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Javad Towfighi

TitleProfessor Emeritus
InstitutionCollege of Medicine
DepartmentPathology
Address500 University Drive Hershey PA 17033
Mailbox: H179
Phone7175318246
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    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Professor Emeritus of Pathology

    EDUCATION:

    M.D., Teheran University Medical School, 1962
    Internship, Methodist Hospital
    Residency, Saint Joseph Hospital
    Residency, Hahnemann University Hospital
    Residency, Hospital of the University of Pennsylvania
    Fellowship, Hospital of the University of Pennsylvania


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sundaram AN, Simmons Z, Towfighi J, Sheehan J, Reichwein R. Contralateral cranial polyneuropathy due to perineural invasion by a cutaneous squamous cell carcinoma. J Clin Neuromuscul Dis. 2010 Mar; 11(3):132-6. PMID: 20215987.
      View in: PubMed
    2. Towfighi J, Sheehan J, Isaacson J. Facial nerve neuroma associated with hemangioma of the geniculate ganglion: case report and review of the literature. J Otolaryngol Head Neck Surg. 2008 Oct; 37(5):E148-50. PMID: 19128660.
      View in: PubMed
    3. Ondik MP, Preston T, Towfighi J, Isaacson JE. Unilateral congenital facial nerve paralysis secondary to a benign epithelioid peripheral nerve sheath tumor. Otol Neurotol. 2007 Dec; 28(8):1091-3. PMID: 18084823.
      View in: PubMed
    4. Harbaugh K, Smith P, Towfighi J. Schwannomatosis in a patient with a pelvic mass: case report. Neurosurg Focus. 2007 Jun 15; 22(6):E8. PMID: 17613225.
      View in: PubMed
    5. Le BH, Towfighi J, Kapadia SB, Lopes MB. Comparative immunohistochemical assessment of craniopharyngioma and related lesions. Endocr Pathol. 2007; 18(1):23-30. PMID: 17652797.
      View in: PubMed
    6. Fisher J, Towfighi J, Darvish D, Simmons Z. A case of hereditary inclusion body myopathy: 1 patient, 2 novel mutations. J Clin Neuromuscul Dis. 2006 Jun; 7(4):179-84. PMID: 19078806.
      View in: PubMed
    7. Garg S, Wright A, Reichwein R, Boyer P, Towfighi J, Kothari MJ. Mononeuritis multiplex secondary to sarcoidosis. Clin Neurol Neurosurg. 2005 Feb; 107(2):140-3. PMID: 15708231.
      View in: PubMed
    8. Vannucci RC, Towfighi J, Vannucci SJ. Secondary energy failure after cerebral hypoxia-ischemia in the immature rat. J Cereb Blood Flow Metab. 2004 Oct; 24(10):1090-7. PMID: 15529009.
      View in: PubMed
    9. Towfighi J, Housman C, Brucklacher R, Vannucci RC. Neuropathology of seizures in the immature rabbit. Brain Res Dev Brain Res. 2004 Sep 17; 152(2):143-52. PMID: 15351502.
      View in: PubMed
    10. Ehrmantant WR, Graham WP, Towfighi J, Mackay DR, Ehrlich HP. A histological and anatomical profile of pacinian corpuscles from Dupuytren's contracture and the expression of nerve growth factor receptor. Plast Reconstr Surg. 2004 Sep 01; 114(3):721-7. PMID: 15318052.
      View in: PubMed
    11. Simmons Z, Peterlin BL, Boyer PJ, Towfighi J. Muscle biopsy in the evaluation of patients with modestly elevated creatine kinase levels. Muscle Nerve. 2003 Feb; 27(2):242-4. PMID: 12548533.
      View in: PubMed
    12. Simmons Z, Towfighi J. Sporadic inclusion body myositis and hereditary inclusion body myopathy. J Clin Neuromuscul Dis. 2002 Mar; 3(3):122-32. PMID: 19078666.
      View in: PubMed
    13. Vannucci RC, Towfighi J, Brucklacher RM, Vannucci SJ. Effect of extreme hypercapnia on hypoxic-ischemic brain damage in the immature rat. Pediatr Res. 2001 Jun; 49(6):799-803. PMID: 11385141.
      View in: PubMed
    14. Krishnamurthy S, Powers SK, Towfighi J. Primitive neuroectodermal tumor of cerebrum with adipose tissue. Arch Pathol Lab Med. 2001 Feb; 125(2):264-6. PMID: 11175648.
      View in: PubMed
    15. Vannucci SJ, Willing LB, Goto S, Alkayed NJ, Brucklacher RM, Wood TL, Towfighi J, Hurn PD, Simpson IA. Experimental stroke in the female diabetic, db/db, mouse. J Cereb Blood Flow Metab. 2001 Jan; 21(1):52-60. PMID: 11149668.
      View in: PubMed
    16. Towfighi J, Housman C, Mauger D, Vannucci RC. Effect of seizures on cerebral hypoxic-ischemic lesions in immature rats. Brain Res Dev Brain Res. 1999 Mar 12; 113(1-2):83-95. PMID: 10064878.
      View in: PubMed
    17. Vannucci RC, Towfighi J. Experimental models of hypothermic circulatory arrest. Semin Pediatr Neurol. 1999 Mar; 6(1):48-54. PMID: 10098229.
      View in: PubMed
    18. Vannucci RC, Connor JR, Mauger DT, Palmer C, Smith MB, Towfighi J, Vannucci SJ. Rat model of perinatal hypoxic-ischemic brain damage. J Neurosci Res. 1999 Jan 15; 55(2):158-63. PMID: 9972818.
      View in: PubMed
    19. Simmons Z, Mahadeen ZI, Kothari MJ, Powers S, Wise S, Towfighi J. Localized hypertrophic neuropathy: magnetic resonance imaging findings and long-term follow-up. Muscle Nerve. 1999 Jan; 22(1):28-36. PMID: 9883854.
      View in: PubMed
    20. Vannucci RC, Towfighi J, Vannucci SJ. Hypoxic preconditioning and hypoxic-ischemic brain damage in the immature rat: pathologic and metabolic correlates. J Neurochem. 1998 Sep; 71(3):1215-20. PMID: 9721747.
      View in: PubMed
    21. Towfighi J, Mauger D. Temporal evolution of neuronal changes in cerebral hypoxia-ischemia in developing rats: a quantitative light microscopic study. Brain Res Dev Brain Res. 1998 Aug 08; 109(2):169-77. PMID: 9729365.
      View in: PubMed
    22. Towfighi J, Mauger D, Vannucci RC, Vannucci SJ. Influence of age on the cerebral lesions in an immature rat model of cerebral hypoxia-ischemia: a light microscopic study. Brain Res Dev Brain Res. 1997 Jun 18; 100(2):149-60. PMID: 9205806.
      View in: PubMed
    23. Towfighi J, Vannucci RC. Neuropathology of normothermic circulatory arrest in newborn dogs. Acta Neuropathol. 1997 May; 93(5):485-93. PMID: 9144587.
      View in: PubMed
    24. Hudome S, Palmer C, Roberts RL, Mauger D, Housman C, Towfighi J. The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat. Pediatr Res. 1997 May; 41(5):607-16. PMID: 9128280.
      View in: PubMed
    25. Vannucci RC, Rossini A, Towfighi J, Vannucci SJ. Measuring the accentuation of the brain damage that arises from perinatal cerebral hypoxia-ischemia. Biol Neonate. 1997; 72(3):187-91. PMID: 9303218.
      View in: PubMed
    26. Vannucci RC, Rossini A, Towfighi J. Effect of hyperglycemia on ischemic brain damage during hypothermic circulatory arrest in newborn dogs. Pediatr Res. 1996 Aug; 40(2):177-84. PMID: 8827764.
      View in: PubMed
    27. Towfighi J, Salam MM, McLendon RE, Powers S, Page RB. Ganglion cell-containing tumors of the pituitary gland. Arch Pathol Lab Med. 1996 Apr; 120(4):369-77. PMID: 8619749.
      View in: PubMed
    28. Cataltepe O, Towfighi J, Vannucci RC. Cerebrospinal fluid concentrations of glutamate and GABA during perinatal cerebral hypoxia-ischemia and seizures. Brain Res. 1996 Feb 19; 709(2):326-30. PMID: 8833771.
      View in: PubMed
    29. Cataltepe O, Vannucci RC, Heitjan DF, Towfighi J. Effect of status epilepticus on hypoxic-ischemic brain damage in the immature rat. Pediatr Res. 1995 Aug; 38(2):251-7. PMID: 7478824.
      View in: PubMed
    30. Cataltepe O, Barron TF, Heitjan DF, Vannucci RC, Towfighi J. Effect of hypoxia/ischemia on bicuculline-induced seizures in immature rats: behavioral and electrocortical phenomena. Epilepsia. 1995 Apr; 36(4):396-403. PMID: 7607119.
      View in: PubMed
    31. Towfighi J, Zec N, Yager J, Housman C, Vannucci RC. Temporal evolution of neuropathologic changes in an immature rat model of cerebral hypoxia: a light microscopic study. Acta Neuropathol. 1995; 90(4):375-86. PMID: 8546028.
      View in: PubMed
    32. Mujsce DJ, Towfighi J, Heitjan DF, Vannucci RC. Differences in intraischemic temperature influence neurological outcome after deep hypothermic circulatory arrest in newborn dogs. Stroke. 1994 Jul; 25(7):1433-41; discussion 1442. PMID: 8023360.
      View in: PubMed
    33. Williams GD, Towfighi J, Smith MB. Cerebral energy metabolism during hypoxia-ischemia correlates with brain damage: a 31P NMR study in unanesthetized immature rats. Neurosci Lett. 1994 Mar 28; 170(1):31-4. PMID: 8041508.
      View in: PubMed
    34. Towfighi J, Housman C, Vannucci RC, Heitjan DF. Effect of unilateral perinatal hypoxic-ischemic brain damage on the gross development of opposite cerebral hemisphere. Biol Neonate. 1994; 65(2):108-18. PMID: 8173008.
      View in: PubMed
    35. Selassie L, Rigotti R, Kepes JJ, Towfighi J. Adipose tissue and smooth muscle in a primitive neuroectodermal tumor of cerebrum. Acta Neuropathol. 1994; 87(2):217-22. PMID: 8171973.
      View in: PubMed
    36. Towfighi J, Housman C, Heitjan DF, Vannucci RC, Yager JY. The effect of focal cerebral cooling on perinatal hypoxic-ischemic brain damage. Acta Neuropathol. 1994; 87(6):598-604. PMID: 8091953.
      View in: PubMed
    37. Kofke WA, Towfighi J, Garman RH, Graybeal JM, Housman C, Hawkins RA. Effect of anesthetics on neuropathologic sequelae of status epilepticus in rats. Anesth Analg. 1993 Aug; 77(2):330-7. PMID: 8346834.
      View in: PubMed
    38. Ahmed SR, Aiello DP, Page R, Hopper K, Towfighi J, Santen RJ. Necrotizing infundibulo-hypophysitis: a unique syndrome of diabetes insipidus and hypopituitarism. J Clin Endocrinol Metab. 1993 Jun; 76(6):1499-504. PMID: 8501157.
      View in: PubMed
    39. Palmer C, Towfighi J, Roberts RL, Heitjan DF. Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats. Pediatr Res. 1993 Apr; 33(4 Pt 1):405-11. PMID: 8479823.
      View in: PubMed
    40. Mujsce DJ, Towfighi J, Yager JY, Vannucci RC. Neuropathologic aspects of hypothermic circulatory arrest in newborn dogs. Acta Neuropathol. 1993; 85(2):190-8. PMID: 8442410.
      View in: PubMed
    41. Sponsler TA, Sassani JW, Johnson LN, Towfighi J. Ocular invasion in mucormycosis. Surv Ophthalmol. 1992 Mar-Apr; 36(5):345-50. PMID: 1566236.
      View in: PubMed
    42. Yager JY, Heitjan DF, Towfighi J, Vannucci RC. Effect of insulin-induced and fasting hypoglycemia on perinatal hypoxic-ischemic brain damage. Pediatr Res. 1992 Feb; 31(2):138-42. PMID: 1542541.
      View in: PubMed
    43. Miller G, Beggs AH, Towfighi J. Early onset autosomal dominant progressive muscular dystrophy presenting in childhood as a Becker phenotype--the importance of dystrophin and molecular genetic analysis. Neuromuscul Disord. 1992; 2(2):121-4. PMID: 1422199.
      View in: PubMed
    44. Galloway G, Fedok FG, Wiegand DA, Towfighi J. Sternohyoid muscle biopsy. A diagnostic technique in respiratory failure of neuromuscular origin. Chest. 1991 Aug; 100(2):540-3. PMID: 1713819.
      View in: PubMed
    45. Zec N, Cera P, Towfighi J. Extramedullary hematopoiesis in cerebellar hemangioblastoma. Neurosurgery. 1991 Jul; 29(1):34-7. PMID: 1870685.
      View in: PubMed
    46. Mamourian AC, Lewandowski AE, Towfighi J. Cystic intraparenchymal meningioma in a child: case report. AJNR Am J Neuroradiol. 1991 Mar-Apr; 12(2):366-7. PMID: 1902046.
      View in: PubMed
    47. Miller G, Ladda RL, Towfighi J. Cerebro-ocular dysplasia--muscular dystrophy (Walker Warburg) syndrome. Findings in 20-week-old fetus. Acta Neuropathol. 1991; 82(3):234-8. PMID: 1927281.
      View in: PubMed
    48. Towfighi J, Housman C. Spinal cord abnormalities in caudal regression syndrome. Acta Neuropathol. 1991; 81(4):458-66. PMID: 2028749.
      View in: PubMed
    49. Towfighi J, Yager JY, Housman C, Vannucci RC. Neuropathology of remote hypoxic-ischemic damage in the immature rat. Acta Neuropathol. 1991; 81(5):578-87. PMID: 1858486.
      View in: PubMed
    50. Ramer JC, Mowrey PN, Robins DB, Ligato S, Towfighi J, Ladda RL. Five children with del (2)(q31q33) and one individual with dup (2)(q31q33) from a single family: review of brain, cardiac, and limb malformations. Am J Med Genet. 1990 Nov; 37(3):392-400. PMID: 2260571.
      View in: PubMed
    51. Miller G, Towfighi J, Page RB. Spinal cord ganglioglioma presenting as hydrocephalus. J Neurooncol. 1990 Oct; 9(2):147-52. PMID: 2262799.
      View in: PubMed
    52. Mujsce DJ, Towfighi J, Vannucci RC. Physiologic and neuropathologic aspects of hypothermic circulatory arrest in newborn dogs. Pediatr Res. 1990 Oct; 28(4):354-60. PMID: 2172901.
      View in: PubMed
    53. Mujsce DJ, Towfighi J, Stern D, Vannucci RC. Mannitol therapy in perinatal hypoxic-ischemic brain damage in rats. Stroke. 1990 Aug; 21(8):1210-4. PMID: 2117785.
      View in: PubMed
    54. Palmer C, Vannucci RC, Towfighi J. Reduction of perinatal hypoxic-ischemic brain damage with allopurinol. Pediatr Res. 1990 Apr; 27(4 Pt 1):332-6. PMID: 2342827.
      View in: PubMed
    55. Sees JN, Towfighi J, Robins DB, Ladda RL. "Marden-Walker syndrome": neuropathologic findings in two siblings. Pediatr Pathol. 1990; 10(5):807-18. PMID: 2235765.
      View in: PubMed
    56. Towfighi J, Yoss BS, Wasiewski WW, Vannucci RC, Bentz MS, Mamourian A. Cerebral glycogenosis, alpha particle type: morphologic and biochemical observations in an infant. Hum Pathol. 1989 Dec; 20(12):1210-5. PMID: 2591952.
      View in: PubMed
    57. Towfighi J, Roberts AF, Foster NE, Abt AB. A protective device for performing cranial autopsies. Hum Pathol. 1989 Mar; 20(3):288-9. PMID: 2722177.
      View in: PubMed
    58. Towfighi J, Kofke WA, O'Connell BK, Housman C, Graybeal JM. Substantia nigra lesions in mercaptopropionic acid induced status epilepticus: a light and electron microscopic study. Acta Neuropathol. 1989; 77(6):612-20. PMID: 2750479.
      View in: PubMed
    59. Geder L, Metz KR, Towfighi J, Mikus JL, Williams GD, Gaydos AJ, Kreider JW. Effect of dimethylsulfoxide on human gliomas: correlations between the nuclear magnetic resonance spectra and the transformed phenotypes of the tumor cells. Neurofibromatosis. 1989; 2(1):23-34. PMID: 2629878.
      View in: PubMed
    60. Pearlman RL, Towfighi J, Pezeshkpour GH, Tenser RB, Turel AP. Clinical significance of types of cerebellar amyloid plaques in human spongiform encephalopathies. Neurology. 1988 Aug; 38(8):1249-54. PMID: 3041312.
      View in: PubMed
    61. Mamourian AC, Rhodes RE, Duda JJ, Towfighi J, White WS, Page RB, Cunningham DE, Lehman RA. MR-directed brain biopsy: feasibility study. AJNR Am J Neuroradiol. 1988 May-Jun; 9(3):510-2. PMID: 3132823.
      View in: PubMed
    62. O'Connell BK, Towfighi J, Kofke WA, Hawkins RA. Neuronal lesions in mercaptopropionic acid-induced status epilepticus. Acta Neuropathol. 1988; 77(1):47-54. PMID: 3239375.
      View in: PubMed
    63. Strauss M, Towfighi J. Modiolar microexostoses with neural impingement and hearing loss in guinea pigs. Am J Otolaryngol. 1987 Nov-Dec; 8(6):381-6. PMID: 3434676.
      View in: PubMed
    64. Geder L, Kreider JW, Towfighi J, Page RB, Ladda RL, Brennan RW, Rapp F. Effect of differentiation inducers on growth characteristics of human glioma cell lines. J Neurooncol. 1987; 5(3):251-71. PMID: 3681388.
      View in: PubMed
    65. Thompson CI, Bergland RM, Towfighi JT. Social and nonsocial behaviors of adult rhesus monkeys after amygdalectomy in infancy or adulthood. J Comp Physiol Psychol. 1977 Jun; 91(3):533-48. PMID: 406291.
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