PSU Profiles
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Last Name
Institution

Henry Donahue

TitleProfessor
InstitutionCollege of Medicine
DepartmentOrthopaedics and Rehabilitation
Address500 University Drive Hershey PA 17033
Mailbox: H089
Phone7175314819

 Overview 
 overview
PREFERRED TITLE/ROLE:

Vice Chair, Michael and Myrtle Baker Professor, Director Division of Musculoskeletal Sciences



GRADUATE PROGRAM AFFILIATIONS:

Biomedical Sciences, Cell and Molecular Biology, MD/PhD Degree Program, Physiology, Bioengineering, Anatomy



EDUCATION:

Ph.D., University of California, Santa Barbara, 1986

Postdoctoral Training, Mayo Graduate School of Medicine, 1986-1989



NARRATIVE:

Our laboratory is interested in the regulation of bone and cartilage cell metabolism by extracellular signals, both chemical and biophysical, the mechanism by which these signals control cell behavior and how this changes as a function of disease and aging. We are especially interested in the mechanism by which bone adapts to mechanical loading and unloading at the cell and molecular level. We also have a strong interest in the role of gap junctional intercellular communication in cellular differentiation, tumorigenesis and metastasis, wound healing and bone turnover. Additionally, we have a research program focusing on developing novel protocols for musculoskeletal regenerative medicine and tissue engineering; This program includes an examination of how biomaterial characteristics, including surface energy and nanoscale topography, affect stem cell differentiation towards the bone cell lineage. Finally, studies in our laboratory also focus on the integrated proteomic and genomic response of cells to biophysical signals. Techniques we use include cell culture, molecular biology, animal transgenics, microspectroflourometry, nanofabrication, atomic force microscopy, biomechanical testing, histology and microCT. Most experiments utilize human and murine bone cell models but we also complete in vivo studies on rats and mice.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lloyd SA, Lang CH, Zhang Y, Paul EM, Laufenberg LJ, Lewis GS, Donahue HJ. Interdependence of muscle atrophy and bone loss induced by mechanical unloading. J Bone Miner Res. 2014 May; 29(5):1118-30.
    View in: PubMed
  2. Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ. Evidence for the role of connexin 43-mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis. BMC Musculoskelet Disord. 2014; 15(1):122.
    View in: PubMed
  3. Govey PM, Jacobs JM, Tilton SC, Loiselle AE, Zhang Y, Freeman WM, Waters KM, Karin NJ, Donahue HJ. Integrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways. J Biomech. 2014 Jun 3; 47(8):1838-45.
    View in: PubMed
  4. Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ. Shifting paradigms on the role of connexin43 in the skeletal response to mechanical load. J Bone Miner Res. 2014 Feb; 29(2):275-86.
    View in: PubMed
  5. Loiselle AE, Lloyd SA, Paul EM, Lewis GS, Donahue HJ. Inhibition of GSK-3ß Rescues the Impairments in Bone Formation and Mechanical Properties Associated with Fracture Healing in Osteoblast Selective Connexin 43 Deficient Mice. PLoS One. 2013; 8(11):e81399.
    View in: PubMed
  6. Lloyd SA, Loiselle AE, Zhang Y, Donahue HJ. Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling. Bone. 2013 Nov; 57(1):76-83.
    View in: PubMed
  7. Donahue HJ, Genetos DC. Genomic approaches in breast cancer research. Brief Funct Genomics. 2013 Sep; 12(5):391-6.
    View in: PubMed
  8. Govey PM, Loiselle AE, Donahue HJ. Biophysical regulation of stem cell differentiation. Curr Osteoporos Rep. 2013 Jun; 11(2):83-91.
    View in: PubMed
  9. Loiselle AE, Wei L, Faryad M, Paul EM, Lewis GS, Gao J, Lakhtakia A, Donahue HJ. Specific biomimetic hydroxyapatite nanotopographies enhance osteoblastic differentiation and bone graft osteointegration. Tissue Eng Part A. 2013 Aug; 19(15-16):1704-12.
    View in: PubMed
  10. Zhang Y, Chin-Quee K, Riddle RC, Li Z, Zhou Z, Donahue HJ. BRMS1 Sensitizes Breast Cancer Cells to ATP-Induced Growth Suppression. Biores Open Access. 2013 Apr; 2(2):77-83.
    View in: PubMed
  11. Lloyd SA, Lewis GS, Zhang Y, Paul EM, Donahue HJ. Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading. J Bone Miner Res. 2012 Nov; 27(11):2359-72.
    View in: PubMed
  12. Loiselle AE, Jiang JX, Donahue HJ. Gap junction and hemichannel functions in osteocytes. Bone. 2013 Jun; 54(2):205-12.
    View in: PubMed
  13. Lim JY, Siedlecki CA, Donahue HJ. Nanotopographic cell culture substrate: polymer-demixed nanotextured films under cell culture conditions. Biores Open Access. 2012 Oct; 1(5):252-5.
    View in: PubMed
  14. Loiselle AE, Paul EM, Lewis GS, Donahue HJ. Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healing. J Orthop Res. 2013 Jan; 31(1):147-54.
    View in: PubMed
  15. Genetos DC, Zhou Z, Li Z, Donahue HJ. Age-related changes in gap junctional intercellular communication in osteoblastic cells. J Orthop Res. 2012 Dec; 30(12):1979-84.
    View in: PubMed
  16. Xing Y, Gu Y, Xu LC, Siedlecki CA, Donahue HJ, You J. Effects of membrane cholesterol depletion and GPI-anchored protein reduction on osteoblastic mechanotransduction. J Cell Physiol. 2011 Sep; 226(9):2350-9.
    View in: PubMed
  17. Zhang Y, Paul EM, Sathyendra V, Davison A, Sharkey N, Bronson S, Srinivasan S, Gross TS, Donahue HJ. Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone. PLoS One. 2011; 6(8):e23516.
    View in: PubMed
  18. Lim JY, Loiselle AE, Lee JS, Zhang Y, Salvi JD, Donahue HJ. Optimizing the osteogenic potential of adult stem cells for skeletal regeneration. J Orthop Res. 2011 Nov; 29(11):1627-33.
    View in: PubMed
  19. Buckwalter JA, Wright TM, Donahue HJ. A new feature of the journal of orthopaedic research: research perspectives. J Orthop Res. 2011 Jun; 29(6):801.
    View in: PubMed
  20. Genetos DC, Karin NJ, Geist DJ, Donahue HJ, Duncan RL. Purinergic signaling is required for fluid shear stress-induced NF-?B translocation in osteoblasts. Exp Cell Res. 2011 Apr 1; 317(6):737-44.
    View in: PubMed
  21. Bridgeman JT, Zhang Y, Donahue H, Wade AM, Juliano PJ. Estrogen receptor expression in posterior tibial tendon dysfunction: a pilot study. Foot Ankle Int. 2010 Dec; 31(12):1081-4.
    View in: PubMed
  22. Lloyd SA, Donahue HJ. Gap Junctions and Biophysical Regulation of Bone Cells. Clin Rev Bone Miner Metab. 2010 Dec 1; 8(4):189-200.
    View in: PubMed
  23. Fitzpatrick LR, Green C, Frauenhoffer EE, French KJ, Zhuang Y, Maines LW, Upson JJ, Paul E, Donahue H, Mosher TJ, Smith CD. Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase. Inflammopharmacology. 2011 Apr; 19(2):75-87.
    View in: PubMed
  24. Salvi JD, Lim JY, Donahue HJ. Increased mechanosensitivity of cells cultured on nanotopographies. J Biomech. 2010 Nov 16; 43(15):3058-62.
    View in: PubMed
  25. Salvi JD, Lim JY, Donahue HJ. Finite element analyses of fluid flow conditions in cell culture. Tissue Eng Part C Methods. 2010 Aug; 16(4):661-70.
    View in: PubMed
  26. Riddle RC, Donahue HJ. From streaming-potentials to shear stress: 25 years of bone cell mechanotransduction. J Orthop Res. 2009 Feb; 27(2):143-9.
    View in: PubMed
  27. Jekir MG, Donahue HJ. Gap junctions and osteoblast-like cell gene expression in response to fluid flow. J Biomech Eng. 2009 Jan; 131(1):011005.
    View in: PubMed
  28. Li Z, Zhou Z, Welch DR, Donahue HJ. Expressing connexin 43 in breast cancer cells reduces their metastasis to lungs. Clin Exp Metastasis. 2008; 25(8):893-901.
    View in: PubMed
  29. Ciovacco WA, Goldberg CG, Taylor AF, Lemieux JM, Horowitz MC, Donahue HJ, Kacena MA. The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation. Bone. 2009 Jan; 44(1):80-6.
    View in: PubMed
  30. Riddle RC, Hippe KR, Donahue HJ. Chemotransport contributes to the effect of oscillatory fluid flow on human bone marrow stromal cell proliferation. J Orthop Res. 2008 Jul; 26(7):918-24.
    View in: PubMed
  31. Lim JY, Shaughnessy MC, Zhou Z, Noh H, Vogler EA, Donahue HJ. Surface energy effects on osteoblast spatial growth and mineralization. Biomaterials. 2008 Apr; 29(12):1776-84.
    View in: PubMed
  32. Li Z, Zhou Z, Donahue HJ. Alterations in Cx43 and OB-cadherin affect breast cancer cell metastatic potential. Clin Exp Metastasis. 2008; 25(3):265-72.
    View in: PubMed
  33. Riddle RC, Taylor AF, Donahue HJ. Fluid flow assays. Methods Mol Biol. 2008; 455:335-45.
    View in: PubMed
  34. Kapoor P, Suva LJ, Welch DR, Donahue HJ. Osteoprotegrin and the bone homing and colonization potential of breast cancer cells. J Cell Biochem. 2008 Jan 1; 103(1):30-41.
    View in: PubMed
  35. Huang X, Zhang Y, Donahue HJ, Lowe TL. Porous thermoresponsive-co-biodegradable hydrogels as tissue-engineering scaffolds for 3-dimensional in vitro culture of chondrocytes. Tissue Eng. 2007 Nov; 13(11):2645-52.
    View in: PubMed
  36. Lim JY, Donahue HJ. Cell sensing and response to micro- and nanostructured surfaces produced by chemical and topographic patterning. Tissue Eng. 2007 Aug; 13(8):1879-91.
    View in: PubMed
  37. Liu X, Lim JY, Donahue HJ, Dhurjati R, Mastro AM, Vogler EA. Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell line hFOB 1.19: Phenotypic and genotypic responses observed in vitro. Biomaterials. 2007 Nov; 28(31):4535-50.
    View in: PubMed
  38. Genetos DC, Kephart CJ, Zhang Y, Yellowley CE, Donahue HJ. Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes. J Cell Physiol. 2007 Jul; 212(1):207-14.
    View in: PubMed
  39. Hansen JC, Lim JY, Xu LC, Siedlecki CA, Mauger DT, Donahue HJ. Effect of surface nanoscale topography on elastic modulus of individual osteoblastic cells as determined by atomic force microscopy. J Biomech. 2007; 40(13):2865-71.
    View in: PubMed
  40. Riddle RC, Taylor AF, Rogers JR, Donahue HJ. ATP release mediates fluid flow-induced proliferation of human bone marrow stromal cells. J Bone Miner Res. 2007 Apr; 22(4):589-600.
    View in: PubMed
  41. Lim JY, Dreiss AD, Zhou Z, Hansen JC, Siedlecki CA, Hengstebeck RW, Cheng J, Winograd N, Donahue HJ. The regulation of integrin-mediated osteoblast focal adhesion and focal adhesion kinase expression by nanoscale topography. Biomaterials. 2007 Apr; 28(10):1787-97.
    View in: PubMed
  42. Godin LM, Suzuki S, Jacobs CR, Donahue HJ, Donahue SW. Mechanically induced intracellular calcium waves in osteoblasts demonstrate calcium fingerprints in bone cell mechanotransduction. Biomech Model Mechanobiol. 2007 Nov; 6(6):391-8.
    View in: PubMed
  43. Le M, Li Z, Cilley RE, Donahue H, Chinoy MR. Connexin 43 gene expression in mice with cardiopulmonary developmental defects. Front Biosci. 2006; 11:3014-25.
    View in: PubMed
  44. Taylor AF, Saunders MM, Shingle DL, Cimbala JM, Zhou Z, Donahue HJ. Mechanically stimulated osteocytes regulate osteoblastic activity via gap junctions. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C545-52.
    View in: PubMed
  45. Cher ML, Towler DA, Rafii S, Rowley D, Donahue HJ, Keller E, Herlyn M, Cho EA, Chung LW. Cancer interaction with the bone microenvironment: a workshop of the National Institutes of Health Tumor Microenvironment Study Section. Am J Pathol. 2006 May; 168(5):1405-12.
    View in: PubMed
  46. Li Z, Zhou Z, Saunders MM, Donahue HJ. Modulation of connexin43 alters expression of osteoblastic differentiation markers. Am J Physiol Cell Physiol. 2006 Apr; 290(4):C1248-55.
    View in: PubMed
  47. Riddle RC, Taylor AF, Genetos DC, Donahue HJ. MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C776-84.
    View in: PubMed
  48. Lim JY, Hansen JC, Siedlecki CA, Hengstebeck RW, Cheng J, Winograd N, Donahue HJ. Osteoblast adhesion on poly(L-lactic acid)/polystyrene demixed thin film blends: effect of nanotopography, surface chemistry, and wettability. Biomacromolecules. 2005 Nov-Dec; 6(6):3319-27.
    View in: PubMed
  49. Saunders MM, Taylor AF, Du C, Zhou Z, Pellegrini VD, Donahue HJ. Mechanical stimulation effects on functional end effectors in osteoblastic MG-63 cells. J Biomech. 2006; 39(8):1419-27.
    View in: PubMed
  50. Lim JY, Hansen JC, Siedlecki CA, Runt J, Donahue HJ. Human foetal osteoblastic cell response to polymer-demixed nanotopographic interfaces. J R Soc Interface. 2005 Mar 22; 2(2):97-108.
    View in: PubMed
  51. Lim JY, Taylor AF, Li Z, Vogler EA, Donahue HJ. Integrin expression and osteopontin regulation in human fetal osteoblastic cells mediated by substratum surface characteristics. Tissue Eng. 2005 Jan-Feb; 11(1-2):19-29.
    View in: PubMed
  52. Kim YS, Lim JY, Donahue HJ, Lowe TL. Thermoresponsive terpolymeric films applicable for osteoblastic cell growth and noninvasive cell sheet harvesting. Tissue Eng. 2005 Jan-Feb; 11(1-2):30-40.
    View in: PubMed
  53. Donahue HJ. Summary--bone metastasis. J Musculoskelet Neuronal Interact. 2004 Dec; 4(4):381-2.
    View in: PubMed
  54. Lim JY, Donahue HJ. Biomaterial characteristics important to skeletal tissue engineering. J Musculoskelet Neuronal Interact. 2004 Dec; 4(4):396-8.
    View in: PubMed
  55. Genetos DC, Geist DJ, Liu D, Donahue HJ, Duncan RL. Fluid shear-induced ATP secretion mediates prostaglandin release in MC3T3-E1 osteoblasts. J Bone Miner Res. 2005 Jan; 20(1):41-9.
    View in: PubMed
  56. Kapoor P, Saunders MM, Li Z, Zhou Z, Sheaffer N, Kunze EL, Samant RS, Welch DR, Donahue HJ. Breast cancer metastatic potential: correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cells. Int J Cancer. 2004 Sep 20; 111(5):693-7.
    View in: PubMed
  57. Saunders MM, Donahue HJ. Development of a cost-effective loading machine for biomechanical evaluation of mouse transgenic models. Med Eng Phys. 2004 Sep; 26(7):595-603.
    View in: PubMed
  58. Haut Donahue TL, Genetos DC, Jacobs CR, Donahue HJ, Yellowley CE. Annexin V disruption impairs mechanically induced calcium signaling in osteoblastic cells. Bone. 2004 Sep; 35(3):656-63.
    View in: PubMed
  59. Oki A, Parveen B, Hossain S, Adeniji S, Donahue H. Preparation and in vitro bioactivity of zinc containing sol-gel-derived bioglass materials. J Biomed Mater Res A. 2004 May 1; 69(2):216-21.
    View in: PubMed
  60. Lim JY, Liu X, Vogler EA, Donahue HJ. Systematic variation in osteoblast adhesion and phenotype with substratum surface characteristics. J Biomed Mater Res A. 2004 Mar 1; 68(3):504-12.
    View in: PubMed
  61. Mastro AM, Gay CV, Welch DR, Donahue HJ, Jewell J, Mercer R, DiGirolamo D, Chislock EM, Guttridge K. Breast cancer cells induce osteoblast apoptosis: a possible contributor to bone degradation. J Cell Biochem. 2004 Feb 1; 91(2):265-76.
    View in: PubMed
  62. Harms JF, Welch DR, Samant RS, Shevde LA, Miele ME, Babu GR, Goldberg SF, Gilman VR, Sosnowski DM, Campo DA, Gay CV, Budgeon LR, Mercer R, Jewell J, Mastro AM, Donahue HJ, Erin N, Debies MT, Meehan WJ, Jones AL, Mbalaviele G, Nickols A, Christensen ND, Melly R, Beck LN, Kent J, Rader RK, Kotyk JJ, Pagel MD, Westlin WF, Griggs DW. A small molecule antagonist of the alpha(v)beta3 integrin suppresses MDA-MB-435 skeletal metastasis. Clin Exp Metastasis. 2004; 21(2):119-28.
    View in: PubMed
  63. Edlich M, Yellowley CE, Jacobs CR, Donahue HJ. Cycle number and waveform of fluid flow affect bovine articular chondrocytes. Biorheology. 2004; 41(3-4):315-22.
    View in: PubMed
  64. Brown KM, Saunders MM, Kirsch T, Donahue HJ, Reid JS. Effect of COX-2-specific inhibition on fracture-healing in the rat femur. J Bone Joint Surg Am. 2004 Jan; 86-A(1):116-23.
    View in: PubMed
  65. Donahue SW, Vaughan MR, Demers LM, Donahue HJ. Bone formation is not impaired by hibernation (disuse) in black bears Ursus americanus. J Exp Biol. 2003 Dec; 206(Pt 23):4233-9.
    View in: PubMed
  66. Alford AI, Yellowley CE, Jacobs CR, Donahue HJ. Increases in cytosolic calcium, but not fluid flow, affect aggrecan mRNA levels in articular chondrocytes. J Cell Biochem. 2003 Dec 1; 90(5):938-44.
    View in: PubMed
  67. Donahue TL, Haut TR, Yellowley CE, Donahue HJ, Jacobs CR. Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport. J Biomech. 2003 Sep; 36(9):1363-71.
    View in: PubMed
  68. Alford AI, Jacobs CR, Donahue HJ. Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP kinase-dependent mechanism small star, filled. Bone. 2003 Jul; 33(1):64-70.
    View in: PubMed
  69. Donahue HJ, Saunders MM, Li Z, Mastro AM, Gay CV, Welch DR. A potential role for gap junctions in breast cancer metastasis to bone. J Musculoskelet Neuronal Interact. 2003 Jun; 3(2):156-61.
    View in: PubMed
  70. Saunders MM, You J, Zhou Z, Li Z, Yellowley CE, Kunze EL, Jacobs CR, Donahue HJ. Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium. Bone. 2003 Apr; 32(4):350-6.
    View in: PubMed
  71. Donahue SW, Vaughan MR, Demers LM, Donahue HJ. Serum markers of bone metabolism show bone loss in hibernating bears. Clin Orthop Relat Res. 2003 Mar; (408):295-301.
    View in: PubMed
  72. Lohmann CH, Schwartz Z, Liu Y, Li Z, Simon BJ, Sylvia VL, Dean DD, Bonewald LF, Donahue HJ, Boyan BD. Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO-Y4 osteocyte-like cells and ROS 17/2.8 osteoblast-like cells. J Orthop Res. 2003 Mar; 21(2):326-34.
    View in: PubMed
  73. Welch DR, Harms JF, Mastro AM, Gay CV, Donahue HJ. Breast cancer metastasis to bone: evolving models and research challenges. J Musculoskelet Neuronal Interact. 2003 Mar; 3(1):30-8.
    View in: PubMed
  74. Reilly GC, Haut TR, Yellowley CE, Donahue HJ, Jacobs CR. Fluid flow induced PGE2 release by bone cells is reduced by glycocalyx degradation whereas calcium signals are not. Biorheology. 2003; 40(6):591-603.
    View in: PubMed
  75. Donahue SW, Donahue HJ, Jacobs CR. Osteoblastic cells have refractory periods for fluid-flow-induced intracellular calcium oscillations for short bouts of flow and display multiple low-magnitude oscillations during long-term flow. J Biomech. 2003 Jan; 36(1):35-43.
    View in: PubMed
  76. You J, Jacobs CR, Steinberg TH, Donahue HJ. P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. J Biol Chem. 2002 Dec 13; 277(50):48724-9.
    View in: PubMed
  77. Sharma R, Yellowley CE, Civelek M, Ainslie K, Hodgson L, Tarbell JM, Donahue HJ. Intracellular calcium changes in rat aortic smooth muscle cells in response to fluid flow. Ann Biomed Eng. 2002 Mar; 30(3):371-8.
    View in: PubMed
  78. Shevde LA, Samant RS, Goldberg SF, Sikaneta T, Alessandrini A, Donahue HJ, Mauger DT, Welch DR. Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. Exp Cell Res. 2002 Feb 15; 273(2):229-39.
    View in: PubMed
  79. Yellowley CE, Hancox JC, Donahue HJ. Effects of cell swelling on intracellular calcium and membrane currents in bovine articular chondrocytes. J Cell Biochem. 2002; 86(2):290-301.
    View in: PubMed
  80. Saunders MM, You J, Trosko JE, Yamasaki H, Li Z, Donahue HJ, Jacobs CR. Gap junctions and fluid flow response in MC3T3-E1 cells. Am J Physiol Cell Physiol. 2001 Dec; 281(6):C1917-25.
    View in: PubMed
  81. Donahue SW, Jacobs CR, Donahue HJ. Flow-induced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent. Am J Physiol Cell Physiol. 2001 Nov; 281(5):C1635-41.
    View in: PubMed
  82. Buhl KM, Jacobs CR, Turner RT, Evans GL, Farrell PA, Donahue HJ. Aged bone displays an increased responsiveness to low-intensity resistance exercise. J Appl Physiol (1985). 2001 Apr; 90(4):1359-64.
    View in: PubMed
  83. Saunders MM, Seraj MJ, Li Z, Zhou Z, Winter CR, Welch DR, Donahue HJ. Breast cancer metastatic potential correlates with a breakdown in homospecific and heterospecific gap junctional intercellular communication. Cancer Res. 2001 Mar 1; 61(5):1765-7.
    View in: PubMed
  84. Guo Y, Martinez-Williams C, Yellowley CE, Donahue HJ, Rannels DE. Connexin expression by alveolar epithelial cells is regulated by extracellular matrix. Am J Physiol Lung Cell Mol Physiol. 2001 Feb; 280(2):L191-202.
    View in: PubMed
  85. You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ, Jacobs CR. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts. J Biol Chem. 2001 Apr 20; 276(16):13365-71.
    View in: PubMed
  86. Edlich M, Yellowley CE, Jacobs CR, Donahue HJ. Oscillating fluid flow regulates cytosolic calcium concentration in bovine articular chondrocytes. J Biomech. 2001 Jan; 34(1):59-65.
    View in: PubMed
  87. Kurokouchi K, Jacobs CR, Donahue HJ. Oscillating fluid flow inhibits TNF-alpha -induced NF-kappa B activation via an Ikappa B kinase pathway in osteoblast-like UMR106 cells. J Biol Chem. 2001 Apr 20; 276(16):13499-504.
    View in: PubMed
  88. You J, Yellowley CE, Donahue HJ, Zhang Y, Chen Q, Jacobs CR. Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow. J Biomech Eng. 2000 Aug; 122(4):387-93.
    View in: PubMed
  89. Vander Molen MA, Donahue HJ, Rubin CT, McLeod KJ. Osteoblastic networks with deficient coupling: differential effects of magnetic and electric field exposure. Bone. 2000 Aug; 27(2):227-31.
    View in: PubMed
  90. Donahue HJ. Gap junctions and biophysical regulation of bone cell differentiation. Bone. 2000 May; 26(5):417-22.
    View in: PubMed
  91. Malecki EA, Buhl KM, Beard JL, Jacobs CR, Connor JR, Donahue HJ. Bone structural and mechanical properties are affected by hypotransferrinemia but not by iron deficiency in mice. J Bone Miner Res. 2000 Feb; 15(2):271-7.
    View in: PubMed
  92. Yellowley CE, Li Z, Zhou Z, Jacobs CR, Donahue HJ. Functional gap junctions between osteocytic and osteoblastic cells. J Bone Miner Res. 2000 Feb; 15(2):209-17.
    View in: PubMed
  93. Donahue HJ, Li Z, Zhou Z, Yellowley CE. Differentiation of human fetal osteoblastic cells and gap junctional intercellular communication. Am J Physiol Cell Physiol. 2000 Feb; 278(2):C315-22.
    View in: PubMed
  94. Samant RS, Seraj MJ, Saunders MM, Sakamaki TS, Shevde LA, Harms JF, Leonard TO, Goldberg SF, Budgeon L, Meehan WJ, Winter CR, Christensen ND, Verderame MF, Donahue HJ, Welch DR. Analysis of mechanisms underlying BRMS1 suppression of metastasis. Clin Exp Metastasis. 2000; 18(8):683-93.
    View in: PubMed
  95. Jacobs CR, Yellowley CE, Nelson DV, Donahue HJ. Analysis of Time-Varying Biological Data Using Rainflow Cycle Counting. Comput Methods Biomech Biomed Engin. 2000; 3(1):31-40.
    View in: PubMed
  96. Li Z, Zhou Z, Yellowley CE, Donahue HJ. Inhibiting gap junctional intercellular communication alters expression of differentiation markers in osteoblastic cells. Bone. 1999 Dec; 25(6):661-6.
    View in: PubMed
  97. Yellowley CE, Jacobs CR, Donahue HJ. Mechanisms contributing to fluid-flow-induced Ca2+ mobilization in articular chondrocytes. J Cell Physiol. 1999 Sep; 180(3):402-8.
    View in: PubMed
  98. Guilak F, Zell RA, Erickson GR, Grande DA, Rubin CT, McLeod KJ, Donahue HJ. Mechanically induced calcium waves in articular chondrocytes are inhibited by gadolinium and amiloride. J Orthop Res. 1999 May; 17(3):421-9.
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  99. Bowman NN, Donahue HJ, Ehrlich HP. Gap junctional intercellular communication contributes to the contraction of rat osteoblast populated collagen lattices. J Bone Miner Res. 1998 Nov; 13(11):1700-6.
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  100. Jacobs CR, Yellowley CE, Davis BR, Zhou Z, Cimbala JM, Donahue HJ. Differential effect of steady versus oscillating flow on bone cells. J Biomech. 1998 Nov; 31(11):969-76.
    View in: PubMed
  101. Donahue HJ. Gap junctional intercellular communication in bone: a cellular basis for the mechanostat set point. Calcif Tissue Int. 1998 Feb; 62(2):85-8.
    View in: PubMed
  102. Donahue HJ, Zhou Z, Li Z, McCauley LK. Age-related decreases in stimulatory G protein-coupled adenylate cyclase activity in osteoblastic cells. Am J Physiol. 1997 Oct; 273(4 Pt 1):E776-81.
    View in: PubMed
  103. Su M, Borke JL, Donahue HJ, Li Z, Warshawsky NM, Russell CM, Lewis JE. Expression of connexin 43 in rat mandibular bone and periodontal ligament (PDL) cells during experimental tooth movement. J Dent Res. 1997 Jul; 76(7):1357-66.
    View in: PubMed
  104. Yellowley CE, Jacobs CR, Li Z, Zhou Z, Donahue HJ. Effects of fluid flow on intracellular calcium in bovine articular chondrocytes. Am J Physiol. 1997 Jul; 273(1 Pt 1):C30-6.
    View in: PubMed
  105. Lee YC, Yellowley CE, Li Z, Donahue HJ, Rannels DE. Expression of functional gap junctions in cultured pulmonary alveolar epithelial cells. Am J Physiol. 1997 Jun; 272(6 Pt 1):L1105-14.
    View in: PubMed
  106. Vander Molen MA, Rubin CT, McLeod KJ, McCauley LK, Donahue HJ. Gap junctional intercellular communication contributes to hormonal responsiveness in osteoblastic networks. J Biol Chem. 1996 May 24; 271(21):12165-71.
    View in: PubMed
  107. Donahue HJ, Guilak F, Vander Molen MA, McLeod KJ, Rubin CT, Grande DA, Brink PR. Chondrocytes isolated from mature articular cartilage retain the capacity to form functional gap junctions. J Bone Miner Res. 1995 Sep; 10(9):1359-64.
    View in: PubMed
  108. Donahue HJ, McLeod KJ, Rubin CT, Andersen J, Grine EA, Hertzberg EL, Brink PR. Cell-to-cell communication in osteoblastic networks: cell line-dependent hormonal regulation of gap junction function. J Bone Miner Res. 1995 Jun; 10(6):881-9.
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  109. Rubin CT, Donahue HJ, Rubin JE, McLeod KJ. Optimization of electric field parameters for the control of bone remodeling: exploitation of an indigenous mechanism for the prevention of osteopenia. J Bone Miner Res. 1993 Dec; 8 Suppl 2:S573-81.
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  110. Greenfield EM, Gornik SA, Horowitz MC, Donahue HJ, Shaw SM. Regulation of cytokine expression in osteoblasts by parathyroid hormone: rapid stimulation of interleukin-6 and leukemia inhibitory factor mRNA. J Bone Miner Res. 1993 Oct; 8(10):1163-71.
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  111. McLeod KJ, Donahue HJ, Levin PE, Fontaine MA, Rubin CT. Electric fields modulate bone cell function in a density-dependent manner. J Bone Miner Res. 1993 Aug; 8(8):977-84.
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  112. Donahue HJ, Iijima K, Goligorsky MS, Rubin CT, Rifkin BR. Regulation of cytoplasmic calcium concentration in tetracycline-treated osteoclasts. J Bone Miner Res. 1992 Nov; 7(11):1313-8.
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  113. Bidwell JP, Fryer MJ, Firek AF, Donahue HJ, Heath H. Desensitization of rat osteoblast-like cells (ROS 17/2.8) to parathyroid hormone uncouples the adenosine 3',5'-monophosphate and cytosolic ionized calcium response limbs. Endocrinology. 1991 Feb; 128(2):1021-8.
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  114. Donahue HJ, Fryer MJ, Heath H. Structure-function relationships for full-length recombinant parathyroid hormone-related peptide and its amino-terminal fragments: effects on cytosolic calcium ion mobilization and adenylate cyclase activation in rat osteoblast-like cells. Endocrinology. 1990 Mar; 126(3):1471-7.
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  115. Donahue HJ, Fryer MJ, Eriksen EF, Heath H. Differential effects of parathyroid hormone and its analogues on cytosolic calcium ion and cAMP levels in cultured rat osteoblast-like cells. J Biol Chem. 1988 Sep 25; 263(27):13522-7.
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  116. Donahue HJ, Mazzeo RS, Horvath SM. Endurance training and bone loss in calcium-deficient and ovariectomized rats. Metabolism. 1988 Aug; 37(8):741-4.
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