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Kathryn Lanoue

TitleProfessor Emeritus
InstitutionCollege of Medicine
DepartmentCellular and Molecular Physiology
Address500 University Drive Hershey PA 17033
Mailbox: H166
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    PREFERRED TITLE/ROLE:



    Professor Emeritus of Cellular and Molecular Physiology



    GRADUATE PROGRAM AFFILIATIONS:



    Cell and Molecular Biology, MD/PhD Degree Program, Physiology, Neuroscience



    EDUCATION:



    Ph.D., Yale University, 1961

    Postdoctoral Training, University of Pennsylvania Medical School, 1968-1970



    NARRATIVE:



    Dr. LaNoue and her colleagues are engaged in an evaluation of factors that control the de novo synthesis and utilization of glutamate in the brain and retina. Glutamate is the most important neurotransmitter in the brain. About half the total cerebral pool of glutamate is used and re-synthesized every 10 minutes. Several drugs, which are known to alter the rate of resynthesis of glutamate specifically in neural tissues, have important influences on epilepsy, chronic pain, and, possibly neurodegeneration. Dr. LaNoue's laboratory is using radioisotopic techniques to map pathways of neuronal glutamate synthesis and degradation and to identify new drug targets for altering glutamate turnover.



    Dr. LaNoue's laboratory is also involved in studies of diabetes and insulin resistance in a strain of genetically obese rats. The laboratory has observed that an A2b adenosine receptor antagonist is able to partially reverse the insulin resistance characteristic of these obese animals without inducing a change in their percent body fat. By independently varying insulin levels, fatty acid levels, and A2b adenosine receptor antagonist levels while measuring radiolabeled glucose uptake in the muscles of these animals, Dr. LaNoue hopes to identify the cause of the insulin resistance and to learn how the A2b adenosine receptor antagonist ameliorates the problem. Measurements of the extent of activation of components of the insulin signaling pathway such as insulin receptor kinase activity, insulin receptor substrate 1 activation, and phosphatidylinositol-3-kinase activity will aid in interpretation of the data obtained.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ola MS, Hosoya K, LaNoue KF. Regulation of glutamate metabolism by hydrocortisone and branched chain keto acids in cultured rat retinal Müller cells (TR-MUL). Neurochem Int. 2011 Oct; 59(5):656-63. PMID: 21756956.
      View in: PubMed
    2. Ola MS, Hosoya K, LaNoue KF. Influence of insulin on glutamine synthetase in the Müller glial cells of retina. Metab Brain Dis. 2011 Sep; 26(3):195-202. PMID: 21626103.
      View in: PubMed
    3. Gowda K, Zinnanti WJ, LaNoue KF. The influence of diabetes on glutamate metabolism in retinas. J Neurochem. 2011 Apr; 117(2):309-20. PMID: 21288239.
      View in: PubMed
    4. Figler RA, Wang G, Srinivasan S, Jung DY, Zhang Z, Pankow JS, Ravid K, Fredholm B, Hedrick CC, Rich SS, Kim JK, LaNoue KF, Linden J. Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans. Diabetes. 2011 Feb; 60(2):669-79. PMID: 21270276; PMCID: PMC3028369.
    5. Li J, Romestaing C, Han X, Li Y, Hao X, Wu Y, Sun C, Liu X, Jefferson LS, Xiong J, Lanoue KF, Chang Z, Lynch CJ, Wang H, Shi Y. Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Cell Metab. 2010 Aug 04; 12(2):154-65. PMID: 20674860; PMCID: PMC2923392.
    6. Freeman WM, Bixler GV, Brucklacher RM, Lin CM, Patel KM, VanGuilder HD, LaNoue KF, Kimball SR, Barber AJ, Antonetti DA, Gardner TW, Bronson SK. A multistep validation process of biomarkers for preclinical drug development. Pharmacogenomics J. 2010 Oct; 10(5):385-95. PMID: 19997081.
      View in: PubMed
    7. Zinnanti WJ, Lazovic J, Griffin K, Skvorak KJ, Paul HS, Homanics GE, Bewley MC, Cheng KC, Lanoue KF, Flanagan JM. Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease. Brain. 2009 Apr; 132(Pt 4):903-18. PMID: 19293241; PMCID: PMC2668944.
    8. Pound KM, Sorokina N, Ballal K, Berkich DA, Fasano M, Lanoue KF, Taegtmeyer H, O'Donnell JM, Lewandowski ED. Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy. Circ Res. 2009 Mar 27; 104(6):805-12. PMID: 19213957; PMCID: PMC2908318.
    9. Abcouwer SF, Shanmugam S, Gomez PF, Shushanov S, Barber AJ, Lanoue KF, Quinn PG, Kester M, Gardner TW. Effect of IL-1beta on survival and energy metabolism of R28 and RGC-5 retinal neurons. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5581-92. PMID: 19037001.
      View in: PubMed
    10. Brucklacher RM, Patel KM, VanGuilder HD, Bixler GV, Barber AJ, Antonetti DA, Lin CM, LaNoue KF, Gardner TW, Bronson SK, Freeman WM. Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response. BMC Med Genomics. 2008 Jun 13; 1:26. PMID: 18554398; PMCID: PMC2442612.
    11. Berkich DA, Ola MS, Cole J, Sweatt AJ, Hutson SM, LaNoue KF. Mitochondrial transport proteins of the brain. J Neurosci Res. 2007 Nov 15; 85(15):3367-77. PMID: 17847082.
      View in: PubMed
    12. Zinnanti WJ, Lazovic J, Housman C, LaNoue K, O'Callaghan JP, Simpson I, Woontner M, Goodman SI, Connor JR, Jacobs RE, Cheng KC. Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I. J Clin Invest. 2007 Nov; 117(11):3258-70. PMID: 17932566; PMCID: PMC2000809.
    13. Cho YR, Kim HJ, Park SY, Ko HJ, Hong EG, Higashimori T, Zhang Z, Jung DY, Ola MS, Lanoue KF, Leiter EH, Kim JK. Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E327-36. PMID: 17616608.
      View in: PubMed
    14. Sorokina N, O'Donnell JM, McKinney RD, Pound KM, Woldegiorgis G, LaNoue KF, Ballal K, Taegtmeyer H, Buttrick PM, Lewandowski ED. Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts. Circulation. 2007 Apr 17; 115(15):2033-41. PMID: 17404155.
      View in: PubMed
    15. Xu Y, Ola MS, Berkich DA, Gardner TW, Barber AJ, Palmieri F, Hutson SM, LaNoue KF. Energy sources for glutamate neurotransmission in the retina: absence of the aspartate/glutamate carrier produces reliance on glycolysis in glia. J Neurochem. 2007 Apr; 101(1):120-31. PMID: 17394462.
      View in: PubMed
    16. Antonetti DA, Barber AJ, Bronson SK, Freeman WM, Gardner TW, Jefferson LS, Kester M, Kimball SR, Krady JK, LaNoue KF, Norbury CC, Quinn PG, Sandirasegarane L, Simpson IA. Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes. 2006 Sep; 55(9):2401-11. PMID: 16936187.
      View in: PubMed
    17. Ola MS, Berkich DA, Xu Y, King MT, Gardner TW, Simpson I, LaNoue KF. Analysis of glucose metabolism in diabetic rat retinas. Am J Physiol Endocrinol Metab. 2006 Jun; 290(6):E1057-67. PMID: 16380392.
      View in: PubMed
    18. Hutson SM, Sweatt AJ, Lanoue KF. Branched-chain [corrected] amino acid metabolism: implications for establishing safe intakes. J Nutr. 2005 Jun; 135(6 Suppl):1557S-64S. PMID: 15930469.
      View in: PubMed
    19. Krady JK, Basu A, Allen CM, Xu Y, LaNoue KF, Gardner TW, Levison SW. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes. 2005 May; 54(5):1559-65. PMID: 15855346.
      View in: PubMed
    20. Berkich DA, Xu Y, LaNoue KF, Gruetter R, Hutson SM. Evaluation of brain mitochondrial glutamate and alpha-ketoglutarate transport under physiologic conditions. J Neurosci Res. 2005 Jan 1-15; 79(1-2):106-13. PMID: 15558751.
      View in: PubMed
    21. Oz G, Berkich DA, Henry PG, Xu Y, LaNoue K, Hutson SM, Gruetter R. Neuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity. J Neurosci. 2004 Dec 15; 24(50):11273-9. PMID: 15601933.
      View in: PubMed
    22. Xu Y, Oz G, LaNoue KF, Keiger CJ, Berkich DA, Gruetter R, Hutson SH. Whole-brain glutamate metabolism evaluated by steady-state kinetics using a double-isotope procedure: effects of gabapentin. J Neurochem. 2004 Sep; 90(5):1104-16. PMID: 15312166.
      View in: PubMed
    23. Berkich DA, Salama G, LaNoue KF. Mitochondrial membrane potentials in ischemic hearts. Arch Biochem Biophys. 2003 Dec 15; 420(2):279-86. PMID: 14654067.
      View in: PubMed
    24. Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Levison SW. Diabetic retinopathy: more than meets the eye. Surv Ophthalmol. 2002 Dec; 47 Suppl 2:S253-62. PMID: 12507627.
      View in: PubMed
    25. Queiroz MS, Shao Y, Berkich DA, Lanoue KF, Ismail-Beigi F. Thyroid hormone regulation of cardiac bioenergetics: role of intracellular creatine. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2527-33. PMID: 12427598.
      View in: PubMed
    26. LaNoue KF, Berkich DA, Conway M, Barber AJ, Hu LY, Taylor C, Hutson S. Role of specific aminotransferases in de novo glutamate synthesis and redox shuttling in the retina. J Neurosci Res. 2001 Dec 01; 66(5):914-22. PMID: 11746419.
      View in: PubMed
    27. Nakamura M, Barber AJ, Antonetti DA, LaNoue KF, Robinson KA, Buse MG, Gardner TW. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. J Biol Chem. 2001 Nov 23; 276(47):43748-55. PMID: 11560942.
      View in: PubMed
    28. Crist GH, Xu B, Berkich DA, LaNoue KF. Effects of adenosine receptor antagonism on protein tyrosine phosphatase in rat skeletal muscle. Int J Biochem Cell Biol. 2001 Aug; 33(8):817-30. PMID: 11404185.
      View in: PubMed
    29. Lieth E, LaNoue KF, Berkich DA, Xu B, Ratz M, Taylor C, Hutson SM. Nitrogen shuttling between neurons and glial cells during glutamate synthesis. J Neurochem. 2001 Mar; 76(6):1712-23. PMID: 11259489.
      View in: PubMed
    30. Hutson SM, Lieth E, LaNoue KF. Function of leucine in excitatory neurotransmitter metabolism in the central nervous system. J Nutr. 2001 Mar; 131(3):846S-850S. PMID: 11238772.
      View in: PubMed
    31. MacLean DA, Ettinger SM, Sinoway LI, Lanoue KF. Determination of muscle-specific glucose flux using radioactive stereoisomers and microdialysis. Am J Physiol Endocrinol Metab. 2001 Jan; 280(1):E187-92. PMID: 11120673.
      View in: PubMed
    32. Lieth E, LaNoue KF, Antonetti DA, Ratz M. Diabetes reduces glutamate oxidation and glutamine synthesis in the retina. The Penn State Retina Research Group. Exp Eye Res. 2000 Jun; 70(6):723-30. PMID: 10843776.
      View in: PubMed
    33. Fatholahi M, LaNoue K, Romani A, Scarpa A. Relationship between total and free cellular Mg(2+) during metabolic stimulation of rat cardiac myocytes and perfused hearts. Arch Biochem Biophys. 2000 Feb 15; 374(2):395-401. PMID: 10666323.
      View in: PubMed
    34. Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Nakamura M. New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets. Diabetes Technol Ther. 2000; 2(4):601-8. PMID: 11469624.
      View in: PubMed
    35. Jayawant AM, Stephenson ER, Matte GS, Prophet GA, LaNoue KF, Griffith JW, Damiano RJ. Potassium-channel opener cardioplegia is superior to St. Thomas' solution in the intact animal. Ann Thorac Surg. 1999 Jul; 68(1):67-74. PMID: 10421117.
      View in: PubMed
    36. MacLean DA, LaNoue KF, Gray KS, Sinoway LI. Effects of hindlimb contraction on pressor and muscle interstitial metabolite responses in the cat. J Appl Physiol (1985). 1998 Oct; 85(4):1583-92. PMID: 9760357.
      View in: PubMed
    37. Crist GH, Xu B, Lanoue KF, Lang CH. Tissue-specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats. FASEB J. 1998 Oct; 12(13):1301-8. PMID: 9761773.
      View in: PubMed
    38. Hutson SM, Berkich D, Drown P, Xu B, Aschner M, LaNoue KF. Role of branched-chain aminotransferase isoenzymes and gabapentin in neurotransmitter metabolism. J Neurochem. 1998 Aug; 71(2):863-74. PMID: 9681479.
      View in: PubMed
    39. Xu B, Berkich DA, Crist GH, LaNoue KF. A1 adenosine receptor antagonism improves glucose tolerance in Zucker rats. Am J Physiol. 1998 Feb; 274(2 Pt 1):E271-9. PMID: 9486158.
      View in: PubMed
    40. O'Donnell JM, Doumen C, LaNoue KF, White LT, Yu X, Alpert NM, Lewandowski ED. Dehydrogenase regulation of metabolite oxidation and efflux from mitochondria in intact hearts. Am J Physiol. 1998 Feb; 274(2 Pt 2):H467-76. PMID: 9486249.
      View in: PubMed
    41. Gamberino WC, Berkich DA, Lynch CJ, Xu B, LaNoue KF. Role of pyruvate carboxylase in facilitation of synthesis of glutamate and glutamine in cultured astrocytes. J Neurochem. 1997 Dec; 69(6):2312-25. PMID: 9375662.
      View in: PubMed
    42. Lewandowski ED, Yu X, LaNoue KF, White LT, Doumen C, O'Donnell JM. Altered metabolite exchange between subcellular compartments in intact postischemic rabbit hearts. Circ Res. 1997 Aug; 81(2):165-75. PMID: 9242177.
      View in: PubMed
    43. Brown LM, Fox HL, Hazen SA, LaNoue KF, Rannels SR, Lynch CJ. Role of the matrixin MMP-2 in multicellular organization of adipocytes cultured in basement membrane components. Am J Physiol. 1997 Mar; 272(3 Pt 1):C937-49. PMID: 9124530.
      View in: PubMed
    44. Hazen SA, Waheed A, Sly WS, LaNoue KF, Lynch CJ. Effect of carbonic anhydrase inhibition and acetoacetate on anaplerotic pyruvate carboxylase activity in cultured rat astrocytes. Dev Neurosci. 1997; 19(2):162-71. PMID: 9097031.
      View in: PubMed
    45. Hazen SA, Waheed A, Sly WS, LaNoue KF, Lynch CJ. Differentiation-dependent expression of CA V and the role of carbonic anhydrase isozymes in pyruvate carboxylation in adipocytes. FASEB J. 1996 Mar; 10(4):481-90. PMID: 8647347.
      View in: PubMed
    46. Lewandowski ED, Doumen C, White LT, LaNoue KF, Damico LA, Yu X. Multiplet structure of 13C NMR signal from glutamate and direct detection of tricarboxylic acid (TCA) cycle intermediates. Magn Reson Med. 1996 Feb; 35(2):149-54. PMID: 8622576.
      View in: PubMed
    47. Yu X, White LT, Doumen C, Damico LA, LaNoue KF, Alpert NM, Lewandowski ED. Kinetic analysis of dynamic 13C NMR spectra: metabolic flux, regulation, and compartmentation in hearts. Biophys J. 1995 Nov; 69(5):2090-102. PMID: 8580353; PMCID: PMC1236443.
    48. Kaartinen JM, LaNoue KF, Martin LF, Vikman HL, Ohisalo JJ. Beta-adrenergic responsiveness of adenylate cyclase in human adipocyte plasma membranes in obesity and after massive weight reduction. Metabolism. 1995 Oct; 44(10):1288-92. PMID: 7476286.
      View in: PubMed
    49. Lynch CJ, Fox H, Hazen SA, Stanley BA, Dodgson S, Lanoue KF. Role of hepatic carbonic anhydrase in de novo lipogenesis. Biochem J. 1995 Aug 15; 310 ( Pt 1):197-202. PMID: 7646445; PMCID: PMC1135873.
    50. Duszynski J, Elensky M, Cheung JY, Tillotson DL, LaNoue KF. Hormone-regulated Ca2+ channel in rat hepatocytes revealed by whole cell patch clamp. Cell Calcium. 1995 Jul; 18(1):19-29. PMID: 7585880.
      View in: PubMed
    51. Vikman HL, Hreniuk SP, Kauffman GF, LaNoue KF, Martin LF, Ohisalo JJ. Cyclic AMP and glycerol concentrations in freeze-clamped human omental and subcutaneous adipose tissues. Int J Obes Relat Metab Disord. 1995 Jun; 19(6):388-91. PMID: 7550522.
      View in: PubMed
    52. Berkich DA, Luthin DR, Woodard RL, Vannucci SJ, Linden J, LaNoue KF. Evidence for regulated coupling of A1 adenosine receptors by phosphorylation in Zucker rats. Am J Physiol. 1995 Apr; 268(4 Pt 1):E693-704. PMID: 7733269.
      View in: PubMed
    53. Kaartinen JM, LaNoue KF, Ohisalo JJ. Quantitation of inhibitory G-proteins in fat cells of obese and normal-weight human subjects. Biochim Biophys Acta. 1994 Sep 28; 1201(1):69-75. PMID: 7918584.
      View in: PubMed
    54. Maillard MC, Nikodijevic O, LaNoue KF, Berkich D, Ji XD, Bartus R, Jacobson KA. Adenosine receptor prodrugs: synthesis and biological activity of derivatives of potent, A1-selective agonists. J Pharm Sci. 1994 Jan; 83(1):46-53. PMID: 8138909; PMCID: PMC3459066.
    55. LaNoue KF, Berdanier CD. The case of the disappearing silver. FASEB J. 1994 Jan; 8(1):132-3. PMID: 8299886.
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    56. LaNoue KF, Martin LF. Abnormal A1 adenosine receptor function in genetic obesity. FASEB J. 1994 Jan; 8(1):72-80. PMID: 8299893.
      View in: PubMed
    57. Smith BC, Hyatt DL, Cheung JY, LaNoue KF. Organ-specific differences in the pH control of liver and kidney alpha-ketoglutarate dehydrogenase. Contrib Nephrol. 1994; 110:158-69. PMID: 7956250.
      View in: PubMed
    58. Wan B, Doumen C, Duszynski J, Salama G, Vary TC, LaNoue KF. Effects of cardiac work on electrical potential gradient across mitochondrial membrane in perfused rat hearts. Am J Physiol. 1993 Aug; 265(2 Pt 2):H453-60. PMID: 8368348.
      View in: PubMed
    59. Wan B, Doumen C, Duszynski J, Salama G, LaNoue KF. A method of determining electrical potential gradient across mitochondrial membrane in perfused rat hearts. Am J Physiol. 1993 Aug; 265(2 Pt 2):H445-52. PMID: 8368347.
      View in: PubMed
    60. Cyran SE, Phillips J, Ditty S, Baylen BG, Cheung J, LaNoue K. Developmental differences in cardiac myocyte calcium homeostasis after steady-state potassium depolarization: mechanisms and implications for cardioplegia. J Pediatr. 1993 Jun; 122(6):S77-83. PMID: 8501553.
      View in: PubMed
    61. Ohisalo JJ, Kaartinen JM, Ranta S, Mustajoki P, Hreniuk SP, LaNoue KF, Martin LF. Weight loss normalizes the inhibitory effect of N6-(phenylisopropyl)adenosine on lipolysis in fat cells of massively obese human subjects. Clin Sci (Lond). 1992 Nov; 83(5):589-92. PMID: 1335396.
      View in: PubMed
    62. LaNoue KF, Duszynski J. Kinetic studies of ATP synthase: the case for the positional change mechanism. J Bioenerg Biomembr. 1992 Oct; 24(5):499-506. PMID: 1429543.
      View in: PubMed
    63. Cyran SE, Ditty SE, Baylen BG, Cheung J, LaNoue KF. Developmental differences in the response of cytosolic free calcium to potassium depolarization and cardioplegia in cardiac myocytes. J Mol Cell Cardiol. 1992 Oct; 24(10):1167-77. PMID: 1479617.
      View in: PubMed
    64. Smith BC, Clotfelter LA, Cheung JY, LaNoue KF. Differences in 2-oxoglutarate dehydrogenase regulation in liver and kidney. Biochem J. 1992 Jun 15; 284 ( Pt 3):819-26. PMID: 1352447; PMCID: PMC1132613.
    65. Mosher TJ, Williams GD, Doumen C, LaNoue KF, Smith MB. Error in the calibration of the MgATP chemical-shift limit: effects on the determination of free magnesium by 31P NMR spectroscopy. Magn Reson Med. 1992 Mar; 24(1):163-9. PMID: 1556922.
      View in: PubMed
    66. Hutson SM, Williams GD, Berkich DA, LaNoue KF, Briggs RW. A 31P NMR study of mitochondrial inorganic phosphate visibility: effects of Ca2+, Mn2+, and the pH gradient. Biochemistry. 1992 Feb 11; 31(5):1322-30. PMID: 1736991.
      View in: PubMed
    67. Kaartinen JM, Hreniuk SP, Martin LF, Ranta S, LaNoue KF, Ohisalo JJ. Attenuated adenosine-sensitivity and decreased adenosine-receptor number in adipocyte plasma membranes in human obesity. Biochem J. 1991 Oct 01; 279 ( Pt 1):17-22. PMID: 1656938; PMCID: PMC1151540.
    68. Zhang Y, Duszynski J, Hreniuk S, Waybill MM, LaNoue KF. Regulation of plasma membrane permeability to calcium in primary cultures of rat hepatocytes. Cell Calcium. 1991 Sep; 12(8):559-75. PMID: 1659496.
      View in: PubMed
    69. Masiakos PT, Williams GD, Berkich DA, Smith MB, LaNoue KF. 31P NMR saturation-transfer study of the in situ kinetics of the mitochondrial adenine nucleotide translocase. Biochemistry. 1991 Aug 27; 30(34):8351-7. PMID: 1883822.
      View in: PubMed
    70. Waybill MM, Yelamarty RV, Zhang YL, Scaduto RC, LaNoue KF, Hsu CJ, Smith BC, Tillotson DL, Yu FT, Cheung JY. Nuclear calcium gradients in cultured rat hepatocytes. Am J Physiol. 1991 Jul; 261(1 Pt 1):E49-57. PMID: 1858874.
      View in: PubMed
    71. Sterniczuk A, Hreniuk S, Scaduto RC, LaNoue KF. The mechanism of Ca2(+)-related control of gluconeogenesis in perfused liver. Eur J Biochem. 1991 Feb 26; 196(1):143-50. PMID: 1672108.
      View in: PubMed
    72. Sterniczuk A, Hreniuk S, Scaduto RC, LaNoue KF. Effect of phenylephrine on pyruvate dehydrogenase in fasting rat livers. Eur J Biochem. 1991 Feb 26; 196(1):151-7. PMID: 1900470.
      View in: PubMed
    73. Berkich DA, Williams GD, Masiakos PT, Smith MB, Boyer PD, LaNoue KF. Rates of various reactions catalyzed by ATP synthase as related to the mechanism of ATP synthesis. J Biol Chem. 1991 Jan 05; 266(1):123-9. PMID: 1824691.
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    74. Martin LF, Klim CM, Vannucci SJ, Dixon LB, Landis JR, LaNoue KF. Alterations in adipocyte adenylate cyclase activity in morbidly obese and formerly morbidly obese humans. Surgery. 1990 Aug; 108(2):228-34; discussion 234-5. PMID: 2166354.
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    75. Vannucci SJ, Klim CM, LaNoue KF, Martin LF. Winner of the 1988 NAASO Young Investigator Award. Regulation of fat cell adenylate cyclase in young Zucker (fa/fa) rats: alterations in GTP sensitivity of adenosine A1 mediated inhibition. Int J Obes. 1990; 14 Suppl 3:125-34. PMID: 1964933.
      View in: PubMed
    76. Chance B, LaNoue K. Metabolic control in exercising skeletal muscle. Am J Physiol. 1990 Jan; 258(1 Pt 2):R288-90. PMID: 2301643.
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    77. Vannucci SJ, Klim CM, Martin LF, LaNoue KF. A1-adenosine receptor-mediated inhibition of adipocyte adenylate cyclase and lipolysis in Zucker rats. Am J Physiol. 1989 Dec; 257(6 Pt 1):E871-8. PMID: 2558574.
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    78. Wan B, LaNoue KF, Cheung JY, Scaduto RC. Regulation of citric acid cycle by calcium. J Biol Chem. 1989 Aug 15; 264(23):13430-9. PMID: 2503501.
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    79. Hutson SM, Berkich D, Williams GD, LaNoue KF, Briggs RW. 31P NMR visibility and characterization of rat liver mitochondrial matrix adenine nucleotides. Biochemistry. 1989 May 16; 28(10):4325-32. PMID: 2569890.
      View in: PubMed
    80. Strzelecki T, Strzelecka D, Koch CD, LaNoue KF. Sites of action of glucagon and other Ca2+ mobilizing hormones on the malate aspartate cycle. Arch Biochem Biophys. 1988 Jul; 264(1):310-20. PMID: 2899419.
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    81. LaNoue KF, Jeffries FM, Radda GK. Kinetic control of mitochondrial ATP synthesis. Biochemistry. 1986 Nov 18; 25(23):7667-75. PMID: 3026457.
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    82. LaNoue KF, Koch C, Strzelecka D, Kobylski TP. Regulation of Na+ transport in brown adipose tissue. Biochem J. 1986 Apr 15; 235(2):545-52. PMID: 2943272; PMCID: PMC1146719.
    83. LaNoue KF, Strzelecki T, Strzelecka D, Koch C. Regulation of the uncoupling protein in brown adipose tissue. J Biol Chem. 1986 Jan 05; 261(1):298-305. PMID: 3941078.
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    84. Werner JC, Whitman V, Schuler HG, Fripp RR, Rannels AM, Kasales CJ, LaNoue KF. Acute myocardial effects of chloramphenicol in newborn pigs: a possible insight into the gray baby syndrome. J Infect Dis. 1985 Aug; 152(2):344-50. PMID: 4031546.
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    85. Schoolwerth AC, LaNoue KF. Transport of metabolic substrates in renal mitochondria. Annu Rev Physiol. 1985; 47:143-71. PMID: 3888072.
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    86. Wickler SJ, Horwitz BA, Flaim SF, LaNoue KF. Isoproterenol-induced blood flow in rats acclimated to room temperature and cold. Am J Physiol. 1984 May; 246(5 Pt 2):R747-52. PMID: 6720997.
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    87. LaNoue KF, Strzelecki T, Finch F. The effect of glucagon on hepatic respiratory capacity. J Biol Chem. 1984 Apr 10; 259(7):4116-21. PMID: 6706994.
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    88. Strzelecki T, Thomas JA, Koch CD, LaNoue KF. The effect of hormones on proton compartmentation in hepatocytes. J Biol Chem. 1984 Apr 10; 259(7):4122-9. PMID: 6323459.
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    89. Schoolwerth AC, LaNoue KF, Hoover WJ. Effect of pH on glutamate efflux from rat kidney mitochondria. Am J Physiol. 1984 Mar; 246(3 Pt 2):F266-71. PMID: 6703060.
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    90. Schoolwerth AC, LaNoue KF. Control of ammoniagenesis by alpha-ketoglutarate in rat kidney mitochondria. Am J Physiol. 1983 Apr; 244(4):F399-408. PMID: 6132557.
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    91. LaNoue KF, Schoolwerth AC, Pease AJ. Ammonia formation in isolated rat liver mitochondria. J Biol Chem. 1983 Feb 10; 258(3):1726-34. PMID: 6130094.
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    92. Schoolwerth AC, LaNoue KF, Hoover WJ. Glutamate transprot in rat kidney mitochondria. J Biol Chem. 1983 Feb 10; 258(3):1735-9. PMID: 6130095.
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    93. LaNoue KF, Koch CD, Meditz RB. Mechanism of action of norepinephrine in hamster brown adipocytes. J Biol Chem. 1982 Nov 25; 257(22):13740-8. PMID: 7142176.
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    94. Schoolwerth AC, Strzelecki T, Lanoue KF, Hoover WJ. Effect of pH and alpha-ketoglutarate on mitochondrial ammonia production. Contrib Nephrol. 1982; 31:127-33. PMID: 7105745.
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    95. LaNoue KF, Watts JA, Koch CD. Adenine nucleotide transport during cardiac ischemia. Am J Physiol. 1981 Nov; 241(5):H663-71. PMID: 7304755.
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    96. Watts JA, Koch CD, LaNoue KF. Effects of Ca2+ antagonism on energy metabolism: Ca2+ and heart function after ischemia. Am J Physiol. 1980 Jun; 238(6):H909-16. PMID: 7386650.
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    97. Schoolwerth AC, LaNoue KF. The role of microcompartmentation in the regulation of glutamate metabolism by rat kidney mitochondria. J Biol Chem. 1980 Apr 25; 255(8):3403-11. PMID: 7364748.
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    98. Schoolwerth AC, Hoover WJ, Daniel CH, LaNoue KF. Effect of aminooxyacetate and alpha-ketoglutarate on glutamate deamination by rat kidney mitochondria. Int J Biochem. 1980; 12(1-2):145-9. PMID: 7399015.
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    99. LaNoue KF, Schoolwerth AC. Metabolite transport in mitochondria. Annu Rev Biochem. 1979; 48:871-922. PMID: 38739.
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    100. Schoolwerth AC, Nazar BL, LaNoue KF. Glutamate dehydrogenase activation and ammonia formation by rat kidney mitochondria. J Biol Chem. 1978 Sep 10; 253(17):6177-83. PMID: 681346.
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    101. Duszynski J, Mueller G, LaNoue K. Microcompartmentation of aspartate in rat liver mitochondria. J Biol Chem. 1978 Sep 10; 253(17):6149-57. PMID: 681344.
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    102. LaNoue K, Mizani SM, Klingenberg M. Electrical imbalance of adenine nucleotide transport across the mitochondrial membrane. J Biol Chem. 1978 Jan 10; 253(1):191-8. PMID: 22542.
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    103. Schoolwerth AC, Nazar BL, Lanoue KF. The role of glutamate metabolism in ammonia formation by rat kidney mitochondria. Curr Probl Clin Biochem. 1977 Oct 23-26; 8:265-72. PMID: 616365.
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    104. LaNoue KF, Bryla J, Bassett DJ. Energy-driven aspartate efflux from heart and liver mitochondria. J Biol Chem. 1974 Dec 10; 249(23):7514-21. PMID: 4436322.
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    105. LaNoue KF, Tischler ME. Electrogenic characteristics of the mitochondrial glutamate-aspartate antiporter. J Biol Chem. 1974 Dec 10; 249(23):7522-8. PMID: 4436323.
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    106. LaNoue KF, Meijer AJ, Brouwer A. Evidence for electrogenic aspartate transport in rat liver mitochondria. Arch Biochem Biophys. 1974 Apr 02; 161(2):544-50. PMID: 4839046.
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    107. Onishi T, Hemington JG, LaNoue KF, Morris HP, Williamson JR. Electron paramagnetic resonance studies of iron-sulfur centers in mitochondria prepared from three Morris hepatomas with different growth rates. Biochem Biophys Res Commun. 1973 Nov 16; 55(2):372-81. PMID: 4358400.
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    108. LaNoue KF, Walajtys EI, Williamson JR. Regulation of glutamate metabolism and interactions with the citric acid cycle in rat heart mitochondria. J Biol Chem. 1973 Oct 25; 248(20):7171-83. PMID: 4355202.
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    109. Fisher AB, Scarpa A, LaNoue KF, Bassett D, Williamson JR. Respiration of rat lung mitochondria and the influence of Ca 2+ on substrate utilization. Biochemistry. 1973 Mar 27; 12(7):1438-45. PMID: 4348834.
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    110. Smith CM, Bryla J, Damon S, LaNoue KF, Williamson JR. Fluorometric assays for succinyl-CoA and propionyl-CoA in mitochondrial extracts. Anal Biochem. 1973 Feb; 51(2):408-20. PMID: 4700191.
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    111. Williamson JR, Safer B, LaNoue KF, Smith CM, Walajtys E. Mitochondrial-cytosolic interactions in cardiac tissue: role of the malate-aspartate cycle in the removal of glycolytic NADH from the cytosol. Symp Soc Exp Biol. 1973; 27:241-81. PMID: 4358367.
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    112. LaNoue KF, Bryla J, Williamson JR. Feedback interactions in the control of citric acid cycle activity in rat heart mitochondria. J Biol Chem. 1972 Feb 10; 247(3):667-79. PMID: 4333508.
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    113. LaNoue KF, Williamson JR. Interrelationships between malate-aspartate shuttle and citric acid cycle in rat heart mitochondria. Metabolism. 1971 Feb; 20(2):119-40. PMID: 4322086.
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    114. LaNoue K, Nicklas WJ, Williamson JR. Control of citric acid cycle activity in rat heart mitochondria. J Biol Chem. 1970 Jan 10; 245(1):102-11. PMID: 4312474.
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    115. Williamson JR, Refino C, LaNoue K. Effects of E. coli lipopolysaccharide B treatment of rats on gluconeogenesis. In: Energy metabolism in trauma. Ciba Found Symp. 1970; 145-54. PMID: 4943823.
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    116. LaNoue KF, Mason AD, Bickel RG. Carbohydrate metabolism in pseudomonas infection. Comput Biomed Res. 1968 Aug; 2(1):51-67. PMID: 4988406.
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    117. LaNoue KF, Mason AD, Daniels JP. The impairment of glucogenesis by gram negative infection. Metabolism. 1968 Jul; 17(7):606-11. PMID: 4297876.
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