PSU Profiles
Keywords
Last Name
Institution

Laurence Demers

TitleProfessor Emeritus
InstitutionCollege of Medicine
DepartmentPathology
Address500 University Drive Hershey PA 17033
Mailbox: H158
Phone7175318316

 Overview 
 overview
PREFERRED TITLE/ROLE:

Distinguished Professor Emeritus of Pathology and Medicine

EDUCATION:

Ph.D., SUNY - Upstate Medical Center, 1970
Residency, Harvard Medical School
Fellowship, University of Oxford

NARRATIVE:

Biomarkers and Metabolic Bone Disease

We have been interested in the effects of bone disease as well as metastatic disease to bone on biomarkers of bone remodeling. We have established specific biochemical assays to monitor bone resorption and bone formation that include bone collagen breakdown products, markers of bone collagen synthesis, markers of osteoclastogenesis and markers of osteoblast function and secretion. These biomarkers have been evaluated in patients with osteoporosis, Paget's disease and skeletal metastases treated with pharmaceutical agents that can attenuate bone turnover and inhibit bone loss or resorption. These agents include the bisphosphonate class of compounds as well as hormone replacement therapy used to treated bone resorption caused by bone disease.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Demers LM, Ziegler R, Santen RJ. Response to the Letter by Labrie et al. J Clin Endocrinol Metab. 2015 Sep; 100(9):L88.
    View in: PubMed
  2. Santen RJ, Demers LM, Ziegler RG. Workshop on measuring estrogen exposure and metabolism: Summary of the presentations. Steroids. 2015 Jul; 99(Pt A):1-7.
    View in: PubMed
  3. Mennenga SE, Koebele SV, Mousa AA, Alderete TJ, Tsang CW, Acosta JI, Camp BW, Demers LM, Bimonte-Nelson HA. Pharmacological blockade of the aromatase enzyme, but not the androgen receptor, reverses androstenedione-induced cognitive impairments in young surgically menopausal rats. Steroids. 2015 Jul; 99(Pt A):16-25.
    View in: PubMed
  4. Schetter SE, Hartman TJ, Liao J, Richie JP, Prokopczyk B, DuBrock C, Signori C, Hamilton C, Demers LM, El-Bayoumy K, Manni A. Differential impact of body mass index on absolute and percent breast density: implications regarding their use as breast cancer risk biomarkers. Breast Cancer Res Treat. 2014 Jul; 146(2):355-63.
    View in: PubMed
  5. Walter KN, Corwin EJ, Ulbrecht J, Demers LM, Bennett JM, Whetzel CA, Klein LC. Elevated thyroid stimulating hormone is associated with elevated cortisol in healthy young men and women. Thyroid Res. 2012; 5(1):13.
    View in: PubMed
  6. Coney P, Demers LM, Dodson WC, Kunselman AR, Ladson G, Legro RS. Determination of vitamin D in relation to body mass index and race in a defined population of black and white women. Int J Gynaecol Obstet. 2012 Oct; 119(1):21-5.
    View in: PubMed
  7. Engler-Chiurazzi EB, Talboom JS, Braden BB, Tsang CW, Mennenga S, Andrews M, Demers LM, Bimonte-Nelson HA. Continuous estrone treatment impairs spatial memory and does not impact number of basal forebrain cholinergic neurons in the surgically menopausal middle-aged rat. Horm Behav. 2012 Jun; 62(1):1-9.
    View in: PubMed
  8. Lipton A, Chapman JA, Demers L, Shepherd LE, Han L, Wilson CF, Pritchard KI, Leitzel KE, Ali SM, Pollak M. Elevated bone turnover predicts for bone metastasis in postmenopausal breast cancer: results of NCIC CTG MA.14. J Clin Oncol. 2011 Sep 20; 29(27):3605-10.
    View in: PubMed
  9. Manni A, Xu H, Washington S, Aliaga C, Das A, Cooper T, Richie JP, Prokopczyk B, Calcagnotto A, Trushin N, Van den Heuvel JP, Hamilton C, Demers LM, Liao J, Verderame MF, El-Bayoumy K. The effects of Tamoxifen and fish oil on mammary carcinogenesis in polyoma middle T transgenic mice. Horm Cancer. 2011 Aug; 2(4):249-59.
    View in: PubMed
  10. Ladson G, Dodson WC, Sweet SD, Archibong AE, Kunselman AR, Demers LM, Williams NI, Coney P, Legro RS. Racial influence on the polycystic ovary syndrome phenotype: a black and white case-control study. Fertil Steril. 2011 Jul; 96(1):224-229.e2.
    View in: PubMed
  11. Ladson G, Dodson WC, Sweet SD, Archibong AE, Kunselman AR, Demers LM, Lee PA, Williams NI, Coney P, Legro RS. Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study. Fertil Steril. 2011 Jun 30; 95(8):2595-8.e1-6.
    View in: PubMed
  12. Witherby S, Johnson J, Demers L, Mount S, Littenberg B, Maclean CD, Wood M, Muss H. Topical testosterone for breast cancer patients with vaginal atrophy related to aromatase inhibitors: a phase I/II study. Oncologist. 2011; 16(4):424-31.
    View in: PubMed
  13. Ladson G, Dodson WC, Sweet SD, Archibong AE, Kunselman AR, Demers LM, Williams NI, Coney P, Legro RS. The effects of metformin with lifestyle therapy in polycystic ovary syndrome: a randomized double-blind study. Fertil Steril. 2011 Mar 1; 95(3):1059-66.e1-7.
    View in: PubMed
  14. Raja-Khan N, Kunselman AR, Hogeman CS, Stetter CM, Demers LM, Legro RS. Effects of atorvastatin on vascular function, inflammation, and androgens in women with polycystic ovary syndrome: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2011 Apr; 95(5):1849-52.
    View in: PubMed
  15. Raja-Khan N, Shuja SA, Kunselman AR, Hogeman CS, Demers LM, Gnatuk CL, Legro RS. Brachial artery conductance during reactive hyperemia is increased in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2011 Mar; 155(1):49-53.
    View in: PubMed
  16. Raja-Khan N, Kunselman AR, Demers LM, Ewens KG, Spielman RS, Legro RS. A variant in the fibrillin-3 gene is associated with TGF-ß and inhibin B levels in women with polycystic ovary syndrome. Fertil Steril. 2010 Dec; 94(7):2916-9.
    View in: PubMed
  17. Demers LM. Androgen deficiency in women; role of accurate testosterone measurements. Maturitas. 2010 Sep; 67(1):39-45.
    View in: PubMed
  18. Lipton A, Campbell-Baird C, Harvey H, Kim C, Demers L, Costa L. Phase I trial of zoledronic acid + imatinib mesylate (Gleevec) in patients with bone metastases. Am J Clin Oncol. 2010 Feb; 33(1):75-8.
    View in: PubMed
  19. Karp DD, Pollak MN, Cohen RB, Eisenberg PD, Haluska P, Yin D, Lipton A, Demers L, Leitzel K, Hixon ML, Terstappen LW, Garland L, Paz-Ares LG, Cardenal F, Langer CJ, Gualberto A. Safety, pharmacokinetics, and pharmacodynamics of the insulin-like growth factor type 1 receptor inhibitor figitumumab (CP-751,871) in combination with paclitaxel and carboplatin. J Thorac Oncol. 2009 Nov; 4(11):1397-403.
    View in: PubMed
  20. Acosta JI, Mayer L, Talboom JS, Zay C, Scheldrup M, Castillo J, Demers LM, Enders CK, Bimonte-Nelson HA. Premarin improves memory, prevents scopolamine-induced amnesia and increases number of basal forebrain choline acetyltransferase positive cells in middle-aged surgically menopausal rats. Horm Behav. 2009 Mar; 55(3):454-64.
    View in: PubMed
  21. Demers LM. Testosterone and estradiol assays: current and future trends. Steroids. 2008 Dec 12; 73(13):1333-8.
    View in: PubMed
  22. Lipton A, Leitzel K, Chaudri-Ross HA, Evans DB, Ali SM, Demers L, Hamer P, Brown-Shimer S, Pierce K, Gaur V, Carney W. Serum TIMP-1 and response to the aromatase inhibitor letrozole versus tamoxifen in metastatic breast cancer. J Clin Oncol. 2008 Jun 1; 26(16):2653-8.
    View in: PubMed
  23. Erickson DR, Tomaszewski JE, Kunselman AR, Stetter CM, Peters KM, Rovner ES, Demers LM, Wheeler MA, Keay SK. Urine markers do not predict biopsy findings or presence of bladder ulcers in interstitial cystitis/painful bladder syndrome. J Urol. 2008 May; 179(5):1850-6.
    View in: PubMed
  24. Katcher HI, Kunselman AR, Dmitrovic R, Demers LM, Gnatuk CL, Kris-Etherton PM, Legro RS. Comparison of hormonal and metabolic markers after a high-fat, Western meal versus a low-fat, high-fiber meal in women with polycystic ovary syndrome. Fertil Steril. 2009 Apr; 91(4):1175-82.
    View in: PubMed
  25. Pauli EM, Legro RS, Demers LM, Kunselman AR, Dodson WC, Lee PA. Diminished paternity and gonadal function with increasing obesity in men. Fertil Steril. 2008 Aug; 90(2):346-51.
    View in: PubMed
  26. Kent SC, Gnatuk CL, Kunselman AR, Demers LM, Lee PA, Legro RS. Hyperandrogenism and hyperinsulinism in children of women with polycystic ovary syndrome: a controlled study. J Clin Endocrinol Metab. 2008 May; 93(5):1662-9.
    View in: PubMed
  27. Katcher HI, Legro RS, Kunselman AR, Gillies PJ, Demers LM, Bagshaw DM, Kris-Etherton PM. The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome. Am J Clin Nutr. 2008 Jan; 87(1):79-90.
    View in: PubMed
  28. Legro RS, Pauli JG, Kunselman AR, Meadows JW, Kesner JS, Zaino RJ, Demers LM, Gnatuk CL, Dodson WC. Effects of continuous versus cyclical oral contraception: a randomized controlled trial. J Clin Endocrinol Metab. 2008 Feb; 93(2):420-9.
    View in: PubMed
  29. Ryan CW, Huo D, Bylow K, Demers LM, Stadler WM, Henderson TO, Vogelzang NJ. Suppression of bone density loss and bone turnover in patients with hormone-sensitive prostate cancer and receiving zoledronic acid. BJU Int. 2007 Jul; 100(1):70-5.
    View in: PubMed
  30. Park H, Aiyar SE, Fan P, Wang J, Yue W, Okouneva T, Cox C, Jordan MA, Demers L, Cho H, Kim S, Song RX, Santen RJ. Effects of tetramethoxystilbene on hormone-resistant breast cancer cells: biological and biochemical mechanisms of action. Cancer Res. 2007 Jun 15; 67(12):5717-26.
    View in: PubMed
  31. Lipton A, Ali SM, Leitzel K, Demers L, Evans DB, Hamer P, Brown-Shimer S, Pierce K, Carney W. Elevated plasma tissue inhibitor of metalloproteinase-1 level predicts decreased response and survival in metastatic breast cancer. Cancer. 2007 May 15; 109(10):1933-9.
    View in: PubMed
  32. Legro RS, Zaino RJ, Demers LM, Kunselman AR, Gnatuk CL, Williams NI, Dodson WC. The effects of metformin and rosiglitazone, alone and in combination, on the ovary and endometrium in polycystic ovary syndrome. Am J Obstet Gynecol. 2007 Apr; 196(4):402.e1-10; discussion 402.e10-1.
    View in: PubMed
  33. Jun JY, Griffith JW, Bruggeman R, Washington S, Demers LM, Verderame MF, Manni A. Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. Breast Cancer Res Treat. 2008 Jan; 107(1):33-40.
    View in: PubMed
  34. Erickson DR, Kunselman AR, Bentley CM, Peters KM, Rovner ES, Demers LM, Wheeler MA, Keay SK. Changes in urine markers and symptoms after bladder distention for interstitial cystitis. J Urol. 2007 Feb; 177(2):556-60.
    View in: PubMed
  35. Jun JY, Griffith JW, Bruggeman R, Washington S, Demers LM, Verderame MF, Manni A. Effects of polyamine depletion by alpha-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. Breast Cancer Res Treat. 2007 Sep; 105(1):29-36.
    View in: PubMed
  36. Souder C, Leitzel K, Ali SM, Demers L, Evans DB, Chaudri-Ross HA, Hackl W, Hamer P, Carney W, Lipton A. Serum epidermal growth factor receptor/HER-2 predicts poor survival in patients with metastatic breast cancer. Cancer. 2006 Nov 15; 107(10):2337-45.
    View in: PubMed
  37. Ryan CW, Huo D, Demers LM, Beer TM, Lacerna LV. Zoledronic acid initiated during the first year of androgen deprivation therapy increases bone mineral density in patients with prostate cancer. J Urol. 2006 Sep; 176(3):972-8; discussion 978.
    View in: PubMed
  38. Donahue SW, Galley SA, Vaughan MR, Patterson-Buckendahl P, Demers LM, Vance JL, McGee ME. Parathyroid hormone may maintain bone formation in hibernating black bears (Ursus americanus) to prevent disuse osteoporosis. J Exp Biol. 2006 May; 209(Pt 9):1630-8.
    View in: PubMed
  39. Theriault RL, Biermann JS, Brown E, Brufsky A, Demers L, Grewal RK, Guise T, Jackson R, McEnery K, Podoloff D, Ravdin P, Shapiro CL, Smith M, Van Poznak CH. NCCN Task Force Report: Bone Health and Cancer Care. J Natl Compr Canc Netw. 2006 May; 4 Suppl 2:S1-20; quiz S21-2.
    View in: PubMed
  40. Richert MM, Phadke PA, Matters G, DiGirolamo DJ, Washington S, Demers LM, Bond JS, Manni A, Welch DR. Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment. Breast Cancer Res. 2005; 7(5):R819-27.
    View in: PubMed
  41. Zhang Y, Lu Y, Yuan BZ, Castranova V, Shi X, Stauffer JL, Demers LM, Chen F. The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer. Oncogene. 2005 Jul 21; 24(31):4873-82.
    View in: PubMed
  42. Lipton A, Leitzel K, Ali SM, Demers L, Harvey HA, Chaudri-Ross HA, Evans D, Lang R, Hackl W, Hamer P, Carney W. Serum HER-2/neu conversion to positive at the time of disease progression in patients with breast carcinoma on hormone therapy. Cancer. 2005 Jul 15; 104(2):257-63.
    View in: PubMed
  43. McNulty PH, King N, Scott S, Hartman G, McCann J, Kozak M, Chambers CE, Demers LM, Sinoway LI. Effects of supplemental oxygen administration on coronary blood flow in patients undergoing cardiac catheterization. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3):H1057-62.
    View in: PubMed
  44. Erickson DR, Tomaszewski JE, Kunselman AR, Bentley CM, Peters KM, Rovner ES, Demers LM, Wheeler MA, Keay SK. Do the National Institute of Diabetes and Digestive and Kidney Diseases cystoscopic criteria associate with other clinical and objective features of interstitial cystitis? J Urol. 2005 Jan; 173(1):93-7.
    View in: PubMed
  45. Manni A, Washington S, Hu X, Griffith JW, Bruggeman R, Demers LM, Mauger D, Verderame MF. Effects of polyamine synthesis inhibitors on primary tumor features and metastatic capacity of human breast cancer cells. Clin Exp Metastasis. 2005; 22(3):255-63.
    View in: PubMed
  46. Hu X, Washington S, Verderame MF, Demers LM, Mauger D, Manni A. Biological activity of the S-adenosylmethionine decarboxylase inhibitor SAM486A in human breast cancer cells in vitro and in vivo. Int J Oncol. 2004 Dec; 25(6):1831-8.
    View in: PubMed
  47. Erickson DR, Kunselman AR, Bentley CM, Peters KM, Rovner ES, Demers LM, Tomaszewski JE. Is urine methylhistamine a useful marker for interstitial cystitis? J Urol. 2004 Dec; 172(6 Pt 1):2256-60.
    View in: PubMed
  48. Wang S, Paris F, Sultan CS, Song RX, Demers LM, Sundaram B, Settlage J, Ohorodnik S, Santen RJ. Recombinant cell ultrasensitive bioassay for measurement of estrogens in postmenopausal women. J Clin Endocrinol Metab. 2005 Mar; 90(3):1407-13.
    View in: PubMed
  49. Ito RK, Demers LM. Pharmacogenomics and pharmacogenetics: future role of molecular diagnostics in the clinical diagnostic laboratory. Clin Chem. 2004 Sep; 50(9):1526-7.
    View in: PubMed
  50. Demers LM. Thyroid disease: pathophysiology and diagnosis. Clin Lab Med. 2004 Mar; 24(1):19-28.
    View in: PubMed
  51. Stamets K, Taylor DS, Kunselman A, Demers LM, Pelkman CL, Legro RS. A randomized trial of the effects of two types of short-term hypocaloric diets on weight loss in women with polycystic ovary syndrome. Fertil Steril. 2004 Mar; 81(3):630-7.
    View in: PubMed
  52. Wang C, Catlin DH, Demers LM, Starcevic B, Swerdloff RS. Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry. J Clin Endocrinol Metab. 2004 Feb; 89(2):534-43.
    View in: PubMed
  53. Donahue SW, Vaughan MR, Demers LM, Donahue HJ. Bone formation is not impaired by hibernation (disuse) in black bears Ursus americanus. J Exp Biol. 2003 Dec; 206(Pt 23):4233-9.
    View in: PubMed
  54. Demers LM, Costa L, Lipton A. Biochemical markers and skeletal metastases. Clin Orthop Relat Res. 2003 Oct; (415 Suppl):S138-47.
    View in: PubMed
  55. Perry PJ, Kutscher EC, Lund BC, Yates WR, Holman TL, Demers L. Measures of aggression and mood changes in male weightlifters with and without androgenic anabolic steroid use. J Forensic Sci. 2003 May; 48(3):646-51.
    View in: PubMed
  56. Donahue SW, Vaughan MR, Demers LM, Donahue HJ. Serum markers of bone metabolism show bone loss in hibernating bears. Clin Orthop Relat Res. 2003 Mar; (408):295-301.
    View in: PubMed
  57. Demers LM. Andropause: an androgen deficiency state in the ageing male. Expert Opin Pharmacother. 2003 Feb; 4(2):183-90.
    View in: PubMed
  58. Demers LM. Bone markers in the management of patients with skeletal metastases. Cancer. 2003 Feb 1; 97(3 Suppl):874-9.
    View in: PubMed
  59. Baloch Z, Carayon P, Conte-Devolx B, Demers LM, Feldt-Rasmussen U, Henry JF, LiVosli VA, Niccoli-Sire P, John R, Ruf J, Smyth PP, Spencer CA, Stockigt JR. Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid. 2003 Jan; 13(1):3-126.
    View in: PubMed
  60. Manni A, Washington S, Craig L, Cloud M, Griffith JW, Verderame MF, Texter LJ, Mauger D, Demers LM, Harms JF, Welch DR. Effects of alpha-difluoromethylornithine on local recurrence and pulmonary metastasis from MDA-MB-435 breast cancer xenografts in nude mice. Clin Exp Metastasis. 2003; 20(4):321-5.
    View in: PubMed
  61. De Souza MJ, Van Heest J, Demers LM, Lasley BL. Luteal phase deficiency in recreational runners: evidence for a hypometabolic state. J Clin Endocrinol Metab. 2003 Jan; 88(1):337-46.
    View in: PubMed
  62. Legro RS, Lin HM, Demers LM, Lloyd T. Urinary free cortisol increases in adolescent caucasian females during perimenarche. J Clin Endocrinol Metab. 2003 Jan; 88(1):215-9.
    View in: PubMed
  63. Whipple T, Sharkey N, Demers L, Williams N. Leptin and the skeleton. Clin Endocrinol (Oxf). 2002 Dec; 57(6):701-11.
    View in: PubMed
  64. Ali SM, Leitzel K, Chinchilli VM, Engle L, Demers L, Harvey HA, Carney W, Allard JW, Lipton A. Relationship of serum HER-2/neu and serum CA 15-3 in patients with metastatic breast cancer. Clin Chem. 2002 Aug; 48(8):1314-20.
    View in: PubMed
  65. Chen F, Demers LM, Shi X. Upstream signal transduction of NF-kappaB activation. Curr Drug Targets Inflamm Allergy. 2002 Jun; 1(2):137-49.
    View in: PubMed
  66. Liben LS, Susman EJ, Finkelstein JW, Chinchilli VM, Kunselman S, Schwab J, Dubas JS, Demers LM, Lookingbill G, Darcangelo MR, Krogh HR, Kulin HE. The effects of sex steroids on spatial performance: a review and an experimental clinical investigation. Dev Psychol. 2002 Mar; 38(2):236-53.
    View in: PubMed
  67. Holman JW, Mifflin TE, Felder RA, Demers LM. Evaluation of an automated preanalytical robotic workstation at two academic health centers. Clin Chem. 2002 Mar; 48(3):540-8.
    View in: PubMed
  68. Costa L, Demers LM, Gouveia-Oliveira A, Schaller J, Costa EB, de Moura MC, Lipton A. Prospective evaluation of the peptide-bound collagen type I cross-links N-telopeptide and C-telopeptide in predicting bone metastases status. J Clin Oncol. 2002 Feb 1; 20(3):850-6.
    View in: PubMed
  69. Vesper HW, Demers LM, Eastell R, Garnero P, Kleerekoper M, Robins SP, Srivastava AK, Warnick GR, Watts NB, Myers GL. Assessment and recommendations on factors contributing to preanalytical variability of urinary pyridinoline and deoxypyridinoline. Clin Chem. 2002 Feb; 48(2):220-35.
    View in: PubMed
  70. Lloyd T, Lin HM, Eggli DF, Dodson WC, Demers LM, Legro RS. Adolescent Caucasian mothers have reduced adult hip bone density. Fertil Steril. 2002 Jan; 77(1):136-40.
    View in: PubMed
  71. Manni A, Washington S, Griffith JW, Verderame MF, Mauger D, Demers LM, Samant RS, Welch DR. Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells. Clin Exp Metastasis. 2002; 19(2):95-105.
    View in: PubMed
Demers's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_