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Gail Matters

TitleAssociate Professor
InstitutionCollege of Medicine
DepartmentBiochemistry and Molecular Biology
Address500 University Drive Hershey PA 17033
Mailbox: H171
Phone7175314098

 Overview 
 overview
PREFERRED TITLE/ROLE:

Associate Professor of Biochemistry and Molecular Biology

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Penn State Hershey Cancer Institute, Experimental Therapeutics

GRADUATE PROGRAM AFFILIATIONS:

Biochemistry and Molecular Biology

EDUCATION:

B.S., Rutgers University, 1979
M.S., Rutgers University, 1981
Ph.D., North Carolina State University, 1986
Postdoctoral, Washington University, St Louis, MO 1990


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Clawson GA, Matters GL, Xin P, Imamura-Kawasawa Y, Du Z, Thiboutot DM, Helm KF, Neves RI, Abraham T. Macrophage-Tumor Cell Fusions from Peripheral Blood of Melanoma Patients. PLoS One. 2015; 10(8):e0134320.
    View in: PubMed
  2. Smith JP, Whitcomb DC, Matters GL, Brand RE, Liao J, Huang YJ, Frazier ML. Distribution of cholecystokinin-B receptor genotype between patients with pancreatic cancer and controls and its impact on survival. Pancreas. 2015 Mar; 44(2):236-42.
    View in: PubMed
  3. Loc WS, Smith JP, Matters G, Kester M, Adair JH. Novel strategies for managing pancreatic cancer. World J Gastroenterol. 2014 Oct 28; 20(40):14717-25.
    View in: PubMed
  4. Smith JP, Cooper TK, McGovern CO, Gilius EL, Zhong Q, Liao J, Molinolo AA, Gutkind JS, Matters GL. Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice. Pancreas. 2014 Oct; 43(7):1050-9.
    View in: PubMed
  5. Matters GL, Cooper TK, McGovern CO, Gilius EL, Liao J, Barth BM, Kester M, Smith JP. Cholecystokinin mediates progression and metastasis of pancreatic cancer associated with dietary fat. Dig Dis Sci. 2014 Jun; 59(6):1180-91.
    View in: PubMed
  6. Bao J, Yura RE, Matters GL, Bradley SG, Shi P, Tian F, Bond JS. Meprin A impairs epithelial barrier function, enhances monocyte migration, and cleaves the tight junction protein occludin. Am J Physiol Renal Physiol. 2013 Sep 1; 305(5):F714-26.
    View in: PubMed
  7. Fino KK, Matters GL, McGovern CO, Gilius EL, Smith JP. Downregulation of the CCK-B receptor in pancreatic cancer cells blocks proliferation and promotes apoptosis. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 1; 302(11):G1244-52.
    View in: PubMed
  8. Smith JP, Harms JF, Matters GL, McGovern CO, Ruggiero FM, Liao J, Fino KK, Ortega EE, Gilius EL, Phillips JA. A single nucleotide polymorphism of the cholecystokinin-B receptor predicts risk for pancreatic cancer. Cancer Biol Ther. 2012 Feb 1; 13(3):164-74.
    View in: PubMed
  9. Matters GL, McGovern C, Harms JF, Markovic K, Anson K, Jayakumar C, Martenis M, Awad C, Smith JP. Role of endogenous cholecystokinin on growth of human pancreatic cancer. Int J Oncol. 2011 Mar; 38(3):593-601.
    View in: PubMed
  10. Banerjee S, Jin G, Bradley SG, Matters GL, Gailey RD, Crisman JM, Bond JS. Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2011 Feb; 300(2):G273-82.
    View in: PubMed
  11. Barth BM, Sharma R, Altinoglu EI, Morgan TT, Shanmugavelandy SS, Kaiser JM, McGovern C, Matters GL, Smith JP, Kester M, Adair JH. Bioconjugation of calcium phosphosilicate composite nanoparticles for selective targeting of human breast and pancreatic cancers in vivo. ACS Nano. 2010 Mar 23; 4(3):1279-87.
    View in: PubMed
  12. Matters GL, Harms JF, McGovern CO, Jayakumar C, Crepin K, Smith ZP, Nelson MC, Stock H, Fenn CW, Kaiser J, Kester M, Smith JP. Growth of human pancreatic cancer is inhibited by down-regulation of gastrin gene expression. Pancreas. 2009 Jul; 38(5):e151-61.
    View in: PubMed
  13. Banerjee S, Oneda B, Yap LM, Jewell DP, Matters GL, Fitzpatrick LR, Seibold F, Sterchi EE, Ahmad T, Lottaz D, Bond JS. MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. Mucosal Immunol. 2009 May; 2(3):220-31.
    View in: PubMed
  14. Matters GL, Harms JF, McGovern C, Fitzpatrick L, Parikh A, Nilo N, Smith JP. The opioid antagonist naltrexone improves murine inflammatory bowel disease. J Immunotoxicol. 2008 Apr; 5(2):179-87.
    View in: PubMed
  15. Bylander JE, Bertenshaw GP, Matters GL, Hubbard SJ, Bond JS. Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities. Biol Chem. 2007 Nov; 388(11):1163-72.
    View in: PubMed
  16. Red Eagle AR, Hanson RL, Jiang W, Han X, Matters GL, Imperatore G, Knowler WC, Bond JS. Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians. Hum Genet. 2005 Oct; 118(1):12-22.
    View in: PubMed
  17. Richert MM, Phadke PA, Matters G, DiGirolamo DJ, Washington S, Demers LM, Bond JS, Manni A, Welch DR. Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment. Breast Cancer Res. 2005; 7(5):R819-27.
    View in: PubMed
  18. Bond JS, Matters GL, Banerjee S, Dusheck RE. Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer. FEBS Lett. 2005 Jun 13; 579(15):3317-22.
    View in: PubMed
  19. Matters GL, Manni A, Bond JS. Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells. Clin Exp Metastasis. 2005; 22(4):331-9.
    View in: PubMed
  20. Norman LP, Matters GL, Crisman JM, Bond JS. Expression of meprins in health and disease. Curr Top Dev Biol. 2003; 54:145-66.
    View in: PubMed
  21. Bertenshaw GP, Turk BE, Hubbard SJ, Matters GL, Bylander JE, Crisman JM, Cantley LC, Bond JS. Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity. J Biol Chem. 2001 Apr 20; 276(16):13248-55.
    View in: PubMed
  22. Jiang W, Kumar JM, Matters GL, Bond JS. Structure of the mouse metalloprotease meprin beta gene (Mep1b): alternative splicing in cancer cells. Gene. 2000 May 2; 248(1-2):77-87.
    View in: PubMed
  23. Matters GL, Bond JS. Expression and regulation of the meprin beta gene in human cancer cells. Mol Carcinog. 1999 Jul; 25(3):169-78.
    View in: PubMed
  24. Matters GL, Bond JS. Meprin B: transcriptional and posttranscriptional regulation of the meprin beta metalloproteinase subunit in human and mouse cancer cells. APMIS. 1999 Jan; 107(1):19-27.
    View in: PubMed
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