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Jiafen Hu

TitleResearch Associate
InstitutionCollege of Medicine
DepartmentPathology
Address500 University Drive Hershey PA 17033
Mailbox: H059
Phone7175314700
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    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Assistant Professor, Department of Pathology,Jake Gittlen laboratories for Cancer Research,

    EDUCATION:

    M.Ed in Adult Education, Penn State University Harrisburg
    Graduate Certificate, Penn State University Harrisburg
    Postdoctoral scholar, College of Medicine, Pennsylvania State University
    Ph.D. Chinese Academy of Sciences
    M.S and B.S Wuhan University


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Cladel NM, Budgeon LR, Balogh KK, Cooper TK, Brendle SA, Christensen ND, Schell TD, Hu J. Mouse papillomavirus infection persists in mucosal tissues of an immunocompetent mouse strain and progresses to cancer. Sci Rep. 2017 Dec 05; 7(1):16932. PMID: 29208932.
      View in: PubMed
    2. Cladel NM, Budgeon LR, Cooper TK, Balogh KK, Christensen ND, Myers R, Majerciak V, Gotte D, Zheng ZM, Hu J. Mouse papillomavirus infections spread to cutaneous sites with progression to malignancy. J Gen Virol. 2017 Sep 25. PMID: 28942760.
      View in: PubMed
    3. Hu J, Cladel NM, Budgeon LR, Balogh KK, Christensen ND. The Mouse Papillomavirus Infection Model. Viruses. 2017 Aug 30; 9(9). PMID: 28867783.
      View in: PubMed
    4. Christensen ND, Budgeon LR, Cladel NM, Hu J. Recent advances in preclinical model systems for papillomaviruses. Virus Res. 2017 Mar 02; 231:108-118. PMID: 27956145.
      View in: PubMed
    5. Hu J, Budgeon LR, Cladel NM, Balogh K, Myers R, Cooper TK, Christensen ND. Tracking vaginal, anal and oral infection in a mouse papillomavirus infection model. J Gen Virol. 2015 Dec; 96(12):3554-65. PMID: 26399579; PMCID: PMC4804763 [Available on 12/01/16].
    6. Cladel NM, Budgeon LR, Balogh KK, Cooper TK, Hu J, Christensen ND. Mouse papillomavirus MmuPV1 infects oral mucosa and preferentially targets the base of the tongue. Virology. 2016 Jan 15; 488:73-80. PMID: 26609937; PMCID: PMC4744521 [Available on 01/15/17].
    7. Cladel NM, Budgeon LR, Balogh KK, Cooper TK, Hu J, Christensen ND. A novel pre-clinical murine model to study the life cycle and progression of cervical and anal papillomavirus infections. PLoS One. 2015; 10(3):e0120128. PMID: 25803616; PMCID: PMC4372414.
    8. Christensen ND, Cladel NM, Hu J, Balogh KK. Formulation of cidofovir improves the anti-papillomaviral activity of topical treatments in the CRPV/rabbit model. Antiviral Res. 2014 Aug; 108:148-55. PMID: 24946003; PMCID: PMC4648240.
    9. Hu J, Brendle S, Balogh K, Bywaters S, Christensen N. Antibody detection in tear samples as a surrogate to monitor host immunity against papillomavirus infections in vaccinated and naturally infected hosts. J Gen Virol. 2014 Sep; 95(Pt 9):2030-7. PMID: 24903329; PMCID: PMC4135090.
    10. Hu J, Budgeon LR, Balogh KK, Peng X, Cladel NM, Christensen ND. Long-peptide therapeutic vaccination against CRPV-induced papillomas in HLA-A2.1 transgenic rabbits. Trials Vaccinol. 2014; 3:134-142. PMID: 25243025.
      View in: PubMed
    11. Cladel NM, Budgeon LR, Cooper TK, Balogh KK, Hu J, Christensen ND. Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus. J Virol. 2013 Aug; 87(16):9391-5. PMID: 23785210; PMCID: PMC3754027.
    12. Cladel NM, Budgeon LR, Hu J, Balogh KK, Christensen ND. Synonymous codon changes in the oncogenes of the cottontail rabbit papillomavirus lead to increased oncogenicity and immunogenicity of the virus. Virology. 2013 Apr 10; 438(2):70-83. PMID: 23433866; PMCID: PMC3683458.
    13. Bounds CE, Hu J, Cladel NM, Balogh K, Christensen ND. Vaccine generated immunity targets an HPV16 E7 HLA-A2.1-restricted CD8(+) T cell epitope relocated to an early gene or a late gene of the cottontail rabbit papillomavirus (CRPV) genome in HLA-A2.1 transgenic rabbits. Vaccine. 2011 Feb 01; 29(6):1194-200. PMID: 21167863; PMCID: PMC3065889.
    14. Hu J, Schell TD, Peng X, Cladel NM, Balogh KK, Christensen ND. Using HLA-A2.1 Transgenic Rabbit Model to Screen and Characterize New HLA-A2.1 Restricted Epitope DNA Vaccines. J Vaccines Vaccin. 2010 Aug 20; 1(1). PMID: 21572916.
      View in: PubMed
    15. Hu J, Cladel N, Balogh K, Christensen N. Mucosally delivered peptides prime strong immunity in HLA-A2.1 transgenic rabbits. Vaccine. 2010 May 07; 28(21):3706-13. PMID: 20332046; PMCID: PMC2879011.
    16. Chentoufi AA, Dasgupta G, Christensen ND, Hu J, Choudhury ZS, Azeem A, Jester JV, Nesburn AB, Wechsler SL, BenMohamed L. A novel HLA (HLA-A*0201) transgenic rabbit model for preclinical evaluation of human CD8+ T cell epitope-based vaccines against ocular herpes. J Immunol. 2010 Mar 01; 184(5):2561-71. PMID: 20124097; PMCID: PMC3752373.
    17. Cladel NM, Hu J, Balogh KK, Christensen ND. Differences in methodology, but not differences in viral strain, account for variable experimental outcomes in laboratories utilizing the cottontail rabbit papillomavirus model. J Virol Methods. 2010 Apr; 165(1):36-41. PMID: 20036285; PMCID: PMC2845176.
    18. Hu J, Cladel NM, Budgeon L, Balogh KK, Christensen ND. Papillomavirus DNA complementation in vivo. Virus Res. 2009 Sep; 144(1-2):117-22. PMID: 19379784; PMCID: PMC2770085.
    19. Cladel NM, Hu J, Balogh KK, Christensen ND. CRPV genomes with synonymous codon optimizations in the CRPV E7 gene show phenotypic differences in growth and altered immunity upon E7 vaccination. PLoS One. 2008 Aug 13; 3(8):e2947. PMID: 18698362; PMCID: PMC2491898.
    20. Hu J, Cladel N, Peng X, Balogh K, Christensen ND. Protective immunity with an E1 multivalent epitope DNA vaccine against cottontail rabbit papillomavirus (CRPV) infection in an HLA-A2.1 transgenic rabbit model. Vaccine. 2008 Feb 06; 26(6):809-16. PMID: 18187239; PMCID: PMC2688781.
    21. Cladel NM, Hu J, Balogh K, Mejia A, Christensen ND. Wounding prior to challenge substantially improves infectivity of cottontail rabbit papillomavirus and allows for standardization of infection. J Virol Methods. 2008 Mar; 148(1-2):34-9. PMID: 18061687; PMCID: PMC2278115.
    22. Hu J, Budgeon LR, Cladel NM, Culp TD, Balogh KK, Christensen ND. Detection of L1, infectious virions and anti-L1 antibody in domestic rabbits infected with cottontail rabbit papillomavirus. J Gen Virol. 2007 Dec; 88(Pt 12):3286-93. PMID: 18024897.
      View in: PubMed
    23. Hu J, Peng X, Budgeon LR, Cladel NM, Balogh KK, Christensen ND. Establishment of a cottontail rabbit papillomavirus/HLA-A2.1 transgenic rabbit model. J Virol. 2007 Jul; 81(13):7171-7. PMID: 17459918; PMCID: PMC1933279.
    24. Hu J, Cladel NM, Christensen ND. Increased immunity to cottontail rabbit papillomavirus infection in EIII/JC inbred rabbits after vaccination with a mutant E6 that correlates with spontaneous regression. Viral Immunol. 2007; 20(2):320-5. PMID: 17603848.
      View in: PubMed
    25. Hu J, Peng X, Schell TD, Budgeon LR, Cladel NM, Christensen ND. An HLA-A2.1-transgenic rabbit model to study immunity to papillomavirus infection. J Immunol. 2006 Dec 01; 177(11):8037-45. PMID: 17114477.
      View in: PubMed
    26. Hu J, Cladel NM, Balogh K, Budgeon L, Christensen ND. Impact of genetic changes to the CRPV genome and their application to the study of pathogenesis in vivo. Virology. 2007 Feb 20; 358(2):384-90. PMID: 17027057; PMCID: PMC1847642.
    27. Hu J, Cladel NM, Budgeon LR, Reed CA, Pickel MD, Christensen ND. Protective cell-mediated immunity by DNA vaccination against Papillomavirus L1 capsid protein in the Cottontail Rabbit Papillomavirus model. Viral Immunol. 2006; 19(3):492-507. PMID: 16987067.
      View in: PubMed
    28. Hu J, Peng X, Cladel NM, Pickel MD, Christensen ND. Large cutaneous rabbit papillomas that persist during cyclosporin A treatment can regress spontaneously after cessation of immunosuppression. J Gen Virol. 2005 Jan; 86(Pt 1):55-63. PMID: 15604431.
      View in: PubMed
    29. Hu J, Cladel NM, Budgeon LR, Christensen ND. Characterization of three rabbit oral papillomavirus oncogenes. Virology. 2004 Jul 20; 325(1):48-55. PMID: 15231385.
      View in: PubMed
    30. Hu J, Cladel NM, Wang Z, Han R, Pickel MD, Christensen ND. GM-CSF enhances protective immunity to cottontail rabbit papillomavirus E8 genetic vaccination in rabbits. Vaccine. 2004 Mar 12; 22(9-10):1124-30. PMID: 15003639.
      View in: PubMed
    31. Hu J, Cladel NM, Pickel MD, Christensen ND. Amino acid residues in the carboxy-terminal region of cottontail rabbit papillomavirus E6 influence spontaneous regression of cutaneous papillomas. J Virol. 2002 Dec; 76(23):11801-8. PMID: 12414922; PMCID: PMC136889.
    32. Hu J, Han R, Cladel NM, Pickel MD, Christensen ND. Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbits. J Virol. 2002 Jul; 76(13):6453-9. PMID: 12050357; PMCID: PMC136259.
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