PSU Profiles
Last Name

John Goldman

TitleProfessor Emeritus
InstitutionCollege of Medicine
Address500 University Drive Hershey PA 17033
Mailbox: H036


Professor Emeritus of Medicine, and Microbiology and Immunology


Microbiology and Immunology


Microbiology and Immunology


M.D., University of Cincinnati College of Medicine, 1964
Residency, Boston City Hospital
Fellowship, Beth Israel Hospital
Postdoctoral Training, Harvard Medical School, 1966-1968, 1970-1971


The Immunologic Control of Gene Expression

The main focus of our laboratory has been in the area of immunologic control of gene expression. Two systems are being examined: (1) immunoregulation of natural products of monocytes, macrophages, and hepatocytes and (2) immunologic control of viral gene expression. In the first area, we have used individual complement components as the target molecules and have elucidated a system in which a network of antibody and lymphoid cells can suppress the synthesis and secretion of the complement molecules. This control has been shown to be chiefly posttranscriptional, and we are currently determining the relative importance of nuclear processing, transport to the cytoplasm, and translation of the mRNA of the suppressed protein. The second area of research is an outgrowth of the first. It examines the hypothesis that similar specific immunologic networks regulate the synthesis of individual viral proteins within infected cells to control viral replication without lysing the cells. Measles-infected murine macrophage cell lines constitute the experimental system currently in use for these studies, since measles virus causes a persistent, non-lytic infection in these cells; the virus itself is relatively simple (encoding only 6 proteins); and the use of cell lines derived from inbred mice enables a variety of cellular studies without encountering problems of histoincompatibility.

 selected publications
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  1. Goldman JN. West Nile virus: a new threat in Pennsylvania. Pa Med. 2000; 103(6):14.
    View in: PubMed
  2. Goldman MB, Buckthal DJ, Picciotto S, O'Bryan TA, Goldman JN. Measles virus persistence in an immortalized murine macrophage cell line. Virology. 1995 Feb 20; 207(1):12-22.
    View in: PubMed
  3. Goldman MB, O'Bryan TA, Buckthal DJ, Tetor LM, Goldman JN. Suppression of measles virus expression by noncytolytic antibody in an immortalized macrophage cell line. J Virol. 1995 Feb; 69(2):734-40.
    View in: PubMed
  4. Goldman MB, Knovich MA, Goldman JN. T lymphocytes mediate immunologic control of C3 gene expression. Eur J Immunol. 1992 Dec; 22(12):3103-9.
    View in: PubMed
  5. Goldman MB, Knovich MA, Goldman JN. Immunologic control of C3 gene expression in tissue macrophages. J Immunol. 1991 Dec 15; 147(12):4248-55.
    View in: PubMed
  6. Joshi N, Goldman JN. Two cases of osteomyelitis due to group G streptococcus. Can J Infect Dis. 1990; 1(2):61-3.
    View in: PubMed
  7. Goldman JN, O'Rourke KS, McMannis JD, Goldman MB. Effects of anti-C4 antibody on complement production by splenic and peritoneal macrophages. Complement. 1988; 5(1):13-26.
    View in: PubMed
  8. Goldman MB, O'Rourke KS, Goldman JN. Antibody-induced suppression and postsuppression stimulation of complement in vitro. 1. Effects of anti-c4 on cultured guinea pig peritoneal cells. Cell Immunol. 1982 Jun; 70(1):118-31.
    View in: PubMed
  9. Goldman JN, Bangalore S, Goldman MB. Activation of murine complement by cobra venom factor in the presence of EDTA. J Immunol. 1979 Nov; 123(5):2421-7.
    View in: PubMed
  10. Goldman MB, Goldman JN. Relationship of functional levels of early components of complement to the H-2 complex of mice. J Immunol. 1976 Nov; 117(5 Pt 1):1584-8.
    View in: PubMed
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