PSU Profiles
Last Name

Edward Lankford

TitleAssociate Professor
InstitutionCollege of Medicine
Address500 University Drive Hershey PA 17033


Physician, Associate Professor


Fellowship, Cardiovascular Disease, University of Pennsylvania Medical Center (Philadelphia) (1995)

Residency, Internal Medicine, Penn State Milton S. Hershey Medical Center (1990)

M.D., University of Maryland School of Medicine (Baltimore) (1984)

Ph.D., Johns Hopkins University (Baltimore) (1991)


My interests are in basic cardiac mechanics, or myocardial biophysics. I have studied the contractile abnormalities in cardiomyopathies, and the way that calcium activates the thin filaments by changing the conformation of the troponin-actin-actomyosin complex.

I am now studying the myocardial response to injuries.

 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bell MG, Lankford EB, Gonye GE, Ellis-Davies GC, Martyn DA, Regnier M, Barsotti RJ. Kinetics of cardiac thin-filament activation probed by fluorescence polarization of rhodamine-labeled troponin C in skinned guinea pig trabeculae. Biophys J. 2006 Jan 15; 90(2):531-43.
    View in: PubMed
  2. Kim DK, Zhu J, Kozyak BW, Burkman JM, Rubinstein NA, Lankford EB, Stedman HH, Nguyen T, Levine S, Shrager JB. Myosin heavy chain and physiological adaptation of the rat diaphragm in elastase-induced emphysema. Respir Res. 2003; 4:1.
    View in: PubMed
  3. Krupnick AS, Zhu J, Nguyen T, Kreisel D, Balsara KR, Lankford EB, Clark CC, Levine S, Stedman HH, Shrager JB. Inspiratory loading does not accelerate dystrophy in mdx mouse diaphragm: implications for regenerative therapy. J Appl Physiol (1985). 2003 Feb; 94(2):411-9.
    View in: PubMed
  4. Sleeper MM, Henthorn PS, Vijayasarathy C, Dambach DM, Bowers T, Tijskens P, Armstrong CF, Lankford EB. Dilated cardiomyopathy in juvenile Portuguese Water Dogs. J Vet Intern Med. 2002 Jan-Feb; 16(1):52-62.
    View in: PubMed
  5. Sleeper MM, Henthorn PS, Lankford EB. Differing opinion regarding the etiology of juvenile cardiomyopathy in Portuguese water dogs. Am J Med Genet. 2001 Dec 1; 104(3):262-4.
    View in: PubMed
  6. Leferovich JM, Bedelbaeva K, Samulewicz S, Zhang XM, Zwas D, Lankford EB, Heber-Katz E. Heart regeneration in adult MRL mice. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9830-5.
    View in: PubMed
  7. Shrager JB, Kim DK, Hashmi YJ, Lankford EB, Wahl P, Stedman HH, Levine S, Kaiser LR. Lung volume reduction surgery restores the normal diaphragmatic length-tension relationship in emphysematous rats. J Thorac Cardiovasc Surg. 2001 Feb; 121(2):217-24.
    View in: PubMed
  8. Patel HJ, Pilla JJ, Polidori DJ, Pusca SV, Plappert TA, Sutton MS, Lankford EB, Acker MA. Ten weeks of rapid ventricular pacing creates a long-term model of left ventricular dysfunction. J Thorac Cardiovasc Surg. 2000 Apr; 119(4 Pt 1):834-41.
    View in: PubMed
  9. Greelish JP, Su LT, Lankford EB, Burkman JM, Chen H, Konig SK, Mercier IM, Desjardins PR, Mitchell MA, Zheng XG, Leferovich J, Gao GP, Balice-Gordon RJ, Wilson JM, Stedman HH. Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector. Nat Med. 1999 Apr; 5(4):439-43.
    View in: PubMed
  10. Vemuri R, Lankford EB, Poetter K, Hassanzadeh S, Takeda K, Yu ZX, Ferrans VJ, Epstein ND. The stretch-activation response may be critical to the proper functioning of the mammalian heart. Proc Natl Acad Sci U S A. 1999 Feb 2; 96(3):1048-53.
    View in: PubMed
  11. Patel HJ, Pilla JJ, Polidori DJ, Sutton MS, Lankford EB, Acker MA. Long-term dynamic cardiomyoplasty improves chronic and acute myocardial energetics in a model of left ventricular dysfunction. Circulation. 1998 Nov 10; 98(19 Suppl):II346-51.
    View in: PubMed
  12. Patel HJ, Pilla JJ, Polidodri DJ, Pusca SV, Plappert TA, St John Sutton M, Lankford EB, Acker MA. Modified rapid ventricular pacing: a chronic model of heart failure for evaluation of new surgical therapies. ASAIO J. 1998 Nov-Dec; 44(6):799-803.
    View in: PubMed
  13. Lankford EB, Korzick DH, Palmer BM, Stauffer BL, Cheung JY, Moore RL. Endurance exercise alters the contractile responsiveness of rat heart to extracellular Na+ and Ca2+. Med Sci Sports Exerc. 1998 Oct; 30(10):1502-9.
    View in: PubMed
  14. Patel HJ, Polidori DJ, Pilla JJ, Plappert T, Kass D, St John Sutton M, Lankford EB, Acker MA. Stabilization of chronic remodeling by asynchronous cardiomyoplasty in dilated cardiomyopathy: effects of a conditioned muscle wrap. Circulation. 1997 Nov 18; 96(10):3665-71.
    View in: PubMed
  15. Patel HJ, Lankford EB, Polidori DJ, Pilla JJ, Plappert T, St John Sutton MS, Acker MA. Dynamic cardiomyoplasty: its chronic and acute effects on the failing heart. J Thorac Cardiovasc Surg. 1997 Aug; 114(2):169-78.
    View in: PubMed
  16. Shah AM, Mebazaa A, Yang ZK, Cuda G, Lankford EB, Pepper CB, Sollott SJ, Sellers JR, Robotham JL, Lakatta EG. Inhibition of myocardial crossbridge cycling by hypoxic endothelial cells: a potential mechanism for matching oxygen supply and demand? Circ Res. 1997 May; 80(5):688-98.
    View in: PubMed
  17. Lankford EB, Epstein ND, Fananapazir L, Sweeney HL. Abnormal contractile properties of muscle fibers expressing beta-myosin heavy chain gene mutations in patients with hypertrophic cardiomyopathy. J Clin Invest. 1995 Mar; 95(3):1409-14.
    View in: PubMed
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