PSU Profiles
Last Name

Gail Matters

TitleAssociate Professor
InstitutionCollege of Medicine
DepartmentBiochemistry and Molecular Biology
Address500 University Drive Hershey PA 17033
Mailbox: H171
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    Collapse overview

    Associate Professor of Biochemistry and Molecular Biology


    Penn State Hershey Cancer Institute, Experimental Therapeutics


    Biochemistry and Molecular Biology


    B.S., Rutgers University, 1979
    M.S., Rutgers University, 1981
    Ph.D., North Carolina State University, 1986
    Postdoctoral, Washington University, St Louis, MO 1990

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Clawson GA, Matters GL, Xin P, McGovern C, Wafula E, dePamphilis C, Meckley M, Wong J, Stewart L, D'Jamoos C, Altman N, Imamura Kawasawa Y, Du Z, Honaas L, Abraham T. "Stealth dissemination" of macrophage-tumor cell fusions cultured from blood of patients with pancreatic ductal adenocarcinoma. PLoS One. 2017; 12(9):e0184451. PMID: 28957348.
      View in: PubMed
    2. Tang X, Loc WS, Dong C, Matters GL, Butler PJ, Kester M, Meyers C, Jiang Y, Adair JH. The use of nanoparticulates to treat breast cancer. Nanomedicine (Lond). 2017 Oct; 12(19):2367-2388. PMID: 28868970.
      View in: PubMed
    3. Loc WS, Linton SS, Wilczynski ZR, Matters GL, McGovern CO, Abraham T, Fox T, Gigliotti CM, Tang X, Tabakovic A, Martin JA, Clawson GA, Smith JP, Butler PJ, Kester M, Adair JH. Effective encapsulation and biological activity of phosphorylated chemotherapeutics in calcium phosphosilicate nanoparticles for the treatment of pancreatic cancer. Nanomedicine. 2017 Oct; 13(7):2313-2324. PMID: 28673852.
      View in: PubMed
    4. Zhang M, Lykke-Andersen S, Zhu B, Xiao W, Hoskins JW, Zhang X, Rost LM, Collins I, Bunt MV, Jia J, Parikh H, Zhang T, Song L, Jermusyk A, Chung CC, Zhu B, Zhou W, Matters GL, Kurtz RC, Yeager M, Jensen TH, Brown KM, Ongen H, Bamlet WR, Murray BA, McCarthy MI, Chanock SJ, Chatterjee N, Wolpin BM, Smith JP, Olson SH, Petersen GM, Shi J, Amundadottir L. Characterising cis-regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues. Gut. 2017 Jun 20. PMID: 28634199.
      View in: PubMed
    5. Hoskins JW, Ibrahim A, Emmanuel MA, Manmiller SM, Wu Y, O'Neill M, Jia J, Collins I, Zhang M, Thomas JV, Rost LM, Das S, Parikh H, Haake JM, Matters GL, Kurtz RC, Bamlet WR, Klein A, Stolzenberg-Solomon R, Wolpin BM, Yarden R, Wang Z, Smith J, Olson SH, Andresson T, Petersen GM, Amundadottir LT. Functional characterization of a chr13q22.1 pancreatic cancer risk locus reveals long-range interaction and allele-specific effects on DIS3 expression. Hum Mol Genet. 2016 11 01; 25(21):4726-4738. PMID: 28172817.
      View in: PubMed
    6. Clawson GA, Abraham T, Pan W, Tang X, Linton SS, McGovern CO, Loc WS, Smith JP, Butler PJ, Kester M, Adair JH, Matters GL. A Cholecystokinin B Receptor-Specific DNA Aptamer for Targeting Pancreatic Ductal Adenocarcinoma. Nucleic Acid Ther. 2017 Feb; 27(1):23-35. PMID: 27754762.
      View in: PubMed
    7. Alsubai J, Matters GL, McGovern CO, Liao J, Gilius EL, Smith JP. Germline Mutation of the CCK Receptor: A Novel Biomarker for Pancreas Cancer. Clin Transl Gastroenterol. 2016 Jan 07; 7:e134. PMID: 26741064; PMCID: PMC4737870.
    8. Clawson GA, Matters GL, Xin P, Imamura-Kawasawa Y, Du Z, Thiboutot DM, Helm KF, Neves RI, Abraham T. Macrophage-tumor cell fusions from peripheral blood of melanoma patients. PLoS One. 2015; 10(8):e0134320. PMID: 26267609.
      View in: PubMed
    9. Smith JP, Whitcomb DC, Matters GL, Brand RE, Liao J, Huang YJ, Frazier ML. Distribution of cholecystokinin-B receptor genotype between patients with pancreatic cancer and controls and its impact on survival. Pancreas. 2015 Mar; 44(2):236-42. PMID: 25469546; PMCID: PMC4326549.
    10. Loc WS, Smith JP, Matters G, Kester M, Adair JH. Novel strategies for managing pancreatic cancer. World J Gastroenterol. 2014 Oct 28; 20(40):14717-25. PMID: 25356034; PMCID: PMC4209537.
    11. Smith JP, Cooper TK, McGovern CO, Gilius EL, Zhong Q, Liao J, Molinolo AA, Gutkind JS, Matters GL. Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice. Pancreas. 2014 Oct; 43(7):1050-9. PMID: 25058882; PMCID: PMC4161619.
    12. Matters GL, Cooper TK, McGovern CO, Gilius EL, Liao J, Barth BM, Kester M, Smith JP. Cholecystokinin mediates progression and metastasis of pancreatic cancer associated with dietary fat. Dig Dis Sci. 2014 Jun; 59(6):1180-91. PMID: 24817409; PMCID: PMC4096234.
    13. Bao J, Yura RE, Matters GL, Bradley SG, Shi P, Tian F, Bond JS. Meprin A impairs epithelial barrier function, enhances monocyte migration, and cleaves the tight junction protein occludin. Am J Physiol Renal Physiol. 2013 Sep 01; 305(5):F714-26. PMID: 23804454; PMCID: PMC3761208.
    14. Matters GL, Clawson GA. A Speculative Role for Stromal Gastrin Signaling in Development and Dissemination of Pancreatic Ductal Adenocarcinoma. Pancreat Disord Ther. 2013 Apr 07; Suppl 4:003. PMID: 25346875.
      View in: PubMed
    15. Fino KK, Matters GL, McGovern CO, Gilius EL, Smith JP. Downregulation of the CCK-B receptor in pancreatic cancer cells blocks proliferation and promotes apoptosis. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 01; 302(11):G1244-52. PMID: 22442157; PMCID: PMC3378167.
    16. Smith JP, Harms JF, Matters GL, McGovern CO, Ruggiero FM, Liao J, Fino KK, Ortega EE, Gilius EL, Phillips JA. A single nucleotide polymorphism of the cholecystokinin-B receptor predicts risk for pancreatic cancer. Cancer Biol Ther. 2012 Feb 01; 13(3):164-74. PMID: 22277584; PMCID: PMC3336072.
    17. Matters GL, McGovern C, Harms JF, Markovic K, Anson K, Jayakumar C, Martenis M, Awad C, Smith JP. Role of endogenous cholecystokinin on growth of human pancreatic cancer. Int J Oncol. 2011 Mar; 38(3):593-601. PMID: 21186400; PMCID: PMC3282828.
    18. Banerjee S, Jin G, Bradley SG, Matters GL, Gailey RD, Crisman JM, Bond JS. Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2011 Feb; 300(2):G273-82. PMID: 21071511; PMCID: PMC3043644.
    19. Barth BM, Sharma R, Altinoglu EI, Morgan TT, Shanmugavelandy SS, Kaiser JM, McGovern C, Matters GL, Smith JP, Kester M, Adair JH. Bioconjugation of calcium phosphosilicate composite nanoparticles for selective targeting of human breast and pancreatic cancers in vivo. ACS Nano. 2010 Mar 23; 4(3):1279-87. PMID: 20180585; PMCID: PMC2894697.
    20. Matters GL, Harms JF, McGovern CO, Jayakumar C, Crepin K, Smith ZP, Nelson MC, Stock H, Fenn CW, Kaiser J, Kester M, Smith JP. Growth of human pancreatic cancer is inhibited by down-regulation of gastrin gene expression. Pancreas. 2009 Jul; 38(5):e151-61. PMID: 19465883; PMCID: PMC2704379.
    21. Banerjee S, Oneda B, Yap LM, Jewell DP, Matters GL, Fitzpatrick LR, Seibold F, Sterchi EE, Ahmad T, Lottaz D, Bond JS. MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. Mucosal Immunol. 2009 May; 2(3):220-31. PMID: 19262505; PMCID: PMC2670347.
    22. Matters GL, Harms JF, McGovern C, Fitzpatrick L, Parikh A, Nilo N, Smith JP. The opioid antagonist naltrexone improves murine inflammatory bowel disease. J Immunotoxicol. 2008 Apr; 5(2):179-87. PMID: 18569389.
      View in: PubMed
    23. Bylander JE, Bertenshaw GP, Matters GL, Hubbard SJ, Bond JS. Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities. Biol Chem. 2007 Nov; 388(11):1163-72. PMID: 17976009.
      View in: PubMed
    24. Red Eagle AR, Hanson RL, Jiang W, Han X, Matters GL, Imperatore G, Knowler WC, Bond JS. Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians. Hum Genet. 2005 Oct; 118(1):12-22. PMID: 16133184.
      View in: PubMed
    25. Richert MM, Phadke PA, Matters G, DiGirolamo DJ, Washington S, Demers LM, Bond JS, Manni A, Welch DR. Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment. Breast Cancer Res. 2005; 7(5):R819-27. PMID: 16168128; PMCID: PMC1242150.
    26. Bond JS, Matters GL, Banerjee S, Dusheck RE. Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer. FEBS Lett. 2005 Jun 13; 579(15):3317-22. PMID: 15943977.
      View in: PubMed
    27. Matters GL, Manni A, Bond JS. Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells. Clin Exp Metastasis. 2005; 22(4):331-9. PMID: 16170669.
      View in: PubMed
    28. Norman LP, Matters GL, Crisman JM, Bond JS. Expression of meprins in health and disease. Curr Top Dev Biol. 2003; 54:145-66. PMID: 12696749.
      View in: PubMed
    29. Bertenshaw GP, Turk BE, Hubbard SJ, Matters GL, Bylander JE, Crisman JM, Cantley LC, Bond JS. Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity. J Biol Chem. 2001 Apr 20; 276(16):13248-55. PMID: 11278902.
      View in: PubMed
    30. Jiang W, Kumar JM, Matters GL, Bond JS. Structure of the mouse metalloprotease meprin beta gene (Mep1b): alternative splicing in cancer cells. Gene. 2000 May 02; 248(1-2):77-87. PMID: 10806353.
      View in: PubMed
    31. Matters GL, Bond JS. Expression and regulation of the meprin beta gene in human cancer cells. Mol Carcinog. 1999 Jul; 25(3):169-78. PMID: 10411143.
      View in: PubMed
    32. Matters GL, Bond JS. Meprin B: transcriptional and posttranscriptional regulation of the meprin beta metalloproteinase subunit in human and mouse cancer cells. APMIS. 1999 Jan; 107(1):19-27. PMID: 10190276.
      View in: PubMed
    33. Matters GL, Beale SI. Blue-Light-Regulated Expression of Genes for Two Early Steps of Chlorophyll Biosynthesis in Chlamydomonas reinhardtii. Plant Physiol. 1995 Oct; 109(2):471-479. PMID: 12228605.
      View in: PubMed
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