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Faoud Ishmael

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentMedicine
Address500 University Drive Hershey PA 17033
Phone7175310003 x3285567

 Overview 
 overview
PREFERRED TITLE/ROLE:

Physician, Assistant Porfessor

EDUCATION:

Fellowship, Allergy/Immunology, Johns Hopkins University School of Medicine (Maryland) (2009)
Residency, Internal Medicine, Penn State Milton S. Hershey Medical Center (2006)
M.D., Penn State Hershey College of Medicine (2004)

NARRATIVE:

Allergic diseases affect as much as 30% of the population and include conditions such as allergic rhinitis, asthma, food allergies, and drug allergy. The mechanisms that cause allergic inflammation are poorly understood, and there are limited treatment options. Our lab is focused on the understanding of the mechanisms that underlie allergic diseases, better methods of diagnosis of these conditions, and the development of novel drugs to effectively treat allergies. We currently have three specific areas of interests:

1. mechanisms of glucocorticoids in post-transcriptional regulation.
2. microRNAs as biomarkers in the diagnosis and pathogenesis of allergic disease.
3. diagnosis of drug allergy by in vitro methods.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Roff AN, Craig TJ, August A, Stellato C, Ishmael FT. MicroRNA-570-3p regulates HuR and cytokine expression in airway epithelial cells. Am J Clin Exp Immunol. 2014; 3(2):68-83.
    View in: PubMed
  2. Panganiban RP, Vonakis BM, Ishmael FT, Stellato C. Coordinated post-transcriptional regulation of the chemokine system: messages from CCL2. J Interferon Cytokine Res. 2014 Apr; 34(4):255-66.
    View in: PubMed
  3. Bajaj P, Clement J, Bayerl MG, Kalra N, Craig TJ, Ishmael FT. High-grade fever and pancytopenia in an adult patient with common variable immune deficiency. Allergy Asthma Proc. 2014 Jan-Feb; 35(1):78-82.
    View in: PubMed
  4. Bhardwaj N, Ishmael FT. Cytokine gene expression profiling to help identify a safe antibiotic in a patient with drug rash with eosinophilia and systemic symptoms. J Allergy Clin Immunol Pract. 2013 Sep-Oct; 1(5):531-3.
    View in: PubMed
  5. Konsavage WM, Roper JN, Ishmael FT, Yochum GS. The Myc 3' Wnt responsive element regulates neutrophil recruitment after acute colonic injury in mice. Dig Dis Sci. 2013 Oct; 58(10):2858-67.
    View in: PubMed
  6. Pinkerton M, Chinchilli V, Banta E, Craig T, August A, Bascom R, Cantorna M, Harvill E, Ishmael FT. Differential expression of microRNAs in exhaled breath condensates of patients with asthma, patients with chronic obstructive pulmonary disease, and healthy adults. J Allergy Clin Immunol. 2013 Jul; 132(1):217-9.
    View in: PubMed
  7. Ishmael FT, Prematta T. Author reply: To PMID 22525391. Allergy Asthma Proc. 2013 Mar-Apr; 34(2):194.
    View in: PubMed
  8. Shah S, Prematta T, Adkinson NF, Ishmael FT. Hypersensitivity to polyethylene glycols. J Clin Pharmacol. 2013 Mar; 53(3):352-5.
    View in: PubMed
  9. Roff AN, Panganiban RP, Bond JS, Ishmael FT. Post-transcriptional regulation of meprin a by the RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP). J Biol Chem. 2013 Feb 15; 288(7):4733-43.
    View in: PubMed
  10. Panganiban RP, Pinkerton MH, Maru SY, Jefferson SJ, Roff AN, Ishmael FT. Differential microRNA epression in asthma and the role of miR-1248 in regulation of IL-5. Am J Clin Exp Immunol. 2012; 1(2):154-65.
    View in: PubMed
  11. Gutierrez MJ, McSherry GD, Ishmael FT, Horwitz AA, Nino G. Residual NADPH oxidase activity and isolated lung involvement in x-linked chronic granulomatous disease. Case Rep Pediatr. 2012; 2012:974561.
    View in: PubMed
  12. Mertz TL, Jacobs SB, Craig TJ, Ishmael FT. The brown marmorated stinkbug as a new aeroallergen. J Allergy Clin Immunol. 2012 Oct; 130(4):999-1001.e1.
    View in: PubMed
  13. Houser KR, Johnson DK, Ishmael FT. Anti-inflammatory effects of methoxyphenolic compounds on human airway cells. J Inflamm (Lond). 2012; 9:6.
    View in: PubMed
  14. Prematta T, Shah S, Ishmael FT. Physician approaches to beta-lactam use in patients with penicillin hypersensitivity. Allergy Asthma Proc. 2012 Mar-Apr; 33(2):145-51.
    View in: PubMed
  15. Ringenbach MR, Banta E, Snyder MR, Craig TJ, Ishmael FT. A challenging diagnosis of alpha-1-antitrypsin deficiency: identification of a patient with a novel F/Null phenotype. Allergy Asthma Clin Immunol. 2011; 7(1):18.
    View in: PubMed
  16. Ishmael FT. The inflammatory response in the pathogenesis of asthma. J Am Osteopath Assoc. 2011 Nov; 111(11 Suppl 7):S11-7.
    View in: PubMed
  17. Fan J, Ishmael FT, Fang X, Myers A, Cheadle C, Huang SK, Atasoy U, Gorospe M, Stellato C. Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium. J Immunol. 2011 Feb 15; 186(4):2482-94.
    View in: PubMed
  18. Ishmael FT, Fang X, Houser KR, Pearce K, Abdelmohsen K, Zhan M, Gorospe M, Stellato C. The human glucocorticoid receptor as an RNA-binding protein: global analysis of glucocorticoid receptor-associated transcripts and identification of a target RNA motif. J Immunol. 2011 Jan 15; 186(2):1189-98.
    View in: PubMed
  19. Ishmael FT, Stellato C. Principles and applications of polymerase chain reaction: basic science for the practicing physician. Ann Allergy Asthma Immunol. 2008 Oct; 101(4):437-43.
    View in: PubMed
  20. Ishmael FT, Fang X, Galdiero MR, Atasoy U, Rigby WF, Gorospe M, Cheadle C, Stellato C. Role of the RNA-binding protein tristetraprolin in glucocorticoid-mediated gene regulation. J Immunol. 2008 Jun 15; 180(12):8342-53.
    View in: PubMed
  21. Ishmael SS, Ishmael FT, Jones AD, Bond JS. Protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin A metalloprotease homo-oligomer. J Biol Chem. 2006 Dec 8; 281(49):37404-15.
    View in: PubMed
  22. Trakselis MA, Alley SC, Ishmael FT. Identification and mapping of protein-protein interactions by a combination of cross-linking, cleavage, and proteomics. Bioconjug Chem. 2005 Jul-Aug; 16(4):741-50.
    View in: PubMed
  23. Norcum MT, Warrington JA, Spiering MM, Ishmael FT, Trakselis MA, Benkovic SJ. Architecture of the bacteriophage T4 primosome: electron microscopy studies of helicase (gp41) and primase (gp61). Proc Natl Acad Sci U S A. 2005 Mar 8; 102(10):3623-6.
    View in: PubMed
  24. Zhang Z, Spiering MM, Trakselis MA, Ishmael FT, Xi J, Benkovic SJ, Hammes GG. Assembly of the bacteriophage T4 primosome: single-molecule and ensemble studies. Proc Natl Acad Sci U S A. 2005 Mar 1; 102(9):3254-9.
    View in: PubMed
  25. Ishmael FT, Shier VK, Ishmael SS, Bond JS. Intersubunit and domain interactions of the meprin B metalloproteinase. Disulfide bonds and protein-protein interactions in the MAM and TRAF domains. J Biol Chem. 2005 Apr 8; 280(14):13895-901.
    View in: PubMed
  26. Ishmael FT, Trakselis MA, Benkovic SJ. Protein-protein interactions in the bacteriophage T4 replisome. The leading strand holoenzyme is physically linked to the lagging strand holoenzyme and the primosome. J Biol Chem. 2003 Jan 31; 278(5):3145-52.
    View in: PubMed
  27. Doll BA, Villa JP, Ishmael FT, Bond JS. Zinc ligands in an astacin family metalloprotease meprin A. Biol Chem. 2002 Jul-Aug; 383(7-8):1167-73.
    View in: PubMed
  28. Ishmael FT, Alley SC, Benkovic SJ. Assembly of the bacteriophage T4 helicase: architecture and stoichiometry of the gp41-gp59 complex. J Biol Chem. 2002 Jun 7; 277(23):20555-62.
    View in: PubMed
  29. Valentine AM, Ishmael FT, Shier VK, Benkovic SJ. A zinc ribbon protein in DNA replication: primer synthesis and macromolecular interactions by the bacteriophage T4 primase. Biochemistry. 2001 Dec 18; 40(50):15074-85.
    View in: PubMed
  30. Trakselis MA, Mayer MU, Ishmael FT, Roccasecca RM, Benkovic SJ. Dynamic protein interactions in the bacteriophage T4 replisome. Trends Biochem Sci. 2001 Sep; 26(9):566-72.
    View in: PubMed
  31. Alley SC, Trakselis MA, Mayer MU, Ishmael FT, Jones AD, Benkovic SJ. Building a replisome solution structure by elucidation of protein-protein interactions in the bacteriophage T4 DNA polymerase holoenzyme. J Biol Chem. 2001 Oct 19; 276(42):39340-9.
    View in: PubMed
  32. Ishmael FT, Alley SC, Benkovic SJ. Identification and mapping of protein-protein interactions between gp32 and gp59 by cross-linking. J Biol Chem. 2001 Jul 6; 276(27):25236-42.
    View in: PubMed
  33. Ishmael FT, Norcum MT, Benkovic SJ, Bond JS. Multimeric structure of the secreted meprin A metalloproteinase and characterization of the functional protomer. J Biol Chem. 2001 Jun 22; 276(25):23207-11.
    View in: PubMed
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