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John Richie

TitleProfessor
InstitutionCollege of Medicine
DepartmentPublic Health Sciences
Address500 University Drive Hershey PA 17033
Mailbox: H069
Phone7175315381

 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Public Health Sciences & Pharmacology

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Pharmacology, Penn State Hershey Cancer Institute

GRADUATE PROGRAM AFFILIATIONS:

Cell and Molecular Biology, Public Health Sciences, Pharmacology, Molecular Medicine, Molecular Toxicology

EDUCATION:

B.S., Biology, Worcester Polytechnic Institute, 1978
M.S., Biochemistry, University of Louisville, 1983
Ph.D., Biochemistry, University of Louisville, 1986

NARRATIVE:

Dr. Richie's research focuses on the elucidation of factors that regulate cancer risk in individuals and in populations. Using an interdisciplinary research approach, the aim is to identify the roles and mechanisms of key factors, alone and in combination, which impact cancer risk with the ultimate goal of utilizing this information in the design and development of targeted prevention strategies. The major areas of focus include aging, nutrition, tobacco and race/ethnicity as regulators or determinants of cancer risk. Particular emphasis is given to factors related to the generation of and protection against oxidative damage. In an ongoing molecular epidemiology study of tobacco-related cancers in black and white Americans, metabolic and genetic factors that may be responsible, in part, for observed racial differences in tobacco related cancer rates are being investigated. In other studies, we are examining the role of glutathione, the major endogenous antioxidant in nearly all cells and tissues, in protecting against oxidative damage during aging and its relationship with cancer development at numerous sites.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Maddineni S, Nichenametla S, Sinha R, Wilson RP, Richie JP. Methionine restriction affects oxidative stress and glutathione-related redox pathways in the rat. Exp Biol Med (Maywood). 2013 Apr; 238(4):392-9.
    View in: PubMed
  2. Das A, Bortner JD, Aliaga CA, Baker A, Stanley A, Stanley BA, Kaag M, Richie JP, El-Bayoumy K. Changes in proteomic profiles in different prostate lobes of male rats throughout growth and development and aging stages of the life span. Prostate. 2013 Mar; 73(4):363-75.
    View in: PubMed
  3. Signori C, DuBrock C, Richie JP, Prokopczyk B, Demers LM, Hamilton C, Hartman TJ, Liao J, El-Bayoumy K, Manni A. Administration of omega-3 fatty acids and Raloxifene to women at high risk of breast cancer: interim feasibility and biomarkers analysis from a clinical trial. Eur J Clin Nutr. 2012 Aug; 66(8):878-84.
    View in: PubMed
  4. Nichenametla SN, Muscat JE, Liao JG, Lazarus P, Richie JP. A functional trinucleotide repeat polymorphism in the 5'-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers. Mol Carcinog. 2013 Oct; 52(10):791-9.
    View in: PubMed
  5. Emmert SW, El-Bayoumy K, Das A, Sun YW, Amin S, Desai D, Aliaga C, Richie JP. Induction of lung glutathione and glutamylcysteine ligase by 1,4-phenylenebis(methylene)selenocyanate and its glutathione conjugate: role of nuclear factor-erythroid 2-related factor 2. Free Radic Biol Med. 2012 May 15; 52(10):2064-71.
    View in: PubMed
  6. Muscat JE, Liu HP, Stellman SD, Richie JP. Menthol smoking in relation to time to first cigarette and cotinine: results from a community-based study. Regul Toxicol Pharmacol. 2012 Jun; 63(1):166-70.
    View in: PubMed
  7. Muscat JE, Liu HP, Livelsberger C, Richie JP, Stellman SD. The nicotine dependence phenotype, time to first cigarette, and larynx cancer risk. Cancer Causes Control. 2012 Mar; 23(3):497-503.
    View in: PubMed
  8. Richie JP, Das A, Calcagnotto AM, Aliaga CA, El-Bayoumy K. Age related changes in selenium and glutathione levels in different lobes of the rat prostate. Exp Gerontol. 2012 Mar; 47(3):223-8.
    View in: PubMed
  9. Southard EB, Roff A, Fortugno T, Richie JP, Kaag M, Chinchilli VM, Virtamo J, Albanes D, Weinstein S, Wilson RT. Lead, calcium uptake, and related genetic variants in association with renal cell carcinoma risk in a cohort of male Finnish smokers. Cancer Epidemiol Biomarkers Prev. 2012 Jan; 21(1):191-201.
    View in: PubMed
  10. Ellison I, Richie JP. Mechanisms of glutathione disulfide efflux from erythrocytes. Biochem Pharmacol. 2012 Jan 1; 83(1):164-9.
    View in: PubMed
  11. Signori C, El-Bayoumy K, Russo J, Thompson HJ, Richie JP, Hartman TJ, Manni A. Chemoprevention of breast cancer by fish oil in preclinical models: trials and tribulations. Cancer Res. 2011 Oct 1; 71(19):6091-6.
    View in: PubMed
  12. Moon MS, Kang BH, Krzeminski J, Amin S, Aliaga C, Zhu J, McDevitt EI, Kocher S, Richie JP, Isom HC. 3,5,5-trimethyl-hexanoyl-ferrocene diet protects mice from moderate transient acetaminophen-induced hepatotoxicity. Toxicol Sci. 2011 Dec; 124(2):348-58.
    View in: PubMed
  13. Muscat JE, Ahn K, Richie JP, Stellman SD. Nicotine dependence phenotype and lung cancer risk. Cancer. 2011 Dec 1; 117(23):5370-6.
    View in: PubMed
  14. Muscat JE, Ahn K, Richie JP, Stellman SD. Nicotine dependence phenotype, time to first cigarette, and risk of head and neck cancer. Cancer. 2011 Dec 1; 117(23):5377-82.
    View in: PubMed
  15. Zhu Z, Jiang W, McGinley JN, Prokopczyk B, Richie JP, El Bayoumy K, Manni A, Thompson HJ. Mammary gland density predicts the cancer inhibitory activity of the N-3 to N-6 ratio of dietary fat. Cancer Prev Res (Phila). 2011 Oct; 4(10):1675-85.
    View in: PubMed
  16. Manni A, Xu H, Washington S, Aliaga C, Das A, Cooper T, Richie JP, Prokopczyk B, Calcagnotto A, Trushin N, Van den Heuvel JP, Hamilton C, Demers LM, Liao J, Verderame MF, El-Bayoumy K. The effects of Tamoxifen and fish oil on mammary carcinogenesis in polyoma middle T transgenic mice. Horm Cancer. 2011 Aug; 2(4):249-59.
    View in: PubMed
  17. Manni A, Richie JP, Xu H, Washington S, Aliaga C, Cooper TK, Bruggeman R, Das A, Prokopczyk B, Calcagnotto A, Trushin N, Dickinson R, Liao J, Verderame MF, El-Bayoumy K. Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Int J Oncol. 2011 Nov; 39(5):1153-64.
    View in: PubMed
  18. Nichenametla SN, Lazarus P, Richie JP. A GAG trinucleotide-repeat polymorphism in the gene for glutathione biosynthetic enzyme, GCLC, affects gene expression through translation. FASEB J. 2011 Jul; 25(7):2180-7.
    View in: PubMed
  19. Bortner JD, Richie JP, Das A, Liao J, Umstead TM, Stanley A, Stanley BA, Belani CP, El-Bayoumy K. Proteomic profiling of human plasma by iTRAQ reveals down-regulation of ITI-HC3 and VDBP by cigarette smoking. J Proteome Res. 2011 Mar 4; 10(3):1151-9.
    View in: PubMed
  20. Muscat JE, Liu A, Richie JP. A comparison of creatinine vs. specific gravity to correct for urinary dilution of cotinine. Biomarkers. 2011 May; 16(3):206-11.
    View in: PubMed
  21. Richie JP, Muscat JE, Ellison I, Calcagnotto A, Kleinman W, El-Bayoumy K. Association of selenium status and blood glutathione concentrations in blacks and whites. Nutr Cancer. 2011; 63(3):367-75.
    View in: PubMed
  22. Moon MS, Richie JP, Isom HC. Iron potentiates acetaminophen-induced oxidative stress and mitochondrial dysfunction in cultured mouse hepatocytes. Toxicol Sci. 2010 Nov; 118(1):119-27.
    View in: PubMed
  23. Sinha R, Sinha I, Facompre N, Russell S, Somiari RI, Richie JP, El-Bayoumy K. Selenium-responsive proteins in the sera of selenium-enriched yeast-supplemented healthy African American and Caucasian men. Cancer Epidemiol Biomarkers Prev. 2010 Sep; 19(9):2332-40.
    View in: PubMed
  24. Manni A, Xu H, Washington S, Aliaga C, Cooper T, Richie JP, Bruggeman R, Prokopczyk B, Calcagnotto A, Trushin N, Mauger D, Verderame MF, El-Bayoumy K. The impact of fish oil on the chemopreventive efficacy of tamoxifen against development of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Cancer Prev Res (Phila). 2010 Mar; 3(3):322-30.
    View in: PubMed
  25. Rundle A, Richie J, Steindorf K, Peluso M, Overvad K, Raaschou-Nielsen O, Clavel-Chapelon F, Linseisen JP, Boeing H, Trichopoulou A, Palli D, Krogh V, Tumino R, Panico S, Bueno-De-Mesquita HB, Peeters PH, Lund E, Gonzalez CA, Martinez C, Dorronsoro M, Barricarte A, Tormo MJ, Quiros J, Agudo A, Berglund G, Jarvholm B, Bingham S, Key TJ, Gormally E, Saracci R, Kaaks R, Riboli E, Vineis P. Physical activity and lung cancer among non-smokers: a pilot molecular epidemiological study within EPIC. Biomarkers. 2010 Feb; 15(1):20-30.
    View in: PubMed
  26. Emmert SW, Desai D, Amin S, Richie JP. Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane. Bioorg Med Chem Lett. 2010 Apr 15; 20(8):2675-9.
    View in: PubMed
  27. Muscat JE, Stellman SD, Caraballo RS, Richie JP. Time to first cigarette after waking predicts cotinine levels. Cancer Epidemiol Biomarkers Prev. 2009 Dec; 18(12):3415-20.
    View in: PubMed
  28. Wilson RT, Wang J, Chinchilli V, Richie JP, Virtamo J, Moore LE, Albanes D. Fish, vitamin D, and flavonoids in relation to renal cell cancer among smokers. Am J Epidemiol. 2009 Sep 15; 170(6):717-29.
    View in: PubMed
  29. Chen KM, Sacks PG, Spratt TE, Lin JM, Boyiri T, Schwartz J, Richie JP, Calcagnotto A, Das A, Bortner J, Zhao Z, Amin S, Guttenplan J, El-Bayoumy K. Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate. Biochem Biophys Res Commun. 2009 May 22; 383(1):151-5.
    View in: PubMed
  30. Muscat JE, Chen G, Knipe A, Stellman SD, Lazarus P, Richie JP. Effects of menthol on tobacco smoke exposure, nicotine dependence, and NNAL glucuronidation. Cancer Epidemiol Biomarkers Prev. 2009 Jan; 18(1):35-41.
    View in: PubMed
  31. Gallagher CJ, Ahn K, Knipe AL, Dyer AM, Richie JP, Lazarus P, Muscat JE. Association between haplotypes of manganese superoxide dismutase (SOD2), smoking, and lung cancer risk. Free Radic Biol Med. 2009 Jan 1; 46(1):20-4.
    View in: PubMed
  32. Muscat JE, Pittman B, Kleinman W, Lazarus P, Stellman SD, Richie JP. Comparison of CYP1A2 and NAT2 phenotypes between black and white smokers. Biochem Pharmacol. 2008 Oct 1; 76(7):929-37.
    View in: PubMed
  33. Nichenametla SN, Ellison I, Calcagnotto A, Lazarus P, Muscat JE, Richie JP. Functional significance of the GAG trinucleotide-repeat polymorphism in the gene for the catalytic subunit of gamma-glutamylcysteine ligase. Free Radic Biol Med. 2008 Sep 1; 45(5):645-50.
    View in: PubMed
  34. Huang Z, Pinto JT, Deng H, Richie JP. Inhibition of caspase-3 activity and activation by protein glutathionylation. Biochem Pharmacol. 2008 Jun 1; 75(11):2234-44.
    View in: PubMed
  35. Richie JP, Kleinman W, Marina P, Abraham P, Wynder EL, Muscat JE. Blood iron, glutathione, and micronutrient levels and the risk of oral cancer. Nutr Cancer. 2008; 60(4):474-82.
    View in: PubMed
  36. Melikian AA, Djordjevic MV, Chen S, Richie J, Stellman SD. Effect of delivered dosage of cigarette smoke toxins on the levels of urinary biomarkers of exposure. Cancer Epidemiol Biomarkers Prev. 2007 Jul; 16(7):1408-15.
    View in: PubMed
  37. Richie JP, Komninou D, Albino AP. Induction of colon tumorigenesis by glutathione depletion in p53-knock-out mice. Int J Oncol. 2007 Jun; 30(6):1539-43.
    View in: PubMed
  38. Huang Z, Komninou D, Kleinman W, Pinto JT, Gilhooly EM, Calcagnotto A, Richie JP. Enhanced levels of glutathione and protein glutathiolation in rat tongue epithelium during 4-NQO-induced carcinogenesis. Int J Cancer. 2007 Apr 1; 120(7):1396-401.
    View in: PubMed
  39. Gallagher CJ, Muscat JE, Hicks AN, Zheng Y, Dyer AM, Chase GA, Richie J, Lazarus P. The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer. Cancer Epidemiol Biomarkers Prev. 2007 Apr; 16(4):823-8.
    View in: PubMed
  40. Vogt BL, Richie JP. Glutathione depletion and recovery after acute ethanol administration in the aging mouse. Biochem Pharmacol. 2007 May 15; 73(10):1613-21.
    View in: PubMed
  41. Richie JP, Kleinman W, Desai DH, Das A, Amin SG, Pinto JT, El-Bayoumy K. The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung. Chem Biol Interact. 2006 Jun 10; 161(2):93-103.
    View in: PubMed
  42. Komninou D, Leutzinger Y, Reddy BS, Richie JP. Methionine restriction inhibits colon carcinogenesis. Nutr Cancer. 2006; 54(2):202-8.
    View in: PubMed
  43. Rundle AG, Orjuela M, Mooney L, Tang D, Kim M, Calcagnotto A, Richie JP, Perera F. Preliminary studies on the effect of moderate physical activity on blood levels of glutathione. Biomarkers. 2005 Sep-Oct; 10(5):390-400.
    View in: PubMed
  44. Muscat JE, Djordjevic MV, Colosimo S, Stellman SD, Richie JP. Racial differences in exposure and glucuronidation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Cancer. 2005 Apr 1; 103(7):1420-6.
    View in: PubMed
  45. Chung FL, Komninou D, Zhang L, Nath R, Pan J, Amin S, Richie J. Glutathione depletion enhances the formation of endogenous cyclic DNA adducts derived from t-4-hydroxy-2-nonenal in rat liver. Chem Res Toxicol. 2005 Jan; 18(1):24-7.
    View in: PubMed
  46. Richie JP, Komninou D, Leutzinger Y, Kleinman W, Orentreich N, Malloy V, Zimmerman JA. Tissue glutathione and cysteine levels in methionine-restricted rats. Nutrition. 2004 Sep; 20(9):800-5.
    View in: PubMed
  47. Muscat JE, Kleinman W, Colosimo S, Muir A, Lazarus P, Park J, Richie JP. Enhanced protein glutathiolation and oxidative stress in cigarette smokers. Free Radic Biol Med. 2004 Feb 15; 36(4):464-70.
    View in: PubMed
  48. Elahi A, Bendaly J, Zheng Z, Muscat JE, Richie JP, Schantz SP, Lazarus P. Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk. Cancer. 2003 Aug 15; 98(4):872-80.
    View in: PubMed
  49. Muscat JE, Chen SQ, Richie JP, Altorki NK, Citron M, Olson S, Neugut AI, Stellman SD. Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs. Cancer. 2003 Apr 1; 97(7):1732-6.
    View in: PubMed
  50. Stellman SD, Chen Y, Muscat JE, Djordjevic MV, Richie JP, Lazarus P, Thompson S, Altorki N, Berwick M, Citron ML, Harlap S, Kaur TB, Neugut AI, Olson S, Travaline JM, Witorsch P, Zhang ZF. Lung cancer risk in white and black Americans. Ann Epidemiol. 2003 Apr; 13(4):294-302.
    View in: PubMed
  51. Komninou D, Ayonote A, Richie JP, Rigas B. Insulin resistance and its contribution to colon carcinogenesis. Exp Biol Med (Maywood). 2003 Apr; 228(4):396-405.
    View in: PubMed
  52. Kleinman WA, Komninou D, Leutzinger Y, Colosimo S, Cox J, Lang CA, Richie JP. Protein glutathiolation in human blood. Biochem Pharmacol. 2003 Mar 1; 65(5):741-6.
    View in: PubMed
  53. Lang CA, Mills BJ, Lang HL, Liu MC, Usui WM, Richie J, Mastropaolo W, Murrell SA. High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years. J Lab Clin Med. 2002 Dec; 140(6):413-7.
    View in: PubMed
  54. Muscat JE, Richie JP, Stellman SD. Mentholated cigarettes and smoking habits in whites and blacks. Tob Control. 2002 Dec; 11(4):368-71.
    View in: PubMed
  55. El-Bayoumy K, Richie JP, Boyiri T, Komninou D, Prokopczyk B, Trushin N, Kleinman W, Cox J, Pittman B, Colosimo S. Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot study. Cancer Epidemiol Biomarkers Prev. 2002 Nov; 11(11):1459-65.
    View in: PubMed
  56. D'Amico AV, Whittington R, Malkowicz SB, Weinstein M, Tomaszewski JE, Schultz D, Rhude M, Rocha S, Wein A, Richie JP. Predicting prostate specific antigen outcome preoperatively in the prostate specific antigen era. J Urol. 2001 Dec; 166(6):2185-8.
    View in: PubMed
  57. D'Amico AV, Whittington R, Malkowicz SB, Renshaw AA, Tomaszewski JE, Bentley C, Schultz D, Rocha S, Wein A, Richie JP. Estimating the impact on prostate cancer mortality of incorporating prostate-specific antigen testing into screening. Urology. 2001 Sep; 58(3):406-10.
    View in: PubMed
  58. Lu ML, Schneider MC, Zheng Y, Zhang X, Richie JP. Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation. J Biol Chem. 2001 Apr 20; 276(16):13442-51.
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  59. Duque JL, Adam RM, Mullen JS, Lin J, Richie JP, Freeman MR. Heparin-binding epidermal growth factor-like growth factor is an autocrine mediator of human prostate stromal cell growth in vitro. J Urol. 2001 Jan; 165(1):284-8.
    View in: PubMed
  60. D'Amico AV, Wu Y, Chen MH, Nash M, Renshaw AA, Richie JP. Perineural invasion as a predictor of biochemical outcome following radical prostatectomy for select men with clinically localized prostate cancer. J Urol. 2001 Jan; 165(1):126-9.
    View in: PubMed
  61. Chen TS, Richie JP, Nagasawa HT, Lang CA. Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice. Mech Ageing Dev. 2000 Dec 1; 120(1-3):127-39.
    View in: PubMed
  62. Hurt RD, Croghan GA, Wolter TD, Croghan IT, Offord KP, Williams GM, Djordjevic MV, Richie JP, Jeffrey AM. Does smoking reduction result in reduction of biomarkers associated with harm? A pilot study using a nicotine inhaler. Nicotine Tob Res. 2000 Nov; 2(4):327-36.
    View in: PubMed
  63. D'Amico AV, Wu Y, Chen MH, Nash M, Renshaw AA, Richie JP. Pathologic findings and prostate specific antigen outcome after radical prostatectomy for patients diagnosed on the basis of a single microscopic focus of prostate carcinoma with a gleason score
    View in: PubMed
  64. Olumi AF, Richie JP, Schultz DJ, D'Amico AV. Calculated volume of prostate cancer identifies patients with clinical stage T1C disease at high risk of biochemical recurrence after radical prostatectomy: a preliminary study. Urology. 2000 Aug 1; 56(2):273-7.
    View in: PubMed
  65. Kleinman WA, Richie JP. Status of glutathione and other thiols and disulfides in human plasma. Biochem Pharmacol. 2000 Jul 1; 60(1):19-29.
    View in: PubMed
  66. D'Amico AV, Schultz D, Schneider L, Hurwitz M, Kantoff PW, Richie JP. Comparing prostate specific antigen outcomes after different types of radiotherapy management of clinically localized prostate cancer highlights the importance of controlling for established prognostic factors. J Urol. 2000 Jun; 163(6):1797-801.
    View in: PubMed
  67. Catalona WJ, Partin AW, Slawin KM, Naughton CK, Brawer MK, Flanigan RC, Richie JP, Patel A, Walsh PC, Scardino PT, Lange PH, deKernion JB, Southwick PC, Loveland KG, Parson RE, Gasior GH. Percentage of free PSA in black versus white men for detection and staging of prostate cancer: a prospective multicenter clinical trial. Urology. 2000 Mar; 55(3):372-6.
    View in: PubMed
  68. Park LY, Muscat JE, Kaur T, Schantz SP, Stern JC, Richie JP, Lazarus P. Comparison of GSTM polymorphisms and risk for oral cancer between African-Americans and Caucasians. Pharmacogenetics. 2000 Mar; 10(2):123-31.
    View in: PubMed
  69. Kaur TB, Travaline JM, Gaughan JP, Richie JP, Stellman SD, Lazarus P. Role of polymorphisms in codons 143 and 160 of the O6-alkylguanine DNA alkyltransferase gene in lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2000 Mar; 9(3):339-42.
    View in: PubMed
  70. D'Amico AV, Whittington R, Malkowicz SB, Schultz D, Silver B, Henry L, Hurwitz M, Kaplan I, Beard CJ, Tomaszewski JE, Renshaw AA, Wein A, Richie JP. Clinical utility of percent-positive prostate biopsies in predicting biochemical outcome after radical prostatectomy or external-beam radiation therapy for patients with clinically localized prostate cancer. Mol Urol. 2000; 4(3):171-5;discussion 177.
    View in: PubMed
  71. Oh WK, Manola J, Renshaw AA, Brodkin D, Loughlin KR, Richie JP, Shapiro CL, Kantoff PW. Smoking and alcohol use may be risk factors for poorer outcome in patients with clear cell renal carcinoma. Urology. 2000 Jan; 55(1):31-5.
    View in: PubMed
  72. D'Amico AV, Renshaw AA, Schultz D, Rocha S, Richie JP. The impact of the biopsy Gleason score on PSA outcome for prostate cancer patients with PSA < or = 10 ng/ml and T1c,2a: implications for patient selection for prostate-only therapy. Int J Radiat Oncol Biol Phys. 1999 Nov 1; 45(4):847-51.
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  73. D'Amico AV, Debruyne F, Huland H, Richie JP. Innovative treatment for clinically localized adenocarcinoma of the prostate: the future role of molecular imaging. Prostate. 1999 Nov 1; 41(3):208-12.
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  74. D'Amico AV, Renshaw AA, Arsenault L, Schultz D, Richie JP. Clinical predictors of upgrading to Gleason grade 4 or 5 disease at radical prostatectomy: potential implications for patient selection for radiation and androgen suppression therapy. Int J Radiat Oncol Biol Phys. 1999 Nov 1; 45(4):841-6.
    View in: PubMed
  75. Hegarty NJ, Fitzpatrick JM, Richie JP, Scardino PT, deVere White RW, Schröder FH, Coffey DS. Future prospects in prostate cancer. Prostate. 1999 Sep 1; 40(4):261-8.
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  76. Renshaw AA, Richie JP. Subtypes of renal cell carcinoma. Different onset and sites of metastatic disease. Am J Clin Pathol. 1999 Apr; 111(4):539-43.
    View in: PubMed
  77. D'Amico AV, Desjardin A, Chen MH, Paik S, Schultz D, Renshaw AA, Loughlin KR, Richie JP. Analyzing outcome-based staging for clinically localized adenocarcinoma of the prostate. Cancer. 1998 Nov 15; 83(10):2172-80.
    View in: PubMed
  78. Duque JL, Loughlin KR, O'Leary MP, Kumar S, Richie JP. Partial nephrectomy: alternative treatment for selected patients with renal cell carcinoma. Urology. 1998 Oct; 52(4):584-90.
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  79. Renshaw AA, Richie JP, Loughlin KR, Jiroutek M, Chung A, D'Amico AV. The greatest dimension of prostate carcinoma is a simple, inexpensive predictor of prostate specific antigen failure in radical prostatectomy specimens. Cancer. 1998 Aug 15; 83(4):748-52.
    View in: PubMed
  80. Whysner J, Steward RE, Chen D, Conaway CC, Verna LK, Richie JP, Ali N, Williams GM. Formation of 8-oxodeoxyguanosine in brain DNA of rats exposed to acrylonitrile. Arch Toxicol. 1998 Jun; 72(7):429-38.
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  81. Zhao Z, Khachik F, Richie JP, Cohen LA. Lycopene uptake and tissue disposition in male and female rats. Proc Soc Exp Biol Med. 1998 Jun; 218(2):109-14.
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  82. D'Amico AV, Desjardin A, Chung A, Chen MH, Schultz D, Whittington R, Malkowicz SB, Wein A, Tomaszewski JE, Renshaw AA, Loughlin K, Richie JP. Assessment of outcome prediction models for patients with localized prostate carcinoma managed with radical prostatectomy or external beam radiation therapy. Cancer. 1998 May 15; 82(10):1887-96.
    View in: PubMed
  83. Lazarus P, Sheikh SN, Ren Q, Schantz SP, Stern JC, Richie JP, Park JY. p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use. Carcinogenesis. 1998 Mar; 19(3):509-14.
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  84. Muscat JE, Stellman SD, Richie JP, Wynder EL. Lung cancer risk and workplace exposures in black men and women. Environ Res. 1998 Feb; 76(2):78-84.
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  85. Nath RG, Ocando JE, Richie JP, Chung FL. Effect of glutathione depletion on exocyclic adduct levels in the liver DNA of F344 rats. Chem Res Toxicol. 1997 Nov; 10(11):1250-3.
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  86. El-Bayoumy K, Chung FL, Richie J, Reddy BS, Cohen L, Weisburger J, Wynder EL. Dietary control of cancer. Proc Soc Exp Biol Med. 1997 Nov; 216(2):211-23.
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  87. Richie JP, Carmella SG, Muscat JE, Scott DG, Akerkar SA, Hecht SS. Differences in the urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in black and white smokers. Cancer Epidemiol Biomarkers Prev. 1997 Oct; 6(10):783-90.
    View in: PubMed
  88. Park JY, Muscat JE, Ren Q, Schantz SP, Harwick RD, Stern JC, Pike V, Richie JP, Lazarus P. CYP1A1 and GSTM1 polymorphisms and oral cancer risk. Cancer Epidemiol Biomarkers Prev. 1997 Oct; 6(10):791-7.
    View in: PubMed
  89. Muscat JE, Richie JP, Thompson S, Wynder EL. Gender differences in smoking and risk for oral cancer. Cancer Res. 1996 Nov 15; 56(22):5192-7.
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  90. Richie JP, Abraham P, Leutzinger Y. Long-term stability of blood glutathione and cysteine in humans. Clin Chem. 1996 Jul; 42(7):1100-5.
    View in: PubMed
  91. Lazarus P, Stern J, Zwiebel N, Fair A, Richie JP, Schantz S. Relationship between p53 mutation incidence in oral cavity squamous cell carcinomas and patient tobacco use. Carcinogenesis. 1996 Apr; 17(4):733-9.
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  92. Van den Abbeele AD, Tutrone RF, Berman RM, Baranowska-Kortylewicz J, Barclay PD, Richie JP, Adelstein SJ, Kassis AI. Tumor-targeting potential of radioiodinated iododeoxyuridine in bladder cancer. J Nucl Med. 1996 Feb; 37(2):315-20.
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  93. Richie JP, Skowronski L, Abraham P, Leutzinger Y. Blood glutathione concentrations in a large-scale human study. Clin Chem. 1996 Jan; 42(1):64-70.
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  94. Hecht SS, Chung FL, Richie JP, Akerkar SA, Borukhova A, Skowronski L, Carmella SG. Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers. Cancer Epidemiol Biomarkers Prev. 1995 Dec; 4(8):877-84.
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  95. Kleinman WA, Richie JP. Determination of thiols and disulfides using high-performance liquid chromatography with electrochemical detection. J Chromatogr B Biomed Appl. 1995 Oct 6; 672(1):73-80.
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  96. Carmella SG, Akerkar SA, Richie JP, Hecht SS. Intraindividual and interindividual differences in metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers' urine. Cancer Epidemiol Biomarkers Prev. 1995 Sep; 4(6):635-42.
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  97. Steinbach F, Novick AC, Zincke H, Miller DP, Williams RD, Lund G, Skinner DG, Esrig D, Richie JP, deKernion JB, et al. Treatment of renal cell carcinoma in von Hippel-Lindau disease: a multicenter study. J Urol. 1995 Jun; 153(6):1812-6.
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  98. Lazarus P, Garewal HS, Sciubba J, Zwiebel N, Calcagnotto A, Fair A, Schaefer S, Richie JP. A low incidence of p53 mutations in pre-malignant lesions of the oral cavity from non-tobacco users. Int J Cancer. 1995 Feb 8; 60(4):458-63.
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  99. Richie JP, Leutzinger Y, Parthasarathy S, Malloy V, Orentreich N, Zimmerman JA. Methionine restriction increases blood glutathione and longevity in F344 rats. FASEB J. 1994 Dec; 8(15):1302-7.
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  100. Mills BJ, Richie JP, Lang CA. Glutathione disulfide variability in normal human blood. Anal Biochem. 1994 Oct; 222(1):95-101.
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  101. Sohn OS, Surace A, Fiala ES, Richie JP, Colosimo S, Zang E, Weisburger JH. Effects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 rat. Xenobiotica. 1994 Feb; 24(2):119-27.
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  102. Chernoff DM, Silverman SG, Kikinis R, Adams DF, Seltzer SE, Richie JP, Loughlin KR. Three-dimensional imaging and display of renal tumors using spiral CT: a potential aid to partial nephrectomy. Urology. 1994 Jan; 43(1):125-9.
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  103. Xiao M, Galanopoulos T, Nevillegolden J, Richie J, Antoniades H. Human prostate adenocarcinomas express in-vivo messenger-rnas and protein products for platelet-derived growth factor-B and its receptor. Int J Oncol. 1993 Nov; 3(5):809-15.
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  104. Vogt BL, Richie JP. Fasting-induced depletion of glutathione in the aging mouse. Biochem Pharmacol. 1993 Jul 20; 46(2):257-63.
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  105. Richie JP. The role of glutathione in aging and cancer. Exp Gerontol. 1992 Sep-Dec; 27(5-6):615-26.
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  106. Richie JP, Lang CA, Chen TS. Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidney. Biochem Pharmacol. 1992 Jul 7; 44(1):129-35.
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  107. Chen TS, Richie JP, Lang CA. Life span profiles of glutathione and acetaminophen detoxification. Drug Metab Dispos. 1990 Nov-Dec; 18(6):882-7.
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  108. Mills BJ, Richie JP, Lang CA. Sample processing alters glutathione and cysteine values in blood. Anal Biochem. 1990 Feb 1; 184(2):263-7.
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  109. Rukstalis DB, Bubley GJ, Donahue JP, Richie JP, Seidman JG, DeWolf WC. Regional loss of chromosome 6 in two urological malignancies. Cancer Res. 1989 Sep 15; 49(18):5087-90.
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  110. Chen TS, Richie JP, Lang CA. The effect of aging on glutathione and cysteine levels in different regions of the mouse brain. Proc Soc Exp Biol Med. 1989 Apr; 190(4):399-402.
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  111. Garnick MB, Reich SD, Maxwell B, Coval-Goldsmith S, Richie JP, Rudnick SA. Phase I/II study of recombinant interferon gamma in advanced renal cell carcinoma. J Urol. 1988 Feb; 139(2):251-5.
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  112. Richie JP, Lang CA. A decrease in cysteine levels causes the glutathione deficiency of aging in the mosquito. Proc Soc Exp Biol Med. 1988 Feb; 187(2):235-40.
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  113. Lipman JC, Loughlin KR, Richie JP, Tumeh SS. Unusual solitary soft tissue metastases from renal cell carcinoma. Urol Radiol. 1988; 10(2):110-2.
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  114. Richie JP, Lang CA. The determination of glutathione, cyst(e)ine, and other thiols and disulfides in biological samples using high-performance liquid chromatography with dual electrochemical detection. Anal Biochem. 1987 May 15; 163(1):9-15.
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  115. Richie JP, Mills BJ, Lang CA. Correction of a glutathione deficiency in the aging mosquito increases its longevity. Proc Soc Exp Biol Med. 1987 Jan; 184(1):113-7.
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  116. Richie JP, Mills BJ, Lang CA. Dietary nordihydroguaiaretic acid increases the life span of the mosquito. Proc Soc Exp Biol Med. 1986 Oct; 183(1):81-5.
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  117. Lang CA, Richie JP. Biogerontological precepts of Nathan Shock which influenced our aging research. Exp Gerontol. 1986; 21(4-5):235-9.
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  118. Richie JP, Lang CA. Aging effects on acetaminophen toxicity and glutathione status in the mosquito. Drug Metab Dispos. 1985 Jan-Feb; 13(1):14-7.
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  119. Richie JP, Mills BJ, Lang CA. The verification of a mammalian toxicant classification using a mosquito screening method. Fundam Appl Toxicol. 1984 Dec; 4(6):1029-35.
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  120. Richie JP, Steele GD, Wilson RE, Ervin T, Wang BS, Mannick JA. Current treatment of metastatic renal cell carcinoma with xenogeneic immune ribonucleic acid. J Urol. 1984 Feb; 131(2):236-8.
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  121. Richie JP, Weichselbaum RR, Little JB. Importance of repair of potentially lethal damage in assays of cytotoxic agents. Surgery. 1982 Aug; 92(2):380-4.
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  122. Kearney GP, Waters WB, Klein LA, Richie JP, Gittes RF. Results of inferior vena cava resection for renal cell carcinoma. J Urol. 1981 Jun; 125(6):769-73.
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  123. Waters WB, Richie JP. Aggressive surgical approach to renal cell carcinoma: review of 130 cases. J Urol. 1979 Sep; 122(3):306-9.
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