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Gary Clawson

TitleProfessor
InstitutionCollege of Medicine
DepartmentPathology
Address500 University Drive Hershey PA 17033
Mailbox: H059
Phone7175315632

 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Pathology, and Biochemistry and Molecular Biology


GRADUATE PROGRAM AFFILIATIONS:

Biochemistry and Molecular Biology, Cell and Molecular Biology, Integrative Biosciences, MD/PhD Degree Program


EDUCATION:

Ph.D., Michigan State University, 1976
Postdoctoral Training, University of California, San Francisco, 1977-1981
M.D., University of Miami, 1983
Anatomic Pathology Residency, University of California, San Francisco, 1983-85


POSITIONS HELD:

Assistant Professor, Pathology, University of California, San Francisco, 1985-1987
Associate Professor, Pathology, George Washington University, 1987-1991
Associate Professor and Professor, Pathology, Hershey Medical Center, Pennsylvania State University, 1991-Present


NARRATIVE:

There are 2 main areas of investigation in the Clawson laboratory.

1) Development of a chip-based sensor platform for detection of circulating tumor cells (CTCs). This work is ongoing in collaboration with the Keating (Chemistry) and Mayer (Electrical Engineering) laboratories at University Park. The approach consists of a hybridization “sandwich” using pre-selected target RNAs for a particular cancer (e.g., PCA3 for prostate cancer). Target RNAs are synthesized, optimal binding sites for antisense oligonucleotides are identified using a library selection technique, and they are tested in pair-wise fashion to optimize the sandwich binding. Nanowires (NWs) are functionalized with one of the ASOs, and 50 nm gold nanoparticles (AuNPs) are functionalized with the 2nd ASO (for mass amplification). NWs are electrofluidically deposited onto pre-determined addresses on CMOS chips, which allows for multiplexing for 10’s-100’s of different target RNAs for various cancers. CTCs are enriched from patient blood specimens using a simple porous membrane centrifugation device (OncoQuickTM), which enriches CTXs ~ 400X, and RNA is extracted. This enriched RNA is then bound to the chip-based NWs and the AuNPs. Detection of the bound complexes (target RNA:AuNPs) is currently accomplished by measuring shifts in the resonance frequency of the NWs, due to the added mass of the sandwich complexes, although direct electrical detection is now being focused on. We currently have clinical trials going on with early stage melanoma patients, as well as protocols for colon and pancreatic cancer patients; we are using conventional QPCR to measure target transcript levels for the various cancers, and will then test the samples using the chip-based platform when it is operational.

2) Role of the potential tumor suppressor HtrA1 in carcinogenesis. Our recent work has identified HtrA1 as a key control element for the epithelial-to-mesenchymal transition (EMT), as well as a control for error-prone DNA damage repair. We are currently investigating molecular mechanisms of action by which HtrA1 regulates the EMT, and how it controls ATM-mediated DNA damage pathways.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Clawson GA. Cancer. Fusion for moving. Science. 2013 Nov 8; 342(6159):699-700.
    View in: PubMed
  2. Erin N, Barkan GA, Clawson GA. Vagus nerve regulates breast cancer metastasis to the adrenal gland. Anticancer Res. 2013 Sep; 33(9):3675-82.
    View in: PubMed
  3. Dean SL, Morrow TJ, Patrick S, Li M, Clawson GA, Mayer TS, Keating CD. Biorecognition by DNA oligonucleotides after exposure to photoresists and resist removers. Langmuir. 2013 Sep 10; 29(36):11535-45.
    View in: PubMed
  4. Clawson GA, Kimchi E, Patrick SD, Xin P, Harouaka R, Zheng S, Berg A, Schell T, Staveley-O'Carroll KF, Neves RI, Mosca PJ, Thiboutot D. Circulating tumor cells in melanoma patients. PLoS One. 2012; 7(7):e41052.
    View in: PubMed
  5. Wang N, Eckert KA, Zomorrodi AR, Xin P, Pan W, Shearer DA, Weisz J, Maranus CD, Clawson GA. Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways. PLoS One. 2012; 7(6):e39446.
    View in: PubMed
  6. Weisz J, Shearer DA, Murata E, Patrick SD, Han B, Berg A, Clawson GA. Identification of mammary epithelial cells subject to chronic oxidative stress in mammary epithelium of young women and teenagers living in USA: implication for breast carcinogenesis. Cancer Biol Ther. 2012 Jan 15; 13(2):101-13.
    View in: PubMed
  7. Sioss JA, Bhiladvala RB, Pan W, Li M, Patrick S, Xin P, Dean SL, Keating CD, Mayer TS, Clawson GA. Nanoresonator chip-based RNA sensor strategy for detection of circulating tumor cells: response using PCA3 as a prostate cancer marker. Nanomedicine. 2012 Aug; 8(6):1017-25.
    View in: PubMed
  8. Pan W, Xin P, Patrick S, Dean S, Keating C, Clawson G. Primer-free aptamer selection using a random DNA library. J Vis Exp. 2010; (41).
    View in: PubMed
  9. Pan W, Xin P, Clawson GA. MicroRNAs align with accessible sites in target mRNAs. J Cell Biochem. 2010 Feb 15; 109(3):509-18.
    View in: PubMed
  10. Pan W, Clawson GA. Primer-free aptamer selection using a random DNA library. Methods Mol Biol. 2010; 629:369-85.
    View in: PubMed
  11. Duncan KJ, Eckert KA, Clawson GA. Mechanisms of growth inhibition in human papillomavirus positive and negative cervical cancer cells by the chloromethyl ketone protease inhibitor, succinyl-alanine-alanine-proline-phenylalanine chloromethyl ketone. J Pharmacol Exp Ther. 2009 Jul; 330(1):359-66.
    View in: PubMed
  12. Erin N, Wang N, Xin P, Bui V, Weisz J, Barkan GA, Zhao W, Shearer D, Clawson GA. Altered gene expression in breast cancer liver metastases. Int J Cancer. 2009 Apr 1; 124(7):1503-16.
    View in: PubMed
  13. Pan W, Clawson GA. The shorter the better: reducing fixed primer regions of oligonucleotide libraries for aptamer selection. Molecules. 2009; 14(4):1353-69.
    View in: PubMed
  14. Clawson GA, Bui V, Xin P, Wang N, Pan W. Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins. J Cell Biochem. 2008 Sep 1; 105(1):81-8.
    View in: PubMed
  15. Pan W, Clawson GA. Catalytic DNAzymes: derivations and functions. Expert Opin Biol Ther. 2008 Aug; 8(8):1071-85.
    View in: PubMed
  16. Erin N, Akdas Barkan G, Harms JF, Clawson GA. Vagotomy enhances experimental metastases of 4THMpc breast cancer cells and alters substance P level. Regul Pept. 2008 Nov 29; 151(1-3):35-42.
    View in: PubMed
  17. Pan W, Xin P, Clawson GA. Minimal primer and primer-free SELEX protocols for selection of aptamers from random DNA libraries. Biotechniques. 2008 Mar; 44(3):351-60.
    View in: PubMed
  18. Smith TM, Gilliland K, Clawson GA, Thiboutot D. IGF-1 induces SREBP-1 expression and lipogenesis in SEB-1 sebocytes via activation of the phosphoinositide 3-kinase/Akt pathway. J Invest Dermatol. 2008 May; 128(5):1286-93.
    View in: PubMed
  19. Yang J, Pan WH, Clawson GA, Richmond A. Systemic targeting inhibitor of kappaB kinase inhibits melanoma tumor growth. Cancer Res. 2007 Apr 1; 67(7):3127-34.
    View in: PubMed
  20. Dhamne C, Drubin DA, Duncan K, Tevethia MJ, Clawson GA. The chloromethylketone protease inhibitor AAPF(CMK) also targets ATP-dependent helicases and SAP-domain proteins. J Cell Biochem. 2007 Feb 15; 100(3):716-26.
    View in: PubMed
  21. Smith TM, Cong Z, Gilliland KL, Clawson GA, Thiboutot DM. Insulin-like growth factor-1 induces lipid production in human SEB-1 sebocytes via sterol response element-binding protein-1. J Invest Dermatol. 2006 Jun; 126(6):1226-32.
    View in: PubMed
  22. Pan WH, Clawson GA. Antisense applications for biological control. J Cell Biochem. 2006 May 1; 98(1):14-35.
    View in: PubMed
  23. Erin N, Zhao W, Bylander J, Chase G, Clawson G. Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. Breast Cancer Res Treat. 2006 Oct; 99(3):351-64.
    View in: PubMed
  24. Drubin DA, McLaughlin-Drubin ME, Clawson GA, Meyers C. A protease inhibitor specifically inhibits growth of HPV-infected keratinocytes. Mol Ther. 2006 Jun; 13(6):1142-8.
    View in: PubMed
  25. Pan WH, Clawson GA. Identifying accessible sites in RNA: the first step in designing antisense reagents. Curr Med Chem. 2006; 13(25):3083-103.
    View in: PubMed
  26. Drubin D, Smith JS, Liu W, Zhao W, Chase GA, Clawson GA. Comparison of cryopreservation and standard needle biopsy for gene expression profiling of human breast cancer specimens. Breast Cancer Res Treat. 2005 Mar; 90(1):93-6.
    View in: PubMed
  27. Drubin DA, Clawson GA. Spontaneous transformation of an immortalized hepatocyte cell line: potential role of a nuclear protease. Cancer Lett. 2004 Sep 15; 213(1):39-48.
    View in: PubMed
  28. Clawson GA, Miranda GQ, Sivarajah A, Xin P, Pan W, Thiboutot D, Christensen ND. Inhibition of papilloma progression by antisense oligonucleotides targeted to HPV11 E6/E7 RNA. Gene Ther. 2004 Sep; 11(17):1331-41.
    View in: PubMed
  29. Erin N, Clawson GA. Parameters affecting substance P measurement in heart, lung, and skin. Biotechniques. 2004 Aug; 37(2):232, 234, 236 passim.
    View in: PubMed
  30. Pan WH, Xin P, Morrey JD, Clawson GA. A self-processing ribozyme cassette: utility against human papillomavirus 11 E6/E7 mRNA and hepatitis B virus. Mol Ther. 2004 Apr; 9(4):596-606.
    View in: PubMed
  31. Erin N, Boyer PJ, Bonneau RH, Clawson GA, Welch DR. Capsaicin-mediated denervation of sensory neurons promotes mammary tumor metastasis to lung and heart. Anticancer Res. 2004 Mar-Apr; 24(2B):1003-9.
    View in: PubMed
  32. Pan WH, Clawson GA. Identification of efficient cleavage sites in long-target RNAs. Methods Mol Biol. 2004; 252:125-44.
    View in: PubMed
  33. Thiboutot D, Jabara S, McAllister JM, Sivarajah A, Gilliland K, Cong Z, Clawson G. Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1). J Invest Dermatol. 2003 Jun; 120(6):905-14.
    View in: PubMed
  34. Pan WH, Xin P, Bui V, Clawson GA. Rapid identification of efficient target cleavage sites using a hammerhead ribozyme library in an iterative manner. Mol Ther. 2003 Jan; 7(1):129-39.
    View in: PubMed
  35. Zhang MY, Huang NN, Clawson GA, Osmani SA, Pan W, Xin P, Razzaque MS, Miller BA. Involvement of the fungal nuclear migration gene nudC human homolog in cell proliferation and mitotic spindle formation. Exp Cell Res. 2002 Feb 1; 273(1):73-84.
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  36. Pan WH, Devlin HF, Kelley C, Isom HC, Clawson GA. A selection system for identifying accessible sites in target RNAs. RNA. 2001 Apr; 7(4):610-21.
    View in: PubMed
  37. Thiboutot D, Sivarajah A, Gilliland K, Cong Z, Clawson G. The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells. J Invest Dermatol. 2000 Oct; 115(4):614-9.
    View in: PubMed
  38. Voelkel-Johnson C, Voeks DJ, Greenberg NM, Barrios R, Maggouta F, Kurtz DT, Schwartz DA, Keller GM, Papenbrock T, Clawson GA, Norris JS. Genomic instability-based transgenic models of prostate cancer. Carcinogenesis. 2000 Aug; 21(8):1623-7.
    View in: PubMed
  39. Weisz J, Fritz-Wolz G, Gestl S, Clawson GA, Creveling CR, Liehr JG, Dabbs D. Nuclear localization of catechol-O-methyltransferase in neoplastic and nonneoplastic mammary epithelial cells. Am J Pathol. 2000 Jun; 156(6):1841-8.
    View in: PubMed
  40. Norris JS, Hoel B, Voeks D, Maggouta F, Dahm M, Pan W, Clawson G. Design and testing of ribozymes for cancer gene therapy. Adv Exp Med Biol. 2000; 465:293-301.
    View in: PubMed
  41. Crone TM, Schalles SL, Benedict CM, Pan W, Ren L, Loy SE, Isom H, Clawson GA. Growth inhibition by a triple ribozyme targeted to repetitive B2 transcripts. Hepatology. 1999 Apr; 29(4):1114-23.
    View in: PubMed
  42. Benedict CM, Pan W, Loy SE, Clawson GA. Triple ribozyme-mediated down-regulation of the retinoblastoma gene. Carcinogenesis. 1998 Jul; 19(7):1223-30.
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  43. Weisz J, Fritz-Wolz G, Clawson GA, Benedict CM, Abendroth C, Creveling CR. Induction of nuclear catechol-O-methyltransferase by estrogens in hamster kidney: implications for estrogen-induced renal cancer. Carcinogenesis. 1998 Jul; 19(7):1307-12.
    View in: PubMed
  44. Weisz J, Clawson GA, Creveling CR. Biogenesis and inactivation of catecholestrogens. Adv Pharmacol. 1998; 42:828-33.
    View in: PubMed
  45. Zhang MY, Clawson GA, Olivieri NF, Bell LL, Begley CG, Miller BA. Expression of SCL is normal in transfusion-dependent Diamond-Blackfan anemia but other bHLH proteins are deficient. Blood. 1997 Sep 1; 90(5):2068-74.
    View in: PubMed
  46. Clawson GA, Benedict CM, Kelley MR, Weisz J. Focal nuclear hepatocyte response to oxidative damage following low dose thioacetamide intoxication. Carcinogenesis. 1997 Aug; 18(8):1663-8.
    View in: PubMed
  47. Ren L, Clawson GA. Studies on rLMP7, a beta-subunit of the multicatalytic proteinase. Exp Cell Res. 1997 Jul 10; 234(1):105-14.
    View in: PubMed
  48. Benedict CM, Clawson GA. Nuclear multicatalytic proteinase subunit RRC3 is important for growth regulation in hepatocytes. Biochemistry. 1996 Sep 10; 35(36):11612-21.
    View in: PubMed
  49. Clawson GA, Schalles SL, Wolz G, Weisz J, Crone TM, Miranda GQ. Focal altered compartmentation of repetitive B2 (Alu-like) sequences in rat liver following hepatocarcinogen exposure. Cell Growth Differ. 1996 May; 7(5):635-46.
    View in: PubMed
  50. Clawson GA. Protease inhibitors and carcinogenesis: a review. Cancer Invest. 1996; 14(6):597-608.
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  51. Clawson GA, Ren L, Isom HC. Nuclear scaffold-associated protease: in situ nuclear localization and effects of a protease inhibitor on growth and morphology of a ras-transformed hepatocyte cell line. Hepatology. 1995 Oct; 22(4 Pt 1):1230-5.
    View in: PubMed
  52. Benedict CM, Ren L, Clawson GA. Nuclear multicatalytic proteinase alpha subunit RRC3: differential size, tyrosine phosphorylation, and susceptibility to antisense oligonucleotide treatment. Biochemistry. 1995 Jul 25; 34(29):9587-98.
    View in: PubMed
  53. Clawson GA, Norbeck LL, Wise JP, Patierno SR. An inhibitor of nuclear scaffold protease blocks chemical transformation of fibroblasts. Cell Growth Differ. 1993 Jul; 4(7):589-94.
    View in: PubMed
  54. Tong CG, Dauwalder M, Clawson GA, Hatem CL, Roux SJ. The major nucleoside triphosphatase in pea (Pisum sativum L.) nuclei and in rat liver nuclei share common epitopes also present in nuclear lamins. Plant Physiol. 1993 Mar; 101(3):1005-11.
    View in: PubMed
  55. Clawson GA, Norbeck LL, Hatem CL, Rhodes C, Amiri P, McKerrow JH, Patierno SR, Fiskum G. Ca(2+)-regulated serine protease associated with the nuclear scaffold. Cell Growth Differ. 1992 Nov; 3(11):827-38.
    View in: PubMed
  56. Clawson GA, Blankenship LJ, Rhame JG, Wilkinson DS. Nuclear enlargement induced by hepatocarcinogens alters ploidy. Cancer Res. 1992 Mar 1; 52(5):1304-8.
    View in: PubMed
  57. Clawson GA, Song YL, Schwartz AM, Shukla RR, Patel SG, Connor L, Blankenship L, Hatem C, Kumar A. Interaction of human immunodeficiency virus type I Rev protein with nuclear scaffold nucleoside triphosphatase activity. Cell Growth Differ. 1991 Nov; 2(11):575-82.
    View in: PubMed
  58. Schwartz AM, Clawson GA. Cooperative ATP binding by cloned lamin C. Exp Cell Res. 1991 Apr; 193(2):432-4.
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  59. Clawson GA, Madsen KR, Blankenship LJ, Hatem CL. Alterations in nuclear scaffold constituents during carbon tetrachloride-induced liver regeneration. Hepatology. 1991 Mar; 13(3):515-22.
    View in: PubMed
  60. Choe WT, Hatem CL, Clawson GA. Demethylation of ribosomal RNA by hepatocyte microsomal preparations. Life Sci. 1991; 48(16):1585-9.
    View in: PubMed
  61. Clawson GA, Wang YF, Schwartz AM, Hatem CL. The Mr 46,000 nuclear scaffold ATP-binding protein: identification of the putative nucleoside triphosphatase by proteolysis and monoclonal antibodies directed against lamins A/C. Cell Growth Differ. 1990 Nov; 1(11):559-68.
    View in: PubMed
  62. Madsen KR, Fiskum G, Clawson GA. Regulation of nuclear scaffold protease activity by calcium. Exp Cell Res. 1990 Apr; 187(2):343-5.
    View in: PubMed
  63. Clawson GA, Sesno J, Milam K, Wang YF, Gabriel C. The hepatocyte protein synthesis defect induced by galactosamine involves hypomethylation of ribosomal RNA. Hepatology. 1990 Mar; 11(3):428-34.
    View in: PubMed
  64. Tökés ZA, Clawson GA. Proteolytic activity associated with the nuclear scaffold. The effect of self-digestion on lamins. J Biol Chem. 1989 Sep 5; 264(25):15059-65.
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  65. Clawson GA. Mechanisms of carbon tetrachloride hepatotoxicity. Pathol Immunopathol Res. 1989; 8(2):104-12.
    View in: PubMed
  66. Clawson GA, Lackey A, Tokes ZA. The 46-kDa nucleoside triphosphatase of rat liver nuclear scaffold represents the N-terminal portion of lamins A/C. Exp Cell Res. 1988 May; 176(1):180-6.
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  67. Moody DE, Clawson GA, Geller DA, Taylor LA, Button J, Loury DN, Hammock BD, Smuckler EA. Sodium cholate extraction of rat liver nuclear xenobiotic-metabolizing enzymes. Biochem Pharmacol. 1988 Apr 1; 37(7):1331-41.
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  68. Clawson GA. Antiheretical speculations on the "prion" protein and scrapie. Perspect Biol Med. 1988; 31(2):212-23.
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  69. Liao YC, Tokes Z, Lim E, Lackey A, Woo CH, Button JD, Clawson GA. Cloning of rat "prion-related protein" cDNA. Lab Invest. 1987 Oct; 57(4):370-4.
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  70. Clawson GA, Button JD, Woo CH. Hepatocarcinogen-induced alterations in nuclear RNA compartmentation. Carcinogenesis. 1987 Sep; 8(9):1235-8.
    View in: PubMed
  71. Clawson GA, MacDonald JR, Woo CH. Early hypomethylation of 2'-O-ribose moieties in hepatocyte cytoplasmic ribosomal RNA underlies the protein synthetic defect produced by CCl4. J Cell Biol. 1987 Aug; 105(2):705-11.
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  72. Clawson GA, Lackey A, Button J, Smuckler EA. The major nucleoside triphosphatase of nuclear scaffold is distinct from actin. Exp Cell Res. 1986 Dec; 167(2):559-62.
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  73. Liao YC, Lebo RV, Clawson GA, Smuckler EA. Human prion protein cDNA: molecular cloning, chromosomal mapping, and biological implications. Science. 1986 Jul 18; 233(4761):364-7.
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  74. Clawson GA, Button JD, Liao YC, Smuckler EA. Cytoplasmic RNA complementary to pre-albumin intron V. Biochem Biophys Res Commun. 1986 May 14; 136(3):989-94.
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  75. Clawson GA, Button J, Woo CH, Liao YC, Smuckler EA. In vitro release of alpha 1-acid glycoprotein RNA sequences shows fidelity with the acute phase response in vivo. Mol Biol Rep. 1986; 11(3):163-72.
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  76. Liao YC, Taylor JM, Vannice JL, Clawson GA, Smuckler EA. Structure of the rat alpha 1-acid glycoprotein gene. Mol Cell Biol. 1985 Dec; 5(12):3634-9.
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  77. Clawson GA, Button J, Smuckler EA. Photoaffinity labelling of a nuclear matrix nucleoside triphosphatase and its modulation in the acute-phase response. Exp Cell Res. 1985 Jul; 159(1):171-5.
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  78. Clawson GA, Feldherr CM, Smuckler EA. Nucleocytoplasmic RNA transport. Mol Cell Biochem. 1985 Jul; 67(2):87-99.
    View in: PubMed
  79. Goldfine ID, Purrello F, Vigneri R, Clawson GA. Insulin and the regulation of isolated nuclei and nuclear subfractions: potential relationship to mRNA metabolism. Diabetes Metab Rev. 1985; 1(1-2):119-37.
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  80. Clawson GA, Moody DE, Ferrell LD, Smuckler EA. Increased nucleoside triphosphatase activity of rat liver nuclear envelope is associated with hepatocarcinogen exposure. Lab Invest. 1984 Dec; 51(6):682-9.
    View in: PubMed
  81. Clawson GA, Button J, Woo CH, Smuckler EA. Modulation of RNA transport by polyvinylpyrrolidone. Mol Biol Rep. 1984 Dec; 10(2):105-7.
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  82. Clawson GA, Friend DS, Smuckler EA. Localization of nucleoside triphosphatase activity to the inner nuclear envelope and associated heterochromatin. Exp Cell Res. 1984 Nov; 155(1):310-4.
    View in: PubMed
  83. Moody DE, Clawson GA, Piper WN, Smuckler EA. Effects of 1,2-dibromo-3-chloropropane on hepatic heme synthesis. Toxicol Appl Pharmacol. 1984 Sep 30; 75(3):561-70.
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  84. Clawson GA, Woo CH, Button J, Smuckler EA. Photoaffinity labeling of the major nucleosidetriphosphatase of rat liver nuclear envelope. Biochemistry. 1984 Jul 17; 23(15):3501-7.
    View in: PubMed
  85. Clawson GA, Smuckler EA. Hybridization of poly(A)-containing ribonucleic acid transported in vitro to cyclic deoxyribonucleic acid-cellulose transcribed from cytoplasmic poly(A)-containing ribonucleic acid. Lab Invest. 1983 Oct; 49(4):506-8.
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  86. Bolton PH, Clawson G, Basus VJ, James TL. Comparison of ribonucleic acid-protein interactions in messenger ribonucleoproteins, ribosomes, MS2 virus, and Q beta virus examined via phosphorus-31 nuclear magnetic resonance relaxation. Biochemistry. 1982 Nov 23; 21(24):6073-81.
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  87. Moody DE, Clawson GA, Woo CH, Smuckler EA. Cellular distribution of cytochrome P-450 loss in rats of different ages treated with alkyl halides. Toxicol Appl Pharmacol. 1982 Nov; 66(2):278-89.
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  88. Clawson GA, Smuckler EA. Increased nucleoside triphosphatase activity of rat liver nuclear matrix following low dose carcinogen intoxication. Biochem Biophys Res Commun. 1982 Oct 15; 108(3):1331-9.
    View in: PubMed
  89. Goldfine ID, Clawson GA, Smuckler EA, Purrello F. Action of insulin at the nuclear envelope. Mol Cell Biochem. 1982 Oct 1; 48(1):3-14.
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  90. Clawson GA, Smuckler EA. Increased amounts of double-stranded RNA in the cytoplasm of rat liver following treatment with carcinogens. Cancer Res. 1982 Aug; 42(8):3228-31.
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  91. Moody DE, Clawson GA, Smuckler EA. The integrity of liver protein synthesis in male rats treated with 1,2-dibromo-3-chloropropane. Toxicol Lett. 1982 Jul; 12(2-3):101-8.
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  92. Purrello F, Vigneri R, Clawson GA, Goldfine ID. Insulin stimulation of nucleoside triphosphatase activity in isolated nuclear envelopes. Science. 1982 May 28; 216(4549):1005-7.
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  93. Clawson GA, Smuckler EA. A model for nucleocytoplasmic transport of ribonucleoprotein particles. J Theor Biol. 1982 Apr 21; 95(4):607-13.
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  94. Goldfine ID, Purrello F, Clawson GA, Vigneri R. Insulin binding sites on the nuclear envelope: potential relationship to mRNA metabolism. J Cell Biochem. 1982; 20(1):29-39.
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  95. Moody DE, James JL, Clawson GA, Smuckler EA. Correlations among the changes in hepatic microsomal components after intoxication with alkyl halides and other hepatotoxins. Mol Pharmacol. 1981 Nov; 20(3):685-93.
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  96. Clawson GA, Moody DE, Woo CH, Smuckler EA. Apparent differential response of nuclear envelope cytochrome P-450 following phenobarbital induction arising from a preferential loss during gradient purification. Cancer Res. 1981 Aug; 41(8):3122-7.
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  97. James JL, Clawson GA, Chan CH, Smuckler EA. Analysis of the phospholipid of the nuclear envelope and endoplasmic reticulum of liver cells by high pressure liquid chromatography. Lipids. 1981 Jul; 16(7):541-5.
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  98. Clawson GA, Moody DE, James J, Smuckler EA. Nuclear envelope alterations accompanying thioacetamide-related enlargement of the nucleus. Cancer Res. 1981 Feb; 41(2):519-26.
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  99. Clawson GA, Smuckler EA. On the nature of nuclear envelope-associated RNA. Biochem Biophys Res Commun. 1980 Sep 30; 96(2):812-6.
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  100. Clawson GA, Woo CH, Smuckler EA. Polypeptide composition of nuclear envelope following thioacetamide-induced nuclear swelling. Biochem Biophys Res Commun. 1980 Sep 16; 96(1):370-6.
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  101. Clawson GA, Woo CH, Smuckler EA. Independent responses of nucleoside triphosphatase and protein kinase activities in nuclear envelope following thioacetamide treatment. Biochem Biophys Res Commun. 1980 Aug 14; 95(3):1200-4.
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  102. Clawson GA, Smuckler EA. Altered restriction of nuclear RNA during incubation in vitro. Biochem Biophys Res Commun. 1980 Jul 31; 95(2):696-700.
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  103. Clawson GA, James J, Woo CH, Friend DS, Moody D, Smuckler EA. Pertinence of nuclear envelope nucleoside triphosphatase activity to ribonucleic acid transport. Biochemistry. 1980 Jun 10; 19(12):2748-56.
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  104. Clawson GA, Koplitz M, Moody DE, Smuckler EA. Effects of thioacetamide treatment on nuclear envelope nucleoside triphosphatase activity and transport of RNA from rat liver nuclei. Cancer Res. 1980 Jan; 40(1):75-9.
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  105. Clawson GA, Smuckler EA. Activation energy for RNA transport from isolated rat liver nuclei. Proc Natl Acad Sci U S A. 1978 Nov; 75(11):5400-4.
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  106. Clawson GA, Koplitz M, Castler-Schechter B, Smuckler EA. Energy utilization and RNA transport: their interdependence. Biochemistry. 1978 Sep 5; 17(18):3747-52.
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  107. Stuart SE, Clawson GA, Rottman FM, Patterson RJ. RNA transport in isolated myeloma nuclei. Transport from membrane-denuded nuclei. J Cell Biol. 1977 Jan; 72(1):57-66.
    View in: PubMed
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