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Faoud Ishmael

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive Hershey PA 17033
Phone7175310003 x3285567
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    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Physician, Assistant Porfessor

    EDUCATION:

    Fellowship, Allergy/Immunology, Johns Hopkins University School of Medicine (Maryland) (2009)
    Residency, Internal Medicine, Penn State Milton S. Hershey Medical Center (2006)
    M.D., Penn State Hershey College of Medicine (2004)

    NARRATIVE:

    Allergic diseases affect as much as 30% of the population and include conditions such as allergic rhinitis, asthma, food allergies, and drug allergy. The mechanisms that cause allergic inflammation are poorly understood, and there are limited treatment options. Our lab is focused on the understanding of the mechanisms that underlie allergic diseases, better methods of diagnosis of these conditions, and the development of novel drugs to effectively treat allergies. We currently have three specific areas of interests:

    1. mechanisms of glucocorticoids in post-transcriptional regulation.
    2. microRNAs as biomarkers in the diagnosis and pathogenesis of allergic disease.
    3. diagnosis of drug allergy by in vitro methods.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Mukadam S, Zacharias J, Henao MP, Kraschnewski J, Ishmael F. Differential effects of obesity on eosinophilic vs. non-eosinophilic asthma subtypes. J Asthma. 2017 Aug 28; 1-6. PMID: 28846451.
      View in: PubMed
    2. Zhou Y, Do DC, Ishmael FT, Squadrito ML, Tang HM, Tang HL, Hsu MH, Qiu L, Li C, Zhang Y, Becker KG, Wan M, Huang SK, Gao P. Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p. J Allergy Clin Immunol. 2018 Jan; 141(1):350-364.e8. PMID: 28629744.
      View in: PubMed
    3. Bhardwaj N, Ishmael F, Lehman E, Bethards D, Ruggiero F, Ghaffari G. Effect of topical beclomethasone on inflammatory markers in adults with eosinophilic esophagitis: A pilot study. Allergy Rhinol (Providence). 2017 Jun 01; 8(2):85-94. PMID: 28583232.
      View in: PubMed
    4. Gutierrez MJ, Gilson J, Zacharias J, Ishmael F, Bingham CA. Childhood Polyarthritis As Early Manifestation of Autoimmune Polyendocrinopathy with Candidiasis and Ectodermal Dystrophy Syndrome. Front Immunol. 2017; 8:377. PMID: 28458664.
      View in: PubMed
    5. Lin SK, Mulieri KM, Ishmael FT. Characterization of Vancomycin Reactions and Linezolid Utilization in the Pediatric Population. J Allergy Clin Immunol Pract. 2017 May - Jun; 5(3):750-756. PMID: 28189630.
      View in: PubMed
    6. Dluzen DF, Sutliff AK, Chen G, Watson CJ, Ishmael FT, Lazarus P. Regulation of UGT2B Expression and Activity by miR-216b-5p in Liver Cancer Cell Lines. J Pharmacol Exp Ther. 2016 10; 359(1):182-93. PMID: 27474751.
      View in: PubMed
    7. Schmitz HM, Kelbel TE, Ishmael F. Peripheral blood mononuclear cell gene expression testing and the heterogeneity of T-cell-mediated drug reaction with eosinophilia and systemic symptoms syndrome. Ann Allergy Asthma Immunol. 2016 Jun; 116(6):584-5. PMID: 27067458.
      View in: PubMed
    8. Panganiban RP, Wang Y, Howrylak J, Chinchilli VM, Craig TJ, August A, Ishmael FT. Circulating microRNAs as biomarkers in patients with allergic rhinitis and asthma. J Allergy Clin Immunol. 2016 May; 137(5):1423-32. PMID: 27025347.
      View in: PubMed
    9. Belser K, Reddy V, Marks J, Ishmael F, Kelbel T. Chronic pruritic dermatitis and peripheral eosinophilia in a 42-year-old man. Allergy Asthma Proc. 2016 Mar-Apr; 37(2):171-4. PMID: 26932174.
      View in: PubMed
    10. Roff AN, Craig TJ, August A, Stellato C, Ishmael FT. MicroRNA-570-3p regulates HuR and cytokine expression in airway epithelial cells. Am J Clin Exp Immunol. 2014; 3(2):68-83. PMID: 25143867; PMCID: PMC4138130.
    11. Panganiban RP, Vonakis BM, Ishmael FT, Stellato C. Coordinated post-transcriptional regulation of the chemokine system: messages from CCL2. J Interferon Cytokine Res. 2014 Apr; 34(4):255-66. PMID: 24697203; PMCID: PMC3976576.
    12. Bajaj P, Clement J, Bayerl MG, Kalra N, Craig TJ, Ishmael FT. High-grade fever and pancytopenia in an adult patient with common variable immune deficiency. Allergy Asthma Proc. 2014 Jan-Feb; 35(1):78-82. PMID: 24433602.
      View in: PubMed
    13. Bhardwaj N, Ishmael FT. Cytokine gene expression profiling to help identify a safe antibiotic in a patient with drug rash with eosinophilia and systemic symptoms. J Allergy Clin Immunol Pract. 2013 Sep-Oct; 1(5):531-3. PMID: 24565631.
      View in: PubMed
    14. Pinkerton M, Chinchilli V, Banta E, Craig T, August A, Bascom R, Cantorna M, Harvill E, Ishmael FT. Differential expression of microRNAs in exhaled breath condensates of patients with asthma, patients with chronic obstructive pulmonary disease, and healthy adults. J Allergy Clin Immunol. 2013 Jul; 132(1):217-9. PMID: 23628339.
      View in: PubMed
    15. Ishmael FT, Prematta T. Author reply: To PMID 22525391. Allergy Asthma Proc. 2013 Mar-Apr; 34(2):194. PMID: 23610776.
      View in: PubMed
    16. Shah S, Prematta T, Adkinson NF, Ishmael FT. Hypersensitivity to polyethylene glycols. J Clin Pharmacol. 2013 Mar; 53(3):352-5. PMID: 23444288.
      View in: PubMed
    17. Roff AN, Panganiban RP, Bond JS, Ishmael FT. Post-transcriptional regulation of meprin a by the RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP). J Biol Chem. 2013 Feb 15; 288(7):4733-43. PMID: 23269677; PMCID: PMC3576078.
    18. Panganiban RP, Pinkerton MH, Maru SY, Jefferson SJ, Roff AN, Ishmael FT. Differential microRNA epression in asthma and the role of miR-1248 in regulation of IL-5. Am J Clin Exp Immunol. 2012; 1(2):154-65. PMID: 23885321; PMCID: PMC3714196.
    19. Gutierrez MJ, McSherry GD, Ishmael FT, Horwitz AA, Nino G. Residual NADPH oxidase activity and isolated lung involvement in x-linked chronic granulomatous disease. Case Rep Pediatr. 2012; 2012:974561. PMID: 23193493; PMCID: PMC3501804.
    20. Mertz TL, Jacobs SB, Craig TJ, Ishmael FT. The brown marmorated stinkbug as a new aeroallergen. J Allergy Clin Immunol. 2012 Oct; 130(4):999-1001.e1. PMID: 22835402.
      View in: PubMed
    21. Houser KR, Johnson DK, Ishmael FT. Anti-inflammatory effects of methoxyphenolic compounds on human airway cells. J Inflamm (Lond). 2012 Mar 13; 9:6. PMID: 22414048; PMCID: PMC3325161.
    22. Prematta T, Shah S, Ishmael FT. Physician approaches to beta-lactam use in patients with penicillin hypersensitivity. Allergy Asthma Proc. 2012 Mar-Apr; 33(2):145-51. PMID: 22525391.
      View in: PubMed
    23. Ringenbach MR, Banta E, Snyder MR, Craig TJ, Ishmael FT. A challenging diagnosis of alpha-1-antitrypsin deficiency: identification of a patient with a novel F/Null phenotype. Allergy Asthma Clin Immunol. 2011 Nov 13; 7(1):18. PMID: 22078084; PMCID: PMC3229436.
    24. Ishmael FT. The inflammatory response in the pathogenesis of asthma. J Am Osteopath Assoc. 2011 Nov; 111(11 Suppl 7):S11-7. PMID: 22162373.
      View in: PubMed
    25. Fan J, Ishmael FT, Fang X, Myers A, Cheadle C, Huang SK, Atasoy U, Gorospe M, Stellato C. Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium. J Immunol. 2011 Feb 15; 186(4):2482-94. PMID: 21220697; PMCID: PMC3872785.
    26. Ishmael FT, Fang X, Houser KR, Pearce K, Abdelmohsen K, Zhan M, Gorospe M, Stellato C. The human glucocorticoid receptor as an RNA-binding protein: global analysis of glucocorticoid receptor-associated transcripts and identification of a target RNA motif. J Immunol. 2011 Jan 15; 186(2):1189-98. PMID: 21148795; PMCID: PMC3017228.
    27. Ishmael FT, Stellato C. Principles and applications of polymerase chain reaction: basic science for the practicing physician. Ann Allergy Asthma Immunol. 2008 Oct; 101(4):437-43. PMID: 18939735.
      View in: PubMed
    28. Ishmael FT, Fang X, Galdiero MR, Atasoy U, Rigby WF, Gorospe M, Cheadle C, Stellato C. Role of the RNA-binding protein tristetraprolin in glucocorticoid-mediated gene regulation. J Immunol. 2008 Jun 15; 180(12):8342-53. PMID: 18523301; PMCID: PMC2505276.
    29. Ishmael SS, Ishmael FT, Jones AD, Bond JS. Protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin A metalloprotease homo-oligomer. J Biol Chem. 2006 Dec 08; 281(49):37404-15. PMID: 17040911.
      View in: PubMed
    30. Trakselis MA, Alley SC, Ishmael FT. Identification and mapping of protein-protein interactions by a combination of cross-linking, cleavage, and proteomics. Bioconjug Chem. 2005 Jul-Aug; 16(4):741-50. PMID: 16029014.
      View in: PubMed
    31. Norcum MT, Warrington JA, Spiering MM, Ishmael FT, Trakselis MA, Benkovic SJ. Architecture of the bacteriophage T4 primosome: electron microscopy studies of helicase (gp41) and primase (gp61). Proc Natl Acad Sci U S A. 2005 Mar 08; 102(10):3623-6. PMID: 15738414; PMCID: PMC553339.
    32. Zhang Z, Spiering MM, Trakselis MA, Ishmael FT, Xi J, Benkovic SJ, Hammes GG. Assembly of the bacteriophage T4 primosome: single-molecule and ensemble studies. Proc Natl Acad Sci U S A. 2005 Mar 01; 102(9):3254-9. PMID: 15728347; PMCID: PMC552937.
    33. Ishmael FT, Shier VK, Ishmael SS, Bond JS. Intersubunit and domain interactions of the meprin B metalloproteinase. Disulfide bonds and protein-protein interactions in the MAM and TRAF domains. J Biol Chem. 2005 Apr 08; 280(14):13895-901. PMID: 15695509.
      View in: PubMed
    34. Ishmael FT, Trakselis MA, Benkovic SJ. Protein-protein interactions in the bacteriophage T4 replisome. The leading strand holoenzyme is physically linked to the lagging strand holoenzyme and the primosome. J Biol Chem. 2003 Jan 31; 278(5):3145-52. PMID: 12427736.
      View in: PubMed
    35. Doll BA, Villa JP, Ishmael FT, Bond JS. Zinc ligands in an astacin family metalloprotease meprin A. Biol Chem. 2002 Jul-Aug; 383(7-8):1167-73. PMID: 12437102.
      View in: PubMed
    36. Ishmael FT, Alley SC, Benkovic SJ. Assembly of the bacteriophage T4 helicase: architecture and stoichiometry of the gp41-gp59 complex. J Biol Chem. 2002 Jun 07; 277(23):20555-62. PMID: 11927580.
      View in: PubMed
    37. Valentine AM, Ishmael FT, Shier VK, Benkovic SJ. A zinc ribbon protein in DNA replication: primer synthesis and macromolecular interactions by the bacteriophage T4 primase. Biochemistry. 2001 Dec 18; 40(50):15074-85. PMID: 11735390.
      View in: PubMed
    38. Trakselis MA, Mayer MU, Ishmael FT, Roccasecca RM, Benkovic SJ. Dynamic protein interactions in the bacteriophage T4 replisome. Trends Biochem Sci. 2001 Sep; 26(9):566-72. PMID: 11551794.
      View in: PubMed
    39. Alley SC, Trakselis MA, Mayer MU, Ishmael FT, Jones AD, Benkovic SJ. Building a replisome solution structure by elucidation of protein-protein interactions in the bacteriophage T4 DNA polymerase holoenzyme. J Biol Chem. 2001 Oct 19; 276(42):39340-9. PMID: 11504721.
      View in: PubMed
    40. Ishmael FT, Alley SC, Benkovic SJ. Identification and mapping of protein-protein interactions between gp32 and gp59 by cross-linking. J Biol Chem. 2001 Jul 06; 276(27):25236-42. PMID: 11309384.
      View in: PubMed
    41. Ishmael FT, Norcum MT, Benkovic SJ, Bond JS. Multimeric structure of the secreted meprin A metalloproteinase and characterization of the functional protomer. J Biol Chem. 2001 Jun 22; 276(25):23207-11. PMID: 11301339.
      View in: PubMed
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