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Last Name
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Kenneth Keiler

Title
InstitutionEberly College of Science
DepartmentBiochemistry and Molecular Biology
Address401 Althouse Lab
University Park, PA 16802
Phone8148630787
Other Positions
InstitutionHuck Institutes of the Life Sciences


 Overview 
 overview
PREFERRED TITLE/ROLE:

Associate Professor of Biochemistry and Molecular Biology

GRADUATE PROGRAM AFFILIATIONS:

Cell and Developmental Biology, Genetics

NARRATIVE:

Dr Keiler's research focuses on understanding how proteins are selectively produced at the right time and in the right place to execute complex biological processes such as cell cycle progression and cellular differentiation. In particular, his lab is studying how protein translation and degradation are regulated by the tmRNA protein-tagging system, and how proteins are localized within the bacterial cell. They are also exploiting what they have learned about these fundamental processes to develop reagents that control bacterial development and proliferation, to be used for novel antibiotics and for basic scientific research.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Alumasa JN, Keiler KC. Clicking on trans-translation drug targets. Front Microbiol. 2015; 6:498.
    View in: PubMed
  2. Keiler KC. Mechanisms of ribosome rescue in bacteria. Nat Rev Microbiol. 2015 May; 13(5):285-97.
    View in: PubMed
  3. Feaga HA, Viollier PH, Keiler KC. Release of nonstop ribosomes is essential. MBio. 2014; 5(6).
    View in: PubMed
  4. El-Mowafi SA, Sineva E, Alumasa JN, Nicoloff H, Tomsho JW, Ades SE, Keiler KC. Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay. Antimicrob Agents Chemother. 2015 Jan; 59(1):193-205.
    View in: PubMed
  5. El-Mowafi SA, Alumasa JN, Ades SE, Keiler KC. Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway. Antimicrob Agents Chemother. 2014 Sep; 58(9):5500-9.
    View in: PubMed
  6. Keiler KC, Feaga HA. Resolving nonstop translation complexes is a matter of life or death. J Bacteriol. 2014 Jun; 196(12):2123-30.
    View in: PubMed
  7. Keiler KC, Alumasa JN. The potential of trans-translation inhibitors as antibiotics. Future Microbiol. 2013 Oct; 8(10):1235-7.
    View in: PubMed
  8. Ramadoss NS, Alumasa JN, Cheng L, Wang Y, Li S, Chambers BS, Chang H, Chatterjee AK, Brinker A, Engels IH, Keiler KC. Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):10282-7.
    View in: PubMed
  9. Ramadoss NS, Zhou X, Keiler KC. tmRNA is essential in Shigella flexneri. PLoS One. 2013; 8(2):e57537.
    View in: PubMed
  10. McGillivray SM, Tran DN, Ramadoss NS, Alumasa JN, Okumura CY, Sakoulas G, Vaughn MM, Zhang DX, Keiler KC, Nizet V. Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics. Antimicrob Agents Chemother. 2012 Apr; 56(4):1854-61.
    View in: PubMed
  11. Russell JH, Keiler KC. RNA visualization in bacteria by fluorescence in situ hybridization. Methods Mol Biol. 2012; 905:87-95.
    View in: PubMed
  12. Keiler KC, Ramadoss NS. Bifunctional transfer-messenger RNA. Biochimie. 2011 Nov; 93(11):1993-7.
    View in: PubMed
  13. Keiler KC. RNA localization in bacteria. Curr Opin Microbiol. 2011 Apr; 14(2):155-9.
    View in: PubMed
  14. Keiler KC. Localization of the bacterial RNA infrastructure. Adv Exp Med Biol. 2011; 722:231-8.
    View in: PubMed
  15. Hughes HV, Huitema E, Pritchard S, Keiler KC, Brun YV, Viollier PH. Protein localization and dynamics within a bacterial organelle. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5599-604.
    View in: PubMed
  16. Hayes CS, Keiler KC. Beyond ribosome rescue: tmRNA and co-translational processes. FEBS Lett. 2010 Jan 21; 584(2):413-9.
    View in: PubMed
  17. Russell JH, Keiler KC. Subcellular localization of a bacterial regulatory RNA. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16405-9.
    View in: PubMed
  18. Cheng L, Keiler KC. Correct timing of dnaA transcription and initiation of DNA replication requires trans translation. J Bacteriol. 2009 Jul; 191(13):4268-75.
    View in: PubMed
  19. Russell JH, Keiler KC. Screen for localized proteins in Caulobacter crescentus. PLoS One. 2008; 3(3):e1756.
    View in: PubMed
  20. Keiler KC. Biology of trans-translation. Annu Rev Microbiol. 2008; 62:133-51.
    View in: PubMed
  21. Hong SJ, Lessner FH, Mahen EM, Keiler KC. Proteomic identification of tmRNA substrates. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17128-33.
    View in: PubMed
  22. Russell JH, Keiler KC. Peptide signals encode protein localization. J Bacteriol. 2007 Nov; 189(21):7581-5.
    View in: PubMed
  23. Cheng L, Naumann TA, Horswill AR, Hong SJ, Venters BJ, Tomsho JW, Benkovic SJ, Keiler KC. Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Sci. 2007 Aug; 16(8):1535-42.
    View in: PubMed
  24. Keiler KC. Physiology of tmRNA: what gets tagged and why? Curr Opin Microbiol. 2007 Apr; 10(2):169-75.
    View in: PubMed
  25. Lessner FH, Venters BJ, Keiler KC. Proteolytic adaptor for transfer-messenger RNA-tagged proteins from alpha-proteobacteria. J Bacteriol. 2007 Jan; 189(1):272-5.
    View in: PubMed
  26. Hong SJ, Tran QA, Keiler KC. Cell cycle-regulated degradation of tmRNA is controlled by RNase R and SmpB. Mol Microbiol. 2005 Jul; 57(2):565-75.
    View in: PubMed
  27. Keiler KC, Shapiro L. tmRNA in Caulobacter crescentus is cell cycle regulated by temporally controlled transcription and RNA degradation. J Bacteriol. 2003 Mar; 185(6):1825-30.
    View in: PubMed
  28. Keiler KC, Shapiro L. TmRNA is required for correct timing of DNA replication in Caulobacter crescentus. J Bacteriol. 2003 Jan; 185(2):573-80.
    View in: PubMed
  29. Keiler KC, Shapiro L. Conserved promoter motif is required for cell cycle timing of dnaX transcription in Caulobacter. J Bacteriol. 2001 Aug; 183(16):4860-5.
    View in: PubMed
  30. Keiler KC, Shapiro L, Williams KP. tmRNAs that encode proteolysis-inducing tags are found in all known bacterial genomes: A two-piece tmRNA functions in Caulobacter. Proc Natl Acad Sci U S A. 2000 Jul 5; 97(14):7778-83.
    View in: PubMed
  31. Keiler KC, Waller PR, Sauer RT. Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA. Science. 1996 Feb 16; 271(5251):990-3.
    View in: PubMed
  32. Keiler KC, Sauer RT. Sequence determinants of C-terminal substrate recognition by the Tsp protease. J Biol Chem. 1996 Feb 2; 271(5):2589-93.
    View in: PubMed
  33. Keiler KC, Sauer RT. Identification of active site residues of the Tsp protease. J Biol Chem. 1995 Dec 1; 270(48):28864-8.
    View in: PubMed
  34. Keiler KC, Silber KR, Downard KM, Papayannopoulos IA, Biemann K, Sauer RT. C-terminal specific protein degradation: activity and substrate specificity of the Tsp protease. Protein Sci. 1995 Aug; 4(8):1507-15.
    View in: PubMed
  35. Silber KR, Keiler KC, Sauer RT. Tsp: a tail-specific protease that selectively degrades proteins with nonpolar C termini. Proc Natl Acad Sci U S A. 1992 Jan 1; 89(1):295-9.
    View in: PubMed
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