metastases. Clin Cancer Res. 2006 Oct 15; 12(20 Pt 2):6305s-6308s. PMID: 17062719.
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    97. Saad F, Lipton A. Zoledronic acid is effective in preventing and delaying skeletal events in patients with bone metastases secondary to genitourinary cancers. BJU Int. 2006 Jun; 97(6):1351-2. PMID: 16686742.
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    98. Cook RJ, Coleman R, Brown J, Lipton A, Major P, Hei YJ, Saad F, Smith MR. Markers of bone metabolism and survival in men with hormone-refractory metastatic prostate cancer. Clin Cancer Res. 2006 Jun 01; 12(11 Pt 1):3361-7. PMID: 16740758.
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    99. Costa L, Lipton A, Coleman RE. Role of bisphosphonates for the management of skeletal complications and bone pain from skeletal metastases. Support Cancer Ther. 2006 Apr 01; 3(3):143-53. PMID: 18632488.
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    100. Body JJ, Facon T, Coleman RE, Lipton A, Geurs F, Fan M, Holloway D, Peterson MC, Bekker PJ. A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin Cancer Res. 2006 Feb 15; 12(4):1221-8. PMID: 16489077.
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    101. Lipton A. Biochemical bone markers in breast cancer. Cancer Treat Rev. 2006; 32 Suppl 1:20-2. PMID: 16680834.
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    102. Saad F, Lipton A. Zoledronic acid is effective in preventing and delaying skeletal events in patients with bone metastases secondary to genitourinary cancers. BJU Int. 2005 Nov; 96(7):964-9. PMID: 16225510.
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    103. Rascovsky K, Salmon DP, Lipton AM, Leverenz JB, DeCarli C, Jagust WJ, Clark CM, Mendez MF, Tang-Wai DF, Graff-Radford NR, Galasko D. Rate of progression differs in frontotemporal dementia and Alzheimer disease. Neurology. 2005 Aug 09; 65(3):397-403. PMID: 16087904.
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    104. Lipton A, Leitzel K, Ali SM, Demers L, Harvey HA, Chaudri-Ross HA, Evans D, Lang R, Hackl W, Hamer P, Carney W. Serum HER-2/neu conversion to positive at the time of disease progression in patients with breast carcinoma on hormone therapy. Cancer. 2005 Jul 15; 104(2):257-63. PMID: 15952182.
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    105. Coleman RE, Major P, Lipton A, Brown JE, Lee KA, Smith M, Saad F, Zheng M, Hei YJ, Seaman J, Cook R. Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid. J Clin Oncol. 2005 Aug 01; 23(22):4925-35. PMID: 15983391.
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    106. Lipton A. New therapeutic agents for the treatment of bone diseases. Expert Opin Biol Ther. 2005 Jun; 5(6):817-32. PMID: 15952912.
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    107. Lipton A. Management of bone metastases in breast cancer. Curr Treat Options Oncol. 2005 Mar; 6(2):161-71. PMID: 15717997.
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    108. Brown JE, Cook RJ, Major P, Lipton A, Saad F, Smith M, Lee KA, Zheng M, Hei YJ, Coleman RE. Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors. J Natl Cancer Inst. 2005 Jan 05; 97(1):59-69. PMID: 15632381.
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    109. Lipton A, Harvey H, Witters L, Kerr S, Legore K, Campbell C. Gemcitabine/Irinotecan/celecoxib in pancreatic cancer. Oncology (Williston Park). 2004 Dec; 18(14 Suppl 14):43-5. PMID: 15685834.
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    110. Atkins MB, Avigan DE, Bukowski RM, Childs RW, Dutcher JP, Eisen TG, Figlin RA, Finke JH, Flanigan RC, George DJ, Goldberg SN, Gordon MS, Iliopoulos O, Kaelin WG, Linehan WM, Lipton A, Motzer RJ, Novick AC, Stadler WM, Teh BT, Yang JC, King L. Innovations and challenges in renal cancer: consensus statement from the first international conference. Clin Cancer Res. 2004 Sep 15; 10(18 Pt 2):6277S-81S. PMID: 15448017.
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    111. Lipton A, Colombo-Berra A, Bukowski RM, Rosen L, Zheng M, Urbanowitz G. Skeletal complications in patients with bone metastases from renal cell carcinoma and therapeutic benefits of zoledronic acid. Clin Cancer Res. 2004 Sep 15; 10(18 Pt 2):6397S-403S. PMID: 15448038.
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    112. Carney WP, Neumann R, Lipton A, Leitzel K, Ali S, Price CP. Monitoring the circulating levels of the HER2/neu oncoprotein in breast cancer. Clin Breast Cancer. 2004 Jun; 5(2):105-16. PMID: 15245613.
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    113. Lipton A. Pathophysiology of bone metastases: how this knowledge may lead to therapeutic intervention. J Support Oncol. 2004 May-Jun; 2(3):205-13; discussion 213-4, 216-7, 219-20. PMID: 15328823.
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    114. Lipton A, Leitzel K, Ali S. Predicting response to herceptin therapy. Clin Cancer Res. 2004 Mar 01; 10(5):1559-60. PMID: 15014003.
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    115. Witters LM, Myers A, Lipton A. Combining flavopiridol with various signal transduction inhibitors. Oncol Rep. 2004 Mar; 11(3):693-8. PMID: 14767524.
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    116. Lipton A. Toward new horizons: the future of bisphosphonate therapy. Oncologist. 2004; 9 Suppl 4:38-47. PMID: 15459428.
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    117. Lipton A. Bisphosphonate therapy in the oncology setting. Expert Opin Emerg Drugs. 2003 Nov; 8(2):469-88. PMID: 14662000.
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    118. Carney WP, Neumann R, Lipton A, Leitzel K, Ali S, Price CP. Potential clinical utility of serum HER-2/neu oncoprotein concentrations in patients with breast cancer. Clin Chem. 2003 Oct; 49(10):1579-98. PMID: 14500583.
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    119. Demers LM, Costa L, Lipton A. Biochemical markers and skeletal metastases. Clin Orthop Relat Res. 2003 Oct; (415 Suppl):S138-47. PMID: 14600604.
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    120. Ali SM, Harvey HA, Lipton A. Metastatic breast cancer: overview of treatment. Clin Orthop Relat Res. 2003 Oct; (415 Suppl):S132-7. PMID: 14600603.
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    121. Hillner BE, Ingle JN, Chlebowski RT, Gralow J, Yee GC, Janjan NA, Cauley JA, Blumenstein BA, Albain KS, Lipton A, Brown S. American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer. J Clin Oncol. 2003 Nov 01; 21(21):4042-57. PMID: 12963702.
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    122. Lipton A, Zheng M, Seaman J. Zoledronic acid delays the onset of skeletal-related events and progression of skeletal disease in patients with advanced renal cell carcinoma. Cancer. 2003 Sep 01; 98(5):962-9. PMID: 12942563.
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    123. Witters LM, Crispino J, Fraterrigo T, Green J, Lipton A. Effect of the combination of docetaxel, zoledronic acid, and a COX-2 inhibitor on the growth of human breast cancer cell lines. Am J Clin Oncol. 2003 Aug; 26(4):S92-7. PMID: 12902864.
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    124. Lipton A. Bone metastases in breast cancer. Curr Treat Options Oncol. 2003 Apr; 4(2):151-8. PMID: 12594941.
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    125. Body JJ, Greipp P, Coleman RE, Facon T, Geurs F, Fermand JP, Harousseau JL, Lipton A, Mariette X, Williams CD, Nakanishi A, Holloway D, Martin SW, Dunstan CR, Bekker PJ. A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer. 2003 Feb 01; 97(3 Suppl):887-92. PMID: 12548591.
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    126. Witters LM, Santala SM, Engle L, Chinchilli V, Lipton A. Decreased response to paclitaxel versus docetaxel in HER-2/neu transfected human breast cancer cells. Am J Clin Oncol. 2003 Feb; 26(1):50-4. PMID: 12576925.
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    127. Lipton A. Bisphosphonates and metastatic breast carcinoma. Cancer. 2003 Feb 01; 97(3 Suppl):848-53. PMID: 12548585.
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    128. Clarke LE, Leitzel K, Smith J, Ali SM, Lipton A. Epidermal growth factor receptor mRNA in peripheral blood of patients with pancreatic, lung, and colon carcinomas detected by RT-PCR. Int J Oncol. 2003 Feb; 22(2):425-30. PMID: 12527944.
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    129. Witters L, Engle L, Lipton A. Restoration of estrogen responsiveness by blocking the HER-2/neu pathway. Oncol Rep. 2002 Nov-Dec; 9(6):1163-6. PMID: 12375012.
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    130. Berenson JR, Hillner BE, Kyle RA, Anderson K, Lipton A, Yee GC, Biermann JS. American Society of Clinical Oncology clinical practice guidelines: the role of bisphosphonates in multiple myeloma. J Clin Oncol. 2002 Sep 01; 20(17):3719-36. PMID: 12202673.
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    131. Ali SM, Leitzel K, Chinchilli VM, Engle L, Demers L, Harvey HA, Carney W, Allard JW, Lipton A. Relationship of serum HER-2/neu and serum CA 15-3 in patients with metastatic breast cancer. Clin Chem. 2002 Aug; 48(8):1314-20. PMID: 12142389.
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    132. Lipton A, Ali SM, Leitzel K, Chinchilli V, Witters L, Engle L, Holloway D, Bekker P, Dunstan CR. Serum osteoprotegerin levels in healthy controls and cancer patients. Clin Cancer Res. 2002 Jul; 8(7):2306-10. PMID: 12114435.
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    133. Lipton A, Ali SM, Leitzel K, Demers L, Chinchilli V, Engle L, Harvey HA, Brady C, Nalin CM, Dugan M, Carney W, Allard J. Elevated serum Her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer. J Clin Oncol. 2002 Mar 15; 20(6):1467-72. PMID: 11896093.
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    134. Costa L, Demers LM, Gouveia-Oliveira A, Schaller J, Costa EB, de Moura MC, Lipton A. Prospective evaluation of the peptide-bound collagen type I cross-links N-telopeptide and C-telopeptide in predicting bone metastases status. J Clin Oncol. 2002 Feb 01; 20(3):850-6. PMID: 11821470.
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    135. Lipton A, Small E, Saad F, Gleason D, Gordon D, Smith M, Rosen L, Kowalski MO, Reitsma D, Seaman J. The new bisphosphonate, Zometa (zoledronic acid), decreases skeletal complications in both osteolytic and osteoblastic lesions: a comparison to pamidronate. Cancer Invest. 2002; 20 Suppl 2:45-54. PMID: 12442349.
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