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Karam El-Bayoumy

TitleProfessor
InstitutionCollege of Medicine
DepartmentBiochemistry and Molecular Biology
Address500 University Drive Hershey PA 17033
Mailbox: CH72
Phone7175311005
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    Collapse overview
    PREFERRED TITLE/ROLE:



    Distinguished Professor



    SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):



    Penn State Hershey Cancer Institute, Chemical Carcinogenesis and Chemoprevention



    GRADUATE PROGRAM AFFILIATIONS:



    Biochemistry and Molecular Biology



    EDUCATION:



    B. S., Ain Shams University, Cairo, Egypt, (with honors), 1968-1970, Chemistry

    M.S., New York University, NY, 1975, Organic Chemistry

    Ph.D., New York University, NY, 1978, Physical Organic Chemistry




    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Manni A, El-Bayoumy K, Thompson H. Docosahexaenoic Acid in Combination with Dietary Energy Restriction for Reducing the Risk of Obesity Related Breast Cancer. Int J Mol Sci. 2017 Dec 22; 19(1). PMID: 29271901.
      View in: PubMed
    2. Chen KM, Guttenplan JB, Sun YW, Cooper T, Shalaby NA, Kosinska W, Benitez G, Aliaga C, Zhu J, Liao J, Gowda K, Amin S, Stoner G, El-Bayoumy K. Effects of Black Raspberry on Dibenzo[a,l]Pyrene Diol Epoxide Induced DNA Adducts, Mutagenesis and Tumorigenesis in the Mouse Oral Cavity. Cancer Prev Res (Phila). 2017 Nov 20. PMID: 29158340.
      View in: PubMed
    3. Guttenplan JB, Chen KM, Sun YW, Lajara B, Shalaby NAE, Kosinska W, Benitez G, Gowda K, Amin S, Stoner G, El-Bayoumy K. Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts. Chem Res Toxicol. 2017 Dec 18; 30(12):2159-2164. PMID: 29068672.
      View in: PubMed
    4. Sun YW, Chen KM, Imamura Kawasawa Y, Salzberg AC, Cooper TK, Caruso C, Aliaga C, Zhu J, Gowda K, Amin S, El-Bayoumy K. Hypomethylated Fgf3 is a potential biomarker for early detection of oral cancer in mice treated with the tobacco carcinogen dibenzo[def,p]chrysene. PLoS One. 2017; 12(10):e0186873. PMID: 29073177.
      View in: PubMed
    5. Chen KM, Schell TD, Richie JP, Sun YW, Zhang SM, Calcagnotto A, Aliaga C, Gowda K, Amin S, El-Bayoumy K. Effects of chronic alcohol consumption on DNA damage and immune regulation induced by the environmental pollutant dibenzo[a,l]pyrene in oral tissues of mice. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2017 Oct 02; 35(4):213-222. PMID: 29106334.
      View in: PubMed
    6. Manni A, Richie JP, Schetter SE, Calcagnotto A, Trushin N, Aliaga C, El-Bayoumy K. Stearoyl-CoA desaturase-1, a novel target of omega-3 fatty acids for reducing breast cancer risk in obese postmenopausal women. Eur J Clin Nutr. 2017 Jun; 71(6):762-765. PMID: 28145413.
      View in: PubMed
    7. El-Bayoumy K, Chen KM, Zhang SM, Sun YW, Amin S, Stoner G, Guttenplan JB. Carcinogenesis of the Oral Cavity: Environmental Causes and Potential Prevention by Black Raspberry. Chem Res Toxicol. 2017 01 17; 30(1):126-144. PMID: 28092946.
      View in: PubMed
    8. Guttenplan JB, Chen KM, Sun YW, Kosinska W, Zhou Y, Kim SA, Sung Y, Gowda K, Amin S, Stoner GD, El-Bayoumy K. Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells. Cancer Prev Res (Phila). 2016 Aug; 9(8):704-12. PMID: 27267891.
      View in: PubMed
    9. Skibinski CG, Das A, Chen KM, Liao J, Manni A, Kester M, El-Bayoumy K. A novel biologically active acid stable liposomal formulation of docosahexaenoic acid in human breast cancer cell lines. Chem Biol Interact. 2016 May 25; 252:1-8. PMID: 27041074.
      View in: PubMed
    10. Sandhu N, Schetter SE, Liao J, Hartman TJ, Richie JP, McGinley J, Thompson HJ, Prokopczyk B, DuBrock C, Signori C, Hamilton C, Calcagnotto A, Trushin N, Aliaga C, Demers LM, El-Bayoumy K, Manni A. Influence of Obesity on Breast Density Reduction by Omega-3 Fatty Acids: Evidence from a Randomized Clinical Trial. Cancer Prev Res (Phila). 2016 Apr; 9(4):275-82. PMID: 26714774.
      View in: PubMed
    11. Manni A, El-Bayoumy K, Skibinski CG, Thompson HJ, Santucci-Pereira J, Bidinotto LT, Russo J. Combination of Antiestrogens and Omega-3 Fatty Acids for Breast Cancer Prevention. Biomed Res Int. 2015; 2015:638645. PMID: 26339626; PMCID: PMC4538406.
    12. Turbitt WJ, Black AJ, Collins SD, Meng H, Xu H, Washington S, Aliaga C, El-Bayoumy K, Manni A, Rogers CJ. Fish Oil Enhances T Cell Function and Tumor Infiltration and Is Correlated With a Cancer Prevention Effect in HER-2/neu But Not PyMT Transgenic Mice. Nutr Cancer. 2015; 67(6):965-75. PMID: 26226376.
      View in: PubMed
    13. Rice SJ, Liu X, Miller B, Joshi M, Zhu J, Caruso C, Gilbert C, Toth J, Reed M, Rassaei N, Das A, Barochia A, El-Bayoumy K, Belani CP. Proteomic profiling of human plasma identifies apolipoprotein E as being associated with smoking and a marker for squamous metaplasia of the lung. Proteomics. 2015 Sep; 15(18):3267-77. PMID: 26058877.
      View in: PubMed
    14. Sun YW, El-Bayoumy K, Aliaga C, Awad AS, Gowda K, Amin S, Chen KM. Tissue Distribution, Excretion and Pharmacokinetics of the Environmental Pollutant Dibenzo[def,p]chrysene in Mice. Chem Res Toxicol. 2015 Jul 20; 28(7):1427-33. PMID: 26034881; PMCID: PMC4863960.
    15. Pogash TJ, El-Bayoumy K, Amin S, Gowda K, de Cicco RL, Barton M, Su Y, Russo IH, Himmelberger JA, Slifker M, Manni A, Russo J. Oxidized derivative of docosahexaenoic acid preferentially inhibit cell proliferation in triple negative over luminal breast cancer cells. In Vitro Cell Dev Biol Anim. 2015 Feb; 51(2):121-7. PMID: 25413005; PMCID: PMC4948656.
    16. Wilson RT, Bortner JD, Roff A, Das A, Battaglioli EJ, Richie JP, Barnholtz-Sloan J, Chinchilli VM, Berg A, Liu G, Salzberg AC, El-Bayoumy K. Genetic and environmental influences on plasma vitamin D binding protein concentrations. Transl Res. 2015 Jun; 165(6):667-76. PMID: 25234352.
      View in: PubMed
    17. Schetter SE, Hartman TJ, Liao J, Richie JP, Prokopczyk B, DuBrock C, Signori C, Hamilton C, Demers LM, El-Bayoumy K, Manni A. Differential impact of body mass index on absolute and percent breast density: implications regarding their use as breast cancer risk biomarkers. Breast Cancer Res Treat. 2014 Jul; 146(2):355-63. PMID: 24951269.
      View in: PubMed
    18. Zhang SM, Chen KM, Sun YW, Aliaga C, Lin JM, Sharma AK, Amin S, El-Bayoumy K. Simultaneous detection of deoxyadenosine and deoxyguanosine adducts in the tongue and other oral tissues of mice treated with Dibenzo[a,l]pyrene. Chem Res Toxicol. 2014 Jul 21; 27(7):1199-206. PMID: 24911113; PMCID: PMC4106691.
    19. Richie JP, Das A, Calcagnotto AM, Sinha R, Neidig W, Liao J, Lengerich EJ, Berg A, Hartman TJ, Ciccarella A, Baker A, Kaag MG, Goodin S, DiPaola RS, El-Bayoumy K. Comparative effects of two different forms of selenium on oxidative stress biomarkers in healthy men: a randomized clinical trial. Cancer Prev Res (Phila). 2014 Aug; 7(8):796-804. PMID: 24938534; PMCID: PMC4125492.
    20. El-Bayoumy K, Thompson H, Manni A. RE: Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial. J Natl Cancer Inst. 2014 Apr; 106(4):dju017. PMID: 24685921.
      View in: PubMed
    21. Krzeminski J, Kropachev K, Reeves D, Kolbanovskiy A, Kolbanovskiy M, Chen KM, Sharma AK, Geacintov N, Amin S, El-Bayoumy K. Adenine-DNA adduct derived from the nitroreduction of 6-nitrochrysene is more resistant to nucleotide excision repair than guanine-DNA adducts. Chem Res Toxicol. 2013 Nov 18; 26(11):1746-54. PMID: 24112095; PMCID: PMC3883057.
    22. Manni A, Richie JP, Xu H, Washington S, Aliaga C, Bruggeman R, Cooper TK, Prokopczyk B, Trushin N, Calcagnotto A, Das A, Liao J, El-Bayoumy K. Influence of omega-3 fatty acids on Tamoxifen-induced suppression of rat mammary carcinogenesis. Int J Cancer. 2014 Apr 01; 134(7):1549-57. PMID: 24122252.
      View in: PubMed
    23. Skibinski CG, Thompson HJ, Das A, Manni A, Bortner JD, Stanley A, Stanley BA, El-Bayoumy K. Proteomic changes induced by effective chemopreventive ratios of n-3:n-6 fatty acids and tamoxifen against MNU-induced mammary cancer in the rat. Cancer Prev Res (Phila). 2013 Sep; 6(9):979-88. PMID: 23880232.
      View in: PubMed
    24. Chen KM, Guttenplan JB, Zhang SM, Aliaga C, Cooper TK, Sun YW, DelTondo J, Kosinska W, Sharma AK, Jiang K, Bruggeman R, Ahn K, Amin S, El-Bayoumy K. Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: an environmental pollutant and a tobacco smoke constituent. Int J Cancer. 2013 Sep 15; 133(6):1300-9. PMID: 23483552; PMCID: PMC3707976.
    25. Sun YW, Guttenplan JB, Cooper T, Krzeminski J, Aliaga C, Boyiri T, Kosinska W, Zhao ZL, Chen KM, Berg A, Amin S, El-Bayoumy K. Mechanisms underlying the varied mammary carcinogenicity of the environmental pollutant 6-nitrochrysene and its metabolites (-)-[R,R]- and (+)-[S,S]-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene in the rat. Chem Res Toxicol. 2013 Apr 15; 26(4):547-54. PMID: 23461617; PMCID: PMC3714335.
    26. Das A, Bortner JD, Aliaga CA, Baker A, Stanley A, Stanley BA, Kaag M, Richie JP, El-Bayoumy K. Changes in proteomic profiles in different prostate lobes of male rats throughout growth and development and aging stages of the life span. Prostate. 2013 Mar; 73(4):363-75. PMID: 22911278; PMCID: PMC3556222.
    27. Signori C, DuBrock C, Richie JP, Prokopczyk B, Demers LM, Hamilton C, Hartman TJ, Liao J, El-Bayoumy K, Manni A. Administration of omega-3 fatty acids and Raloxifene to women at high risk of breast cancer: interim feasibility and biomarkers analysis from a clinical trial. Eur J Clin Nutr. 2012 Aug; 66(8):878-84. PMID: 22669332.
      View in: PubMed
    28. Emmert SW, El-Bayoumy K, Das A, Sun YW, Amin S, Desai D, Aliaga C, Richie JP. Induction of lung glutathione and glutamylcysteine ligase by 1,4-phenylenebis(methylene)selenocyanate and its glutathione conjugate: role of nuclear factor-erythroid 2-related factor 2. Free Radic Biol Med. 2012 May 15; 52(10):2064-71. PMID: 22542796; PMCID: PMC3475320.
    29. Facompre ND, Sinha I, El-Bayoumy K, Pinto JT, Sinha R. Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells. Int J Cancer. 2012 Nov 01; 131(9):2134-42. PMID: 22307455; PMCID: PMC3398165.
    30. Trushin N, Alam S, El-Bayoumy K, Krzeminski J, Amin SG, Gullett J, Meyers C, Prokopczyk B. Comparative metabolism of benzo[a]pyrene by human keratinocytes infected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes. J Carcinog. 2012; 11:1. PMID: 22368516; PMCID: PMC3284083.
    31. Chen KM, Zhang SM, Aliaga C, Sun YW, Cooper T, Gowdahalli K, Zhu J, Amin S, El-Bayoumy K. Induction of ovarian cancer and DNA adducts by Dibenzo[a,l]pyrene in the mouse. Chem Res Toxicol. 2012 Feb 20; 25(2):374-80. PMID: 22107356; PMCID: PMC3288413.
    32. Trushin N, Alam S, El-Bayoumy K, Krzeminski J, Amin SG, Gullett J, Meyers C, Prokopczyk B . J. Carcinogenesis. Comparative metabolism of benzo[a]pyrected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes. 2012; 11:1-9.
    33. Bidinotto LT, de Cicco RL, Vanegas JE, Santucci-Pereira J, Vanden Heuvel JP, Washington S, Aliaga C, Xu H, Russo IH, Manni A, El-Bayoumy K, Russo J. Fish oil alters tamoxifen-modulated expression of mRNAs that encode genes related to differentiation, proliferation, metastasis, and immune response in rat mammary tumors. Nutr Cancer. 2012; 64(7):991-9. PMID: 23061905; PMCID: PMC3595161.
    34. Richie JP, Das A, Calcagnotto AM, Aliaga CA, El-Bayoumy K. Age related changes in selenium and glutathione levels in different lobes of the rat prostate. Exp Gerontol. 2012 Mar; 47(3):223-8. PMID: 22212532; PMCID: PMC3288890.
    35. Guttenplan JB, Kosinska W, Zhao ZL, Chen KM, Aliaga C, DelTondo J, Cooper T, Sun YW, Zhang SM, Jiang K, Bruggeman R, Sharma AK, Amin S, Ahn K, El-Bayoumy K. Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer. Int J Cancer. 2012 Jun 15; 130(12):2783-90. PMID: 21815141; PMCID: PMC3596885.
    36. El-Bayoumy K, Das A, Russell S, Wolfe S, Jordan R, Renganathan K, Loughran TP, Somiari R. The effect of selenium enrichment on baker's yeast proteome. J Proteomics. 2012 Jan 04; 75(3):1018-30. PMID: 22067702; PMCID: PMC3246083.
    37. Signori C, El-Bayoumy K, Russo J, Thompson HJ, Richie JP, Hartman TJ, Manni A. Chemoprevention of breast cancer by fish oil in preclinical models: trials and tribulations. Cancer Res. 2011 Oct 01; 71(19):6091-6. PMID: 21933885.
      View in: PubMed
    38. Zhu Z, Jiang W, McGinley JN, Prokopczyk B, Richie JP, El Bayoumy K, Manni A, Thompson HJ. Mammary gland density predicts the cancer inhibitory activity of the N-3 to N-6 ratio of dietary fat. Cancer Prev Res (Phila). 2011 Oct; 4(10):1675-85. PMID: 21813405.
      View in: PubMed
    39. Manni A, Xu H, Washington S, Aliaga C, Das A, Cooper T, Richie JP, Prokopczyk B, Calcagnotto A, Trushin N, Van den Heuvel JP, Hamilton C, Demers LM, Liao J, Verderame MF, El-Bayoumy K. The effects of Tamoxifen and fish oil on mammary carcinogenesis in polyoma middle T transgenic mice. Horm Cancer. 2011 Aug; 2(4):249-59. PMID: 21769696.
      View in: PubMed
    40. Manni A, Richie JP, Xu H, Washington S, Aliaga C, Cooper TK, Bruggeman R, Das A, Prokopczyk B, Calcagnotto A, Trushin N, Dickinson R, Liao J, Verderame MF, El-Bayoumy K. Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Int J Oncol. 2011 Nov; 39(5):1153-64. PMID: 21892590.
      View in: PubMed
    41. Zhang SM, Chen KM, Aliaga C, Sun YW, Lin JM, Sharma AK, Amin S, El-Bayoumy K. Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[a,l]pyrene by HPLC-MS/MS. Chem Res Toxicol. 2011 Aug 15; 24(8):1297-303. PMID: 21736370; PMCID: PMC3160270.
    42. Bortner JD, Richie JP, Das A, Liao J, Umstead TM, Stanley A, Stanley BA, Belani CP, El-Bayoumy K. Proteomic profiling of human plasma by iTRAQ reveals down-regulation of ITI-HC3 and VDBP by cigarette smoking. J Proteome Res. 2011 Mar 04; 10(3):1151-9. PMID: 21186835.
      View in: PubMed
    43. Richie JP, Muscat JE, Ellison I, Calcagnotto A, Kleinman W, El-Bayoumy K. Association of selenium status and blood glutathione concentrations in blacks and whites. Nutr Cancer. 2011; 63(3):367-75. PMID: 21462082; PMCID: PMC3087599.
    44. Krzeminski J, Kropachev K, Kolbanovskiy M, Reeves D, Kolbanovskiy A, Yun BH, Geacintov NE, Amin S, El-Bayoumy K. Inefficient nucleotide excision repair in human cell extracts of the N-(deoxyguanosin-8-yl)-6-aminochrysene and 5-(deoxyguanosin-N(2)-yl)-6-aminochrysene adducts derived from 6-nitrochrysene. Chem Res Toxicol. 2011 Jan 14; 24(1):65-72. PMID: 21114286; PMCID: PMC3078039.
    45. Desai D, Kaushal N, Gandhi UH, Arner RJ, D'Souza C, Chen G, Vunta H, El-Bayoumy K, Amin S, Prabhu KS. Synthesis and evaluation of the anti-inflammatory properties of selenium-derivatives of celecoxib. Chem Biol Interact. 2010 Dec 05; 188(3):446-56. PMID: 20883674; PMCID: PMC3004533.
    46. Sinha R, Sinha I, Facompre N, Russell S, Somiari RI, Richie JP, El-Bayoumy K. Selenium-responsive proteins in the sera of selenium-enriched yeast-supplemented healthy African American and Caucasian men. Cancer Epidemiol Biomarkers Prev. 2010 Sep; 19(9):2332-40. PMID: 20643827; PMCID: PMC3326597.
    47. Facompre ND, El-Bayoumy K, Sun YW, Pinto JT, Sinha R. 1,4-phenylenebis(methylene)selenocyanate, but not selenomethionine, inhibits androgen receptor and Akt signaling in human prostate cancer cells. Cancer Prev Res (Phila). 2010 Aug; 3(8):975-84. PMID: 20606040; PMCID: PMC2923922.
    48. Manni A, Xu H, Washington S, Aliaga C, Cooper T, Richie JP, Bruggeman R, Prokopczyk B, Calcagnotto A, Trushin N, Mauger D, Verderame MF, El-Bayoumy K. The impact of fish oil on the chemopreventive efficacy of tamoxifen against development of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Cancer Prev Res (Phila). 2010 Mar; 3(3):322-30. PMID: 20179301.
      View in: PubMed
    49. Sun YW, Guttenplan JB, Khmelnitsky M, Krzeminski J, Boyiri T, Amin S, El-Bayoumy K. Stereoselective metabolism of the environmental mammary carcinogen 6-nitrochrysene to trans-1,2-dihydroxy-1,2-dihydro-6-nitrochrysene by aroclor 1254-treated rat liver microsomes and their comparative mutation profiles in a laci mammary epithelial cell line. Chem Res Toxicol. 2009 Dec; 22(12):1992-7. PMID: 19886636; PMCID: PMC2818434.
    50. Desai D, Madhunapantula SV, Gowdahalli K, Sharma A, Chandagaludoreswamy R, El-Bayoumy K, Robertson GP, Amin S. Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer. Bioorg Med Chem Lett. 2010 Mar 15; 20(6):2038-43. PMID: 20153642; PMCID: PMC2892985.
    51. Boyiri T, Somiari RI, Russell S, Aliaga C, El-Bayoumy K. Proteomics of rat prostate lobes treated with 2-N-hydroxylamino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 5alpha-dihydrotestosterone, individually and in combination. Int J Oncol. 2009 Sep; 35(3):559-67. PMID: 19639176; PMCID: PMC3679651.
    52. Bortner JD, Das A, Umstead TM, Freeman WM, Somiari R, Aliaga C, Phelps DS, El-Bayoumy K. Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis. J Proteome Res. 2009 Aug; 8(8):4050-61. PMID: 19563208; PMCID: PMC2761226.
    53. Chen KM, Sacks PG, Spratt TE, Lin JM, Boyiri T, Schwartz J, Richie JP, Calcagnotto A, Das A, Bortner J, Zhao Z, Amin S, Guttenplan J, El-Bayoumy K. Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate. Biochem Biophys Res Commun. 2009 May 22; 383(1):151-5. PMID: 19344691; PMCID: PMC2693912.
    54. Facompre N, El-Bayoumy K. Potential stages for prostate cancer prevention with selenium: implications for cancer survivors. Cancer Res. 2009 Apr 01; 69(7):2699-703. PMID: 19318549; PMCID: PMC2909787.
    55. Das A, Bortner J, Desai D, Amin S, El-Bayoumy K. The selenium analog of the chemopreventive compound S,S'-(1,4-phenylenebis[1,2-ethanediyl])bisisothiourea is a remarkable inducer of apoptosis and inhibitor of cell growth in human non-small cell lung cancer. Chem Biol Interact. 2009 Jul 15; 180(2):158-64. PMID: 19497413; PMCID: PMC3690934.
    56. Rao CV, Cohen L, El-Bayoumy K. Bandaru S. Reddy: in memoriam (1930-2009). Nutr Cancer. 2009; 61(6):903-5. PMID: 20155634.
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    57. Prokopczyk B, Sinha I, Trushin N, Freeman WM, El-Bayoumy K. Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chem Biol Interact. 2009 Feb 12; 177(3):173-80. PMID: 19038236; PMCID: PMC2723790.
    58. He P, Borland MG, Zhu B, Sharma AK, Amin S, El-Bayoumy K, Gonzalez FJ, Peters JM. Effect of ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in human lung cancer cell lines. Toxicology. 2008 Dec 05; 254(1-2):112-7. PMID: 18950674; PMCID: PMC2653217.
    59. Melikian AA, Chen KM, Li H, Sodum R, Fiala E, El-Bayoumy K. The role of nitric oxide on DNA damage induced by benzene metabolites. Oncol Rep. 2008 May; 19(5):1331-7. PMID: 18425395; PMCID: PMC3607205.
    60. Trushin N, Leder G, El-Bayoumy K, Hoffmann D, Beger HG, Henne-Bruns D, Ramadani M, Prokopczyk B. The tobacco carcinogen NNK is stereoselectively reduced by human pancreatic microsomes and cytosols. Langenbecks Arch Surg. 2008 Jul; 393(4):571-9. PMID: 18259773.
      View in: PubMed
    61. Sinha R, Pinto JT, Facompre N, Kilheffer J, Baatz JE, El-Bayoumy K. Effects of naturally occurring and synthetic organoselenium compounds on protein profiling in androgen responsive and androgen independent human prostate cancer cells. Nutr Cancer. 2008; 60(2):267-75. PMID: 18444160.
      View in: PubMed
    62. Chen KM, Spratt TE, Stanley BA, De Cotiis DA, Bewley MC, Flanagan JM, Desai D, Das A, Fiala ES, Amin S, El-Bayoumy K. Inhibition of nuclear factor-kappaB DNA binding by organoselenocyanates through covalent modification of the p50 subunit. Cancer Res. 2007 Nov 01; 67(21):10475-83. PMID: 17974991.
      View in: PubMed
    63. Guttenplan J, Chen KM, Khmelnitsky M, Kosinska W, Hennessy J, Bruggeman R, Desai D, Amin S, Sun YW, Spratt TE, El-Bayoumy K. Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide. Mutat Res. 2007 Dec 01; 634(1-2):146-55. PMID: 17720616; PMCID: PMC2700054.
    64. Guttenplan JB, Zhao ZL, Kosinska W, Norman RG, Krzeminski J, Sun YW, Amin S, El-Bayoumy K. Comparative mutational profiles of the environmental mammary carcinogen, 6-nitrochrysene and its metabolites in a lacI mammary epithelial cell line. Carcinogenesis. 2007 Nov; 28(11):2391-7. PMID: 17602172.
      View in: PubMed
    65. Sun YW, Herzog CR, Krzeminski J, Amin S, Perdew G, El-Bayoumy K. Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21(Cip1) protein expression and cell cycle regulation in MCF-7 and MCF-10A cells. Chem Biol Interact. 2007 Oct 20; 170(1):31-9. PMID: 17678638; PMCID: PMC2682711.
    66. Pinto JT, Sinha R, Papp K, Facompre ND, Desai D, El-Bayoumy K. Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells. Int J Cancer. 2007 Apr 01; 120(7):1410-7. PMID: 17205524.
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    67. Chang SI, El-Bayoumy K, Sinha I, Trushin N, Stanley B, Pittman B, Prokopczyk B. 4-(Methylnitrosamino)-I-(3-pyridyl)-1-butanone enhances the expression of apolipoprotein A-I and Clara cell 17-kDa protein in the lung proteomes of rats fed a corn oil diet but not a fish oil diet. Cancer Epidemiol Biomarkers Prev. 2007 Feb; 16(2):228-35. PMID: 17301254.
      View in: PubMed
    68. Richie JP, Kleinman W, Desai DH, Das A, Amin SG, Pinto JT, El-Bayoumy K. The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung. Chem Biol Interact. 2006 Jun 10; 161(2):93-103. PMID: 16620795.
      View in: PubMed
    69. El-Bayoumy K, Das A, Narayanan B, Narayanan N, Fiala ES, Desai D, Rao CV, Amin S, Sinha R. Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer. Carcinogenesis. 2006 Jul; 27(7):1369-76. PMID: 16399772.
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    70. Chen KM, El-Bayoumy K, Hosey J, Cunningham J, Aliaga C, Melikian AA. Benzene increases protein-bound 3-nitrotyrosine in bone marrow of B6C3F1 mice. Chem Biol Interact. 2005 Oct 20; 156(2-3):81-91. PMID: 16139254.
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    71. Prokopczyk B, Leder G, Trushin N, Cunningham AJ, Akerkar S, Pittman B, Ramadani M, Straeter J, Beger HG, Henne-Bruns D, El-Bayoumy K. 4-Hydroxy-1-(3-pyridyl)-1-butanone, an indicator for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA damage, is not detected in human pancreatic tissue. Cancer Epidemiol Biomarkers Prev. 2005 Feb; 14(2):540-1. PMID: 15734986.
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    72. Sohn OS, Desai DH, Das A, Rodriguez JG, Amin SG, El-Bayoumy K. Comparative excretion and tissue distribution of selenium in mice and rats following treatment with the chemopreventive agent 1,4-phenylenebis(methylene)selenocyanate. Chem Biol Interact. 2005 Feb 10; 151(3):193-202. PMID: 15733540.
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    73. Fiala ES, Sohn OS, Wang CX, Seibert E, Tsurutani J, Dennis PA, El-Bayoumy K, Sodum RS, Desai D, Reinhardt J, Aliaga C. Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E. Carcinogenesis. 2005 Mar; 26(3):605-12. PMID: 15579485.
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    74. Sun YW, Guengerich FP, Sharma AK, Boyiri T, Amin S, el-Bayoumy K. Human cytochromes P450 1A1 and 1B1 catalyze ring oxidation but not nitroreduction of environmental pollutant mononitropyrene isomers in primary cultures of human breast cells and cultured MCF-10A and MCF-7 cell lines. Chem Res Toxicol. 2004 Aug; 17(8):1077-85. PMID: 15310239.
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    75. El-Bayoumy K, Sinha R. Mechanisms of mammary cancer chemoprevention by organoselenium compounds. Mutat Res. 2004 Jul 13; 551(1-2):181-97. PMID: 15225592.
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    76. Guttenplan JB, Spratt TE, Khmelnitsky M, Kosinska W, Desai D, El-Bayoumy K. Effects of 3H-1,2-dithiole-3-thione, 1,4-phenylenebis(methylene)selenocyanate, and selenium-enriched yeast individually and in combination on benzo[a]pyrene-induced mutagenesis in oral tissue and esophagus in lacZ mice. Mutat Res. 2004 Apr 11; 559(1-2):199-210. PMID: 15066587.
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    77. Chen KM, El-Bayoumy K, Cunningham J, Aliaga C, Li H, Melikian AA. Detection of nitrated benzene metabolites in bone marrow of B6C3F1 mice treated with benzene. Chem Res Toxicol. 2004 Mar; 17(3):370-7. PMID: 15025507.
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    78. Sinha R, El-Bayoumy K. Apoptosis is a critical cellular event in cancer chemoprevention and chemotherapy by selenium compounds. Curr Cancer Drug Targets. 2004 Feb; 4(1):13-28. PMID: 14965264.
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    79. Boyiri T, Guttenplan J, Khmelnitsky M, Kosinska W, Lin JM, Desai D, Amin S, Pittman B, El-Bayoumy K. Mammary carcinogenesis and molecular analysis of in vivo cII gene mutations in the mammary tissue of female transgenic rats treated with the environmental pollutant 6-nitrochrysene. Carcinogenesis. 2004 Apr; 25(4):637-43. PMID: 14656939.
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    80. Bartram HP, Kr├╝ger S, Dusel G, El-Bayoumy K, Upadhyaya P, Scheppach W. Antiproliferative effect of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) on colonic epithelium of patients with adenomatous polyps in vitro. Eur J Cancer Prev. 2003 Dec; 12(6):463-8. PMID: 14639123.
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    81. El-Bayoumy K, Das A, Boyiri T, Desai D, Sinha R, Pittman B, Amin S. Comparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz[a]anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cells. Chem Biol Interact. 2003 Oct 25; 146(2):179-90. PMID: 14597131.
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    82. El-Bayoumy K, Narayanan BA, Desai DH, Narayanan NK, Pittman B, Amin SG, Schwartz J, Nixon DW. Elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cDNA microarray. Carcinogenesis. 2003 Sep; 24(9):1505-14. PMID: 12844480.
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    83. Amin S, Lin JM, Krzeminski J, Boyiri T, Desai D, El-Bayoumy K. Metabolism of benzo[c]chrysene and comparative mammary gland tumorigenesis of benzo[c]chrysene bay and fjord region diol epoxides in female CD rats. Chem Res Toxicol. 2003 Feb; 16(2):227-31. PMID: 12588194.
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    84. Das A, Desai D, Pittman B, Amin S, El-Bayoumy K. Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse. Nutr Cancer. 2003; 46(2):179-85. PMID: 14690794.
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    85. Desai D, Das A, Cohen L, el-Bayoumy K, Amin S. Chemopreventive efficacy of suberoylanilide hydroxamic acid (SAHA) against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J mice. Anticancer Res. 2003 Jan-Feb; 23(1A):499-503. PMID: 12680257.
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    86. El-Bayoumy K, Richie JP, Boyiri T, Komninou D, Prokopczyk B, Trushin N, Kleinman W, Cox J, Pittman B, Colosimo S. Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot study. Cancer Epidemiol Biomarkers Prev. 2002 Nov; 11(11):1459-65. PMID: 12433727.
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    87. Boyiri T, Leszczynska J, Desai D, Amin S, Nixon DW, El-Bayoumy K. Metabolism and DNA binding of the environmental pollutant 6-nitrochrysene in primary culture of human breast cells and in cultured MCF-10A, MCF-7 and MDA-MB-435s cell lines. Int J Cancer. 2002 Aug 01; 100(4):395-400. PMID: 12115519.
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    88. El-Bayoumy K, Desai D, Boyiri T, Rosa J, Krzeminski J, Sharma AK, Pittman B, Amin S. Comparative tumorigenicity of the environmental pollutant 6-nitrochrysene and its metabolites in the rat mammary gland. Chem Res Toxicol. 2002 Jul; 15(7):972-8. PMID: 12119009.
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    89. Desai D, Sharma AK, Lin JM, Krzeminski J, Pimentel M, El-Bayoumy K, Nesnow S, Amin S. Synthesis, in vitro metabolism, cell transformation, mutagenicity, and DNA adduction of dibenzo[c,mno]chrysene. Chem Res Toxicol. 2002 Jul; 15(7):964-71. PMID: 12119008.
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    90. Guttenplan JB, Kosinska W, von Pressentin Md, Rosa J, El-Bayoumy K. Effects of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) and vitamin E on 4-nitroquinoline-N-oxide (4-NQO)-induced mutagenesis in lacZ mouse upper aerodigestive tissue. Mutat Res. 2002 Jun 27; 518(1):85-93. PMID: 12063070.
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    91. Prokopczyk B, Hoffmann D, Bologna M, Cunningham AJ, Trushin N, Akerkar S, Boyiri T, Amin S, Desai D, Colosimo S, Pittman B, Leder G, Ramadani M, Henne-Bruns D, Beger HG, El-Bayoumy K. Identification of tobacco-derived compounds in human pancreatic juice. Chem Res Toxicol. 2002 May; 15(5):677-85. PMID: 12018989.
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    92. El-Bayoumy K, Rose DP, Papanikolaou N, Leszczynska J, Swamy MV, Rao CV. Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation. Int J Oncol. 2002 Mar; 20(3):557-61. PMID: 11836568.
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    93. Li JJ, Papa D, Davis MF, Weroha SJ, Aldaz CM, El-Bayoumy K, Ballenger J, Tawfik O, Li SA. Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: comparison to invasive human ductal breast cancer. Mol Carcinog. 2002 Jan; 33(1):56-65. PMID: 11807958.
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    94. Ghose A, Fleming J, El-Bayoumy K, Harrison PR. Enhanced sensitivity of human oral carcinomas to induction of apoptosis by selenium compounds: involvement of mitogen-activated protein kinase and Fas pathways. Cancer Res. 2001 Oct 15; 61(20):7479-87. PMID: 11606383.
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    95. Hoffmann D, Hoffmann I, El-Bayoumy K. The less harmful cigarette: a controversial issue. a tribute to Ernst L. Wynder. Chem Res Toxicol. 2001 Jul; 14(7):767-90. PMID: 11453723.
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    96. Rao CV, Wang CQ, Simi B, Rodriguez JG, Cooma I, El-Bayoumy K, Reddy BS. Chemoprevention of colon cancer by a glutathione conjugate of 1,4-phenylenebis(methylene)selenocyanate, a novel organoselenium compound with low toxicity. Cancer Res. 2001 May 01; 61(9):3647-52. PMID: 11325834.
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    97. El-Bayoumy K. The protective role of selenium on genetic damage and on cancer. Mutat Res. 2001 Apr 18; 475(1-2):123-39. PMID: 11295158.
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    98. el-Bayoumy K. Overview: the late Larry C. Clark showed the bright side of the moon element (selenium) in a clinical cancer prevention trial. Nutr Cancer. 2001; 40(1):4-5. PMID: 11799921.
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    99. el-Bayoumy K, Rao CV, Reddy BS. Multiorgan sensitivity to anticarcinogenesis by the organoselenium 1,4-phenylenebis(methylene)selenocyanate. Nutr Cancer. 2001; 40(1):18-27. PMID: 11799918.
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    100. Prokopczyk B, Trushin N, Leszczynska J, Waggoner SE, El-Bayoumy K. Human cervical tissue metabolizes the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, via alpha-hydroxylation and carbonyl reduction pathways. Carcinogenesis. 2001 Jan; 22(1):107-14. PMID: 11159748.
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    101. Prokopczyk B, Rosa JG, Desai D, Amin S, Sohn OS, Fiala ES, El-Bayoumy K. Chemoprevention of lung tumorigenesis induced by a mixture of benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by the organoselenium compound 1,4-phenylenebis(methylene)selenocyanate. Cancer Lett. 2000 Dec 08; 161(1):35-46. PMID: 11078911.
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    102. Krzeminski J, Desai D, Lin JM, Serebryany V, El-Bayoumy K, Amin S. Synthesis of anti-1,2-dihydroxy-3,4-epoxy-1,2,3, 4-tetrahydro-6-nitrochrysene and its reaction with 2'-deoxyguanosine- 5'-monophosphate, 2'-deoxyadenosine-5'-monophosphate, and calf thymus DNA in vitro. Chem Res Toxicol. 2000 Nov; 13(11):1143-8. PMID: 11087436.
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    103. Tanaka T, Kohno H, Murakami M, Kagami S, El-Bayoumy K. Suppressing effects of dietary supplementation of the organoselenium 1,4-phenylenebis(methylene)selenocyanate and the Citrus antioxidant auraptene on lung metastasis of melanoma cells in mice. Cancer Res. 2000 Jul 15; 60(14):3713-6. PMID: 10919638.
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    104. El-Bayoumy K, Chae YH, Rosa JG, Williams LK, Desai D, Amin S, Fiala E. The effects of 1-nitropyrene, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene on 8-hydroxy-2'-deoxyguanosine levels in the rat mammary gland and modulation by dietary 1,4-phenylenebis(methylene) selenocyanate. Cancer Lett. 2000 Apr 03; 151(1):7-13. PMID: 10766416.
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    105. Rao CV, Cooma I, Rodriguez JG, Simi B, El-Bayoumy K, Reddy BS. Chemoprevention of familial adenomatous polyposis development in the APC(min) mouse model by 1,4-phenylene bis(methylene)selenocyanate. Carcinogenesis. 2000 Apr; 21(4):617-21. PMID: 10753194.
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    106. von Pressentin MM, El-Bayoumy K, Guttenplan JB. Mutagenic activity of 4-nitroquinoline-N-oxide in upper aerodigestive tissue in lacZ mice (MutaMouse) and the effects of 1, 4-phenylenebis(methylene)selenocyanate. Mutat Res. 2000 Mar 03; 466(1):71-8. PMID: 10751728.
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    107. Rao CV, Simi B, Hirose Y, Upadhyaya P, El-Bayoumy K, Reddy BS. Mechanisms in the chemoprevention of colon cancer: modulation of protein kinase C, tyrosine protein kinase and diacylglycerol kinase activities by 1,4-phenylenebis-(methylene)selenocyanate and impact of low-fat diet. Int J Oncol. 2000 Mar; 16(3):519-27. PMID: 10675484.
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    108. Melikian AA, Sun P, Prokopczyk B, El-Bayoumy K, Hoffmann D, Wang X, Waggoner S. Identification of benzo[a]pyrene metabolites in cervical mucus and DNA adducts in cervical tissues in humans by gas chromatography-mass spectrometry. Cancer Lett. 1999 Nov 15; 146(2):127-34. PMID: 10656617.
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    109. Melikian AA, Wang X, Waggoner S, Hoffmann D, El-Bayoumy K. Comparative response of normal and of human papillomavirus-16 immortalized human epithelial cervical cells to benzo[a]pyrene. Oncol Rep. 1999 Nov-Dec; 6(6):1371-6. PMID: 10523714.
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    110. El-Bayoumy K, Iatropoulos M, Amin S, Hoffmann D, Wynder EL. Increased expression of cyclooxygenase-2 in rat lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone: the impact of a high-fat diet. Cancer Res. 1999 Apr 01; 59(7):1400-3. PMID: 10197601.
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    111. Sohn OS, Fiala ES, Upadhyaya P, Chae YH, El-Bayoumy K. Comparative effects of phenylenebis(methylene)selenocyanate isomers on xenobiotic metabolizing enzymes in organs of female CD rats. Carcinogenesis. 1999 Apr; 20(4):615-21. PMID: 10223189.
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    112. Chae YH, Thomas T, Guengerich FP, Fu PP, El-Bayoumy K. Comparative metabolism of 1-, 2-, and 4-nitropyrene by human hepatic and pulmonary microsomes. Cancer Res. 1999 Apr 01; 59(7):1473-80. PMID: 10197616.
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    113. Chae YH, Ji BY, Lin JM, Fu PP, Cho BP, El-Bayoumy K. Nitroreduction of 4-nitropyrene is primarily responsible for DNA adduct formation in the mammary gland of female CD rats. Chem Res Toxicol. 1999 Feb; 12(2):180-6. PMID: 10027796.
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    114. Upadhyaya P, El-Bayoumy K. Effect of dietary soy protein isolate, genistein, and 1,4-phenylenebis(methylene)selenocyanate on DNA binding of 7,12-dimethylbenz[a]anthracene in mammary glands of CD rats. Oncol Rep. 1998 Nov-Dec; 5(6):1541-5. PMID: 9769402.
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    115. Rosa JG, Prokopczyk B, Desai DH, Amin SG, El-Bayoumy K. Elevated 8-hydroxy-2'-deoxyguanosine levels in lung DNA of A/J mice and F344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and inhibition by dietary 1,4-phenylenebis(methylene)selenocyanate. Carcinogenesis. 1998 Oct; 19(10):1783-8. PMID: 9806159.
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    116. El-Bayoumy K, Upadhyaya P, Sohn OS, Rosa JG, Fiala ES. Synthesis and excretion profile of 1,4-[14C]phenylenebis(methylene)selenocyanate in the rat. Carcinogenesis. 1998 Sep; 19(9):1603-7. PMID: 9771931.
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    117. Kawamori T, El-Bayoumy K, Ji BY, Rodriguez JG, Rao CV, Reddy BS. Evaluation of benzyl selenocyanate glutathione conjugate for potential chemopreventive properties in colon carcinogenesis. Int J Oncol. 1998 Jul; 13(1):29-34. PMID: 9625800.
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    118. Fiala ES, Staretz ME, Pandya GA, El-Bayoumy K, Hamilton SR. Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation. Carcinogenesis. 1998 Apr; 19(4):597-604. PMID: 9600343.
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    119. El-Bayoumy K, Chung FL, Richie J, Reddy BS, Cohen L, Weisburger J, Wynder EL. Dietary control of cancer. Proc Soc Exp Biol Med. 1997 Nov; 216(2):211-23. PMID: 9349690.
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    120. Shimada T, El-Bayoumy K, Upadhyaya P, Sutter TR, Guengerich FP, Yamazaki H. Inhibition of human cytochrome P450-catalyzed oxidations of xenobiotics and procarcinogens by synthetic organoselenium compounds. Cancer Res. 1997 Nov 01; 57(21):4757-64. PMID: 9354437.
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    121. Fiala ES, Sohn OS, Li H, El-Bayoumy K, Sodum RS. Inhibition of 2-nitropropane-induced rat liver DNA and RNA damage by benzyl selenocyanate. Carcinogenesis. 1997 Sep; 18(9):1809-15. PMID: 9328179.
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    122. Tanaka T, Makita H, Kawabata K, Mori H, El-Bayoumy K. 1,4-phenylenebis(methylene)selenocyanate exerts exceptional chemopreventive activity in rat tongue carcinogenesis. Cancer Res. 1997 Sep 01; 57(17):3644-8. PMID: 9288763.
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    123. Samaha HS, Hamid R, el-Bayoumy K, Rao CV, Reddy BS. The role of apoptosis in the modulation of colon carcinogenesis by dietary fat and by the organoselenium compound 1,4-phenylenebis(methylene)selenocyanate. Cancer Epidemiol Biomarkers Prev. 1997 Sep; 6(9):699-704. PMID: 9298577.
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    124. Prokopczyk B, Amin S, Desai DH, Kurtzke C, Upadhyaya P, El-Bayoumy K. Effects of 1,4-phenylenebis(methylene)selenocyanate and selenomethionine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mouse lung. Carcinogenesis. 1997 Sep; 18(9):1855-7. PMID: 9328187.
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    125. Chae YH, Upadhyaya P, Ji BY, Fu PP, el-Bayoumy K. Comparative metabolism and DNA binding of 1-, 2-, and 4-nitropyrene in rats. Mutat Res. 1997 May 12; 376(1-2):21-8. PMID: 9202734.
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    126. Reddy BS, Rivenson A, El-Bayoumy K, Upadhyaya P, Pittman B, Rao CV. Chemoprevention of colon cancer by organoselenium compounds and impact of high- or low-fat diets. J Natl Cancer Inst. 1997 Apr 02; 89(7):506-12. PMID: 9086007.
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    127. Hecht SS, Rivenson A, Amin S, Krzeminski J, el-Bayoumy K, Reddy BS, Kurtzke C, La Voie EJ. Mammary carcinogenicity of diol epoxide metabolites of benzo[j]fluoranthene in female CD rats. Cancer Lett. 1996 Sep 10; 106(2):251-5. PMID: 8844980.
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    128. el-Bayoumy K, Upadhyaya P, Desai DH, Amin S, Hoffmann D, Wynder EL. Effects of 1,4-phenylenebis(methylene)selenocyanate, phenethyl isothiocyanate, indole-3-carbinol, and d-limonene individually and in combination on the tumorigenicity of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung. Anticancer Res. 1996 Sep-Oct; 16(5A):2709-12. PMID: 8917375.
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    129. el-Bayoumy K, Chae YH, Upadhyaya P, Ip C. Chemoprevention of mammary cancer by diallyl selenide, a novel organoselenium compound. Anticancer Res. 1996 Sep-Oct; 16(5A):2911-5. PMID: 8917406.
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    130. Adler V, Pincus MR, Posner S, Upadhyaya P, El-Bayoumy K, Ronai Z. Effects of chemopreventive selenium compounds on Jun N-kinase activities. Carcinogenesis. 1996 Sep; 17(9):1849-54. PMID: 8824505.
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    131. Chae YH, Delclos KB, Blaydes B, el-Bayoumy K. Metabolism and DNA binding of the environmental colon carcinogen 6-nitrochrysene in rats. Cancer Res. 1996 May 01; 56(9):2052-8. PMID: 8616850.
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    132. el-Bayoumy K, Ji BY, Upadhyaya P, Chae YH, Kurtzke C, Rivenson A, Reddy BS, Amin S, Hecht SS. Lack of tumorigenicity of cholesterol epoxides and estrone-3,4-quinone in the rat mammary gland. Cancer Res. 1996 May 01; 56(9):1970-3. PMID: 8616833.
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    133. Reddy BS, Wynn TT, el-Bayoumy K, Upadhyaya P, Fiala E, Rao CV. Evaluation of organoselenium compounds for potential chemopreventive properties in colon cancer. Anticancer Res. 1996 May-Jun; 16(3A):1123-7. PMID: 8702223.
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    134. Prokopczyk B, Cox JE, Upadhyaya P, Amin S, Desai D, Hoffmann D, el-Bayoumy K. Effects of dietary 1,4-phenylenebis(methylene)selenocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation in lung and liver of A/J mice and F344 rats. Carcinogenesis. 1996 Apr; 17(4):749-53. PMID: 8625486.
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    135. el-Bayoumy K, Prokopczyk B, Peterson LA, Desai D, Amin S, Reddy BS, Hoffmann D, Wynder E. Effects of dietary fat content on the metabolism of NNK and on DNA methylation induced by NNK. Nutr Cancer. 1996; 26(1):1-10. PMID: 8844716.
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    136. Ronai Z, Tillotson JK, Traganos F, Darzynkiewicz Z, Conaway CC, Upadhyaya P, el-Bayoumy K. Effects of organic and inorganic selenium compounds on rat mammary tumor cells. Int J Cancer. 1995 Nov 03; 63(3):428-34. PMID: 7591244.
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    137. Sohni OS, Li H, Surace A, el-Bayoumy K, Upadhyaya P, Fiala ES. Contrasting patterns of selenium excretion by female CD rats treated with chemically related chemopreventive organic selenocyanate compounds. Anticancer Res. 1995 Sep-Oct; 15(5B):1849-56. PMID: 8572569.
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    138. Amin S, Krzeminski J, Rivenson A, Kurtzke C, Hecht SS, el-Bayoumy K. Mammary carcinogenicity in female CD rats of fjord region diol epoxides of benzo[c]phenanthrene, benzo[g]chrysene and dibenzo[a,l]pyrene. Carcinogenesis. 1995 Aug; 16(8):1971-4. PMID: 7634428.
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    139. Hecht SS, Amin S, Lin JM, Rivenson A, Kurtzke C, el-Bayoumy K. Mammary carcinogenicity in female CD rats of a diol epoxide metabolite of fluoranthene, a commonly occurring environmental pollutant. Carcinogenesis. 1995 Jun; 16(6):1433-5. PMID: 7788865.
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    140. el-Bayoumy K, Chae YH, Upadhyaya P, Rivenson A, Kurtzke C, Reddy B, Hecht SS. Comparative tumorigenicity of benzo[a]pyrene, 1-nitropyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine administered by gavage to female CD rats. Carcinogenesis. 1995 Feb; 16(2):431-4. PMID: 7859378.
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    141. el-Bayoumy K, Upadhyaya P, Chae YH, Sohn OS, Rao CV, Fiala E, Reddy BS. Chemoprevention of cancer by organoselenium compounds. J Cell Biochem Suppl. 1995; 22:92-100. PMID: 8538214.
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    142. el-Bayoumy K. Evaluation of chemopreventive agents against breast cancer and proposed strategies for future clinical intervention trials. Carcinogenesis. 1994 Nov; 15(11):2395-420. PMID: 7955084.
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    143. el-Bayoumy K, Johnson B, Roy AK, Upadhyaya P, Partian S, Hecht SS. Development of methods to monitor exposure to 1-nitropyrene. Environ Health Perspect. 1994 Oct; 102 Suppl 6:31-7. PMID: 7889855; PMCID: PMC1566839.
    144. Ronai ZA, Gradia S, el-Bayoumy K, Amin S, Hecht SS. Contrasting incidence of ras mutations in rat mammary and mouse skin tumors induced by anti-benzo[c]phenanthrene-3,4-diol-1,2-epoxide. Carcinogenesis. 1994 Oct; 15(10):2113-6. PMID: 7955041.
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    145. Upadhyaya P, Von Tungeln LS, Fu PP, el-Bayoumy K. In vitro and in vivo metabolism of the carcinogen 4-nitropyrene. Chem Res Toxicol. 1994 Sep-Oct; 7(5):690-5. PMID: 7841349.
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    146. el-Bayoumy K, Johnson BE, Roy AK, Upadhyaya P, Partian SJ. Biomonitoring of nitropolynuclear aromatic hydrocarbons via protein and DNA adducts. Res Rep Health Eff Inst. 1994 Apr; (64):1-27; discussion 29-37. PMID: 8037891.
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    147. Yamazaki H, Mimura M, Oda Y, Gonzalez FJ, el-Bayoumy K, Chae YH, Guengerich FP, Shimada T. Activation of trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450. Carcinogenesis. 1994 Mar; 15(3):465-70. PMID: 8118930.
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    148. Ip C, el-Bayoumy K, Upadhyaya P, Ganther H, Vadhanavikit S, Thompson H. Comparative effect of inorganic and organic selenocyanate derivatives in mammary cancer chemoprevention. Carcinogenesis. 1994 Feb; 15(2):187-92. PMID: 8313507.
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    149. Thompson HJ, Wilson A, Lu J, Singh M, Jiang C, Upadhyaya P, el-Bayoumy K, Ip C. Comparison of the effects of an organic and an inorganic form of selenium on a mammary carcinoma cell line. Carcinogenesis. 1994 Feb; 15(2):183-6. PMID: 8313506.
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    150. el-Bayoumy K, Johnson B, Partian S, Upadhyaya P, Hecht SS. In vivo binding of 1-nitropyrene to albumin in the rat. Carcinogenesis. 1994 Jan; 15(1):119-23. PMID: 8293536.
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    151. Hecht SS, el-Bayoumy K, Rivenson A, Amin S. Potent mammary carcinogenicity in female CD rats of a fjord region diol-epoxide of benzo[c]phenanthrene compared to a bay region diol-epoxide of benzo[a]pyrene. Cancer Res. 1994 Jan 01; 54(1):21-4. PMID: 8261440.
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    152. el-Bayoumy K, Rivenson A, Upadhyaya P, Chae YH, Hecht SS. Induction of mammary cancer by 6-nitrochrysene in female CD rats. Cancer Res. 1993 Aug 15; 53(16):3719-22. PMID: 8339281.
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    153. Swenson DH, el-Bayoumy K, Shuie GH, Hecht SS, Fiala E, Kadlubar FF, Freeman JP. Synthesis of N-(purin-8-yl)arylamines. Chem Res Toxicol. 1993 Jul-Aug; 6(4):480-5. PMID: 8374045.
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    154. el-Bayoumy K, Upadhyaya P, Desai DH, Amin S, Hecht SS. Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenicity in mouse lung by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate. Carcinogenesis. 1993 Jun; 14(6):1111-3. PMID: 8508496.
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    155. Chae YH, Yun CH, Guengerich FP, Kadlubar FF, el-Bayoumy K. Roles of human hepatic and pulmonary cytochrome P450 enzymes in the metabolism of the environmental carcinogen 6-nitrochrysene. Cancer Res. 1993 May 01; 53(9):2028-34. PMID: 8481905.
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    156. el-Bayoumy K, Desai D, Upadhyaya P, Amin S, Hecht SS. Comparative tumorigenicity of nitrochrysene isomers in newborn mice. Carcinogenesis. 1992 Dec; 13(12):2271-5. PMID: 1473233.
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    157. Conaway CC, Upadhyaya P, Meschter CL, Kurtzke C, Marcus LA, el-Bayoumy K. Subchronic toxicity of benzyl selenocyanate and 1,4-phenylenebis(methylene)selenocyanate in F344 rats. Fundam Appl Toxicol. 1992 Nov; 19(4):563-74. PMID: 1426715.
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    158. Reddy BS, Rivenson A, Kulkarni N, Upadhyaya P, el-Bayoumy K. Chemoprevention of colon carcinogenesis by the synthetic organoselenium compound 1,4-phenylenebis(methylene)selenocyanate. Cancer Res. 1992 Oct 15; 52(20):5635-40. PMID: 1394188.
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    159. el-Bayoumy K. Environmental carcinogens that may be involved in human breast cancer etiology. Chem Res Toxicol. 1992 Sep-Oct; 5(5):585-90. PMID: 1445997.
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    160. el-Bayoumy K, Chae YH, Upadhyaya P, Meschter C, Cohen LA, Reddy BS. Inhibition of 7,12-dimethylbenz(a)anthracene-induced tumors and DNA adduct formation in the mammary glands of female Sprague-Dawley rats by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate. Cancer Res. 1992 May 01; 52(9):2402-7. PMID: 1568209.
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    161. Upadhyaya P, Roy AK, Fu PP, el-Bayoumy K. Metabolism and DNA binding of 2-nitropyrene in the rat. Cancer Res. 1992 Mar 01; 52(5):1176-81. PMID: 1737377.
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    162. el-Bayoumy K, Upadhyaya P, Date V, Sohn OS, Fiala ES, Reddy B. Metabolism of [14C]benzyl selenocyanate in the F344 rat. Chem Res Toxicol. 1991 Sep-Oct; 4(5):560-5. PMID: 1793806.
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    163. Sohn OS, Blackwell L, Mathis J, Asaad WW, Reddy BS, el-Bayoumy K. Excretion and tissue distribution of selenium following treatment of male F344 rats with benzylselenocyanate or sodium selenite. Drug Metab Dispos. 1991 Sep-Oct; 19(5):865-70. PMID: 1686229.
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    164. Yu SY, Heflich RH, Von Tungeln LS, el-Bayoumy K, Kadlubar FF, Fu PP. Comparative direct-acting mutagenicity of 1- and 2-nitropyrene: evidence for 2-nitropyrene mutagenesis by both guanine and adenine adducts. Mutat Res. 1991 Sep-Oct; 250(1-2):145-52. PMID: 1944329.
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    165. Fiala ES, Joseph C, Sohn OS, el-Bayoumy K, Reddy BS. Mechanism of benzylselenocyanate inhibition of azoxymethane-induced colon carcinogenesis in F344 rats. Cancer Res. 1991 Jun 01; 51(11):2826-30. PMID: 2032223.
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    166. Roy AK, Upadhyaya P, Evans FE, el-Bayoumy K. Structural characterization of the major adducts formed by reaction of 4,5-epoxy-4,5-dihydro-1-nitropyrene with DNA. Carcinogenesis. 1991 Apr; 12(4):577-81. PMID: 1849468.
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    167. Roy AK, Upadhyaya P, Fu PP, el-Bayoumy K. Identification of the major metabolites and DNA adducts formed from 2-nitropyrene in vitro. Carcinogenesis. 1991 Mar; 12(3):475-9. PMID: 2009592.
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    168. Nayini JR, Sugie S, el-Bayoumy K, Rao CV, Rigotty J, Sohn OS, Reddy BS. Effect of dietary benzylselenocyanate on azoxymethane-induced colon carcinogenesis in male F344 rats. Nutr Cancer. 1991; 15(2):129-39. PMID: 1645468.
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    169. Sugie S, Reddy BS, el-Bayoumy K, Tanaka T. Inhibition by dietary benzylselenocyanate of hepatocarcinogenesis induced by azoxymethane in Fischer 344 rats. Jpn J Cancer Res. 1989 Oct; 80(10):952-7. PMID: 2515179.
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    170. el-Bayoumy K, Shiue GH, Amin S, Hecht SS. The effects of bay-region methyl substitution on 6-nitrochrysene mutagenicity in Salmonella typhimurium and tumorigenicity in newborn mice. Carcinogenesis. 1989 Sep; 10(9):1685-9. PMID: 2670305.
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    171. Delclos KB, el-Bayoumy K, Casciano DA, Walker RP, Kadlubar FF, Hecht SS, Shivapurkar N, Mandal S, Stoner GD. Metabolic activation of 6-nitrochrysene in explants of human bronchus and in isolated rat hepatocytes. Cancer Res. 1989 Jun 01; 49(11):2909-13. PMID: 2720650.
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    172. el-Bayoumy K, Delclos KB, Heflich RH, Walker R, Shiue GH, Hecht SS. Mutagenicity, metabolism and DNA adduct formation of 6-nitrochrysene in Salmonella typhimurium. Mutagenesis. 1989 May; 4(3):235-40. PMID: 2659942.
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    173. Nayini J, el-Bayoumy K, Sugie S, Cohen LA, Reddy BS. Chemoprevention of experimental mammary carcinogenesis by the synthetic organoselenium compound, benzylselenocyanate, in rats. Carcinogenesis. 1989 Mar; 10(3):509-12. PMID: 2538274.
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    174. el-Bayoumy K, Shiue GH, Hecht SS. Comparative tumorigenicity of 6-nitrochrysene and its metabolites in newborn mice. Carcinogenesis. 1989 Feb; 10(2):369-72. PMID: 2912588.
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    175. Roy AK, el-Bayoumy K, Hecht SS. 32P-postlabeling analysis of 1-nitropyrene-DNA adducts in female Sprague-Dawley rats. Carcinogenesis. 1989 Jan; 10(1):195-8. PMID: 2910523.
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    176. Delclos KB, el-Bayoumy K, Hecht SS, Walker RP, Kadlubar FF. Metabolism of the carcinogen [3H]6-nitrochrysene in the preweanling mouse: identification of 6-aminochrysene-1,2-dihydrodiol as the probable proximate carcinogenic metabolite. Carcinogenesis. 1988 Oct; 9(10):1875-84. PMID: 3168165.
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    177. el-Bayoumy K, Rivenson A, Johnson B, DiBello J, Little P, Hecht SS. Comparative tumorigenicity of 1-nitropyrene, 1-nitrosopyrene, and 1-aminopyrene administered by gavage to Sprague-Dawley rats. Cancer Res. 1988 Aug 01; 48(15):4256-60. PMID: 3390821.
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    178. el-Bayoumy K, Shiue GH, Hecht SS. Metabolism and DNA binding of 1-nitropyrene and 1-nitrosopyrene in newborn mice. Chem Res Toxicol. 1988 Jul-Aug; 1(4):243-7. PMID: 2979739.
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    179. Roy AK, el-Bayoumy K, Hecht SS. Metabolism of K-region derivatives of 1-nitropyrene by rat liver in vitro. Carcinogenesis. 1988 Feb; 9(2):255-8. PMID: 3338108.
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    180. Reddy BS, Sugie S, Maruyama H, el-Bayoumy K, Marra P. Chemoprevention of colon carcinogenesis by dietary organoselenium, benzylselenocyanate, in F344 rats. Cancer Res. 1987 Nov 15; 47(22):5901-4. PMID: 3664491.
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    181. Shiue GH, el-Bayoumy K, Hecht SS. Comparative metabolism and DNA binding of 6-nitro-5-methylchrysene and 5-methylchrysene. Carcinogenesis. 1987 Sep; 8(9):1327-31. PMID: 3621469.
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    182. el-Bayoumy K, O'Donnell M, Hoffmann D. Determination of aromatic amines in sidestream smoke by gas chromatography. IARC Sci Publ. 1987; (81):269-77. PMID: 3429016.
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    183. el-Bayoumy K, Donahue JM, Hecht SS, Hoffmann D. Identification and quantitative determination of aniline and toluidines in human urine. Cancer Res. 1986 Dec; 46(12 Pt 1):6064-7. PMID: 3779628.
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    184. el-Bayoumy K, Villucci P, Roy AK, Hecht SS. Synthesis of K-region derivatives of the carcinogen 1-nitropyrene. Carcinogenesis. 1986 Sep; 7(9):1577-80. PMID: 3742729.
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    185. el-Bayoumy K, Hecht SS. Mutagenicity of K-region derivatives of 1-nitropyrene; remarkable activity of 1- and 3-nitro-5H-phenanthro[4,5-bcd]pyran-5-one. Mutat Res. 1986 Apr-May; 170(1-2):31-40. PMID: 3515166.
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    186. el-Bayoumy K, Amin S, Hecht SS. Effects of 6-nitro substitution on 5-methylchrysene tumorigenicity, mutagenicity and metabolism. Carcinogenesis. 1986 Apr; 7(4):673-6. PMID: 3509952.
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    187. el-Bayoumy K. Effects of organoselenium compounds on induction of mouse forestomach tumors by benzo(a)pyrene. Cancer Res. 1985 Aug; 45(8):3631-5. PMID: 4016744.
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    188. Reddy BS, Tanaka T, El-Bayoumy K. Inhibitory effect of dietary p-methoxybenzeneselenol on azoxymethane-induced colon and kidney carcinogenesis in female F344 rats. J Natl Cancer Inst. 1985 Jun; 74(6):1325-8. PMID: 2987595.
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    189. Tanaka T, Reddy BS, el-Bayoumy K. Inhibition by dietary organoselenium, p-methoxybenzene-selenol, of hepatocarcinogenesis induced by azoxymethane in rats. Jpn J Cancer Res. 1985 Jun; 76(6):462-7. PMID: 3926580.
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    190. el-Bayoumy K, O'Donnell M, Hecht SS, Hoffmann D. On the analysis of 1-nitronaphthalene, 1-nitropyrene and 6-nitrochrysene in cigarette smoke. Carcinogenesis. 1985 Apr; 6(4):505-7. PMID: 3986957.
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    191. Reddy BS, el-Bayoumy K, Louis YM. Germfree animal as a tool to study role of gut microflora and nutrition in cancer. Prog Clin Biol Res. 1985; 181:293-6. PMID: 4022986.
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    192. El-Bayoumy K, Hecht SS, Sackl T, Stoner GD. Tumorigenicity and metabolism of 1-nitropyrene in A/J mice. Carcinogenesis. 1984 Nov; 5(11):1449-52. PMID: 6488469.
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    193. El-Bayoumy K, Reddy B, Hecht SS. Identification of ring oxidized metabolites of 1-nitropyrene in the feces and urine of germfree F344 rats. Carcinogenesis. 1984 Oct; 5(10):1371-3. PMID: 6488459.
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    194. El-Bayoumy K, Hecht SS. Metabolism of 1-nitro[U-4,5,9,10-14C]pyrene in the F344 rat. Cancer Res. 1984 Oct; 44(10):4317-22. PMID: 6467193.
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    195. El-Bayoumy K, Hecht SS. Identification of trans-1,2-dihydro-1,2-dihydroxy-6-nitrochrysene as a major mutagenic metabolite of 6-nitrochrysene. Cancer Res. 1984 Aug; 44(8):3408-13. PMID: 6378368.
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    196. Hecht SS, El-Bayoumy K, Rivenson A, Fiala ES. Bioassay for carcinogenicity of 3,2'-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters. Cancer Lett. 1983 Oct; 20(3):349-54. PMID: 6627231.
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    197. El-Bayoumy K, Hecht SS. Identification and mutagenicity of metabolites of 1-nitropyrene formed by rat liver. Cancer Res. 1983 Jul; 43(7):3132-7. PMID: 6687833.
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    198. El-Bayoumy K, Sharma C, Louis YM, Reddy B, Hecht SS. The role of intestinal microflora in the metabolic reduction of 1-nitropyrene to 1-aminopyrene in conventional and germfree rats and in humans. Cancer Lett. 1983 Jul; 19(3):311-6. PMID: 6688375.
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    199. Nussbaum M, Fiala ES, Kulkarni B, El-Bayoumy K, Weisburger JH. In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat. Environ Health Perspect. 1983 Mar; 49:223-31. PMID: 6682032; PMCID: PMC1569144.
    200. El-Bayoumy K, Hecht SS, Hoffmann D. Comparative tumor initiating activity on mouse skin of 6-nitrobenzo[a]pyrene, 6-nitrochrysene, 3-nitroperylene, 1-nitropyrene and their parent hydrocarbons. Cancer Lett. 1982 Sep; 16(3):333-7. PMID: 6295624.
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    201. Hecht SS, El-Bayoumy K, Rivenson A, Fiala E. Comparative carcinogenicity of o-toluidine hydrochloride and o-nitrosotoluene in F-344 rats. Cancer Lett. 1982 May-Jun; 16(1):103-8. PMID: 7116337.
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    202. EL-Bayoumy K, Hecht SS. Identification of mutagenic metabolites formed by C-hydroxylation and nitroreduction of 5-nitroacenaphthene in rat liver. Cancer Res. 1982 Apr; 42(4):1243-8. PMID: 7060001.
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    203. El-Bayoumy K, LaVoie EJ, Tulley-Freiler L, Hecht SS. Effects of ortho-methyl substituents on the mutagenicity of aminobiphenyls and aminonaphthalenes. Mutat Res. 1981 Dec; 90(4):345-54. PMID: 7038458.
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    204. El-Bayoumy K, Lavoie EJ, Hecht SS, Fow EA, Hoffmann D. The influence of methyl substitution of the mutagenicity of nitronaphthalenes and nitrobiphenyls. Mutat Res. 1981 Apr; 81(2):143-53. PMID: 7017386.
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    205. Hecht SS, El-Bayoumy K, Tulley L, LaVoie E. Structure-mutagenicity relationships of N-oxidized derivatives of aniline, o-toluidine, 2'-methyl-4-aminobiphenyl, and 3,2'-dimethyl-4-aminobiphenyl. J Med Chem. 1979 Aug; 22(8):981-7. PMID: 385878.
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