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Jack Vanden Heuvel

Title
InstitutionCollege of Agricultural Sciences
DepartmentVeterinary and Biomedical Sciences
Address325 Life Sciences Bldg
University Park, PA 16802
Phone8148638532
Other Positions
InstitutionHuck Institutes of the Life Sciences


 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Molecular Toxicology

GRADUATE PROGRAM AFFILIATIONS:

Bioinformatics and Genomics, Molecular Medicine, Molecular Toxicology

EDUCATION:

B.S., Pharmacology and Toxicology, University of Wisconsin (1986)
Ph.D., Environmental Toxicology, University of Wisconsin (1991)
Postdoctoral training in molecular toxicology, National Institute of Environmental Health Sciences (1991-1993)

NARRATIVE:

Dr. Vanden Heuvel's research focuses on the emerging disciplines of molecular toxicology and nutrigenomics. He is interested in nuclear receptors (NR), such as the peroxisome proliferator-activated receptors (PPARs), that play important roles in both toxicology and nutrition. In particular, the peroxisome proliferator-activated receptors (PPARs; PPARa, ß/d and ?) are of interest as they serve key roles in toxicology, carcinogenesis and nutrition. Dr. Vanden Heuvel studies the ligands of these receptors, the genes they affect, and the physiological consequences of their activation.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Belda BJ, Thompson JT, Sinha R, Prabhu KS, Vanden Heuvel JP. The dietary fatty acid 10E12Z-CLA induces epiregulin expression through COX-2 dependent PGF(2a) synthesis in adipocytes. Prostaglandins Other Lipid Mediat. 2012 Oct; 99(1-2):30-7.
    View in: PubMed
  2. Gillies PJ, Bhatia SK, Belcher LA, Hannon DB, Thompson JT, Vanden Heuvel JP. Regulation of inflammatory and lipid metabolism genes by eicosapentaenoic acid-rich oil. J Lipid Res. 2012 Aug; 53(8):1679-89.
    View in: PubMed
  3. Vanden Heuvel JP. Nutrigenomics and nutrigenetics of ?3 polyunsaturated fatty acids. Prog Mol Biol Transl Sci. 2012; 108:75-112.
    View in: PubMed
  4. Roussell MA, Hill AM, Gaugler TL, West SG, Heuvel JP, Alaupovic P, Gillies PJ, Kris-Etherton PM. Beef in an Optimal Lean Diet study: effects on lipids, lipoproteins, and apolipoproteins. Am J Clin Nutr. 2012 Jan; 95(1):9-16.
    View in: PubMed
  5. Hegde S, Kaushal N, Ravindra KC, Chiaro C, Hafer KT, Gandhi UH, Thompson JT, van den Heuvel JP, Kennett MJ, Hankey P, Paulson RF, Prabhu KS. ?12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice. Blood. 2011 Dec 22; 118(26):6909-19.
    View in: PubMed
  6. Zhang J, Grieger JA, Kris-Etherton PM, Thompson JT, Gillies PJ, Fleming JA, Vanden Heuvel JP. Walnut oil increases cholesterol efflux through inhibition of stearoyl CoA desaturase 1 in THP-1 macrophage-derived foam cells. Nutr Metab (Lond). 2011; 8:61.
    View in: PubMed
  7. Manni A, Xu H, Washington S, Aliaga C, Das A, Cooper T, Richie JP, Prokopczyk B, Calcagnotto A, Trushin N, Van den Heuvel JP, Hamilton C, Demers LM, Liao J, Verderame MF, El-Bayoumy K. The effects of Tamoxifen and fish oil on mammary carcinogenesis in polyoma middle T transgenic mice. Horm Cancer. 2011 Aug; 2(4):249-59.
    View in: PubMed
  8. Belda BJ, Thompson JT, Eser PO, Vanden Heuvel JP. 10e12z CLA alters adipocyte differentiation and adipocyte cytokine expression and induces macrophage proliferation. J Nutr Biochem. 2012 May; 23(5):510-8.
    View in: PubMed
  9. Skulas-Ray AC, Kris-Etherton PM, Teeter DL, Chen CY, Vanden Heuvel JP, West SG. A high antioxidant spice blend attenuates postprandial insulin and triglyceride responses and increases some plasma measures of antioxidant activity in healthy, overweight men. J Nutr. 2011 Aug; 141(8):1451-7.
    View in: PubMed
  10. Zhang J, Kris-Etherton PM, Thompson JT, Hannon DB, Gillies PJ, Heuvel JP. Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. J Nutr Biochem. 2012 Apr; 23(4):400-9.
    View in: PubMed
  11. Raman P, Kaplan BL, Thompson JT, Vanden Heuvel JP, Kaminski NE. 15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma. Mol Pharmacol. 2011 Jul; 80(1):201-9.
    View in: PubMed
  12. Skulas-Ray AC, Kris-Etherton PM, Harris WS, Vanden Heuvel JP, Wagner PR, West SG. Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr. 2011 Feb; 93(2):243-52.
    View in: PubMed
  13. Omiecinski CJ, Vanden Heuvel JP, Perdew GH, Peters JM. Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities. Toxicol Sci. 2011 Mar; 120 Suppl 1:S49-75.
    View in: PubMed
  14. Zhang J, Cai S, Peterson BR, Kris-Etherton PM, Heuvel JP. Development of a cell-based, high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol. Assay Drug Dev Technol. 2011 Apr; 9(2):136-46.
    View in: PubMed
  15. Zhang J, Kris-Etherton PM, Thompson JT, Vanden Heuvel JP. Effect of pistachio oil on gene expression of IFN-induced protein with tetratricopeptide repeats 2: a biomarker of inflammatory response. Mol Nutr Food Res. 2010 May; 54 Suppl 1:S83-92.
    View in: PubMed
  16. Vanden Heuvel JP. Cardiovascular disease-related genes and regulation by diet. Curr Atheroscler Rep. 2009 Nov; 11(6):448-55.
    View in: PubMed
  17. Lee Y, Thompson JT, Vanden Heuvel JP. 9E,11E-conjugated linoleic acid increases expression of the endogenous antiinflammatory factor, interleukin-1 receptor antagonist, in RAW 264.7 cells. J Nutr. 2009 Oct; 139(10):1861-6.
    View in: PubMed
  18. Velliquette RA, Gillies PJ, Kris-Etherton PM, Green JW, Zhao G, Vanden Heuvel JP. Regulation of human stearoyl-CoA desaturase by omega-3 and omega-6 fatty acids: Implications for the dietary management of elevated serum triglycerides. J Clin Lipidol. 2009 Aug; 3(4):281-8.
    View in: PubMed
  19. Lee Y, Vanden Heuvel JP. Inhibition of macrophage adhesion activity by 9trans,11trans-conjugated linoleic acid. J Nutr Biochem. 2010 Jun; 21(6):490-7.
    View in: PubMed
  20. Gopinathan L, Hannon DB, Peters JM, Vanden Heuvel JP. Regulation of peroxisome proliferator-activated receptor-alpha by MDM2. Toxicol Sci. 2009 Mar; 108(1):48-58.
    View in: PubMed
  21. Gopinathan L, Hannon DB, Smith Iii RW, Peters JM, Vanden Heuvel JP. Regulation of peroxisome proliferator-activated receptors by e6-associated protein. PPAR Res. 2008; 2008:746935.
    View in: PubMed
  22. Lee Y, Thompson JT, de Lera AR, Vanden Heuvel JP. Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7. J Nutr Biochem. 2009 Nov; 20(11):848-59, 859.e1-5.
    View in: PubMed
  23. Vunta H, Belda BJ, Arner RJ, Channa Reddy C, Vanden Heuvel JP, Sandeep Prabhu K. Selenium attenuates pro-inflammatory gene expression in macrophages. Mol Nutr Food Res. 2008 Nov; 52(11):1316-23.
    View in: PubMed
  24. Davis PA, Jenab M, Vanden Heuvel JP, Furlong T, Taylor S. Tree nut and peanut consumption in relation to chronic and metabolic diseases including allergy. J Nutr. 2008 Sep; 138(9):1757S-1762S.
    View in: PubMed
  25. Bionaz M, Baumrucker CR, Shirk E, Vanden Heuvel JP, Block E, Varga GA. Characterization of Madin-Darby bovine kidney cell line for peroxisome proliferator-activated receptors: temporal response and sensitivity to fatty acids. J Dairy Sci. 2008 Jul; 91(7):2808-13.
    View in: PubMed
  26. Woods CG, Heuvel JP, Rusyn I. Genomic profiling in nuclear receptor-mediated toxicity. Toxicol Pathol. 2007 Jun; 35(4):474-94.
    View in: PubMed
  27. Burns KA, Vanden Heuvel JP. Modulation of PPAR activity via phosphorylation. Biochim Biophys Acta. 2007 Aug; 1771(8):952-60.
    View in: PubMed
  28. Vanden Heuvel JP. The PPAR resource page. Biochim Biophys Acta. 2007 Aug; 1771(8):1108-12.
    View in: PubMed
  29. Dancu MB, Berardi DE, Vanden Heuvel JP, Tarbell JM. Atherogenic Endothelial Cell eNOS and ET-1 Responses to Asynchronous Hemodynamics are Mitigated by Conjugated Linoleic Acid. Ann Biomed Eng. 2007 Jul; 35(7):1111-9.
    View in: PubMed
  30. Coleman JD, Prabhu KS, Thompson JT, Reddy PS, Peters JM, Peterson BR, Reddy CC, Vanden Heuvel JP. The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta). Free Radic Biol Med. 2007 Apr 15; 42(8):1155-64.
    View in: PubMed
  31. Vanden Heuvel JP, Thompson JT, Frame SR, Gillies PJ. Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. Toxicol Sci. 2006 Aug; 92(2):476-89.
    View in: PubMed
  32. Rockwell CE, Snider NT, Thompson JT, Vanden Heuvel JP, Kaminski NE. Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. Mol Pharmacol. 2006 Jul; 70(1):101-11.
    View in: PubMed
  33. Tien ES, Hannon DB, Thompson JT, Vanden Heuvel JP. Examination of Ligand-Dependent Coactivator Recruitment by Peroxisome Proliferator-Activated Receptor-alpha (PPARalpha). PPAR Res. 2006; 2006:69612.
    View in: PubMed
  34. Gray JP, Davis JW, Gopinathan L, Leas TL, Nugent CA, Vanden Heuvel JP. The ribosomal protein rpL11 associates with and inhibits the transcriptional activity of peroxisome proliferator-activated receptor-alpha. Toxicol Sci. 2006 Feb; 89(2):535-46.
    View in: PubMed
  35. Zhao G, Etherton TD, Martin KR, Vanden Heuvel JP, Gillies PJ, West SG, Kris-Etherton PM. Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. Biochem Biophys Res Commun. 2005 Oct 28; 336(3):909-17.
    View in: PubMed
  36. Gray JP, Burns KA, Leas TL, Perdew GH, Vanden Heuvel JP. Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C. Biochemistry. 2005 Aug 2; 44(30):10313-21.
    View in: PubMed
  37. Vanden Heuvel JP. Diet, fatty acids, and regulation of genes important for heart disease. Curr Atheroscler Rep. 2004 Nov; 6(6):432-40.
    View in: PubMed
  38. Dancu MB, Berardi DE, Vanden Heuvel JP, Tarbell JM. Asynchronous shear stress and circumferential strain reduces endothelial NO synthase and cyclooxygenase-2 but induces endothelin-1 gene expression in endothelial cells. Arterioscler Thromb Vasc Biol. 2004 Nov; 24(11):2088-94.
    View in: PubMed
  39. Bility MT, Thompson JT, McKee RH, David RM, Butala JH, Vanden Heuvel JP, Peters JM. Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters. Toxicol Sci. 2004 Nov; 82(1):170-82.
    View in: PubMed
  40. Tien ES, Davis JW, Vanden Heuvel JP. Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator. J Biol Chem. 2004 Jun 4; 279(23):24053-63.
    View in: PubMed
  41. Mueller C, Weaver V, Vanden Heuvel JP, August A, Cantorna MT. Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma. Arch Biochem Biophys. 2003 Oct 15; 418(2):186-96.
    View in: PubMed
  42. Khan SA, Vanden Heuvel JP. Role of nuclear receptors in the regulation of gene expression by dietary fatty acids (review). J Nutr Biochem. 2003 Oct; 14(10):554-67.
    View in: PubMed
  43. DeGrazia MJ, Thompson J, Heuvel JP, Peterson BR. Synthesis of a high-affinity fluorescent PPARgamma ligand for high-throughput fluorescence polarization assays. Bioorg Med Chem. 2003 Oct 1; 11(20):4325-32.
    View in: PubMed
  44. Sumanasekera WK, Tien ES, Davis JW, Turpey R, Perdew GH, Vanden Heuvel JP. Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity. Biochemistry. 2003 Sep 16; 42(36):10726-35.
    View in: PubMed
  45. Tien ES, Gray JP, Peters JM, Vanden Heuvel JP. Comprehensive gene expression analysis of peroxisome proliferator-treated immortalized hepatocytes: identification of peroxisome proliferator-activated receptor alpha-dependent growth regulatory genes. Cancer Res. 2003 Sep 15; 63(18):5767-80.
    View in: PubMed
  46. Gray JP, Leas TL, Obert E, Brown D, Clark GC, Vanden Heuvel JP. Evidence of aryl hydrocarbon receptor ligands in Presque Isle Bay of Lake Erie. Aquat Toxicol. 2003 Aug 20; 64(3):343-58.
    View in: PubMed
  47. Vanden Heuvel JP, Kreder D, Belda B, Hannon DB, Nugent CA, Burns KA, Taylor MJ. Comprehensive analysis of gene expression in rat and human hepatoma cells exposed to the peroxisome proliferator WY14,643. Toxicol Appl Pharmacol. 2003 May 1; 188(3):185-98.
    View in: PubMed
  48. B Rees C, McCormick SD, Vanden Heuvel JP, Li W. Quantitative PCR analysis of CYP1A induction in Atlantic salmon (Salmo salar). Aquat Toxicol. 2003 Jan 10; 62(1):67-78.
    View in: PubMed
  49. Sumanasekera WK, Tien ES, Turpey R, Vanden Heuvel JP, Perdew GH. Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. J Biol Chem. 2003 Feb 14; 278(7):4467-73.
    View in: PubMed
  50. Yu Y, Correll PH, Vanden Heuvel JP. Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. Biochim Biophys Acta. 2002 Apr 15; 1581(3):89-99.
    View in: PubMed
  51. Kumar MB, Ramadoss P, Reen RK, Vanden Heuvel JP, Perdew GH. The Q-rich subdomain of the human Ah receptor transactivation domain is required for dioxin-mediated transcriptional activity. J Biol Chem. 2001 Nov 9; 276(45):42302-10.
    View in: PubMed
  52. Kehrer JP, Biswal SS, La E, Thuillier P, Datta K, Fischer SM, Vanden Heuvel JP. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J. 2001 Jun 15; 356(Pt 3):899-906.
    View in: PubMed
  53. Moya-Camarena SY, Vanden Heuvel JP, Blanchard SG, Leesnitzer LA, Belury MA. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. J Lipid Res. 1999 Aug; 40(8):1426-33.
    View in: PubMed
  54. Vanden Heuvel JP. Peroxisome proliferator-activated receptors: a critical link among fatty acids, gene expression and carcinogenesis. J Nutr. 1999 Feb; 129(2S Suppl):575S-580S.
    View in: PubMed
  55. Moya-Camarena SY, Van den Heuvel JP, Belury MA. Conjugated linoleic acid activates peroxisome proliferator-activated receptor alpha and beta subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats. Biochim Biophys Acta. 1999 Jan 4; 1436(3):331-42.
    View in: PubMed
  56. Vanden Heuvel JP. Peroxisome proliferator-activated receptors (PPARS) and carcinogenesis. Toxicol Sci. 1999 Jan; 47(1):1-8.
    View in: PubMed
  57. Vanden Heuvel JP, Holden P, Tugwood J, Ingle C, Yen W, Galjart N, Greenlee WF. Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc-finger protein ZFP-37. Toxicol Appl Pharmacol. 1998 Sep; 152(1):107-18.
    View in: PubMed
  58. Kane MD, Vanden Heuvel JP, Isom GE, Schwarz RD. Differential expression of group I metabotropic glutamate receptors (mGluRs) in the rat pheochromocytoma cell line PC12: role of nerve growth factor and ras. Neurosci Lett. 1998 Aug 7; 252(1):1-4.
    View in: PubMed
  59. Belury MA, Moya-Camarena SY, Sun H, Snyder E, Davis JW, Cunningham ML, Vanden Heuvel JP. Comparison of dose-response relationships for induction of lipid metabolizing and growth regulatory genes by peroxisome proliferators in rat liver. Toxicol Appl Pharmacol. 1998 Aug; 151(2):254-61.
    View in: PubMed
  60. Houseknecht KL, Vanden Heuvel JP, Moya-Camarena SY, Portocarrero CP, Peck LW, Nickel KP, Belury MA. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun. 1998 Mar 27; 244(3):678-82.
    View in: PubMed
  61. Meyer BK, Pray-Grant MG, Vanden Heuvel JP, Perdew GH. Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Mol Cell Biol. 1998 Feb; 18(2):978-88.
    View in: PubMed
  62. Martinez E, Moore DD, Keller E, Pearce D, Vanden Heuvel JP, Robinson V, Gottlieb B, MacDonald P, Simons S, Sanchez E, Danielsen M. The Nuclear Receptor Resource: a growing family. Nucleic Acids Res. 1998 Jan 1; 26(1):239-41.
    View in: PubMed
  63. Perdew GH, Wiegand H, Vanden Heuvel JP, Mitchell C, Singh SS. A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37. Biochemistry. 1997 Mar 25; 36(12):3600-7.
    View in: PubMed
  64. Selmin O, Lucier GW, Clark GC, Tritscher AM, Vanden Heuvel JP, Gastel JA, Walker NJ, Sutter TR, Bell DA. Isolation and characterization of a novel gene induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver. Carcinogenesis. 1996 Dec; 17(12):2609-15.
    View in: PubMed
  65. Vanden Heuvel JP. Perfluorodecanoic acid as a useful pharmacologic tool for the study of peroxisome proliferation. Gen Pharmacol. 1996 Oct; 27(7):1123-9.
    View in: PubMed
  66. Sterchele PF, Sun H, Peterson RE, Vanden Heuvel JP. Regulation of peroxisome proliferator-activated receptor-alpha mRNA in rat liver. Arch Biochem Biophys. 1996 Feb 15; 326(2):281-9.
    View in: PubMed
  67. Sewall CH, Flagler N, Vanden Heuvel JP, Clark GC, Tritscher AM, Maronpot RM, Lucier GW. Alterations in thyroid function in female Sprague-Dawley rats following chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1995 Jun; 132(2):237-44.
    View in: PubMed
  68. Vanden Heuvel JP, Clark GC, Tritscher Am, Lucier GW. Accumulation of polychlorinated dibenzo-p-dioxins and dibenzofurans in liver of control laboratory rats. Fundam Appl Toxicol. 1994 Oct; 23(3):465-9.
    View in: PubMed
  69. Sterchele PF, Vanden Heuvel JP, Davis JW, Shrago E, Knudsen J, Peterson RE. Induction of hepatic acyl-CoA-binding protein and liver fatty acid-binding protein by perfluorodecanoic acid in rats. Lack of correlation with hepatic long-chain acyl-CoA levels. Biochem Pharmacol. 1994 Aug 30; 48(5):955-66.
    View in: PubMed
  70. Vanden Heuvel JP, Clark GC, Kohn MC, Tritscher AM, Greenlee WF, Lucier GW, Bell DA. Dioxin-responsive genes: examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction. Cancer Res. 1994 Jan 1; 54(1):62-8.
    View in: PubMed
  71. Vanden Heuvel JP, Clark GC, Thompson CL, McCoy Z, Miller CR, Lucier GW, Bell DA. CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes. Carcinogenesis. 1993 Oct; 14(10):2003-6.
    View in: PubMed
  72. Vanden Heuvel JP, Sterchele PF, Nesbit DJ, Peterson RE. Coordinate induction of acyl-CoA binding protein, fatty acid binding protein and peroxisomal beta-oxidation by peroxisome proliferators. Biochim Biophys Acta. 1993 Jun 6; 1177(2):183-90.
    View in: PubMed
  73. Vanden Heuvel JP, Lucier G. Environmental toxicology of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans. Environ Health Perspect. 1993 Apr; 100:189-200.
    View in: PubMed
  74. Vanden Heuvel JP, Tyson FL, Bell DA. Construction of recombinant RNA templates for use as internal standards in quantitative RT-PCR. Biotechniques. 1993 Mar; 14(3):395-8.
    View in: PubMed
  75. Vanden Heuvel JP, Kuslikis BI, Peterson RE. Covalent binding of perfluorinated fatty acids to proteins in the plasma, liver and testes of rats. Chem Biol Interact. 1992 May; 82(3):317-28.
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  76. Vanden Heuvel JP, Davis JW, Sommers R, Peterson RE. Renal excretion of perfluorooctanoic acid in male rats: inhibitory effect of testosterone. J Biochem Toxicol. 1992; 7(1):31-6.
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  77. Kuslikis BI, Vanden Heuvel JP, Peterson RE. Lack of evidence for perfluorodecanoyl- or perfluorooctanoyl-coenzyme A formation in male and female rats. J Biochem Toxicol. 1992; 7(1):25-9.
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  78. Davis JW, Vanden Heuvel JP, Peterson RE. Effects of perfluorodecanoic acid on de novo fatty acid and cholesterol synthesis in the rat. Lipids. 1991 Oct; 26(10):857-9.
    View in: PubMed
  79. Vanden Heuvel JP, Kuslikis BI, Shrago E, Peterson RE. Inhibition of long-chain acyl-CoA synthetase by the peroxisome proliferator perfluorodecanoic acid in rat hepatocytes. Biochem Pharmacol. 1991 Jul 5; 42(2):295-302.
    View in: PubMed
  80. Vanden Heuvel JP, Kuslikis BI, Van Rafelghem MJ, Peterson RE. Disposition of perfluorodecanoic acid in male and female rats. Toxicol Appl Pharmacol. 1991 Mar 1; 107(3):450-9.
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  81. Vanden Heuvel JP, Kuslikis BI, Van Rafelghem MJ, Peterson RE. Tissue distribution, metabolism, and elimination of perfluorooctanoic acid in male and female rats. J Biochem Toxicol. 1991; 6(2):83-92.
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  82. Vanden Heuvel JP, Van Rafelghem MJ, Menahan LA, Peterson RE. Isolation and purification of perfluorodecanoic and perfluorooctanoic acids from rat tissues. Lipids. 1989 Jun; 24(6):526-31.
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  83. Van Rafelghem MJ, Vanden Heuvel JP, Menahan LA, Peterson RE. Perfluorodecanoic acid and lipid metabolism in the rat. Lipids. 1988 Jul; 23(7):671-8.
    View in: PubMed
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