PSU Profiles
Last Name

Hiroko Shike

TitleAssistant Professor
InstitutionCollege of Medicine
Address500 University Drive Hershey PA 17033
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    Physician, Assistant Professor of Clinical Pathology
    Medical Co-Director, Histocompatibility Laboratory
    Medical Director, PSU State College Laboratory


    Residency, Pathology, University of California - San Diego, School of Medicine (2008)
    M.D., University of Tokushima, School of Medicine (1986)

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Habig DF, Gaspari JL, Lokhandwala PM, Domen RE, Abendroth CS, Kadry Z, Ghahramani N, Shah RA, Jain A, Shike H. Donor-specific antibody to trans-encoded donor HLA-DQ heterodimer. Hum Immunol. 2015 Aug; 76(8):587-90. PMID: 26382246.
      View in: PubMed
    2. Leonard GR, Shike H, Uemura T, Gaspari JL, Ruggiero FM, Shah RA, Riley TR, Kadry Z. Liver transplantation with a strongly positive crossmatch: case study and literature review. Liver Transpl. 2013 Sep; 19(9):1001-10. PMID: 23798324.
      View in: PubMed
    3. Pham HT, Jousset FX, Perreault J, Shike H, Szelei J, Bergoin M, Tijssen P. Expression strategy of Aedes albopictus densovirus. J Virol. 2013 Sep; 87(17):9928-32. PMID: 23804640; PMCID: PMC3754130.
    4. Uemura T, Ramprasad V, Matsushima K, Shike H, Valania T, Kwon O, Ghahramani N, Shah R, Farooq U, Khan A, Kadry Z. Single dose of alemtuzumab induction with steroid-free maintenance immunosuppression in pancreas transplantation. Transplantation. 2011 Sep 27; 92(6):678-85. PMID: 21841541; PMCID: PMC3353259.
    5. Shimizu C, Matsubara T, Onouchi Y, Jain S, Sun S, Nievergelt CM, Shike H, Brophy VH, Takegawa T, Furukawa S, Akagi T, Newburger JW, Baker AL, Burgner D, Hibberd ML, Davila S, Levin M, Mamtani M, He W, Ahuja SK, Burns JC. Matrix metalloproteinase haplotypes associated with coronary artery aneurysm formation in patients with Kawasaki disease. J Hum Genet. 2010 Dec; 55(12):779-84. PMID: 20827277; PMCID: PMC3005773.
    6. Shike H, Kanegaye JT, Best BM, Pancheri J, Burns JC. Pyuria associated with acute Kawasaki disease and fever from other causes. Pediatr Infect Dis J. 2009 May; 28(5):440-3. PMID: 19319019; PMCID: PMC2738928.
    7. Popper SJ, Shimizu C, Shike H, Kanegaye JT, Newburger JW, Sundel RP, Brown PO, Burns JC, Relman DA. Gene-expression patterns reveal underlying biological processes in Kawasaki disease. Genome Biol. 2007; 8(12):R261. PMID: 18067656; PMCID: PMC2246263.
    8. Baker SC, Shimizu C, Shike H, Garcia F, van der Hoek L, Kuijper TW, Reed SL, Rowley AH, Shulman ST, Talbot HK, Williams JV, Burns JC. Human coronavirus-NL63 infection is not associated with acute Kawasaki disease. Adv Exp Med Biol. 2006; 581:523-6. PMID: 17037590; PMCID: PMC2868826.
    9. Shike H, Shimizu C, Kanegaye JT, Foley JL, Schnurr DP, Wold LJ, Burns JC. Adenovirus, adeno-associated virus and Kawasaki disease. Pediatr Infect Dis J. 2005 Nov; 24(11):1011-4. PMID: 16282942.
      View in: PubMed
    10. Shimizu C, Shike H, Baker SC, Garcia F, van der Hoek L, Kuijpers TW, Reed SL, Rowley AH, Shulman ST, Talbot HK, Williams JV, Burns JC. Human coronavirus NL63 is not detected in the respiratory tracts of children with acute Kawasaki disease. J Infect Dis. 2005 Nov 15; 192(10):1767-71. PMID: 16235175; PMCID: PMC2888540.
    11. Burns JC, Shimizu C, Shike H, Newburger JW, Sundel RP, Baker AL, Matsubara T, Ishikawa Y, Brophy VA, Cheng S, Grow MA, Steiner LL, Kono N, Cantor RM. Family-based association analysis implicates IL-4 in susceptibility to Kawasaki disease. Genes Immun. 2005 Aug; 6(5):438-44. PMID: 15889128; PMCID: PMC2911125.
    12. Burns JC, Shimizu C, Gonzalez E, Kulkarni H, Patel S, Shike H, Sundel RS, Newburger JW, Ahuja SK. Genetic variations in the receptor-ligand pair CCR5 and CCL3L1 are important determinants of susceptibility to Kawasaki disease. J Infect Dis. 2005 Jul 15; 192(2):344-9. PMID: 15962231; PMCID: PMC2894631.
    13. Burns JC, Cayan DR, Tong G, Bainto EV, Turner CL, Shike H, Kawasaki T, Nakamura Y, Yashiro M, Yanagawa H. Seasonality and temporal clustering of Kawasaki syndrome. Epidemiology. 2005 Mar; 16(2):220-5. PMID: 15703537; PMCID: PMC2894624.
    14. Shike H, Shimizu C, Kanegaye J, Foley JL, Burns JC. Quantitation of adenovirus genome during acute infection in normal children. Pediatr Infect Dis J. 2005 Jan; 24(1):29-33. PMID: 15665707; PMCID: PMC2891530.
    15. Shike H, Shimizu C, Lauth X, Burns JC. Organization and expression analysis of the zebrafish hepcidin gene, an antimicrobial peptide gene conserved among vertebrates. Dev Comp Immunol. 2004 Jun; 28(7-8):747-54. PMID: 15043943.
      View in: PubMed
    16. Shimizu C, Shike H, Malicki DM, Breisch E, Westerman M, Buchanan J, Ligman HR, Phillips RB, Carlberg JM, Van Olst J, Burns JC. Characterization of a white bass (Morone chrysops) embryonic cell line with epithelial features. In Vitro Cell Dev Biol Anim. 2003 Jan-Feb; 39(1-2):29-35. PMID: 12892524.
      View in: PubMed
    17. Shike H, Lauth X, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Shimizu C, Bulet P, Burns JC. Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge. Eur J Biochem. 2002 Apr; 269(8):2232-7. PMID: 11985602.
      View in: PubMed
    18. Lauth X, Shike H, Burns JC, Westerman ME, Ostland VE, Carlberg JM, Van Olst JC, Nizet V, Taylor SW, Shimizu C, Bulet P. Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass. J Biol Chem. 2002 Feb 15; 277(7):5030-9. PMID: 11739390.
      View in: PubMed
    19. Paul TA, Burns JC, Shike H, Getchell R, Bowser PR, Whitlock KE, Casey JW. Reporter gene expression in fish following cutaneous infection with pantropic retroviral vectors. Mar Biotechnol (NY). 2001 Jun; 3(Supplement 1):S81-7. PMID: 14961303.
      View in: PubMed
    20. Shimizu C, Shike H, Klimpel KR, Burns JC. Hemolymph analysis and evaluation of newly formulated media for culture of shrimp cells (Penaeus stylirostris). In Vitro Cell Dev Biol Anim. 2001 Jun; 37(6):322-9. PMID: 11515962.
      View in: PubMed
    21. Quasney MW, Bronstein DE, Cantor RM, Zhang Q, Stroupe C, Shike H, Bastian JF, Matsubara T, Fujiwara M, Akimoto K, Newburger JW, Burns JC. Increased frequency of alleles associated with elevated tumor necrosis factor-alpha levels in children with Kawasaki disease. Pediatr Res. 2001 May; 49(5):686-90. PMID: 11328953.
      View in: PubMed
    22. Shike H, Dhar AK, Burns JC, Shimizu C, Jousset FX, Klimpel KR, Bergoin M. Infectious hypodermal and hematopoietic necrosis virus of shrimp is related to mosquito brevidensoviruses. Virology. 2000 Nov 10; 277(1):167-77. PMID: 11062047.
      View in: PubMed
    23. Burns JC, Kushner HI, Bastian JF, Shike H, Shimizu C, Matsubara T, Turner CL. Kawasaki disease: A brief history. Pediatrics. 2000 Aug; 106(2):E27. PMID: 10920183.
      View in: PubMed
    24. Boulo V, Cadoret JP, Shike H, Shimizu C, Miyanohara A, Burns JC. Infection of cultured embryo cells of the pacific oyster, Crassostrea gigas, by pantropic retroviral vectors. In Vitro Cell Dev Biol Anim. 2000 Jun; 36(6):395-9. PMID: 10949999.
      View in: PubMed
    25. Que X, Kim D, Alagon A, Hirata K, Shike H, Shimizu C, Gonzalez A, Burns JC, Reed SL. Pantropic retroviral vectors mediate gene transfer and expression in Entamoeba histolytica. Mol Biochem Parasitol. 1999 Apr 30; 99(2):237-45. PMID: 10340487.
      View in: PubMed
    26. Franco M, Rogers ME, Shimizu C, Shike H, Vogt RG, Burns JC. Infection of lepidoptera with a pseudotyped retroviral vector. Insect Biochem Mol Biol. 1998 Nov; 28(11):819-25. PMID: 9818383.
      View in: PubMed
    27. Jordan TV, Shike H, Boulo V, Cedeno V, Fang Q, Davis BS, Jacobs-Lorena M, Higgs S, Fryxell KJ, Burns JC. Pantropic retroviral vectors mediate somatic cell transformation and expression of foreign genes in dipteran insects. Insect Mol Biol. 1998 Aug; 7(3):215-22. PMID: 9662470.
      View in: PubMed
    28. Teysset L, Burns JC, Shike H, Sullivan BL, Bucheton A, Terzian C. A Moloney murine leukemia virus-based retroviral vector pseudotyped by the insect retroviral gypsy envelope can infect Drosophila cells. J Virol. 1998 Jan; 72(1):853-6. PMID: 9420299; PMCID: PMC109448.
    29. Burns JC, Shike H, Gordon JB, Malhotra A, Schoenwetter M, Kawasaki T. Sequelae of Kawasaki disease in adolescents and young adults. J Am Coll Cardiol. 1996 Jul; 28(1):253-7. PMID: 8752822.
      View in: PubMed
    30. Matsubara T, Beeman RW, Shike H, Besansky NJ, Mukabayire O, Higgs S, James AA, Burns JC. Pantropic retroviral vectors integrate and express in cells of the malaria mosquito, Anopheles gambiae. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):6181-5. PMID: 8650240; PMCID: PMC39210.
    31. Aihara Y, Mori M, Ibe M, Kuriyama T, Takahashi Y, Shimizu C, Shike H, Mitsuda T, Yokota S. [A case of juvenile dermatomyositis with calcinosis universalis--remarkable improvement with aluminum hydroxide therapy]. Ryumachi. 1994 Oct; 34(5):879-84. PMID: 7801200.
      View in: PubMed
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