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Jianxun Song

TitleAssociate Professor
InstitutionCollege of Medicine
DepartmentMicrobiology and Immunology
Address500 University Drive Hershey PA 17033
Mailbox: H107
Phone7175310003
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    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Associate Professor of Microbiology and Immunology

    GRADUATE PROGRAM AFFILIATIONS:

    Microbiology and Immunology, Cell and Molecular Biology, Biomedical Science

    EDUCATION:

    Ph.D., Third Military Medical University, China
    Postdoctoral Training, La Jolla Institute for Allergy and Immunology, San Diego, CA

    NARRATIVE:

    Costimulation in T lymphocyte memory
    Costimulatory signals expressed by professional antigen presenting cells (APCs) are capable of promoting the formation of highly active effector T cells, which are able to develop into memory populations. However, the mechanisms by which constimlation regulates T lymphocyte memory remain uncertain. Several molecular targets of costimulation (e.g., aurora B, survivin, bcl-xL, PKB) have been identified to sustain T cell proliferation or survival, and their cooperation in promoting T cell persistence as well as tumor regression is being investigated. Findings related to this project will provide new insights into why costimulatory signals might need to be sustained over time and suggest a potential novel approach to augment cellular immunotherapy for cancer.

    Immune cell differentiation from induced pluripotent stem cells
    Most effort is being expended to generate and characterize highly reactive immune cells from induced pluripotent stem (iPS) cells. Because of the plasticity and potentially unlimited capacity for self-renewal, iPS cell-derived immune cells have great potential in the treatment of disease (e.g., cancer, autoimmune disease, infectious disease, aging-related disease). Highly reactive antigen-specific T cells can be generated by genetic modification of iPS cells with specific T cell receptor and costimulation and stimulation with in vitro Notch signaling, and their therapeutic potential in the treatments of cancer and autoimmune disease is being determined. Findings related to this project will contribute important information in the areas of vaccine design, autoimmune therapy, and immune-based anti-cancer strategies.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lei F, Haque M, Sandhu P, Ravi S, Song J, Ni B, Zheng S, Fang D, Jia H, Yang JM, Song J. Development and characterization of naive single-type tumor antigen-specific CD8+ T lymphocytes from murine pluripotent stem cells. Oncoimmunology. 2017; 6(7):e1334027. PMID: 28811978.
      View in: PubMed
    2. Sandhu P, Haque M, Humphries-Bickley T, Ravi S, Song J. Hepatitis B Virus Immunopathology, Model Systems, and Current Therapies. Front Immunol. 2017; 8:436. PMID: 28450868.
      View in: PubMed
    3. Haque R, Song J, Haque M, Lei F, Sandhu P, Ni B, Zheng S, Fang D, Yang JM, Song J. c-Myc-Induced Survivin Is Essential for Promoting  the Notch-Dependent T Cell Differentiation from  Hematopoietic Stem Cells. Genes (Basel). 2017 Mar 06; 8(3). PMID: 28272325.
      View in: PubMed
    4. Haque M, Fino K, Sandhu P, Song J. Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity. J Vis Exp. 2016 Nov 08; (117). PMID: 27911371.
      View in: PubMed
    5. Song J. Development of Auto Antigen-specific Regulatory T Cells for Diabetes Immunotherapy. Immune Netw. 2016 Oct; 16(5):281-285. PMID: 27799873.
      View in: PubMed
    6. Song J. Stem Cell-Derived Regulatory T Cells for Therapeutic Use in Arthritis. Autoimmune Infect Dis. 2016 06; 2(3). PMID: 28042612.
      View in: PubMed
    7. Haque M, Song J, Fino K, Sandhu P, Song X, Lei F, Zheng S, Ni B, Fang D, Song J. Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity. Sci Rep. 2016 Feb 05; 6:20588. PMID: 26846186; PMCID: PMC4742827.
    8. Haque M, Song J, Fino K, Sandhu P, Wang Y, Ni B, Fang D, Song J. Melanoma Immunotherapy in Mice Using Genetically Engineered Pluripotent Stem Cells. Cell Transplant. 2016; 25(5):811-27. PMID: 26777320.
      View in: PubMed
    9. Haque M, Song J, Fino K, Wang Y, Sandhu P, Song X, Norbury C, Ni B, Fang D, Salek-Ardakani S, Song J. C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection. Open Biol. 2016 Jan; 6(1):150208. PMID: 26791245; PMCID: PMC4736826.
    10. Kong S, Dong H, Song J, Thiruppathi M, Prabhakar BS, Qiu Q, Lin Z, Chini E, Zhang B, Fang D. Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKa Phosphorylation. J Immunol. 2015 Oct 15; 195(8):3685-93. PMID: 26378077; PMCID: PMC4642440 [Available on 10/15/16].
    11. Haque M, Fino K, Lei F, Xiong X, Song J. Utilizing regulatory T cells against rheumatoid arthritis. Front Oncol. 2014; 4:209. PMID: 25152867; PMCID: PMC4125784.
    12. Lei F, Haque R, Xiong X, Song J. Modulation of autoimmune diseases by iPS cells. Methods Mol Biol. 2014; 1213:365-77. PMID: 25173398.
      View in: PubMed
    13. Lei F, Song J, Haque R, Haque M, Xiong X, Fang D, Croft M, Song J. Regulation of A1 by OX40 contributes to CD8(+) T cell survival and anti-tumor activity. PLoS One. 2013; 8(8):e70635. PMID: 23936461; PMCID: PMC3731243.
    14. Lei F, Song J, Haque R, Xiong X, Fang D, Wu Y, Lens SM, Croft M, Song J. Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation. Eur J Immunol. 2013 Jul; 43(7):1914-24. PMID: 23616302; PMCID: PMC3876962.
    15. Haque R, Lei F, Xiong X, Bian Y, Zhao B, Wu Y, Song J. Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity. J Immunol. 2012 Aug 01; 189(3):1228-36. PMID: 22732595; PMCID: PMC3401327.
    16. Lei F, Haque R, Xiong X, Song J. Directed differentiation of induced pluripotent stem cells towards T lymphocytes. J Vis Exp. 2012 May 14; (63):e3986. PMID: 22617911; PMCID: PMC3389997.
    17. Haque R, Lei F, Xiong X, Song J. The regulation of FoxP3-expressing regulatory T cells. Endocr Metab Immune Disord Drug Targets. 2011 Dec; 11(4):334-46. PMID: 21696363.
      View in: PubMed
    18. Lei F, Zhao B, Haque R, Xiong X, Budgeon L, Christensen ND, Wu Y, Song J. In vivo programming of tumor antigen-specific T lymphocytes from pluripotent stem cells to promote cancer immunosurveillance. Cancer Res. 2011 Jul 15; 71(14):4742-7. PMID: 21628492.
      View in: PubMed
    19. Haque R, Lei F, Xiong X, Wu Y, Song J. FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development. Arthritis Res Ther. 2010; 12(2):R66. PMID: 20384988; PMCID: PMC2888221.
    20. Lei F, Haque R, Weiler L, Vrana KE, Song J. T lineage differentiation from induced pluripotent stem cells. Cell Immunol. 2009; 260(1):1-5. PMID: 19811778.
      View in: PubMed
    21. Zhao B, Song A, Haque R, Lei F, Weiler L, Xiong X, Wu Y, Croft M, Song J. Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression. J Immunol. 2009 Jun 01; 182(11):6744-52. PMID: 19454669; PMCID: PMC2748393.
    22. Song J, Lei FT, Xiong X, Haque R. Intracellular signals of T cell costimulation. Cell Mol Immunol. 2008 Aug; 5(4):239-47. PMID: 18761811; PMCID: PMC4651295.
    23. Song J, So T, Croft M. Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival. J Immunol. 2008 Jun 01; 180(11):7240-8. PMID: 18490723; PMCID: PMC2410213.
    24. Song J, Salek-Ardakani S, So T, Croft M. The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat Immunol. 2007 Jan; 8(1):64-73. PMID: 17128276.
      View in: PubMed
    25. So T, Song J, Sugie K, Altman A, Croft M. Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3740-5. PMID: 16501042; PMCID: PMC1450148.
    26. Song J, So T, Cheng M, Tang X, Croft M. Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity. 2005 May; 22(5):621-31. PMID: 15894279.
      View in: PubMed
    27. Song J, Salek-Ardakani S, Rogers PR, Cheng M, Van Parijs L, Croft M. The costimulation-regulated duration of PKB activation controls T cell longevity. Nat Immunol. 2004 Feb; 5(2):150-8. PMID: 14730361.
      View in: PubMed
    28. Salek-Ardakani S, Song J, Halteman BS, Jember AG, Akiba H, Yagita H, Croft M. OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation. J Exp Med. 2003 Jul 21; 198(2):315-24. PMID: 12860930; PMCID: PMC2194076.
    29. Rogers PR, Song J, Gramaglia I, Killeen N, Croft M. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity. 2001 Sep; 15(3):445-55. PMID: 11567634.
      View in: PubMed
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