PSU Profiles
Last Name

Edward Gunther

TitleAssociate Professor
InstitutionCollege of Medicine
Address500 University Drive Hershey PA 17033
Mailbox: H059


Physician, Associate Professor of Medicine


M.D., Yale University School of Medicine, 1993
Internship, University of Pennsylvania
Residency, University of Pennsylvania, 1995
Fellowship, University of Pennsylvania, 1999


My colleagues and I employ genetically modified mice to uncover molecular and cell biological mechanisms underlying tumor escape. Toward this end, we use novel mouse models that permit reversible activation of oncogenic signaling pathways within mammary epithelium, the tissue compartment in which breast cancers arise. The resulting mice are programmed to develop mammary tumors that faithfully recapitulate key features of human breast cancer, including local invasion at the primary tumor site and metastatic spread to distant organs. Importantly, these mouse models permit oncogenic signaling to be shut off in established tumors, thereby simulating the action of an idealized targeted therapeutic.

We find that, although established mammary cancers regress following abrogation of oncogenic signaling, they invariably leave behind subclinical disease with latent malignant potential. By developing methods for propagating latent malignancy in vivo, we have begun to define biological properties of dormant mammary cancer, an essential and largely unexplored link to breast cancer relapse. Ultimately, by mapping routes to tumor escape and uncovering mechanisms that enable tumor dormancy, we hope to design improved treatment strategies that prevent breast cancer relapse in patients.

 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Cleary AS, Leonard TL, Gestl SA, Gunther EJ. Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers. Nature. 2014 Apr 3; 508(7494):113-7.
    View in: PubMed
  2. Plichta KA, Mathers JL, Gestl SA, Glick AB, Gunther EJ. Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth. Cancer Res. 2012 Nov 15; 72(22):5856-66.
    View in: PubMed
  3. Jia W, Wang S, Horner JW, Wang N, Wang H, Gunther EJ, DePinho RA, Zhu J. A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis. FASEB J. 2011 Mar; 25(3):979-89.
    View in: PubMed
  4. McHenry PR, Sears JC, Herrick MP, Chang P, Heckman-Stoddard BM, Rybarczyk M, Chodosh LA, Gunther EJ, Hilsenbeck SG, Rosen JM, Vargo-Gogola T. P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. Breast Cancer Res. 2010; 12(5):R73.
    View in: PubMed
  5. Shen Q, Uray IP, Li Y, Zhang Y, Hill J, Xu XC, Young MR, Gunther EJ, Hilsenbeck SG, Colburn NH, Chodosh LA, Brown PH. Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors. Cancer Prev Res (Phila). 2008 Jun; 1(1):45-55.
    View in: PubMed
  6. Debies MT, Gestl SA, Mathers JL, Mikse OR, Leonard TL, Moody SE, Chodosh LA, Cardiff RD, Gunther EJ. Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss. J Clin Invest. 2008 Jan; 118(1):51-63.
    View in: PubMed
  7. Gestl SA, Leonard TL, Biddle JL, Debies MT, Gunther EJ. Dormant Wnt-initiated mammary cancer can participate in reconstituting functional mammary glands. Mol Cell Biol. 2007 Jan; 27(1):195-207.
    View in: PubMed
  8. Jones RA, Campbell CI, Gunther EJ, Chodosh LA, Petrik JJ, Khokha R, Moorehead RA. Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation. Oncogene. 2007 Mar 8; 26(11):1636-44.
    View in: PubMed
  9. Shen Q, Zhang Y, Uray IP, Hill JL, Kim HT, Lu C, Young MR, Gunther EJ, Hilsenbeck SG, Chodosh LA, Colburn NH, Brown PH. The AP-1 transcription factor regulates postnatal mammary gland development. Dev Biol. 2006 Jul 15; 295(2):589-603.
    View in: PubMed
  10. Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM. P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland. Mol Endocrinol. 2006 Jun; 20(6):1391-405.
    View in: PubMed
  11. Frech MS, Halama ED, Tilli MT, Singh B, Gunther EJ, Chodosh LA, Flaws JA, Furth PA. Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ. Cancer Res. 2005 Feb 1; 65(3):681-5.
    View in: PubMed
  12. Gunther EJ, Moody SE, Belka GK, Hahn KT, Innocent N, Dugan KD, Cardiff RD, Chodosh LA. Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. Genes Dev. 2003 Feb 15; 17(4):488-501.
    View in: PubMed
  13. Moody SE, Sarkisian CJ, Hahn KT, Gunther EJ, Pickup S, Dugan KD, Innocent N, Cardiff RD, Schnall MD, Chodosh LA. Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis. Cancer Cell. 2002 Dec; 2(6):451-61.
    View in: PubMed
  14. Gunther EJ, Belka GK, Wertheim GB, Wang J, Hartman JL, Boxer RB, Chodosh LA. A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology. FASEB J. 2002 Mar; 16(3):283-92.
    View in: PubMed
  15. D'Cruz CM, Gunther EJ, Boxer RB, Hartman JL, Sintasath L, Moody SE, Cox JD, Ha SI, Belka GK, Golant A, Cardiff RD, Chodosh LA. c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations. Nat Med. 2001 Feb; 7(2):235-9.
    View in: PubMed
  16. Ayyanathan K, Fredericks WJ, Berking C, Herlyn M, Balakrishnan C, Gunther E, Rauscher FJ. Hormone-dependent tumor regression in vivo by an inducible transcriptional repressor directed at the PAX3-FKHR oncogene. Cancer Res. 2000 Oct 15; 60(20):5803-14.
    View in: PubMed
  17. Leach EG, Narayanan L, Havre PA, Gunther EJ, Yeasky TM, Glazer PM. Tissue specificity of spontaneous point mutations in lambda supF transgenic mice. Environ Mol Mutagen. 1996; 28(4):459-64.
    View in: PubMed
  18. Gunther EJ, Yeasky TM, Gasparro FP, Glazer PM. Mutagenesis by 8-methoxypsoralen and 5-methylangelicin photoadducts in mouse fibroblasts: mutations at cross-linkable sites induced by offoadducts as well as cross-links. Cancer Res. 1995 Mar 15; 55(6):1283-8.
    View in: PubMed
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