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Andras Hajnal

TitleProfessor
InstitutionCollege of Medicine
DepartmentNeural and Behavioral Sciences
Address500 University Drive Hershey PA 17033
Mailbox: H181
Phone7175315735

 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Neural and Behavioral Sciences

SECONDARY APPOINTMENT

Professor of Surgery

GRADUATE PROGRAM AFFILIATIONS:

Neuroscience, Biomedical Sciences, Nutrition Sciences,
MD-PhD Program

EDUCATION:

M.D., Pecs University Medical School, Hungary
Ph.D. in Neuroscience
Postdoctoral Training: Princeton University; Oregon Health Sciences University; Pennsylvania State University

NARRATIVE:

My research is broadly concerned with understanding the role of orosensory, viscerosensory, hormonal and metabolic signals in the control of reward-seeking behaviors such as hedonic eating or the use of alcohol and drugs.

Specific projects address changes in the gut-brain signaling influencing taste and reward functions in obesity and following surgical (e.g. Roux-en-Y gastric bypass surgery) and non-surgical weight reduction. We use behavioral, neurochemical, molecular, and electrophysiological methods in dietary and genetic obese (diabetic, or non-diabetic) rats and surgical models to investigate gustatory and dopamine signaling in the brain. The primary focus is on sweet taste and effects of carbohydrates on gut-brain peptides upstream to forebrain and hindbrain reward centers, and the outcome measures include anticipatory and consummatory behaviors such as sucrose or alcohol self-administration.

This research is relevant to the pathophysiology of eating, diet-induced obesity, and alcohol/drug addiction, and may help with developing a non-invasive alternative to bariatric surgery as well as new pharmacological interventions to treat eating and drug use disorders.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Olson KC, Chen G, Xu Y, Hajnal A, Lynch CJ. Alloisoleucine differentiates the branched-chain aminoacidemia of Zucker and dietary obese rats. Obesity (Silver Spring). 2014 May; 22(5):1212-5.
    View in: PubMed
  2. Polston JE, Pritchett CE, Tomasko JM, Rogers AM, Leggio L, Thanos PK, Volkow ND, Hajnal A. Roux-en-Y gastric bypass increases intravenous ethanol self-administration in dietary obese rats. PLoS One. 2013; 8(12):e83741.
    View in: PubMed
  3. Browning KN, Hajnal A. The effects of bariatric surgery: will understanding its mechanism render the knife unnecessary? Expert Rev Gastroenterol Hepatol. 2014 Jan; 8(1):1-4.
    View in: PubMed
  4. Hajnal A, Thanos PK, Volkow ND. Notes on "roux en y gastric bypass increases ethanol intake in the rat" by Davis et al. Obes Surg. 2013 Aug; 23(8):1317.
    View in: PubMed
  5. Armbruszt S, Abraham H, Figler M, Kozicz T, Hajnal A. Cocaine- and amphetamine-regulated transcript (CART) peptide immunoreactivity in feeding- and reward-related brain areas of young OLETF rats. J Chem Neuroanat. 2013 May; 50-51:75-84.
    View in: PubMed
  6. Browning KN, Fortna SR, Hajnal A. Roux-en-Y gastric bypass reverses the effects of diet-induced obesity to inhibit the responsiveness of central vagal motoneurones. J Physiol. 2013 May 1; 591(Pt 9):2357-72.
    View in: PubMed
  7. Thanos PK, Subrize M, Delis F, Cooney RN, Culnan D, Sun M, Wang GJ, Volkow ND, Hajnal A. Gastric bypass increases ethanol and water consumption in diet-induced obese rats. Obes Surg. 2012 Dec; 22(12):1884-92.
    View in: PubMed
  8. Hajnal A, Zharikov A, Polston JE, Fields MR, Tomasko J, Rogers AM, Volkow ND, Thanos PK. Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism. PLoS One. 2012; 7(11):e49121.
    View in: PubMed
  9. Geraedts MC, Takahashi T, Vigues S, Markwardt ML, Nkobena A, Cockerham RE, Hajnal A, Dotson CD, Rizzo MA, Munger SD. Transformation of postingestive glucose responses after deletion of sweet taste receptor subunits or gastric bypass surgery. Am J Physiol Endocrinol Metab. 2012 Aug 15; 303(4):E464-74.
    View in: PubMed
  10. Pritchett CE, Hajnal A. Glucagon-like peptide-1 regulation of carbohydrate intake is differentially affected by obesogenic diets. Obesity (Silver Spring). 2012 Feb; 20(2):313-7.
    View in: PubMed
  11. Tam CS, Berthoud HR, Bueter M, Chakravarthy MV, Geliebter A, Hajnal A, Holst J, Kaplan L, Pories W, Raybould H, Seeley R, Strader A, Ravussin E. Could the mechanisms of bariatric surgery hold the key for novel therapies? report from a Pennington Scientific Symposium. Obes Rev. 2011 Nov; 12(11):984-94.
    View in: PubMed
  12. Pritchett CE, Hajnal A. Obesogenic diets may differentially alter dopamine control of sucrose and fructose intake in rats. Physiol Behav. 2011 Jul 25; 104(1):111-6.
    View in: PubMed
  13. Hajnal A, Kovacs P, Ahmed T, Meirelles K, Lynch CJ, Cooney RN. Gastric bypass surgery alters behavioral and neural taste functions for sweet taste in obese rats. Am J Physiol Gastrointest Liver Physiol. 2010 Oct; 299(4):G967-79.
    View in: PubMed
  14. Bello NT, Hajnal A. Dopamine and binge eating behaviors. Pharmacol Biochem Behav. 2010 Nov; 97(1):25-33.
    View in: PubMed
  15. Swartz TD, Hajnal A, Covasa M. Altered orosensory sensitivity to oils in CCK-1 receptor deficient rats. Physiol Behav. 2010 Jan 12; 99(1):109-17.
    View in: PubMed
  16. Hajnal A, Norgren R, Kovacs P. Parabrachial coding of sapid sucrose: relevance to reward and obesity. Ann N Y Acad Sci. 2009 Jul; 1170:347-64.
    View in: PubMed
  17. Kovacs P, Hajnal A. In vivo electrophysiological effects of insulin in the rat brain. Neuropeptides. 2009 Aug; 43(4):283-93.
    View in: PubMed
  18. Abraham H, Covasa M, Hajnal A. Cocaine- and amphetamine-regulated transcript peptide immunoreactivity in the brain of the CCK-1 receptor deficient obese OLETF rat. Exp Brain Res. 2009 Jul; 196(4):545-56.
    View in: PubMed
  19. Kovacs P, Hajnal A. Altered pontine taste processing in a rat model of obesity. J Neurophysiol. 2008 Oct; 100(4):2145-57.
    View in: PubMed
  20. Hajnal A and Norgren R. Dopamine Release by Sucrose. In: A. I. Basbaum, A. Kanake, G. M. Shepherd and G. Westheimer, editors. Olfaction & Taste. 2008; 4:459-468.
  21. Grigson PS, Hajnal A. Once is too much: conditioned changes in accumbens dopamine following a single saccharin-morphine pairing. Behav Neurosci. 2007 Dec; 121(6):1234-42.
    View in: PubMed
  22. Hajnal A, Acharya NK, Grigson PS, Covasa M, Twining RC. Obese OLETF rats exhibit increased operant performance for palatable sucrose solutions and differential sensitivity to D2 receptor antagonism. Am J Physiol Regul Integr Comp Physiol. 2007 Nov; 293(5):R1846-54.
    View in: PubMed
  23. She P, Reid TM, Bronson SK, Vary TC, Hajnal A, Lynch CJ, Hutson SM. Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab. 2007 Sep; 6(3):181-94.
    View in: PubMed
  24. Hajnal A, Margas WM, Covasa M. Altered dopamine D2 receptor function and binding in obese OLETF rat. Brain Res Bull. 2008 Jan 31; 75(1):70-6.
    View in: PubMed
  25. Hajnal A, De Jonghe BC, Covasa M. Dopamine D2 receptors contribute to increased avidity for sucrose in obese rats lacking CCK-1 receptors. Neuroscience. 2007 Aug 24; 148(2):584-92.
    View in: PubMed
  26. Anderzhanova E, Covasa M, Hajnal A. Altered basal and stimulated accumbens dopamine release in obese OLETF rats as a function of age and diabetic status. Am J Physiol Regul Integr Comp Physiol. 2007 Aug; 293(2):R603-11.
    View in: PubMed
  27. De Jonghe BC, Hajnal A, Covasa M. Conditioned preference for sweet stimuli in OLETF rat: effects of food deprivation. Am J Physiol Regul Integr Comp Physiol. 2007 May; 292(5):R1819-27.
    View in: PubMed
  28. Bello NT, Hajnal A. Acute methylphenidate treatments reduce sucrose intake in restricted-fed bingeing rats. Brain Res Bull. 2006 Oct 16; 70(4-6):422-9.
    View in: PubMed
  29. Norgren R, Hajnal A, Mungarndee SS. Gustatory reward and the nucleus accumbens. Physiol Behav. 2006 Nov 30; 89(4):531-5.
    View in: PubMed
  30. Liang NC, Hajnal A, Norgren R. Sham feeding corn oil increases accumbens dopamine in the rat. Am J Physiol Regul Integr Comp Physiol. 2006 Nov; 291(5):R1236-9.
    View in: PubMed
  31. De Jonghe BC, Hajnal A, Covasa M. Decreased gastric mechanodetection, but preserved gastric emptying, in CCK-1 receptor-deficient OLETF rats. Am J Physiol Gastrointest Liver Physiol. 2006 Oct; 291(4):G640-9.
    View in: PubMed
  32. Bello NT, Hajnal A. Alterations in blood glucose levels under hyperinsulinemia affect accumbens dopamine. Physiol Behav. 2006 Jun 15; 88(1-2):138-45.
    View in: PubMed
  33. Albaugh VL, Henry CR, Bello NT, Hajnal A, Lynch SL, Halle B, Lynch CJ. Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents. Obesity (Silver Spring). 2006 Jan; 14(1):36-51.
    View in: PubMed
  34. Corwin RL, Hajnal A. Too much of a good thing: neurobiology of non-homeostatic eating and drug abuse. Physiol Behav. 2005 Sep 15; 86(1-2):5-8.
    View in: PubMed
  35. Hajnal A, Covasa M, Bello NT. Altered taste sensitivity in obese, prediabetic OLETF rats lacking CCK-1 receptors. Am J Physiol Regul Integr Comp Physiol. 2005 Dec; 289(6):R1675-86.
    View in: PubMed
  36. De Jonghe BC, Di Martino C, Hajnal A, Covasa M. Brief intermittent access to sucrose differentially modulates prepulse inhibition and acoustic startle response in obese CCK-1 receptor deficient rats. Brain Res. 2005 Aug 2; 1052(1):22-7.
    View in: PubMed
  37. Hajnal A, Norgren R. Taste pathways that mediate accumbens dopamine release by sapid sucrose. Physiol Behav. 2005 Mar 16; 84(3):363-9.
    View in: PubMed
  38. De Jonghe BC, Hajnal A, Covasa M. Increased oral and decreased intestinal sensitivity to sucrose in obese, prediabetic CCK-A receptor-deficient OLETF rats. Am J Physiol Regul Integr Comp Physiol. 2005 Jan; 288(1):R292-300.
    View in: PubMed
  39. Hajnal A, Norgren R. Sucrose sham feeding decreases accumbens norepinephrine in the rat. Physiol Behav. 2004 Aug; 82(1):43-7.
    View in: PubMed
  40. Hajnal A, Smith GP, Norgren R. Oral sucrose stimulation increases accumbens dopamine in the rat. Am J Physiol Regul Integr Comp Physiol. 2004 Jan; 286(1):R31-7.
    View in: PubMed
  41. Bello NT, Sweigart KL, Lakoski JM, Norgren R, Hajnal A. Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter. Am J Physiol Regul Integr Comp Physiol. 2003 May; 284(5):R1260-8.
    View in: PubMed
  42. Norgren R, Grigson PS, Hajnal A and Lundy RF Jr. . Motivational modulation of taste. In: Cognition and Emotion in the Brain, Ed: T. Ono, G. Matsumoto, R. Llinas, A. Berthoz, R. Norgren, H. Nishijo, and R. Tamura. 2003; 319 – 334.
  43. Hajnal A, Norgren R. Repeated access to sucrose augments dopamine turnover in the nucleus accumbens. Neuroreport. 2002 Dec 3; 13(17):2213-6.
    View in: PubMed
  44. Bello NT, Lucas LR, Hajnal A. Repeated sucrose access influences dopamine D2 receptor density in the striatum. Neuroreport. 2002 Aug 27; 13(12):1575-8.
    View in: PubMed
  45. Hajnal A, Norgren R. Accumbens dopamine mechanisms in sucrose intake. Brain Res. 2001 Jun 15; 904(1):76-84.
    View in: PubMed
  46. Hajnal A, Székely M, Gálosi R, Lénárd L. Accumbens cholinergic interneurons play a role in the regulation of body weight and metabolism. Physiol Behav. 2000 Jul 1-15; 70(1-2):95-103.
    View in: PubMed
  47. Hajnal A, Takenouchi K, Norgren R. Effect of intraduodenal lipid on parabrachial gustatory coding in awake rats. J Neurosci. 1999 Aug 15; 19(16):7182-90.
    View in: PubMed
  48. Mark GP, Hajnal A, Kinney AE, Keys AS. Self-administration of cocaine increases the release of acetylcholine to a greater extent than response-independent cocaine in the nucleus accumbens of rats. Psychopharmacology (Berl). 1999 Mar; 143(1):47-53.
    View in: PubMed
  49. Hajnal A, Pothos EN, Lénárd L, Hoebel BG. Effects of feeding and insulin on extracellular acetylcholine in the amygdala of freely moving rats. Brain Res. 1998 Feb 23; 785(1):41-8.
    View in: PubMed
  50. Hajnal A, Mark GP, Keys AS, Lénárd L. Involvement of dopamine and acetylcholine in the interaction between amygdala and nucleus accumbens: chronic microdialysis in rats. Neurobiology (Bp). 1998; 6(3):363-7.
    View in: PubMed
  51. Hajnal A, Mark GP, Rada PV, Lénárd L, Hoebel BG. Norepinephrine microinjections in the hypothalamic paraventricular nucleus increase extracellular dopamine and decrease acetylcholine in the nucleus accumbens: relevance to feeding reinforcement. J Neurochem. 1997 Feb; 68(2):667-74.
    View in: PubMed
  52. Petykó Z, Lénád L, Sümegi B, Hajnal A, Csete B, Faludi B, Jandó G. Learning disturbances in offsprings of zidovudine (AZT) treated rats. Neurobiology (Bp). 1997; 5(1):83-5.
    View in: PubMed
  53. Hajnal A, Gálosi R, Lénárd L. Role of accumbens cholinergic interneurons in the maintenance of body weight. Neurobiology (Bp). 1997; 5(4):473-6.
    View in: PubMed
  54. Gálosi R, Hajnal A, Fendler K, Lénárd L. Effect of catecholaminergic lesions of medial prefrontal cortex on regulation of body weight and glucose preference. Neurobiology (Bp). 1997; 5(4):469-72.
    View in: PubMed
  55. Hajnal A, Lénárd L, Czurkó A, Sándor P, Karádi Z. Distribution and time course of appearance of "dark" neurons and EEG activity after amygdaloid kainate lesion. Brain Res Bull. 1997; 43(2):235-43.
    View in: PubMed
  56. Hajnal A, Pothos EN, Lénárd L, Hoebel BG. Feeding and acetylcholine in the amygdala: microdialysis in freely moving rats. Neurobiology (Bp). 1996; 4(1-2):109-10.
    View in: PubMed
  57. Pungor K, Hajnal A, Kékesi KA, Juhász G. Paradoxical sleep deprivatory effect of a single low dose of MPTP which did not produce dopaminergic cell loss. Exp Brain Res. 1993; 95(3):473-6.
    View in: PubMed
  58. Hajnal A, Sándor P, Jandó G, Vida I, Czurkó A, Karádi Z, Lénárd L. Feeding disturbances and EEG activity changes after amygdaloid kainate lesions in the rat. Brain Res Bull. 1992 Dec; 29(6):909-16.
    View in: PubMed
  59. Sándor P, Hajnal A, Jandó G, Karádi Z, Lénárd L. Microelectrophoretic application of kainic acid into the globus pallidus: disturbances in feeding behavior. Brain Res Bull. 1992 May; 28(5):751-6.
    View in: PubMed
  60. Hajnal A, Abrahám I, Vida I, Karádi Z, Lénárd L. Hunger- and satiety-related changes of amygdaloid catecholamines: a microdialytic study in freely moving rats. Acta Biochim Biophys Hung. 1991-1992; 26(1-4):67-9.
    View in: PubMed
  61. Lénárd L, Jandó G, Karádi Z, Hajnal A, Sándor P. Lateral hypothalamic feeding mechanisms: iontophoretic effects of kainic acid, ibotenic acid and 6-hydroxydopamine. Brain Res Bull. 1988 Jun; 20(6):847-56.
    View in: PubMed
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