PSU Profiles
Loading...
Keywords
Last Name
Institution

Gary Perdew

TitleJohn T. and Paige S. Smith Professor in Agricultural Sciences
InstitutionCollege of Agricultural Sciences
DepartmentVeterinary and Biomedical Sciences
Address309 Life Sciences Bldg
University Park, PA 16802
Phone8148650400
vCardDownload vCard
    Other Positions
    InstitutionHuck Institutes of the Life Sciences


    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    John T. and Paige S. Smith Professor in Agricultural Sciences

    GRADUATE PROGRAM AFFILIATIONS:

    Genetics, Molecular Medicine, Molecular Toxicology

    EDUCATION:

    B.S., Food Science, University of Maryland, 1978
    M.S., Food Science, University of Maryland, 1981
    Ph.D., Food Toxicology, Oregon State University, 1984

    NARRATIVE:

    Dr. Perdew's research focuses on molecular mechanism(s) of toxicity, dioxin-mediated signal transduction, regulation of cellular homeostasis by the Ah receptor, Ah receptor-mediated control of gene expression, anti-inflammatory properties of selective Ah receptor ligands, role of the Ah receptor/ARNT heterodimer in inflammation.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Smith KJ, Murray IA, Boyer JA, Perdew GH. Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice. Toxicology. 2018 Feb 01; 394:27-34. PMID: 29197551.
      View in: PubMed
    2. Smith KJ, Boyer JA, Muku GE, Murray IA, Gowda K, Desai D, Amin SG, Glick AB, Perdew GH. Editor's Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin. Toxicol Sci. 2017 Nov 01; 160(1):83-94. PMID: 28973351.
      View in: PubMed
    3. Organtini KL, Hubbard TD, Perdew GH, Dorman FL. Assessment of Ah receptor transcriptional activity mediated by halogenated dibenzo-p-dioxins and dibenzofurans (PXDD/Fs) in human and mouse cell systems. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2017 Dec 06; 52(14):1295-1302. PMID: 28922086.
      View in: PubMed
    4. Muku GE, Lahoti TS, Murray IA, Podolsky MA, Smith KJ, Hubbard TD, Kuzu G, Gowda K, Amin SG, Perdew GH. Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses. Lab Invest. 2017 Dec; 97(12):1471-1487. PMID: 28892097.
      View in: PubMed
    5. Hubbard TD, Murray IA, Nichols RG, Cassel K, Podolsky M, Kuzu G, Tian Y, Smith P, Kennett MJ, Patterson AD, Perdew GH. Dietary Broccoli Impacts Microbial Community Structure and Attenuates Chemically Induced Colitis in Mice in an Ah receptor dependent manner. J Funct Foods. 2017 Oct; 37:685-698. PMID: 29242716.
      View in: PubMed
    6. Moyer BJ, Rojas IY, Murray IA, Lee S, Hazlett HF, Perdew GH, Tomlinson CR. Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor. Toxicol Appl Pharmacol. 2017 05 15; 323:74-80. PMID: 28336214.
      View in: PubMed
    7. Murray IA, Perdew GH. Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis. Curr Opin Toxicol. 2017 Feb; 2:15-23. PMID: 28944314.
      View in: PubMed
    8. Koga T, Yao PL, Goudarzi M, Murray IA, Balandaram G, Gonzalez FJ, Perdew GH, Fornace AJ, Peters JM. Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-ß/d Modulation of SP1 Promoter Occupancy. J Biol Chem. 2016 Nov 25; 291(48):25255-25263. PMID: 27765815.
      View in: PubMed
    9. Murray IA, Nichols RG, Zhang L, Patterson AD, Perdew GH. Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice. Sci Rep. 2016 Sep 23; 6:33969. PMID: 27659481.
      View in: PubMed
    10. Hubbard TD, Murray IA, Bisson WH, Sullivan AP, Sebastian A, Perry GH, Jablonski NG, Perdew GH. Divergent Ah Receptor Ligand Selectivity during Hominin Evolution. Mol Biol Evol. 2016 10; 33(10):2648-58. PMID: 27486223.
      View in: PubMed
    11. Balandaram G, Kramer LR, Kang BH, Murray IA, Perdew GH, Gonzalez FJ, Peters JM. Ligand activation of peroxisome proliferator-activated receptor-ß/d suppresses liver tumorigenesis in hepatitis B transgenic mice. Toxicology. 2016 07 01; 363-364:1-9. PMID: 27427494.
      View in: PubMed
    12. Gutierrez MA, Davis SS, Rosko A, Nguyen SM, Mitchell KP, Mateen S, Neves J, Garcia TY, Mooney S, Perdew GH, Hubbard TD, Lamba DA, Ramanathan A. A novel AhR ligand, 2AI, protects the retina from environmental stress. Sci Rep. 2016 Jul 01; 6:29025. PMID: 27364765; PMCID: PMC4929558.
    13. Yang J, Hu S, Zhao L, Kaplan DH, Perdew GH, Xiong N. Selective programming of CCR10(+) innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation. Nat Immunol. 2016 Jan; 17(1):48-56. PMID: 26523865; PMCID: PMC4838393.
    14. Lahoti TS, Boyer JA, Kusnadi A, Muku GE, Murray IA, Perdew GH. Aryl Hydrocarbon Receptor Activation Synergistically Induces Lipopolysaccharide-Mediated Expression of Proinflammatory Chemokine (c-c motif) Ligand 20. Toxicol Sci. 2015 Nov; 148(1):229-40. PMID: 26259605; PMCID: PMC4731409 [Available on 11/01/16].
    15. Hubbard TD, Murray IA, Bisson WH, Lahoti TS, Gowda K, Amin SG, Patterson AD, Perdew GH. Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles. Sci Rep. 2015 Aug 03; 5:12689. PMID: 26235394; PMCID: PMC4522678.
    16. Zhang L, Hatzakis E, Nichols RG, Hao R, Correll J, Smith PB, Chiaro CR, Perdew GH, Patterson AD. Metabolomics Reveals that Aryl Hydrocarbon Receptor Activation by Environmental Chemicals Induces Systemic Metabolic Dysfunction in Mice. Environ Sci Technol. 2015 Jul 07; 49(13):8067-77. PMID: 26023891; PMCID: PMC4890155.
    17. Hubbard TD, Murray IA, Perdew GH. Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation. Drug Metab Dispos. 2015 Oct; 43(10):1522-35. PMID: 26041783; PMCID: PMC4576673 [Available on 10/01/16].
    18. Zhang L, Nichols RG, Correll J, Murray IA, Tanaka N, Smith PB, Hubbard TD, Sebastian A, Albert I, Hatzakis E, Gonzalez FJ, Perdew GH, Patterson AD. Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation. Environ Health Perspect. 2015 Jul; 123(7):679-88. PMID: 25768209; PMCID: PMC4492271.
    19. Mohinta S, Kannan AK, Gowda K, Amin SG, Perdew GH, August A. Differential regulation of Th17 and T regulatory cell differentiation by aryl hydrocarbon receptor dependent xenobiotic response element dependent and independent pathways. Toxicol Sci. 2015 Jun; 145(2):233-43. PMID: 25716673; PMCID: PMC4471441.
    20. van den Bogaard EH, Podolsky MA, Smits JP, Cui X, John C, Gowda K, Desai D, Amin SG, Schalkwijk J, Perdew GH, Glick AB. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May; 135(5):1320-1328. PMID: 25602157; PMCID: PMC4402116.
    21. Murray IA, Patterson AD, Perdew GH. Aryl hydrocarbon receptor ligands in cancer: friend and foe. Nat Rev Cancer. 2014 12; 14(12):801-14. PMID: 25568920; PMCID: PMC4401080.
    22. Perkins A, Phillips JL, Kerkvliet NI, Tanguay RL, Perdew GH, Kolluri SK, Bisson WH. A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain. Biology (Basel). 2014 Oct 17; 3(4):645-69. PMID: 25329374; PMCID: PMC4280506.
    23. Fang ZZ, Krausz KW, Nagaoka K, Tanaka N, Gowda K, Amin SG, Perdew GH, Gonzalez FJ. In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract. Br J Pharmacol. 2014 Apr; 171(7):1735-46. PMID: 24417285; PMCID: PMC3966752.
    24. Borland MG, Krishnan P, Lee C, Albrecht PP, Shan W, Bility MT, Marcus CB, Lin JM, Amin S, Gonzalez FJ, Perdew GH, Peters JM. Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor ß/d (PPARß/d) in keratinocytes. Carcinogenesis. 2014 Jul; 35(7):1602-12. PMID: 24639079; PMCID: PMC4076811.
    25. Lahoti TS, Hughes JM, Kusnadi A, John K, Zhu B, Murray IA, Gowda K, Peters JM, Amin SG, Perdew GH. Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Pharmacol Exp Ther. 2014 Feb; 348(2):236-45. PMID: 24309559; PMCID: PMC3912548.
    26. Budinsky RA, Schrenk D, Simon T, Van den Berg M, Reichard JF, Silkworth JB, Aylward LL, Brix A, Gasiewicz T, Kaminski N, Perdew G, Starr TB, Walker NJ, Rowlands JC. Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study. Crit Rev Toxicol. 2014 Jan; 44(1):83-119. PMID: 24245878.
      View in: PubMed
    27. John K, Lahoti TS, Wagner K, Hughes JM, Perdew GH. The Ah receptor regulates growth factor expression in head and neck squamous cell carcinoma cell lines. Mol Carcinog. 2014 Oct; 53(10):765-76. PMID: 23625689; PMCID: PMC4388041.
    28. Lahoti TS, John K, Hughes JM, Kusnadi A, Murray IA, Krishnegowda G, Amin S, Perdew GH. Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes. Ann Rheum Dis. 2013 Oct; 72(10):1708-16. PMID: 23349129; PMCID: PMC4041386.
    29. DiNatale BC, Smith K, John K, Krishnegowda G, Amin SG, Perdew GH. Ah receptor antagonism represses head and neck tumor cell aggressive phenotype. Mol Cancer Res. 2012 Oct; 10(10):1369-79. PMID: 22912337; PMCID: PMC3477495.
    30. Tanos R, Murray IA, Smith PB, Patterson A, Perdew GH. Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver. Toxicol Sci. 2012 Oct; 129(2):372-9. PMID: 22696238; PMCID: PMC3491957.
    31. Tanos R, Patel RD, Murray IA, Smith PB, Patterson AD, Perdew GH. Aryl hydrocarbon receptor regulates the cholesterol biosynthetic pathway in a dioxin response element-independent manner. Hepatology. 2012 Jun; 55(6):1994-2004. PMID: 22234961; PMCID: PMC3340481.
    32. Narayanan GA, Murray IA, Krishnegowda G, Amin S, Perdew GH. Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure. J Pharmacol Exp Ther. 2012 Aug; 342(2):345-55. PMID: 22553215; PMCID: PMC3400802.
    33. Labrecque MP, Takhar MK, Hollingshead BD, Prefontaine GG, Perdew GH, Beischlag TV. Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines. PLoS One. 2012; 7(1):e29545. PMID: 22235307; PMCID: PMC3250444.
    34. Smith KJ, Murray IA, Tanos R, Tellew J, Boitano AE, Bisson WH, Kolluri SK, Cooke MP, Perdew GH. Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism. J Pharmacol Exp Ther. 2011 Jul; 338(1):318-27. PMID: 21493753; PMCID: PMC3126639.
    35. Murray IA, Flaveny CA, Chiaro CR, Sharma AK, Tanos RS, Schroeder JC, Amin SG, Bisson WH, Kolluri SK, Perdew GH. Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-a-naphthoflavone. Mol Pharmacol. 2011 Mar; 79(3):508-19. PMID: 21127131; PMCID: PMC3061363.
    36. DiNatale BC, Schroeder JC, Perdew GH. Ah receptor antagonism inhibits constitutive and cytokine inducible IL6 production in head and neck tumor cell lines. Mol Carcinog. 2011 Mar; 50(3):173-83. PMID: 21104991; PMCID: PMC3044777.
    37. Omiecinski CJ, Vanden Heuvel JP, Perdew GH, Peters JM. Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities. Toxicol Sci. 2011 Mar; 120 Suppl 1:S49-75. PMID: 21059794; PMCID: PMC3145385.
    38. Perdew GH, Hollingshead BD, Dinatale BC, Morales JL, Labrecque MP, Takhar MK, Tam KJ, Beischlag TV. Estrogen receptor expression is required for low-dose resveratrol-mediated repression of aryl hydrocarbon receptor activity. J Pharmacol Exp Ther. 2010 Nov; 335(2):273-83. PMID: 20716622; PMCID: PMC2967400.
    39. Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010 Sep 10; 329(5997):1345-8. PMID: 20688981; PMCID: PMC3033342.
    40. Palkar PS, Borland MG, Naruhn S, Ferry CH, Lee C, Sk UH, Sharma AK, Amin S, Murray IA, Anderson CR, Perdew GH, Gonzalez FJ, Müller R, Peters JM. Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787. Mol Pharmacol. 2010 Sep; 78(3):419-30. PMID: 20516370; PMCID: PMC2939490.
    41. DiNatale BC, Schroeder JC, Francey LJ, Kusnadi A, Perdew GH. Mechanistic insights into the events that lead to synergistic induction of interleukin 6 transcription upon activation of the aryl hydrocarbon receptor and inflammatory signaling. J Biol Chem. 2010 Aug 06; 285(32):24388-97. PMID: 20511231; PMCID: PMC2915674.
    42. Murray IA, Krishnegowda G, DiNatale BC, Flaveny C, Chiaro C, Lin JM, Sharma AK, Amin S, Perdew GH. Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties. Chem Res Toxicol. 2010 May 17; 23(5):955-66. PMID: 20423157; PMCID: PMC2871980.
    43. DiNatale BC, Perdew GH. Protein function analysis: rapid, cell-based siRNA-mediated ablation of endogenous expression with simultaneous ectopic replacement. Cytotechnology. 2010 Apr; 62(2):495-503. PMID: 20390449.
      View in: PubMed
    44. DiNatale BC, Murray IA, Schroeder JC, Flaveny CA, Lahoti TS, Laurenzana EM, Omiecinski CJ, Perdew GH. Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol Sci. 2010 May; 115(1):89-97. PMID: 20106948; PMCID: PMC2855350.
    45. Schroeder JC, Dinatale BC, Murray IA, Flaveny CA, Liu Q, Laurenzana EM, Lin JM, Strom SC, Omiecinski CJ, Amin S, Perdew GH. The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor. Biochemistry. 2010 Jan 19; 49(2):393-400. PMID: 20000589; PMCID: PMC2805781.
    46. Flaveny CA, Murray IA, Perdew GH. Differential gene regulation by the human and mouse aryl hydrocarbon receptor. Toxicol Sci. 2010 Apr; 114(2):217-25. PMID: 20044593; PMCID: PMC2840214.
    47. Murray IA, Morales JL, Flaveny CA, Dinatale BC, Chiaro C, Gowdahalli K, Amin S, Perdew GH. Evidence for ligand-mediated selective modulation of aryl hydrocarbon receptor activity. Mol Pharmacol. 2010 Feb; 77(2):247-54. PMID: 19903824; PMCID: PMC2812074.
    48. Murray IA, Flaveny CA, DiNatale BC, Chairo CR, Schroeder JC, Kusnadi A, Perdew GH. Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone. J Pharmacol Exp Ther. 2010 Jan; 332(1):135-44. PMID: 19828881; PMCID: PMC2802483.
    49. Flaveny C, Perdew GH, Miller CA. The Aryl-hydrocarbon receptor does not require the p23 co-chaperone for ligand binding and target gene expression in vivo. Toxicol Lett. 2009 Aug 25; 189(1):57-62. PMID: 19447165; PMCID: PMC3070407.
    50. Patel RD, Murray IA, Flaveny CA, Kusnadi A, Perdew GH. Ah receptor represses acute-phase response gene expression without binding to its cognate response element. Lab Invest. 2009 Jun; 89(6):695-707. PMID: 19333233; PMCID: PMC2743259.
    51. Flaveny CA, Murray IA, Chiaro CR, Perdew GH. Ligand selectivity and gene regulation by the human aryl hydrocarbon receptor in transgenic mice. Mol Pharmacol. 2009 Jun; 75(6):1412-20. PMID: 19299563; PMCID: PMC2684888.
    52. Flaveny CA, Perdew GH. Transgenic Humanized AHR Mouse Reveals Differences between Human and Mouse AHR Ligand Selectivity. Mol Cell Pharmacol. 2009 Jan 01; 1(3):119-123. PMID: 20419055.
      View in: PubMed
    53. Perdew GH. Ah receptor binding to its cognate response element is required for dioxin-mediated toxicity. Toxicol Sci. 2008 Dec; 106(2):301-3. PMID: 18930947; PMCID: PMC2581677.
    54. Chiaro CR, Patel RD, Perdew GH. 12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid [12(R)-HETE], an arachidonic acid derivative, is an activator of the aryl hydrocarbon receptor. Mol Pharmacol. 2008 Dec; 74(6):1649-56. PMID: 18779363.
      View in: PubMed
    55. Shan W, Palkar PS, Murray IA, McDevitt EI, Kennett MJ, Kang BH, Isom HC, Perdew GH, Gonzalez FJ, Peters JM. Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression. Toxicol Sci. 2008 Oct; 105(2):418-28. PMID: 18622026; PMCID: PMC2527639.
    56. Chiaro CR, Morales JL, Prabhu KS, Perdew GH. Leukotriene A4 metabolites are endogenous ligands for the Ah receptor. Biochemistry. 2008 Aug 12; 47(32):8445-55. PMID: 18616291.
      View in: PubMed
    57. Hollingshead BD, Beischlag TV, Dinatale BC, Ramadoss P, Perdew GH. Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells. Cancer Res. 2008 May 15; 68(10):3609-17. PMID: 18483242; PMCID: PMC2568985.
    58. Girroir EE, Hollingshead HE, He P, Zhu B, Perdew GH, Peters JM. Quantitative expression patterns of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) protein in mice. Biochem Biophys Res Commun. 2008 Jul 04; 371(3):456-61. PMID: 18442472; PMCID: PMC2586836.
    59. Flaveny C, Reen RK, Kusnadi A, Perdew GH. The mouse and human Ah receptor differ in recognition of LXXLL motifs. Arch Biochem Biophys. 2008 Mar 15; 471(2):215-23. PMID: 18242161; PMCID: PMC2293825.
    60. Morales JL, Krzeminski J, Amin S, Perdew GH. Characterization of the antiallergic drugs 3-[2-(2-phenylethyl) benzoimidazole-4-yl]-3-hydroxypropanoic acid and ethyl 3-hydroxy-3-[2-(2-phenylethyl)benzoimidazol-4-yl]propanoate as full aryl hydrocarbon receptor agonists. Chem Res Toxicol. 2008 Feb; 21(2):472-82. PMID: 18179178; PMCID: PMC2599926.
    61. Beischlag TV, Luis Morales J, Hollingshead BD, Perdew GH. The aryl hydrocarbon receptor complex and the control of gene expression. Crit Rev Eukaryot Gene Expr. 2008; 18(3):207-50. PMID: 18540824; PMCID: PMC2583464.
    62. Murray IA, Perdew GH. Omeprazole stimulates the induction of human insulin-like growth factor binding protein-1 through aryl hydrocarbon receptor activation. J Pharmacol Exp Ther. 2008 Mar; 324(3):1102-10. PMID: 18055878; PMCID: PMC2527780.
    63. Chiaro CR, Patel RD, Marcus CB, Perdew GH. Evidence for an aryl hydrocarbon receptor-mediated cytochrome p450 autoregulatory pathway. Mol Pharmacol. 2007 Nov; 72(5):1369-79. PMID: 17720764.
      View in: PubMed
    64. Patel RD, Hollingshead BD, Omiecinski CJ, Perdew GH. Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver. Hepatology. 2007 Jul; 46(1):209-18. PMID: 17596880; PMCID: PMC4098831.
    65. Sun YW, Herzog CR, Krzeminski J, Amin S, Perdew G, El-Bayoumy K. Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21(Cip1) protein expression and cell cycle regulation in MCF-7 and MCF-10A cells. Chem Biol Interact. 2007 Oct 20; 170(1):31-9. PMID: 17678638; PMCID: PMC2682711.
    66. Morales JL, Perdew GH. Carboxyl terminus of hsc70-interacting protein (CHIP) can remodel mature aryl hydrocarbon receptor (AhR) complexes and mediate ubiquitination of both the AhR and the 90 kDa heat-shock protein (hsp90) in vitro. Biochemistry. 2007 Jan 16; 46(2):610-21. PMID: 17209571; PMCID: PMC2527729.
    67. Hollingshead BD, Patel RD, Perdew GH. Endogenous hepatic expression of the hepatitis B virus X-associated protein 2 is adequate for maximal association with aryl hydrocarbon receptor-90-kDa heat shock protein complexes. Mol Pharmacol. 2006 Dec; 70(6):2096-107. PMID: 16988012.
      View in: PubMed
    68. Chen YH, Beischlag TV, Kim JH, Perdew GH, Stallcup MR. Role of GAC63 in transcriptional activation mediated by the aryl hydrocarbon receptor. J Biol Chem. 2006 May 05; 281(18):12242-7. PMID: 16513642; PMCID: PMC1770942.
    69. Murray IA, Reen RK, Leathery N, Ramadoss P, Bonati L, Gonzalez FJ, Peters JM, Perdew GH. Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity. Arch Biochem Biophys. 2005 Oct 01; 442(1):59-71. PMID: 16137638.
      View in: PubMed
    70. Patel RD, Kim DJ, Peters JM, Perdew GH. The aryl hydrocarbon receptor directly regulates expression of the potent mitogen epiregulin. Toxicol Sci. 2006 Jan; 89(1):75-82. PMID: 16192470.
      View in: PubMed
    71. Ramadoss P, Perdew GH. The transactivation domain of the Ah receptor is a key determinant of cellular localization and ligand-independent nucleocytoplasmic shuttling properties. Biochemistry. 2005 Aug 23; 44(33):11148-59. PMID: 16101299.
      View in: PubMed
    72. Gray JP, Burns KA, Leas TL, Perdew GH, Vanden Heuvel JP. Regulation of peroxisome proliferator-activated receptor alpha by protein kinase C. Biochemistry. 2005 Aug 02; 44(30):10313-21. PMID: 16042408.
      View in: PubMed
    73. Ramadoss P, Marcus C, Perdew GH. Role of the aryl hydrocarbon receptor in drug metabolism. Expert Opin Drug Metab Toxicol. 2005 Jun; 1(1):9-21. PMID: 16922649.
      View in: PubMed
    74. Beischlag TV, Perdew GH. ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription. J Biol Chem. 2005 Jun 03; 280(22):21607-11. PMID: 15837795.
      View in: PubMed
    75. Kim DJ, Murray IA, Burns AM, Gonzalez FJ, Perdew GH, Peters JM. Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity. J Biol Chem. 2005 Mar 11; 280(10):9519-27. PMID: 15632134.
      View in: PubMed
    76. Hollingshead BD, Petrulis JR, Perdew GH. The aryl hydrocarbon (Ah) receptor transcriptional regulator hepatitis B virus X-associated protein 2 antagonizes p23 binding to Ah receptor-Hsp90 complexes and is dispensable for receptor function. J Biol Chem. 2004 Oct 29; 279(44):45652-61. PMID: 15322122.
      View in: PubMed
    77. Ramadoss P, Perdew GH. Use of 2-azido-3-[125I]iodo-7,8-dibromodibenzo-p-dioxin as a probe to determine the relative ligand affinity of human versus mouse aryl hydrocarbon receptor in cultured cells. Mol Pharmacol. 2004 Jul; 66(1):129-36. PMID: 15213304.
      View in: PubMed
    78. Ramadoss P, Petrulis JR, Hollingshead BD, Kusnadi A, Perdew GH. Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes. Biochemistry. 2004 Jan 27; 43(3):700-9. PMID: 14730974.
      View in: PubMed
    79. Sumanasekera WK, Tien ES, Davis JW, Turpey R, Perdew GH, Vanden Heuvel JP. Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity. Biochemistry. 2003 Sep 16; 42(36):10726-35. PMID: 12962497.
      View in: PubMed
    80. Sumanasekera WK, Tien ES, Turpey R, Vanden Heuvel JP, Perdew GH. Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. J Biol Chem. 2003 Feb 14; 278(7):4467-73. PMID: 12482853.
      View in: PubMed
    81. Reen RK, Cadwallader A, Perdew GH. The subdomains of the transactivation domain of the aryl hydrocarbon receptor (AhR) inhibit AhR and estrogen receptor transcriptional activity. Arch Biochem Biophys. 2002 Dec 01; 408(1):93-102. PMID: 12485607.
      View in: PubMed
    82. Petrulis JR, Kusnadi A, Ramadoss P, Hollingshead B, Perdew GH. The hsp90 Co-chaperone XAP2 alters importin beta recognition of the bipartite nuclear localization signal of the Ah receptor and represses transcriptional activity. J Biol Chem. 2003 Jan 24; 278(4):2677-85. PMID: 12431985.
      View in: PubMed
    83. Dull AB, Carlson DB, Petrulis JR, Perdew GH. Characterization of the phosphorylation status of the hepatitis B virus X-associated protein 2. Arch Biochem Biophys. 2002 Oct 15; 406(2):209-21. PMID: 12361709.
      View in: PubMed
    84. Petrulis JR, Perdew GH. The role of chaperone proteins in the aryl hydrocarbon receptor core complex. Chem Biol Interact. 2002 Sep 20; 141(1-2):25-40. PMID: 12213383.
      View in: PubMed
    85. Levine SL, Perdew GH. Okadaic acid increases ARNT homodimer transactivation potential. Cell Biol Toxicol. 2002; 18(2):109-20. PMID: 12046689.
      View in: PubMed
    86. Swanson HI, Whitelaw ML, Petrulis JR, Perdew GH. Use of [125I]4'-iodoflavone as a tool to characterize ligand-dependent differences in Ah receptor behavior. J Biochem Mol Toxicol. 2002; 16(6):298-310. PMID: 12481305.
      View in: PubMed
    87. Carlson DB, Perdew GH. A dynamic role for the Ah receptor in cell signaling? Insights from a diverse group of Ah receptor interacting proteins. J Biochem Mol Toxicol. 2002; 16(6):317-25. PMID: 12481307.
      View in: PubMed
    88. Petrulis JR, Perdew GH. Monitoring nuclear import with GFP-variant fusion proteins in digitonin-permeabilized cells. Biotechniques. 2001 Oct; 31(4):772-5. PMID: 11680706.
      View in: PubMed
    89. Kumar MB, Ramadoss P, Reen RK, Vanden Heuvel JP, Perdew GH. The Q-rich subdomain of the human Ah receptor transactivation domain is required for dioxin-mediated transcriptional activity. J Biol Chem. 2001 Nov 09; 276(45):42302-10. PMID: 11551916.
      View in: PubMed
    90. Levine SL, Perdew GH. Aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) activity is unaltered by phosphorylation of a periodicity/ARNT/single-minded (PAS)-region serine residue. Mol Pharmacol. 2001 Mar; 59(3):557-66. PMID: 11179451.
      View in: PubMed
    91. Petrulis JR, Hord NG, Perdew GH. Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2. J Biol Chem. 2000 Dec 01; 275(48):37448-53. PMID: 10986286.
      View in: PubMed
    92. Levine SL, Petrulis JR, Dubil A, Perdew GH. A tetratricopeptide repeat half-site in the aryl hydrocarbon receptor is important for DNA binding and trans-activation potential. Mol Pharmacol. 2000 Dec; 58(6):1517-24. PMID: 11093792.
      View in: PubMed
    93. Meyer BK, Petrulis JR, Perdew GH. Aryl hydrocarbon (Ah) receptor levels are selectively modulated by hsp90-associated immunophilin homolog XAP2. Cell Stress Chaperones. 2000 Jul; 5(3):243-54. PMID: 11005382; PMCID: PMC312890.
    94. Long WP, Perdew GH. Lack of an absolute requirement for the native aryl hydrocarbon receptor (AhR) and AhR nuclear translocator transactivation domains in protein kinase C-mediated modulation of the AhR pathway. Arch Biochem Biophys. 1999 Nov 15; 371(2):246-59. PMID: 10545212.
      View in: PubMed
    95. Kumar MB, Tarpey RW, Perdew GH. Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs. J Biol Chem. 1999 Aug 06; 274(32):22155-64. PMID: 10428779.
      View in: PubMed
    96. Meyer BK, Perdew GH. Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization. Biochemistry. 1999 Jul 13; 38(28):8907-17. PMID: 10413464.
      View in: PubMed
    97. Long WP, Chen X, Perdew GH. Protein kinase C modulates aryl hydrocarbon receptor nuclear translocator protein-mediated transactivation potential in a dimer context. J Biol Chem. 1999 Apr 30; 274(18):12391-400. PMID: 10212212.
      View in: PubMed
    98. Kumar MB, Perdew GH. Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential. Gene Expr. 1999; 8(5-6):273-86. PMID: 10947077.
      View in: PubMed
    99. Abbott BD, Probst MR, Perdew GH, Buckalew AR. AH receptor, ARNT, glucocorticoid receptor, EGF receptor, EGF, TGF alpha, TGF beta 1, TGF beta 2, and TGF beta 3 expression in human embryonic palate, and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Teratology. 1998 Aug; 58(2):30-43. PMID: 9787404.
      View in: PubMed
    100. Long WP, Pray-Grant M, Tsai JC, Perdew GH. Protein kinase C activity is required for aryl hydrocarbon receptor pathway-mediated signal transduction. Mol Pharmacol. 1998 Apr; 53(4):691-700. PMID: 9547360.
      View in: PubMed
    101. Brunt SA, Perdew GH, Toft DO, Silver JC. Hsp90-containing multiprotein complexes in the eukaryotic microbe Achlya. Cell Stress Chaperones. 1998 Mar; 3(1):44-56. PMID: 9585181; PMCID: PMC312947.
    102. Meyer BK, Pray-Grant MG, Vanden Heuvel JP, Perdew GH. Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. Mol Cell Biol. 1998 Feb; 18(2):978-88. PMID: 9447995; PMCID: PMC108810.
    103. Chen HS, Singh SS, Perdew GH. The Ah receptor is a sensitive target of geldanamycin-induced protein turnover. Arch Biochem Biophys. 1997 Dec 01; 348(1):190-8. PMID: 9390191.
      View in: PubMed
    104. Tsai JC, Perdew GH. Ah receptor nuclear translocator protein heterogeneity is altered after heterodimerization with the Ah receptor. Biochemistry. 1997 Jul 22; 36(29):9066-72. PMID: 9220996.
      View in: PubMed
    105. Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem. 1997 Mar 28; 272(13):8581-93. PMID: 9079689.
      View in: PubMed
    106. Perdew GH, Wiegand H, Vanden Heuvel JP, Mitchell C, Singh SS. A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37. Biochemistry. 1997 Mar 25; 36(12):3600-7. PMID: 9132011.
      View in: PubMed
    107. Owens-Grillo JK, Czar MJ, Hutchison KA, Hoffmann K, Perdew GH, Pratt WB. A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains. J Biol Chem. 1996 Jun 07; 271(23):13468-75. PMID: 8662874.
      View in: PubMed
    108. Perdew GH, Bradfield CA. Mapping the 90 kDa heat shock protein binding region of the Ah receptor. Biochem Mol Biol Int. 1996 Jun; 39(3):589-93. PMID: 8828811.
      View in: PubMed
    109. Singh SS, Hord NG, Perdew GH. Characterization of the activated form of the aryl hydrocarbon receptor in the nucleus of HeLa cells in the absence of exogenous ligand. Arch Biochem Biophys. 1996 May 01; 329(1):47-55. PMID: 8619634.
      View in: PubMed
    110. Wang X, Thomsen JS, Santostefano M, Rosengren R, Safe S, Perdew GH. Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines. Eur J Pharmacol. 1995 Oct 06; 293(3):191-205. PMID: 8666036.
      View in: PubMed
    111. Abbott BD, Birnbaum LS, Perdew GH. Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL/6N mouse embryo. Dev Dyn. 1995 Oct; 204(2):133-43. PMID: 8589437.
      View in: PubMed
    112. Perdew GH, Abbott B, Stanker LH. Production and characterization of monoclonal antibodies directed against the Ah receptor. Hybridoma. 1995 Jun; 14(3):279-83. PMID: 7590792.
      View in: PubMed
    113. Perdew GH, Hollenback CE. Evidence for two functionally distinct forms of the human Ah receptor. J Biochem Toxicol. 1995 Apr; 10(2):95-102. PMID: 7562958.
      View in: PubMed
    114. Chen HS, Perdew GH. Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex. J Biol Chem. 1994 Nov 04; 269(44):27554-8. PMID: 7961671.
      View in: PubMed
    115. Abbott BD, Probst MR, Perdew GH. Immunohistochemical double-staining for Ah receptor and ARNT in human embryonic palatal shelves. Teratology. 1994 Nov; 50(5):361-6. PMID: 7716743.
      View in: PubMed
    116. Hord NG, Perdew GH. Physicochemical and immunocytochemical analysis of the aryl hydrocarbon receptor nuclear translocator: characterization of two monoclonal antibodies to the aryl hydrocarbon receptor nuclear translocator. Mol Pharmacol. 1994 Oct; 46(4):618-26. PMID: 7526149.
      View in: PubMed
    117. Abbott BD, Perdew GH, Buckalew AR, Birnbaum LS. Interactive regulation of Ah and glucocorticoid receptors in the synergistic induction of cleft palate by 2,3,7,8-tetrachlorodibenzo-p-dioxin and hydrocortisone. Toxicol Appl Pharmacol. 1994 Sep; 128(1):138-50. PMID: 8079347.
      View in: PubMed
    118. Perdew GH. Production of murine anti-peptide polyclonal antibodies utilizing a nonantigenic adjuvant. Anal Biochem. 1994 Jul; 220(1):214-6. PMID: 7978249.
      View in: PubMed
    119. Abbott BD, Perdew GH, Birnbaum LS. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. Toxicol Appl Pharmacol. 1994 May; 126(1):16-25. PMID: 8184424.
      View in: PubMed
    120. Perdew GH, Hord N, Hollenback CE, Welsh MJ. Localization and characterization of the 86- and 84-kDa heat shock proteins in Hepa 1c1c7 cells. Exp Cell Res. 1993 Dec; 209(2):350-6. PMID: 8262153.
      View in: PubMed
    121. Stancato LF, Chow YH, Hutchison KA, Perdew GH, Jove R, Pratt WB. Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system. J Biol Chem. 1993 Oct 15; 268(29):21711-6. PMID: 8408024.
      View in: PubMed
    122. Singh SS, Perdew GH. Alterations in the Ah receptor level after staurosporine treatment. Arch Biochem Biophys. 1993 Aug 15; 305(1):170-5. PMID: 8393644.
      View in: PubMed
    123. Swanson HI, Perdew GH. Half-life of aryl hydrocarbon receptor in Hepa 1 cells: evidence for ligand-dependent alterations in cytosolic receptor levels. Arch Biochem Biophys. 1993 Apr; 302(1):167-74. PMID: 8385898.
      View in: PubMed
    124. Hutchison KA, Brott BK, De Leon JH, Perdew GH, Jove R, Pratt WB. Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system. J Biol Chem. 1992 Feb 15; 267(5):2902-8. PMID: 1310678.
      View in: PubMed
    125. Perdew GH. Chemical cross-linking of the cytosolic and nuclear forms of the Ah receptor in hepatoma cell line 1c1c7. Biochem Biophys Res Commun. 1992 Jan 15; 182(1):55-62. PMID: 1310021.
      View in: PubMed
    126. Perdew GH. Comparison of the nuclear and cytosolic forms of the Ah receptor from Hepa 1c1c7 cells: charge heterogeneity and ATP binding properties. Arch Biochem Biophys. 1991 Dec; 291(2):284-90. PMID: 1659322.
      View in: PubMed
    127. Whitelaw ML, Hutchison K, Perdew GH. A 50-kDa cytosolic protein complexed with the 90-kDa heat shock protein (hsp90) is the same protein complexed with pp60v-src hsp90 in cells transformed by the Rous sarcoma virus. J Biol Chem. 1991 Sep 05; 266(25):16436-40. PMID: 1653236.
      View in: PubMed
    128. Swanson HI, Perdew GH. Detection of the Ah receptor in rainbow trout: use of 2-azido-3-[125I]iodo-7,8-dibromodibenzo-p-dioxin in cell culture. Toxicol Lett. 1991 Sep; 58(1):85-95. PMID: 1654604.
      View in: PubMed
    129. Dalman FC, Sturzenbecker LJ, Levin AA, Lucas DA, Perdew GH, Petkovitch M, Chambon P, Grippo JF, Pratt WB. Retinoic acid receptor belongs to a subclass of nuclear receptors that do not form "docking" complexes with hsp90. Biochemistry. 1991 Jun 04; 30(22):5605-8. PMID: 1645195.
      View in: PubMed
    130. Perdew GH, Whitelaw ML. Evidence that the 90-kDa heat shock protein (HSP90) exists in cytosol in heteromeric complexes containing HSP70 and three other proteins with Mr of 63,000, 56,000, and 50,000. J Biol Chem. 1991 Apr 15; 266(11):6708-13. PMID: 2016286.
      View in: PubMed
    131. Perdew GH, Babbs CF. Production of Ah receptor ligands in rat fecal suspensions containing tryptophan or indole-3-carbinol. Nutr Cancer. 1991; 16(3-4):209-18. PMID: 1663613.
      View in: PubMed
    132. Perdew GH, Hollenback CE. Analysis of photoaffinity-labeled aryl hydrocarbon receptor heterogeneity by two-dimensional gel electrophoresis. Biochemistry. 1990 Jul 03; 29(26):6210-4. PMID: 2169866.
      View in: PubMed
    133. Dalman FC, Koenig RJ, Perdew GH, Massa E, Pratt WB. In contrast to the glucocorticoid receptor, the thyroid hormone receptor is translated in the DNA binding state and is not associated with hsp90. J Biol Chem. 1990 Mar 05; 265(7):3615-8. PMID: 2303466.
      View in: PubMed
    134. Dalman FC, Bresnick EH, Patel PD, Perdew GH, Watson SJ, Pratt WB. Direct evidence that the glucocorticoid receptor binds to hsp90 at or near the termination of receptor translation in vitro. J Biol Chem. 1989 Nov 25; 264(33):19815-21. PMID: 2584195.
      View in: PubMed
    135. Perdew GH. Association of the Ah receptor with the 90-kDa heat shock protein. J Biol Chem. 1988 Sep 25; 263(27):13802-5. PMID: 2843537.
      View in: PubMed
    136. Perdew GH, Poland A. Purification of the Ah receptor from C57BL/6J mouse liver. J Biol Chem. 1988 Jul 15; 263(20):9848-52. PMID: 2838484.
      View in: PubMed
    137. Perdew GH, Schaup HW, Williams DE, Buhler DR, Selivonchick DP. Alterations in hepatic microsomal protein levels in rainbow trout fed cyclopropenoid fatty acids analyzed by two-dimensional gel electrophoresis. Biochem Cell Biol. 1988 Feb; 66(2):138-43. PMID: 2453207.
      View in: PubMed
    138. Perdew GH, Schaup HW, Becker MM, Williams JL, Selivonchick DP. Alterations in the synthesis of proteins in hepatocytes of rainbow trout fed cyclopropenoid fatty acids. Biochim Biophys Acta. 1986 Jun 11; 877(1):9-19. PMID: 2872926.
      View in: PubMed
    139. Perdew GH, Schaup HW, Selivonchick DP. The use of a zwitterionic detergent in two-dimensional gel electrophoresis of trout liver microsomes. Anal Biochem. 1983 Dec; 135(2):453-5. PMID: 6660519.
      View in: PubMed
    140. Vijay IK, Perdew GH. Characterization of lipid-linked octa-, nona-, and decasaccharides formed during in vitro synthesis of mammary glycoproteins. Arch Biochem Biophys. 1983 Feb 01; 220(2):605-14. PMID: 6824342.
      View in: PubMed
    141. Vijay IK, Perdew GH. Biosynthesis of mammary glycoproteins. Structural characterization of lipid-linked glucosyloligosaccharides. Eur J Biochem. 1982 Aug; 126(1):167-72. PMID: 6889958.
      View in: PubMed
    142. Vijay IK, Perdew GH. Characterization of a new isomer of lipid-linked heptasaccharide formed during in vitro biosynthesis of mammary glycoproteins. FEBS Lett. 1982 Mar 22; 139(2):321-4. PMID: 7075782.
      View in: PubMed
    143. Vijay IK, Perdew GH, Lewis DE. Biosynthesis of mammary glycoproteins. Partial characterization of the sequence for the assembly of lipid-linked saccharides. J Biol Chem. 1980 Dec 10; 255(23):11210-20. PMID: 6160147.
      View in: PubMed
    144. Vijay IK, Perdew GH. Biosynthesis of mammary glycoproteins. Structural characterization of different isomers of lipid-linked hexa- and heptasaccharides. J Biol Chem. 1980 Dec 10; 255(23):11221-6. PMID: 6160148.
      View in: PubMed
    Perdew's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _