PSU Profiles
Last Name

Achuthamangalam Madhankumar

TitleAssistant Professor
InstitutionCollege of Medicine
Address500 University Drive Hershey PA 17033
Mailbox: H110
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    Assistant Professor of Neurosurgery


    Biomedical Sciences (BMS) program: Translational therapeutics option


    B.Sc. (Chemistry, Physics, Maths), Vivekananda College, Chennai,1989
    M.Sc. (Chemistry), University of Madras, 1991
    Ph.D. (Drug Delivery), Biomaterials Department- CSIR-CLRI (University of Madras), 1999

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Payne R, Mrowczynski OD, Slagle-Webb B, Bourcier A, Mau C, Aregawi D, Madhankumar AB, Lee SY, Harbaugh K, Connor J, Rizk EB. MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors. J Neurosurg. 2018 Feb 23; 1-11. PMID: 29473773.
      View in: PubMed
    2. Madhankumar AB, Mrowczynski OD, Slagle-Webb B, Ravi V, Bourcier AJ, Payne R, Harbaugh KS, Rizk E, Connor JR. Tumor targeted delivery of doxorubicin in malignant peripheral nerve sheath tumors. PLoS One. 2018; 13(1):e0181529. PMID: 29304038.
      View in: PubMed
    3. Madhankumar AB, Mrowczynski OD, Patel SR, Weston CL, Zacharia BE, Glantz MJ, Siedlecki CA, Xu LC, Connor JR. Interleukin-13 conjugated quantum dots for identification of glioma initiating cells and their extracellular vesicles. Acta Biomater. 2017 Aug; 58:205-213. PMID: 28583903.
      View in: PubMed
    4. Mrowczynski OD, Madhankumar AB, Slagle-Webb B, Lee SY, Zacharia BE, Connor JR. HFE genotype affects exosome phenotype in cancer. Biochim Biophys Acta. 2017 08; 1861(8):1921-1928. PMID: 28527894.
      View in: PubMed
    5. Liu X, Madhankumar AB, Miller PA, Duck KA, Hafenstein S, Rizk E, Slagle-Webb B, Sheehan JM, Connor JR, Yang QX. MRI contrast agent for targeting glioma: interleukin-13 labeled liposome encapsulating gadolinium-DTPA. Neuro Oncol. 2016 05; 18(5):691-9. PMID: 26519740; PMCID: PMC4827043 [Available on 05/01/17].
    6. Dellinger A, Zhou Z, Connor J, Madhankumar AB, Pamujula S, Sayes CM, Kepley CL. Application of fullerenes in nanomedicine: an update. Nanomedicine (Lond). 2013 Jul; 8(7):1191-208. PMID: 23837857.
      View in: PubMed
    7. Wiley NJ, Madhankumar AB, Michell RM, Neely EB, Rizk E, Douds GL, Simmons Z, Connor JR . Lipopolysaccharide Modified Liposomes for Amyotropic Lateral Sclerosis Therapy: Efficacy in SOD1 Mouse Model, Advances in Nanoparticles. 2012; 1(3):44-53.
    8. Liu X, Madhankumar AB, Slagle-Webb B, Sheehan JM, Surguladze N, Connor JR. Heavy chain ferritin siRNA delivered by cationic liposomes increases sensitivity of cancer cells to chemotherapeutic agents. Cancer Res. 2011 Mar 15; 71(6):2240-9. PMID: 21385903.
      View in: PubMed
    9. Madhankumar AB, Slagle-Webb B, Wang X, Yang QX, Antonetti DA, Miller PA, Sheehan JM, Connor JR. Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the intracranial brain tumor model. Mol Cancer Ther. 2009 Mar; 8(3):648-54. PMID: 19276162.
      View in: PubMed
    10. Mintz A, Gibo DM, Madhankumar AB, Cladel NM, Christensen ND, Debinski W. Protein- and DNA-based active immunotherapy targeting interleukin-13 receptor alpha2. Cancer Biother Radiopharm. 2008 Oct; 23(5):581-9. PMID: 18976118; PMCID: PMC2936944.
    11. Fisher J, Devraj K, Ingram J, Slagle-Webb B, Madhankumar AB, Liu X, Klinger M, Simpson IA, Connor JR. Ferritin: a novel mechanism for delivery of iron to the brain and other organs. Am J Physiol Cell Physiol. 2007 Aug; 293(2):C641-9. PMID: 17459943.
      View in: PubMed
    12. Madhankumar AB, Slagle-Webb B, Mintz A, Sheehan JM, Connor JR. Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme. Mol Cancer Ther. 2006 Dec; 5(12):3162-9. PMID: 17172420.
      View in: PubMed
    13. Madhankumar AB, Mintz A, Debinski W. Interleukin 13 mutants of enhanced avidity toward the glioma-associated receptor, IL13Ralpha2. Neoplasia. 2004 Jan-Feb; 6(1):15-22. PMID: 15068667; PMCID: PMC1508627.
    14. Mintz A, Gibo DM, Madhankumar AB, Debinski W. Molecular targeting with recombinant cytotoxins of interleukin-13 receptor alpha2-expressing glioma. J Neurooncol. 2003 Aug-Sep; 64(1-2):117-23. PMID: 12952292.
      View in: PubMed
    15. Madhankumar AB, Mintz A, Debinski W. Alanine-scanning mutagenesis of alpha-helix D segment of interleukin-13 reveals new functionally important residues of the cytokine. J Biol Chem. 2002 Nov 08; 277(45):43194-205. PMID: 12189139.
      View in: PubMed
    16. Madhan Kumar AB, Panduranga Rao K. Preparation and characterization of pH-sensitive proteinoid microspheres for the oral delivery of methotrexate. Biomaterials. 1998 Apr-May; 19(7-9):725-32. PMID: 9663746.
      View in: PubMed
    17. A.B. Madhan Kumar, K. Panduranga Rao. Poly(palmitoyl-l-hydroxyproline ester) microspheres as potential oral controlled drug delivery system. International Journal of Pharmaceutics. 1997; 149(1):107-114.
    18. A. B. Madhan Kumar, R. Jayakumar, K. Panduranga Rao. Synthesis and aggregational behavior of acidic proteinoid. Journal of Polymer Science A-Polymer Chemistry. 1996; 34(14):2915-2924.
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