|Institution||College of Medicine|
|Address||500 University Drive Hershey PA 17033|
Distinguished Professor Emeritus of Pathology and Medicine
Ph.D., SUNY - Upstate Medical Center, 1970
Residency, Harvard Medical School
Fellowship, University of Oxford
Biomarkers and Metabolic Bone Disease
We have been interested in the effects of bone disease as well as metastatic disease to bone on biomarkers of bone remodeling. We have established specific biochemical assays to monitor bone resorption and bone formation that include bone collagen breakdown products, markers of bone collagen synthesis, markers of osteoclastogenesis and markers of osteoblast function and secretion. These biomarkers have been evaluated in patients with osteoporosis, Paget's disease and skeletal metastases treated with pharmaceutical agents that can attenuate bone turnover and inhibit bone loss or resorption. These agents include the bisphosphonate class of compounds as well as hormone replacement therapy used to treated bone resorption caused by bone disease.
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