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Daniel Rifkin

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentPediatrics
Address500 University Drive Hershey PA 17033
Phone7175315412
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    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Physician, Assistant Professor

    EDUCATION:

    Fellowship, Pediatric Pulmonology, Children's Hospital of Philadelphia (2000)
    Fellowship, Pediatric Pulmonology, St. Christopher's Hospital for Children (1998)
    Residency, Pediatrics, University of Maryland Medical System (1997)
    Internship, Pediatrics, University of Maryland Medical System (1995)
    M.D., Jefferson Medical College (1994)


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rifkin DB, Rifkin WJ, Zilberberg L. LTBPs in biology and medicine: LTBP diseases. Matrix Biol. 2017 Dec 05. PMID: 29217273.
      View in: PubMed
    2. Bellini C, Bersi MR, Caulk AW, Ferruzzi J, Milewicz DM, Ramirez F, Rifkin DB, Tellides G, Yanagisawa H, Humphrey JD. Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms. J R Soc Interface. 2017 May; 14(130). PMID: 28490606.
      View in: PubMed
    3. Selvamurugan N, He Z, Rifkin D, Dabovic B, Partridge NC. Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-ß Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation. Stem Cells Int. 2017; 2017:2450327. PMID: 28512472.
      View in: PubMed
    4. Morkmued S, Hemmerle J, Mathieu E, Laugel-Haushalter V, Dabovic B, Rifkin DB, Dollé P, Niederreither K, Bloch-Zupan A. Enamel and dental anomalies in latent-transforming growth factor beta-binding protein 3 mutant mice. Eur J Oral Sci. 2017 Feb; 125(1):8-17. PMID: 28084688.
      View in: PubMed
    5. Dietzel E, Weiskirchen S, Floehr J, Horiguchi M, Todorovic V, Rifkin DB, Jahnen-Dechent W, Weiskirchen R. Latent TGF-ß binding protein-1 deficiency decreases female fertility. Biochem Biophys Res Commun. 2017 Jan 22; 482(4):1387-1392. PMID: 27956181.
      View in: PubMed
    6. Solaiman SS, Rifkin DS, Rao H. Sleep Apnea in Hurler Syndrome: Looking Beyond the Upper Airway. J Clin Sleep Med. 2016 Oct 15; 12(10):1423-1424. PMID: 27397665.
      View in: PubMed
    7. Robertson IB, Rifkin DB. Regulation of the Bioavailability of TGF-ß and TGF-ß-Related Proteins. Cold Spring Harb Perspect Biol. 2016 06 01; 8(6). PMID: 27252363.
      View in: PubMed
    8. Recouvreux MV, Camilletti MA, Rifkin DB, Díaz-Torga G. The pituitary TGFß1 system as a novel target for the treatment of resistant prolactinomas. J Endocrinol. 2016 Mar; 228(3):R73-83. PMID: 26698564; PMCID: PMC4760866.
    9. Bellini C, Korneva A, Zilberberg L, Ramirez F, Rifkin DB, Humphrey JD. Differential ascending and descending aortic mechanics parallel aneurysmal propensity in a mouse model of Marfan syndrome. J Biomech. 2016 08 16; 49(12):2383-2389. PMID: 26755343; PMCID: PMC4917480 [Available on 06/22/17].
    10. Zilberberg L, Phoon CK, Robertson I, Dabovic B, Ramirez F, Rifkin DB. Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):14012-7. PMID: 26494287; PMCID: PMC4653215.
    11. Hara M, Inoue I, Yamazaki Y, Kirita A, Matsuura T, Friedman SL, Rifkin DB, Kojima S. L(59) TGF-ß LAP degradation products serve as a promising blood biomarker for liver fibrogenesis in mice. Fibrogenesis Tissue Repair. 2015; 8:17. PMID: 26379781; PMCID: PMC4570586.
    12. Robertson IB, Horiguchi M, Zilberberg L, Dabovic B, Hadjiolova K, Rifkin DB. Latent TGF-ß-binding proteins. Matrix Biol. 2015 Sep; 47:44-53. PMID: 25960419; PMCID: PMC4844006.
    13. Horiguchi M, Todorovic V, Hadjiolova K, Weiskirchen R, Rifkin DB. Abrogation of both short and long forms of latent transforming growth factor-ß binding protein-1 causes defective cardiovascular development and is perinatally lethal. Matrix Biol. 2015 Apr; 43:61-70. PMID: 25805620; PMCID: PMC4547347.
    14. Bowcutt R, Malter LB, Chen LA, Wolff MJ, Robertson I, Rifkin DB, Poles M, Cho I, Loke P. Isolation and cytokine analysis of lamina propria lymphocytes from mucosal biopsies of the human colon. J Immunol Methods. 2015 Jun; 421:27-35. PMID: 25769417; PMCID: PMC4725193.
    15. Thomopoulos S, Parks WC, Rifkin DB, Derwin KA. Mechanisms of tendon injury and repair. J Orthop Res. 2015 Jun; 33(6):832-9. PMID: 25641114; PMCID: PMC4418182.
    16. Huckert M, Stoetzel C, Morkmued S, Laugel-Haushalter V, Geoffroy V, Muller J, Clauss F, Prasad MK, Obry F, Raymond JL, Switala M, Alembik Y, Soskin S, Mathieu E, Hemmerlé J, Weickert JL, Dabovic BB, Rifkin DB, Dheedene A, Boudin E, Caluseriu O, Cholette MC, Mcleod R, Antequera R, Gellé MP, Coeuriot JL, Jacquelin LF, Bailleul-Forestier I, Manière MC, Van Hul W, Bertola D, Dollé P, Verloes A, Mortier G, Dollfus H, Bloch-Zupan A. Mutations in the latent TGF-beta binding protein 3 (LTBP3) gene cause brachyolmia with amelogenesis imperfecta. Hum Mol Genet. 2015 Jun 01; 24(11):3038-49. PMID: 25669657; PMCID: PMC4424950.
    17. Dabovic B, Robertson IB, Zilberberg L, Vassallo M, Davis EC, Rifkin DB. Function of latent TGFß binding protein 4 and fibulin 5 in elastogenesis and lung development. J Cell Physiol. 2015 Jan; 230(1):226-36. PMID: 24962333; PMCID: PMC4436707.
    18. Hara M, Kirita A, Kondo W, Matsuura T, Nagatsuma K, Dohmae N, Ogawa S, Imajoh-Ohmi S, Friedman SL, Rifkin DB, Kojima S. LAP degradation product reflects plasma kallikrein-dependent TGF-ß activation in patients with hepatic fibrosis. Springerplus. 2014; 3:221. PMID: 24877031; PMCID: PMC4033717.
    19. Rognoni E, Widmaier M, Jakobson M, Ruppert R, Ussar S, Katsougkri D, Böttcher RT, Lai-Cheong JE, Rifkin DB, McGrath JA, Fässler R. Kindlin-1 controls Wnt and TGF-ß availability to regulate cutaneous stem cell proliferation. Nat Med. 2014 Apr; 20(4):350-9. PMID: 24681597; PMCID: PMC3982140.
    20. Ota M, Horiguchi M, Fang V, Shibahara K, Kadota K, Loomis C, Cammer M, Rifkin DB. Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-ß in gastric tissue. Cancer Res. 2014 May 01; 74(9):2642-51. PMID: 24590056; PMCID: PMC4158836.
    21. Bassani L, Graffeo CS, Behrooz N, Tyagi V, Wilson T, Penaranda S, Zagzag D, Rifkin DB, Barcellos-Hoff MH, Fatterpekar G, Placantonakis D. Noninvasive diagnosis and management of spontaneous intracranial hypotension in patients with marfan syndrome: Case Report and Review of the Literature. Surg Neurol Int. 2014; 5:8. PMID: 24575323; PMCID: PMC3927088.
    22. Recouvreux MV, Lapyckyj L, Camilletti MA, Guida MC, Ornstein A, Rifkin DB, Becu-Villalobos D, Díaz-Torga G. Sex differences in the pituitary transforming growth factor-ß1 system: studies in a model of resistant prolactinomas. Endocrinology. 2013 Nov; 154(11):4192-205. PMID: 24008346; PMCID: PMC3800752.
    23. Blois SM, Sulkowski G, Tirado-González I, Warren J, Freitag N, Klapp BF, Rifkin D, Fuss I, Strober W, Dveksler GS. Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-ß and prevents dextran sodium sulfate (DSS)-induced colitis in mice. Mucosal Immunol. 2014 Mar; 7(2):348-58. PMID: 23945545; PMCID: PMC3844031.
    24. Robertson IB, Rifkin DB. Unchaining the beast; insights from structural and evolutionary studies on TGFß secretion, sequestration, and activation. Cytokine Growth Factor Rev. 2013 Aug; 24(4):355-72. PMID: 23849989; PMCID: PMC3780968.
    25. Kim SV, Xiang WV, Kwak C, Yang Y, Lin XW, Ota M, Sarpel U, Rifkin DB, Xu R, Littman DR. GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science. 2013 Jun 21; 340(6139):1456-9. PMID: 23661644; PMCID: PMC3762262.
    26. Noda K, Dabovic B, Takagi K, Inoue T, Horiguchi M, Hirai M, Fujikawa Y, Akama TO, Kusumoto K, Zilberberg L, Sakai LY, Koli K, Naitoh M, von Melchner H, Suzuki S, Rifkin DB, Nakamura T. Latent TGF-ß binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2852-7. PMID: 23382201; PMCID: PMC3581912.
    27. Zilberberg L, Todorovic V, Dabovic B, Horiguchi M, Couroussé T, Sakai LY, Rifkin DB. Specificity of latent TGF-ß binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin. J Cell Physiol. 2012 Dec; 227(12):3828-36. PMID: 22495824; PMCID: PMC3404192.
    28. Shibahara K, Ota M, Horiguchi M, Yoshinaga K, Melamed J, Rifkin DB. Production of gastrointestinal tumors in mice by modulating latent TGF-ß1 activation. Cancer Res. 2013 Jan 01; 73(1):459-68. PMID: 23117884; PMCID: PMC3537847.
    29. Horiguchi M, Ota M, Rifkin DB. Matrix control of transforming growth factor-ß function. J Biochem. 2012 Oct; 152(4):321-9. PMID: 22923731; PMCID: PMC3529568.
    30. Recouvreux MV, Camilletti MA, Rifkin DB, Becu-Villalobos D, Díaz-Torga G. Thrombospondin-1 (TSP-1) analogs ABT-510 and ABT-898 inhibit prolactinoma growth and recover active pituitary transforming growth factor-ß1 (TGF-ß1). Endocrinology. 2012 Aug; 153(8):3861-71. PMID: 22700773; PMCID: PMC3404347.
    31. Ramirez F, Rifkin DB. Is losartan the drug for all seasons? Curr Opin Pharmacol. 2012 Apr; 12(2):223-4. PMID: 22445547.
      View in: PubMed
    32. Todorovic V, Rifkin DB. LTBPs, more than just an escort service. J Cell Biochem. 2012 Feb; 113(2):410-8. PMID: 22223425; PMCID: PMC3254144.
    33. Thiolloy S, Edwards JR, Fingleton B, Rifkin DB, Matrisian LM, Lynch CC. An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment. PLoS One. 2012; 7(1):e29862. PMID: 22238668; PMCID: PMC3251607.
    34. Briassouli P, Rifkin D, Clancy RM, Buyon JP. Binding of anti-SSA antibodies to apoptotic fetal cardiocytes stimulates urokinase plasminogen activator (uPA)/uPA receptor-dependent activation of TGF-ß and potentiates fibrosis. J Immunol. 2011 Nov 15; 187(10):5392-401. PMID: 22013113; PMCID: PMC3208032.
    35. Dabovic B, Chen Y, Choi J, Davis EC, Sakai LY, Todorovic V, Vassallo M, Zilberberg L, Singh A, Rifkin DB. Control of lung development by latent TGF-ß binding proteins. J Cell Physiol. 2011 Jun; 226(6):1499-509. PMID: 20945348; PMCID: PMC3060286.
    36. Recouvreux MV, Guida MC, Rifkin DB, Becu-Villalobos D, Díaz-Torga G. Active and total transforming growth factor-ß1 are differentially regulated by dopamine and estradiol in the pituitary. Endocrinology. 2011 Jul; 152(7):2722-30. PMID: 21521749; PMCID: PMC3115611.
    37. Todorovic V, Finnegan E, Freyer L, Zilberberg L, Ota M, Rifkin DB. Long form of latent TGF-ß binding protein 1 (Ltbp1L) regulates cardiac valve development. Dev Dyn. 2011 Jan; 240(1):176-87. PMID: 21181942; PMCID: PMC3012267.
    38. Nistala H, Lee-Arteaga S, Carta L, Cook JR, Smaldone S, Siciliano G, Rifkin AN, Dietz HC, Rifkin DB, Ramirez F. Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome. Hum Mol Genet. 2010 Dec 15; 19(24):4790-8. PMID: 20871099; PMCID: PMC2989889.
    39. Rifkin DB, Todorovic V. Bone matrix to growth factors: location, location, location. J Cell Biol. 2010 Sep 20; 190(6):949-51. PMID: 20855500; PMCID: PMC3101590.
    40. Yang T, Mendoza-Londono R, Lu H, Tao J, Li K, Keller B, Jiang MM, Shah R, Chen Y, Bertin TK, Engin F, Dabovic B, Rifkin DB, Hicks J, Jamrich M, Beaudet AL, Lee B. E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J Clin Invest. 2010 Jul; 120(7):2474-85. PMID: 20530870.
      View in: PubMed
    41. Charbonneau NL, Jordan CD, Keene DR, Lee-Arteaga S, Dietz HC, Rifkin DB, Ramirez F, Sakai LY. Microfibril structure masks fibrillin-2 in postnatal tissues. J Biol Chem. 2010 Jun 25; 285(26):20242-51. PMID: 20404337; PMCID: PMC2888437.
    42. Urban Z, Hucthagowder V, Schürmann N, Todorovic V, Zilberberg L, Choi J, Sens C, Brown CW, Clark RD, Holland KE, Marble M, Sakai LY, Dabovic B, Rifkin DB, Davis EC. Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development. Am J Hum Genet. 2009 Nov; 85(5):593-605. PMID: 19836010; PMCID: PMC2775835.
    43. Ramirez F, Rifkin DB. Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling. Curr Opin Cell Biol. 2009 Oct; 21(5):616-22. PMID: 19525102; PMCID: PMC2767232.
    44. Ono RN, Sengle G, Charbonneau NL, Carlberg V, Bächinger HP, Sasaki T, Lee-Arteaga S, Zilberberg L, Rifkin DB, Ramirez F, Chu ML, Sakai LY. Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites. J Biol Chem. 2009 Jun 19; 284(25):16872-81. PMID: 19349279; PMCID: PMC2719323.
    45. Dabovic B, Chen Y, Choi J, Vassallo M, Dietz HC, Ramirez F, von Melchner H, Davis EC, Rifkin DB. Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity. J Cell Physiol. 2009 Apr; 219(1):14-22. PMID: 19016471; PMCID: PMC2719250.
    46. Carta L, Smaldone S, Zilberberg L, Loch D, Dietz HC, Rifkin DB, Ramirez F. p38 MAPK is an early determinant of promiscuous Smad2/3 signaling in the aortas of fibrillin-1 (Fbn1)-null mice. J Biol Chem. 2009 Feb 27; 284(9):5630-6. PMID: 19109253; PMCID: PMC2645821.
    47. Zhou Y, Koli K, Hagood JS, Miao M, Mavalli M, Rifkin DB, Murphy-Ullrich JE. Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin. Am J Pathol. 2009 Jan; 174(1):21-33. PMID: 19056849; PMCID: PMC2631315.
    48. Yoshinaga K, Obata H, Jurukovski V, Mazzieri R, Chen Y, Zilberberg L, Huso D, Melamed J, Prijatelj P, Todorovic V, Dabovic B, Rifkin DB. Perturbation of transforming growth factor (TGF)-beta1 association with latent TGF-beta binding protein yields inflammation and tumors. Proc Natl Acad Sci U S A. 2008 Dec 02; 105(48):18758-63. PMID: 19022904; PMCID: PMC2596235.
    49. Ivanov II, Frutos Rde L, Manel N, Yoshinaga K, Rifkin DB, Sartor RB, Finlay BB, Littman DR. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 2008 Oct 16; 4(4):337-49. PMID: 18854238; PMCID: PMC2597589.
    50. Attur MG, Palmer GD, Al-Mussawir HE, Dave M, Teixeira CC, Rifkin DB, Appleton CT, Beier F, Abramson SB. F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation. FASEB J. 2009 Jan; 23(1):79-89. PMID: 18780763; PMCID: PMC2626615.
    51. Pearson GD, Devereux R, Loeys B, Maslen C, Milewicz D, Pyeritz R, Ramirez F, Rifkin D, Sakai L, Svensson L, Wessels A, Van Eyk J, Dietz HC. Report of the National Heart, Lung, and Blood Institute and National Marfan Foundation Working Group on research in Marfan syndrome and related disorders. Circulation. 2008 Aug 12; 118(7):785-91. PMID: 18695204; PMCID: PMC2909440.
    52. Ahamed J, Burg N, Yoshinaga K, Janczak CA, Rifkin DB, Coller BS. In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1. Blood. 2008 Nov 01; 112(9):3650-60. PMID: 18544680; PMCID: PMC2572792.
    53. Wipff PJ, Rifkin DB, Meister JJ, Hinz B. Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol. 2007 Dec 17; 179(6):1311-23. PMID: 18086923; PMCID: PMC2140013.
    54. Zilberberg L, ten Dijke P, Sakai LY, Rifkin DB. A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol. 2007 Sep 19; 8:41. PMID: 17880711; PMCID: PMC2094707.
    55. Todorovic V, Frendewey D, Gutstein DE, Chen Y, Freyer L, Finnegan E, Liu F, Murphy A, Valenzuela D, Yancopoulos G, Rifkin DB. Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling. Development. 2007 Oct; 134(20):3723-32. PMID: 17804598.
      View in: PubMed
    56. Ramirez F, Sakai LY, Rifkin DB, Dietz HC. Extracellular microfibrils in development and disease. Cell Mol Life Sci. 2007 Sep; 64(18):2437-46. PMID: 17585369.
      View in: PubMed
    57. Jobling MF, Mott JD, Finnegan MT, Jurukovski V, Erickson AC, Walian PJ, Taylor SE, Ledbetter S, Lawrence CM, Rifkin DB, Barcellos-Hoff MH. Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species. Radiat Res. 2006 Dec; 166(6):839-48. PMID: 17149983.
      View in: PubMed
    58. Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, Podowski M, Neptune ER, Halushka MK, Bedja D, Gabrielson K, Rifkin DB, Carta L, Ramirez F, Huso DL, Dietz HC. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science. 2006 Apr 07; 312(5770):117-21. PMID: 16601194; PMCID: PMC1482474.
    59. Fontana L, Chen Y, Prijatelj P, Sakai T, Fässler R, Sakai LY, Rifkin DB. Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J. 2005 Nov; 19(13):1798-808. PMID: 16260650.
      View in: PubMed
    60. Colarossi C, Chen Y, Obata H, Jurukovski V, Fontana L, Dabovic B, Rifkin DB. Lung alveolar septation defects in Ltbp-3-null mice. Am J Pathol. 2005 Aug; 167(2):419-28. PMID: 16049328; PMCID: PMC1603559.
    61. Dabovic B, Levasseur R, Zambuto L, Chen Y, Karsenty G, Rifkin DB. Osteopetrosis-like phenotype in latent TGF-beta binding protein 3 deficient mice. Bone. 2005 Jul; 37(1):25-31. PMID: 15878314.
      View in: PubMed
    62. Mazzieri R, Jurukovski V, Obata H, Sung J, Platt A, Annes E, Karaman-Jurukovska N, Gleizes PE, Rifkin DB. Expression of truncated latent TGF-beta-binding protein modulates TGF-beta signaling. J Cell Sci. 2005 May 15; 118(Pt 10):2177-87. PMID: 15870109.
      View in: PubMed
    63. Loeys BL, Chen J, Neptune ER, Judge DP, Podowski M, Holm T, Meyers J, Leitch CC, Katsanis N, Sharifi N, Xu FL, Myers LA, Spevak PJ, Cameron DE, De Backer J, Hellemans J, Chen Y, Davis EC, Webb CL, Kress W, Coucke P, Rifkin DB, De Paepe AM, Dietz HC. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet. 2005 Mar; 37(3):275-81. PMID: 15731757.
      View in: PubMed
    64. Chen Y, Ali T, Todorovic V, O'leary JM, Kristina Downing A, Rifkin DB. Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes. J Mol Biol. 2005 Jan 07; 345(1):175-86. PMID: 15567420.
      View in: PubMed
    65. Jurukovski V, Dabovic B, Todorovic V, Chen Y, Rifkin DB. Methods for measuring TGF-b using antibodies, cells, and mice. Methods Mol Med. 2005; 117:161-75. PMID: 16118451.
      View in: PubMed
    66. Todorovic V, Jurukovski V, Chen Y, Fontana L, Dabovic B, Rifkin DB. Latent TGF-beta binding proteins. Int J Biochem Cell Biol. 2005 Jan; 37(1):38-41. PMID: 15381147.
      View in: PubMed
    67. Rifkin DB. Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability. J Biol Chem. 2005 Mar 04; 280(9):7409-12. PMID: 15611103.
      View in: PubMed
    68. Ramirez F, Sakai LY, Dietz HC, Rifkin DB. Fibrillin microfibrils: multipurpose extracellular networks in organismal physiology. Physiol Genomics. 2004 Oct 04; 19(2):151-4. PMID: 15466717.
      View in: PubMed
    69. Annes JP, Chen Y, Munger JS, Rifkin DB. Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1. J Cell Biol. 2004 Jun 07; 165(5):723-34. PMID: 15184403; PMCID: PMC2172370.
    70. Annes J, Vassallo M, Munger JS, Rifkin DB. A genetic screen to identify latent transforming growth factor beta activators. Anal Biochem. 2004 Apr 01; 327(1):45-54. PMID: 15033509.
      View in: PubMed
    71. Krishnan S, Deora AB, Annes JP, Osoria J, Rifkin DB, Hajjar KA. Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart. Dev Biol. 2004 Jan 01; 265(1):140-54. PMID: 14697359.
      View in: PubMed
    72. Lack J, O'Leary JM, Knott V, Yuan X, Rifkin DB, Handford PA, Downing AK. Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta. J Mol Biol. 2003 Nov 21; 334(2):281-91. PMID: 14607119.
      View in: PubMed
    73. Chen Y, Dabovic B, Colarossi C, Santori FR, Lilic M, Vukmanovic S, Rifkin DB. Growth retardation as well as spleen and thymus involution in latent TGF-beta binding protein (Ltbp)-3 null mice. J Cell Physiol. 2003 Aug; 196(2):319-25. PMID: 12811825.
      View in: PubMed
    74. Noguera I, Obata H, Gualandris A, Cowin P, Rifkin DB. Molecular cloning of the mouse Ltbp-1 gene reveals tissue specific expression of alternatively spliced forms. Gene. 2003 Apr 10; 308:31-41. PMID: 12711388.
      View in: PubMed
    75. Ramirez F, Rifkin DB. Cell signaling events: a view from the matrix. Matrix Biol. 2003 Apr; 22(2):101-7. PMID: 12782137.
      View in: PubMed
    76. Annes JP, Munger JS, Rifkin DB. Making sense of latent TGFbeta activation. J Cell Sci. 2003 Jan 15; 116(Pt 2):217-24. PMID: 12482908.
      View in: PubMed
    77. Isogai Z, Ono RN, Ushiro S, Keene DR, Chen Y, Mazzieri R, Charbonneau NL, Reinhardt DP, Rifkin DB, Sakai LY. Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem. 2003 Jan 24; 278(4):2750-7. PMID: 12429738.
      View in: PubMed
    78. Dabovic B, Chen Y, Colarossi C, Zambuto L, Obata H, Rifkin DB. Bone defects in latent TGF-beta binding protein (Ltbp)-3 null mice; a role for Ltbp in TGF-beta presentation. J Endocrinol. 2002 Oct; 175(1):129-41. PMID: 12379497.
      View in: PubMed
    79. Dini G, Funghini S, Witort E, Magnelli L, Fanti E, Rifkin DB, Del Rosso M. Overexpression of the 18 kDa and 22/24 kDa FGF-2 isoforms results in differential drug resistance and amplification potential. J Cell Physiol. 2002 Oct; 193(1):64-72. PMID: 12209881.
      View in: PubMed
    80. Altmann CR, Chang C, Muñoz-Sanjuán I, Bell E, Heke M, Rifkin DB, Brivanlou AH. The latent-TGFbeta-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling. Dev Biol. 2002 Aug 01; 248(1):118-27. PMID: 12142025.
      View in: PubMed
    81. Chen Y, Dabovic B, Annes JP, Rifkin DB. Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion. FEBS Lett. 2002 Apr 24; 517(1-3):277-80. PMID: 12062452.
      View in: PubMed
    82. Annes JP, Rifkin DB, Munger JS. The integrin alphaVbeta6 binds and activates latent TGFbeta3. FEBS Lett. 2002 Jan 30; 511(1-3):65-8. PMID: 11821050.
      View in: PubMed
    83. Dabovic B, Chen Y, Colarossi C, Obata H, Zambuto L, Perle MA, Rifkin DB. Bone abnormalities in latent TGF-[beta] binding protein (Ltbp)-3-null mice indicate a role for Ltbp-3 in modulating TGF-[beta] bioavailability. J Cell Biol. 2002 Jan 21; 156(2):227-32. PMID: 11790802; PMCID: PMC2199217.
    84. O'Connor S, Rifkin D, Yang YH, Wang JF, Levine OS, Dowell SF. Physician control of pediatric antimicrobial use in Beijing, China, and its rural environs. Pediatr Infect Dis J. 2001 Jul; 20(7):679-84. PMID: 11465840.
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    85. Harpel JG, Schultz-Cherry S, Murphy-Ullrich JE, Rifkin DB. Tamoxifen and estrogen effects on TGF-beta formation: role of thrombospondin-1, alphavbeta3, and integrin-associated protein. Biochem Biophys Res Commun. 2001 Jun 01; 284(1):11-4. PMID: 11374863.
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    86. Bishop B, Silva G, Krasney J, Nakano H, Roberts A, Farkas G, Rifkin D, Shucard D. Ambient temperature modulates hypoxic-induced changes in rat body temperature and activity differentially. Am J Physiol Regul Integr Comp Physiol. 2001 Apr; 280(4):R1190-6. PMID: 11247844.
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    87. Gualandris A, Annes JP, Arese M, Noguera I, Jurukovski V, Rifkin DB. The latent transforming growth factor-beta-binding protein-1 promotes in vitro differentiation of embryonic stem cells into endothelium. Mol Biol Cell. 2000 Dec; 11(12):4295-308. PMID: 11102524; PMCID: PMC15073.
    88. Bishop B, Silva G, Krasney J, Salloum A, Roberts A, Nakano H, Shucard D, Rifkin D, Farkas G. Circadian rhythms of body temperature and activity levels during 63 h of hypoxia in the rat. Am J Physiol Regul Integr Comp Physiol. 2000 Oct; 279(4):R1378-85. PMID: 11004007.
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    89. Rudd PM, Downing AK, Cadene M, Harvey DJ, Wormald MR, Weir I, Dwek RA, Rifkin DB, Gleizes PE. Hybrid and complex glycans are linked to the conserved N-glycosylation site of the third eight-cysteine domain of LTBP-1 in insect cells. Biochemistry. 2000 Feb 22; 39(7):1596-603. PMID: 10677208.
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    90. Klein S, Carroll JA, Chen Y, Henry MF, Henry PA, Ortonowski IE, Pintucci G, Beavis RC, Burgess WH, Rifkin DB. Biochemical analysis of the arginine methylation of high molecular weight fibroblast growth factor-2. J Biol Chem. 2000 Feb 04; 275(5):3150-7. PMID: 10652299.
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    91. Mignatti P, Rifkin DB. Nonenzymatic interactions between proteinases and the cell surface: novel roles in normal and malignant cell physiology. Adv Cancer Res. 2000; 78:103-57. PMID: 10547669.
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    92. Mazzieri R, Munger JS, Rifkin DB. Measurement of active TGF-beta generated by cultured cells. Methods Mol Biol. 2000; 142:13-27. PMID: 10806610.
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    93. Gualandris A, Arese M, Shen B, Rifkin DB. Modulation of cell growth and transformation by doxycycline-regulated FGF-2 expression in NIH-3T3 cells. J Cell Physiol. 1999 Nov; 181(2):273-84. PMID: 10497306.
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    94. Wilhelm OG, Wilhelm S, Escott GM, Lutz V, Magdolen V, Schmitt M, Rifkin DB, Wilson EL, Graeff H, Brunner G. Cellular glycosylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression. J Cell Physiol. 1999 Aug; 180(2):225-35. PMID: 10395292.
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    95. Arese M, Chen Y, Florkiewicz RZ, Gualandris A, Shen B, Rifkin DB. Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals. Mol Biol Cell. 1999 May; 10(5):1429-44. PMID: 10233154; PMCID: PMC25296.
    96. Gleizes PE, Rifkin DB. [Activation of latent TGF-beta. A required mechanism for vascular integrity]. Pathol Biol (Paris). 1999 Apr; 47(4):322-9. PMID: 10372400.
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    97. Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, Rifkin DB, Sheppard D. The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell. 1999 Feb 05; 96(3):319-28. PMID: 10025398.
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    98. Higgins RD, Yu K, Sanders RJ, Nandgaonkar BN, Rotschild T, Rifkin DB. Diltiazem reduces retinal neovascularization in a mouse model of oxygen induced retinopathy. Curr Eye Res. 1999 Jan; 18(1):20-7. PMID: 10075199.
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    99. Rifkin DB, Mazzieri R, Munger JS, Noguera I, Sung J. Proteolytic control of growth factor availability. APMIS. 1999 Jan; 107(1):80-5. PMID: 10190283.
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    100. Shen B, Arese M, Gualandris A, Rifkin DB. Intracellular association of FGF-2 with the ribosomal protein L6/TAXREB107. Biochem Biophys Res Commun. 1998 Nov 18; 252(2):524-8. PMID: 9826564.
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    101. Nunes I, Munger J, Harpel JG, Nagano Y, Shapiro R, Gleizes PE, Rifkin DB. Structure and activation of the large latent transforming growth factor-Beta complex. J Am Optom Assoc. 1998 Oct; 69(10):643-8. PMID: 9805445.
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    102. Munger JS, Harpel JG, Giancotti FG, Rifkin DB. Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1. Mol Biol Cell. 1998 Sep; 9(9):2627-38. PMID: 9725916; PMCID: PMC25536.
    103. Ren CJ, Ueda F, Roses DF, Harris MN, Mignatti P, Rifkin DB, Shapiro RL. Irsogladine maleate inhibits angiogenesis in wild-type and plasminogen activator-deficient mice. J Surg Res. 1998 Jul 01; 77(2):126-31. PMID: 9733598.
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    104. Seghezzi G, Patel S, Ren CJ, Gualandris A, Pintucci G, Robbins ES, Shapiro RL, Galloway AC, Rifkin DB, Mignatti P. Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis. J Cell Biol. 1998 Jun 29; 141(7):1659-73. PMID: 9647657; PMCID: PMC2132998.
    105. Munger JS, Harpel JG, Gleizes PE, Mazzieri R, Nunes I, Rifkin DB. Latent transforming growth factor-beta: structural features and mechanisms of activation. Kidney Int. 1997 May; 51(5):1376-82. PMID: 9150447.
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    106. Nunes I, Gleizes PE, Metz CN, Rifkin DB. Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta. J Cell Biol. 1997 Mar 10; 136(5):1151-63. PMID: 9060478; PMCID: PMC2132473.
    107. Bikfalvi A, Klein S, Pintucci G, Rifkin DB. Biological roles of fibroblast growth factor-2. Endocr Rev. 1997 Feb; 18(1):26-45. PMID: 9034785.
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    108. Shapiro RL, Duquette JG, Nunes I, Roses DF, Harris MN, Wilson EL, Rifkin DB. Urokinase-type plasminogen activator-deficient mice are predisposed to staphylococcal botryomycosis, pleuritis, and effacement of lymphoid follicles. Am J Pathol. 1997 Jan; 150(1):359-69. PMID: 9006351; PMCID: PMC1858536.
    109. Rifkin DB, Gleizes PE, Harpel J, Nunes I, Munger J, Mazzieri R, Noguera I. Plasminogen/plasminogen activator and growth factor activation. Ciba Found Symp. 1997; 212:105-15; discussion 116-8. PMID: 9524766.
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    110. Klein S, Roghani M, Rifkin DB. Fibroblast growth factors as angiogenesis factors: new insights into their mechanism of action. EXS. 1997; 79:159-92. PMID: 9002232.
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    111. Gleizes PE, Munger JS, Nunes I, Harpel JG, Mazzieri R, Noguera I, Rifkin DB. TGF-beta latency: biological significance and mechanisms of activation. Stem Cells. 1997; 15(3):190-7. PMID: 9170210.
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    112. Gleizes PE, Beavis RC, Mazzieri R, Shen B, Rifkin DB. Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-beta binding protein-1 that mediates bonding to the latent transforming growth factor-beta1. J Biol Chem. 1996 Nov 22; 271(47):29891-6. PMID: 8939931.
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    113. Klein S, Bikfalvi A, Birkenmeier TM, Giancotti FG, Rifkin DB. Integrin regulation by endogenous expression of 18-kDa fibroblast growth factor-2. J Biol Chem. 1996 Sep 13; 271(37):22583-90. PMID: 8798427.
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    114. Brunner G, Zalkow L, Burgess E, Rifkin DB, Wilson EL, Gruszecka-Kowalik E, Powis G. Inhibition of glycosylphosphatidylinositol (GPI) phospholipase D by suramin-like compounds. Anticancer Res. 1996 Sep-Oct; 16(5A):2513-6. PMID: 8917344.
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    115. Pintucci G, Quarto N, Rifkin DB. Methylation of high molecular weight fibroblast growth factor-2 determines post-translational increases in molecular weight and affects its intracellular distribution. Mol Biol Cell. 1996 Aug; 7(8):1249-58. PMID: 8856668; PMCID: PMC275976.
    116. Shapiro RL, Duquette JG, Roses DF, Nunes I, Harris MN, Kamino H, Wilson EL, Rifkin DB. Induction of primary cutaneous melanocytic neoplasms in urokinase-type plasminogen activator (uPA)-deficient and wild-type mice: cellular blue nevi invade but do not progress to malignant melanoma in uPA-deficient animals. Cancer Res. 1996 Aug 01; 56(15):3597-604. PMID: 8758932.
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    117. Nunes I, Munger JS, Harpel JG, Nagano Y, Shapiro RL, Gleizes PE, Rifkin DB. Structure and activation of the large latent transforming growth factor-beta complex. Int J Obes Relat Metab Disord. 1996 Mar; 20 Suppl 3:S4-8. PMID: 8680476.
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    118. Nunes I, Kojima S, Rifkin DB. Effects of endogenously activated transforming growth factor-beta on growth and differentiation of retinoic acid-treated HL-60 cells. Cancer Res. 1996 Feb 01; 56(3):495-9. PMID: 8564960.
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    119. Klein S, Morimoto T, Rifkin DB. Characterization of fibroblast growth factor-2 binding to ribosomes. Growth Factors. 1996; 13(3-4):219-28. PMID: 8919029.
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    120. Pintucci G, Bikfalvi A, Klein S, Rifkin DB. Angiogenesis and the fibrinolytic system. Semin Thromb Hemost. 1996; 22(6):517-24. PMID: 9122718.
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    121. Chow RL, Roux GD, Roghani M, Palmer MA, Rifkin DB, Moscatelli DA, Lang RA. FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens. Development. 1995 Dec; 121(12):4383-93. PMID: 8575338.
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    122. Nunes I, Shapiro RL, Rifkin DB. Characterization of latent TGF-beta activation by murine peritoneal macrophages. J Immunol. 1995 Aug 01; 155(3):1450-9. PMID: 7636210.
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    123. Parish MA, Grossi EA, Baumann FG, Asai T, Rifkin DB, Colvin SB, Galloway AC. Effects of a single administration of fibroblast growth factor on vascular wall reaction to injury. Ann Thorac Surg. 1995 Apr; 59(4):948-54. PMID: 7695423.
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    124. Einheber S, Hannocks MJ, Metz CN, Rifkin DB, Salzer JL. Transforming growth factor-beta 1 regulates axon/Schwann cell interactions. J Cell Biol. 1995 Apr; 129(2):443-58. PMID: 7536747; PMCID: PMC2199906.
    125. Bikfalvi A, Klein S, Pintucci G, Quarto N, Mignatti P, Rifkin DB. Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor: possible intracellular signaling by the high molecular weight forms. J Cell Biol. 1995 Apr; 129(1):233-43. PMID: 7698988; PMCID: PMC2120362.
    126. Kojima S, Vernooy R, Moscatelli D, Amanuma H, Rifkin DB. Lipopolysaccharide inhibits activation of latent transforming growth factor-beta in bovine endothelial cells. J Cell Physiol. 1995 Apr; 163(1):210-9. PMID: 7896898.
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    127. Peverali FA, Mandriota SJ, Ciana P, Marelli R, Quax P, Rifkin DB, Della Valle G, Mignatti P. Tumor cells secrete an angiogenic factor that stimulates basic fibroblast growth factor and urokinase expression in vascular endothelial cells. J Cell Physiol. 1994 Oct; 161(1):1-14. PMID: 7523424.
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    128. Rifkin DB, Moscatelli D, Roghani M, Nagano Y, Quarto N, Klein S, Bikfalvi A. Studies on FGF-2: nuclear localization and function of high molecular weight forms and receptor binding in the absence of heparin. Mol Reprod Dev. 1994 Sep; 39(1):102-4; discussion 104-5. PMID: 7999354.
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    129. Nguyen HC, Steinberg BM, LeBoutillier M, Baumann FG, Rifkin DB, Grossi EA, Galloway AC. Suppression of neointimal lesions after vascular injury: a role for polyclonal anti-basic fibroblast growth factor antibody. Surgery. 1994 Aug; 116(2):456-61; discussion 461-2. PMID: 8048011.
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    130. Nguyen HC, Grossi EA, LeBoutillier M, Steinberg BM, Rifkin DB, Baumann FG, Colvin SB, Galloway AC. Mammary artery versus saphenous vein grafts: assessment of basic fibroblast growth factor receptors. Ann Thorac Surg. 1994 Aug; 58(2):308-10; discussion 310-1. PMID: 8067825.
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    131. Brunner G, Metz CN, Nguyen H, Gabrilove J, Patel SR, Davitz MA, Rifkin DB, Wilson EL. An endogenous glycosylphosphatidylinositol-specific phospholipase D releases basic fibroblast growth factor-heparan sulfate proteoglycan complexes from human bone marrow cultures. Blood. 1994 Apr 15; 83(8):2115-25. PMID: 8161780.
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    132. Metz CN, Brunner G, Choi-Muira NH, Nguyen H, Gabrilove J, Caras IW, Altszuler N, Rifkin DB, Wilson EL, Davitz MA. Release of GPI-anchored membrane proteins by a cell-associated GPI-specific phospholipase D. EMBO J. 1994 Apr 01; 13(7):1741-51. PMID: 7512501; PMCID: PMC395007.
    133. Odekon LE, Blasi F, Rifkin DB. Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-beta to TGF-beta. J Cell Physiol. 1994 Mar; 158(3):398-407. PMID: 8126064.
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    134. Roghani M, Mansukhani A, Dell'Era P, Bellosta P, Basilico C, Rifkin DB, Moscatelli D. Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding. J Biol Chem. 1994 Feb 11; 269(6):3976-84. PMID: 8307953.
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    135. Abe M, Harpel JG, Metz CN, Nunes I, Loskutoff DJ, Rifkin DB. An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem. 1994 Feb 01; 216(2):276-84. PMID: 8179182.
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    136. Klein S, Giancotti FG, Presta M, Albelda SM, Buck CA, Rifkin DB. Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells. Mol Biol Cell. 1993 Oct; 4(10):973-82. PMID: 8298194; PMCID: PMC275731.
    137. Rifkin DB, Kojima S, Abe M, Harpel JG. TGF-beta: structure, function, and formation. Thromb Haemost. 1993 Jul 01; 70(1):177-9. PMID: 8236098.
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    138. Blei F, Wilson EL, Mignatti P, Rifkin DB. Mechanism of action of angiostatic steroids: suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis. J Cell Physiol. 1993 Jun; 155(3):568-78. PMID: 7684043.
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    139. Kojima S, Rifkin DB. Mechanism of retinoid-induced activation of latent transforming growth factor-beta in bovine endothelial cells. J Cell Physiol. 1993 May; 155(2):323-32. PMID: 8482724.
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    140. Kojima S, Nara K, Rifkin DB. Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells. J Cell Biol. 1993 Apr; 121(2):439-48. PMID: 8096847; PMCID: PMC2200108.
    141. Krätzschmar J, Haendler B, Kojima S, Rifkin DB, Schleuning WD. Bovine urokinase-type plasminogen activator and its receptor: cloning and induction by retinoic acid. Gene. 1993 Mar 30; 125(2):177-83. PMID: 8385052.
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    142. Brunner G, Nguyen H, Gabrilove J, Rifkin DB, Wilson EL. Basic fibroblast growth factor expression in human bone marrow and peripheral blood cells. Blood. 1993 Feb 01; 81(3):631-8. PMID: 8427958.
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    143. Flaumenhaft R, Abe M, Sato Y, Miyazono K, Harpel J, Heldin CH, Rifkin DB. Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells. J Cell Biol. 1993 Feb; 120(4):995-1002. PMID: 8432736; PMCID: PMC2200078.
    144. Mignatti P, Rifkin DB. Biology and biochemistry of proteinases in tumor invasion. Physiol Rev. 1993 Jan; 73(1):161-95. PMID: 8419965.
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    145. Flaumenhaft R, Kojima S, Abe M, Rifkin DB. Activation of latent transforming growth factor beta. Adv Pharmacol. 1993; 24:51-76. PMID: 8504067.
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    146. Tsuboi R, Shi CM, Rifkin DB, Ogawa H. A wound healing model using healing-impaired diabetic mice. J Dermatol. 1992 Nov; 19(11):673-5. PMID: 1293153.
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    147. Flaumenhaft R, Rifkin DB. The extracellular regulation of growth factor action. Mol Biol Cell. 1992 Oct; 3(10):1057-65. PMID: 1421565; PMCID: PMC275670.
    148. Flaumenhaft R, Abe M, Mignatti P, Rifkin DB. Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity. J Cell Biol. 1992 Aug; 118(4):901-9. PMID: 1380001; PMCID: PMC2289566.
    149. Flaumenhaft R, Rifkin DB. Cell density dependent effects of TGF-beta demonstrated by a plasminogen activator-based assay for TGF-beta. J Cell Physiol. 1992 Jul; 152(1):48-55. PMID: 1618922.
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    150. Mignatti P, Morimoto T, Rifkin DB. Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex. J Cell Physiol. 1992 Apr; 151(1):81-93. PMID: 1560052.
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    151. Odekon LE, Sato Y, Rifkin DB. Urokinase-type plasminogen activator mediates basic fibroblast growth factor-induced bovine endothelial cell migration independent of its proteolytic activity. J Cell Physiol. 1992 Feb; 150(2):258-63. PMID: 1734031.
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    152. Rifkin DB. Plasminogen activator expression and matrix degradation. Matrix Suppl. 1992; 1:20-2. PMID: 1480022.
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    153. Kurita Y, Tsuboi R, Ueki R, Rifkin DB, Ogawa H. Immunohistochemical localization of basic fibroblast growth factor in wound healing sites of mouse skin. Arch Dermatol Res. 1992; 284(4):193-7. PMID: 1417064.
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    154. Harpel JG, Metz CN, Kojima S, Rifkin DB. Control of transforming growth factor-beta activity: latency vs. activation. Prog Growth Factor Res. 1992; 4(4):321-35. PMID: 1340213.
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    155. Mignatti P, Morimoto T, Rifkin DB. Basic fibroblast growth factor released by single, isolated cells stimulates their migration in an autocrine manner. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11007-11. PMID: 1763016; PMCID: PMC53062.
    156. Mignatti P, Rifkin DB. Release of basic fibroblast growth factor, an angiogenic factor devoid of secretory signal sequence: a trivial phenomenon or a novel secretion mechanism? J Cell Biochem. 1991 Nov; 47(3):201-7. PMID: 1724242.
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    157. Flaumenhaft R, Rifkin DB. Extracellular matrix regulation of growth factor and protease activity. Curr Opin Cell Biol. 1991 Oct; 3(5):817-23. PMID: 1931082.
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    158. Brunner G, Gabrilove J, Rifkin DB, Wilson EL. Phospholipase C release of basic fibroblast growth factor from human bone marrow cultures as a biologically active complex with a phosphatidylinositol-anchored heparan sulfate proteoglycan. J Cell Biol. 1991 Sep; 114(6):1275-83. PMID: 1654337; PMCID: PMC2289137.
    159. Quarto N, Talarico D, Florkiewicz R, Rifkin DB. Selective expression of high molecular weight basic fibroblast growth factor confers a unique phenotype to NIH 3T3 cells. Cell Regul. 1991 Sep; 2(9):699-708. PMID: 1660309; PMCID: PMC361864.
    160. Mignatti P, Mazzieri R, Rifkin DB. Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor. J Cell Biol. 1991 Jun; 113(5):1193-201. PMID: 1645739; PMCID: PMC2289004.
    161. Kojima S, Harpel PC, Rifkin DB. Lipoprotein (a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration. J Cell Biol. 1991 Jun; 113(6):1439-45. PMID: 1828468; PMCID: PMC2289027.
    162. Quarto N, Finger FP, Rifkin DB. The NH2-terminal extension of high molecular weight bFGF is a nuclear targeting signal. J Cell Physiol. 1991 May; 147(2):311-8. PMID: 1904065.
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    163. Wilson EL, Rifkin DB, Kelly F, Hannocks MJ, Gabrilove JL. Basic fibroblast growth factor stimulates myelopoiesis in long-term human bone marrow cultures. Blood. 1991 Mar 01; 77(5):954-60. PMID: 1995102.
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    164. Sato Y, Hamanaka R, Ono J, Kuwano M, Rifkin DB, Takaki R. The stimulatory effect of PDGF on vascular smooth muscle cell migration is mediated by the induction of endogenous basic FGF. Biochem Biophys Res Commun. 1991 Feb 14; 174(3):1260-6. PMID: 1996989.
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    165. Burgess WH, Bizik J, Mehlman T, Quarto N, Rifkin DB. Direct evidence for methylation of arginine residues in high molecular weight forms of basic fibroblast growth factor. Cell Regul. 1991 Feb; 2(2):87-93. PMID: 1713785.
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    166. Dennis PA, Rifkin DB. Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci U S A. 1991 Jan 15; 88(2):580-4. PMID: 1846448; PMCID: PMC50855.
    167. Rifkin DB, Quarto N, Mignatti P, Bizik J, Moscatelli D. New observations on the intracellular localization and release of bFGF. Ann N Y Acad Sci. 1991; 638:204-6. PMID: 1785802.
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    168. Rifkin DB, Moscatelli D, Flaumenhaft R, Sato Y, Saksela O, Tsuboi R. Mechanisms controlling the extracellular activity of basic fibroblast growth factor and transforming growth factor. Ann N Y Acad Sci. 1991; 614:250-8. PMID: 2024887.
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    169. Rifkin DB, Moscatelli D, Bizik J, Quarto N, Blei F, Dennis P, Flaumenhaft R, Mignatti P. Growth factor control of extracellular proteolysis. Cell Differ Dev. 1990 Dec 02; 32(3):313-8. PMID: 1711916.
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    170. Zagzag D, Miller DC, Sato Y, Rifkin DB, Burstein DE. Immunohistochemical localization of basic fibroblast growth factor in astrocytomas. Cancer Res. 1990 Nov 15; 50(22):7393-8. PMID: 2171762.
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    171. Flaumenhaft R, Moscatelli D, Rifkin DB. Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor. J Cell Biol. 1990 Oct; 111(4):1651-9. PMID: 2170425; PMCID: PMC2116237.
    172. Bach R, Rifkin DB. Expression of tissue factor procoagulant activity: regulation by cytosolic calcium. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):6995-9. PMID: 2119499; PMCID: PMC54669.
    173. Sato Y, Tsuboi R, Lyons R, Moses H, Rifkin DB. Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system. J Cell Biol. 1990 Aug; 111(2):757-63. PMID: 1696270; PMCID: PMC2116212.
    174. Tsuboi R, Rifkin DB. Bimodal relationship between invasion of the amniotic membrane and plasminogen activator activity. Int J Cancer. 1990 Jul 15; 46(1):56-60. PMID: 2142142.
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    175. Renko M, Quarto N, Morimoto T, Rifkin DB. Nuclear and cytoplasmic localization of different basic fibroblast growth factor species. J Cell Physiol. 1990 Jul; 144(1):108-14. PMID: 2195042.
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    176. Tsuboi R, Rifkin DB. Recombinant basic fibroblast growth factor stimulates wound healing in healing-impaired db/db mice. J Exp Med. 1990 Jul 01; 172(1):245-51. PMID: 2358777; PMCID: PMC2188158.
    177. Dennis PA, Rifkin DB. Studies on the role of basic fibroblast growth factor in vivo: inability of neutralizing antibodies to block tumor growth. J Cell Physiol. 1990 Jul; 144(1):84-98. PMID: 2195045.
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    178. Saksela O, Rifkin DB. Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity. J Cell Biol. 1990 Mar; 110(3):767-75. PMID: 2137829; PMCID: PMC2116040.
    179. Tsuboi R, Sato Y, Rifkin DB. Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells. J Cell Biol. 1990 Feb; 110(2):511-7. PMID: 2404994; PMCID: PMC2116001.
    180. Oliver LJ, Rifkin DB, Gabrilove J, Hannocks MJ, Wilson EL. Long-term culture of human bone marrow stromal cells in the presence of basic fibroblast growth factor. Growth Factors. 1990; 3(3):231-6. PMID: 2245044.
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    181. Broadley KN, Aquino AM, Woodward SC, Buckley-Sturrock A, Sato Y, Rifkin DB, Davidson JM. Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair. Lab Invest. 1989 Nov; 61(5):571-5. PMID: 2811305.
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    182. Rifkin DB, Tsuboi R, Mignatti P. The role of proteases in matrix breakdown during cellular invasion. Am Rev Respir Dis. 1989 Oct; 140(4):1112-3. PMID: 2679264.
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    183. Flaumenhaft R, Moscatelli D, Saksela O, Rifkin DB. Role of extracellular matrix in the action of basic fibroblast growth factor: matrix as a source of growth factor for long-term stimulation of plasminogen activator production and DNA synthesis. J Cell Physiol. 1989 Jul; 140(1):75-81. PMID: 2738111.
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    184. Rifkin DB, Moscatelli D. Recent developments in the cell biology of basic fibroblast growth factor. J Cell Biol. 1989 Jul; 109(1):1-6. PMID: 2545723; PMCID: PMC2115467.
    185. Sato Y, Rifkin DB. Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture. J Cell Biol. 1989 Jul; 109(1):309-15. PMID: 2526131; PMCID: PMC2115489.
    186. Sommer A, Moscatelli D, Rifkin DB. An amino-terminally extended and post-translationally modified form of a 25kD basic fibroblast growth factor. Biochem Biophys Res Commun. 1989 May 15; 160(3):1267-74. PMID: 2730645.
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    187. Dennis PA, Saksela O, Harpel P, Rifkin DB. Alpha 2-macroglobulin is a binding protein for basic fibroblast growth factor. J Biol Chem. 1989 May 05; 264(13):7210-6. PMID: 2468667.
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    188. Mignatti P, Tsuboi R, Robbins E, Rifkin DB. In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases. J Cell Biol. 1989 Feb; 108(2):671-82. PMID: 2465298; PMCID: PMC2115414.
    189. Sommer A, Rifkin DB. Interaction of heparin with human basic fibroblast growth factor: protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan. J Cell Physiol. 1989 Jan; 138(1):215-20. PMID: 2910884.
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    190. Quarto N, Talarico D, Sommer A, Florkiewicz R, Basilico C, Rifkin DB. Transformation by basic fibroblast growth factor requires high levels of expression: comparison with transformation by hst/K-fgf. Oncogene Res. 1989; 5(2):101-10. PMID: 2608276.
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    191. Sato Y, Rifkin DB. Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. J Cell Biol. 1988 Sep; 107(3):1199-205. PMID: 3417781; PMCID: PMC2115297.
    192. Moscatelli D, Rifkin DB. Membrane and matrix localization of proteinases: a common theme in tumor cell invasion and angiogenesis. Biochim Biophys Acta. 1988 Aug 03; 948(1):67-85. PMID: 2456098.
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    193. Saksela O, Moscatelli D, Sommer A, Rifkin DB. Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation. J Cell Biol. 1988 Aug; 107(2):743-51. PMID: 2971068; PMCID: PMC2115214.
    194. Delli-Bovi P, Curatola AM, Newman KM, Sato Y, Moscatelli D, Hewick RM, Rifkin DB, Basilico C. Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential. Mol Cell Biol. 1988 Jul; 8(7):2933-41. PMID: 3043199; PMCID: PMC363513.
    195. Joseph-Silverstein J, Moscatelli D, Rifkin DB. The development of a quantitative RIA for basic fibroblast growth factor using polyclonal antibodies against the 157 amino acid form of human bFGF. The identification of bFGF in adherent elicited murine peritoneal macrophages. J Immunol Methods. 1988 Jun 13; 110(2):183-92. PMID: 3379311.
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    196. Hatten ME, Lynch M, Rydel RE, Sanchez J, Joseph-Silverstein J, Moscatelli D, Rifkin DB. In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor. Dev Biol. 1988 Feb; 125(2):280-9. PMID: 3338615.
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    197. Moscatelli D, Joseph-Silverstein J, Presta M, Rifkin DB. Multiple forms of an angiogenesis factor: basic fibroblast growth factor. Biochimie. 1988 Jan; 70(1):83-7. PMID: 2840975.
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    198. Saksela O, Rifkin DB. Cell-associated plasminogen activation: regulation and physiological functions. Annu Rev Cell Biol. 1988; 4:93-126. PMID: 3143380.
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    199. Joseph-Silverstein J, Rifkin DB. Endothelial cell growth factors and the vessel wall. Semin Thromb Hemost. 1987 Oct; 13(4):504-13. PMID: 3321439.
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    200. Saksela O, Moscatelli D, Rifkin DB. The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells. J Cell Biol. 1987 Aug; 105(2):957-63. PMID: 3114269; PMCID: PMC2114776.
    201. Moscatelli D, Joseph-Silverstein J, Manejias R, Rifkin DB. Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor. Proc Natl Acad Sci U S A. 1987 Aug; 84(16):5778-82. PMID: 3475702; PMCID: PMC298946.
    202. Sommer A, Brewer MT, Thompson RC, Moscatelli D, Presta M, Rifkin DB. A form of human basic fibroblast growth factor with an extended amino terminus. Biochem Biophys Res Commun. 1987 Apr 29; 144(2):543-50. PMID: 3579930.
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    203. Presta M, Moscatelli D, Joseph-Silverstein J, Rifkin DB. Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis, and migration. Mol Cell Biol. 1986 Nov; 6(11):4060-6. PMID: 3025628; PMCID: PMC367172.
    204. Moscatelli D, Presta M, Joseph-Silverstein J, Rifkin DB. Both normal and tumor cells produce basic fibroblast growth factor. J Cell Physiol. 1986 Nov; 129(2):273-6. PMID: 3021787.
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    205. Moscatelli DA, Rifkin DB, Jaffe EA. Production of latent collagenase by human umbilical vein endothelial cells in response to angiogenic preparations. Exp Cell Res. 1985 Feb; 156(2):379-90. PMID: 2981692.
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    206. Levin RI, Harpel PC, Weil D, Chang TS, Rifkin DB. Aspirin inhibits vascular plasminogen activator activity in vivo. Studies utilizing a new assay to quantify plasminogen activator activity. J Clin Invest. 1984 Aug; 74(2):571-80. PMID: 6235245; PMCID: PMC370509.
    207. Mullins DE, Rifkin DB. Stimulation of motility in cultured bovine capillary endothelial cells by angiogenic preparations. J Cell Physiol. 1984 May; 119(2):247-54. PMID: 6325476.
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    208. Davies RL, Rifkin DB, Tepper R, Miller A, Kucherlapati R. A polypeptide secreted by transformed cells that modulates human plasminogen activator production. Science. 1983 Jul 08; 221(4606):171-3. PMID: 6682999.
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    209. Gross JL, Moscatelli D, Jaffe EA, Rifkin DB. Plasminogen activator and collagenase production by cultured capillary endothelial cells. J Cell Biol. 1982 Dec; 95(3):974-81. PMID: 6185506; PMCID: PMC2112903.
    210. Rohrlich ST, Rifkin DB. Isolation of the major serine protease inhibitor from the 5-day serum-free conditioned medium of human embryonic lung cells and demonstration that it is fetuin. J Cell Physiol. 1981 Oct; 109(1):1-15. PMID: 6173391.
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    211. Topp WC, Rifkin DB, Sleigh MJ. SV40 mutants with an altered small-t protein are tumorigenic in newborn hamsters. Virology. 1981 Jun; 111(2):341-50. PMID: 6264666.
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    212. Rifkin DB, Crowe RM. Studies on the control of plasminogen activator production by cultured human embryonic lung cells: requirements for inhibition by corticosteroids. J Cell Physiol. 1980 Dec; 105(3):417-22. PMID: 7193216.
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    213. Topp WC, Rifkin DB. The small-t protein of SV40 is required for loss of actin cable networks and plasminogen activator synthesis in transformed rat cells. Virology. 1980 Oct 30; 106(2):282-91. PMID: 6254251.
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    214. Eger R, Rifkin D. Characterization of a temperature-sensitive membrane alteration in chick embryo fibroblasts infected with a temperature-sensitive mutant of Rous sarcoma virus. Biochim Biophys Acta. 1980 Aug 04; 600(2):313-9. PMID: 6250596.
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    215. Hassell JA, Topp WC, Rifkin DB, Moreau PE. Transformation of rat embryo fibroblasts by cloned polyoma virus DNA fragments containing only part of the early region. Proc Natl Acad Sci U S A. 1980 Jul; 77(7):3978-82. PMID: 6254006; PMCID: PMC349751.
    216. Frisque RJ, Rifkin DB, Walker DL. Transformation of primary hamster brain cells with JC virus and its DNA. J Virol. 1980 Jul; 35(1):265-9. PMID: 6251275; PMCID: PMC288805.
    217. Israel MA, Martin MA, Miyamura T, Takemoto KK, Rifkin D, Pollack R. Phenotype of polyoma-induced hamster tumor cells lines. J Virol. 1980 Jul; 35(1):252-5. PMID: 6251273; PMCID: PMC288802.
    218. Frisque RJ, Rifkin DB, Topp WC. Requirement for the large T and small T proteins of SV40 in the maintenance of the transformed state. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:325-31. PMID: 6253147.
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    219. Griffin BE, Ito Y, Novak U, Spurr N, Dilworth S, Smolar N, Pollack R, Smith K, Rifkin DB. Early mutants of polyoma virus (dl8 and dl23) with altered transformation properties: is polyoma virus middle T antigen a transforming gene product? Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:271-83. PMID: 6253141.
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    220. Gross JL, Rifkin DB. The effect of avian retroviruses on limb bud chondrogenesis in vitro. Cell. 1979 Nov; 18(3):707-18. PMID: 519754.
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    221. Teng MH, Rifkin DB. Fibronectin from chicken embryo fibroblasts contains covalently bound phosphate. J Cell Biol. 1979 Mar; 80(3):784-91. PMID: 457771; PMCID: PMC2110372.
    222. Rifkin DB. Plasminogen activator synthesis by cultured human embryonic lung cells: characterization of the suppressive effect of corticosteroids. J Cell Physiol. 1978 Dec; 97(3 Pt 2 Suppl 1):421-8. PMID: 83324.
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    223. Imada M, Sueoka N, Rifkin DB. Clonal sublines of rat neurotumor RT4 and cell differentiation. II. A conversion coupling of tumorigenicity and a glial property. Dev Biol. 1978 Sep; 66(1):109-16. PMID: 751831.
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    224. Topp W, Hall JD, Rifkin D, Levine AJ, Pollack R. The characterization of SV40-transformed cell lines derived from mouse teratocarcinoma: growth properties and differentiated characteristics. J Cell Physiol. 1977 Nov; 93(2):269-76. PMID: 201648.
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    225. Rohrlich ST, Rifkin DB. Patterns of plasminogen activator production in cultured normal embryonic cells. J Cell Biol. 1977 Oct; 75(1):31-42. PMID: 21193; PMCID: PMC2111562.
    226. Rifkin DB, Crowe RM. A sensitive assay for elastase employing radioactive elastin coupled to sepharose. Anal Biochem. 1977 May 01; 79(1-2):268-75. PMID: 869181.
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    227. Rifkin DB, Pollack R. Production of plasminogen activator by established cell lines of mouse origin. J Cell Biol. 1977 Apr; 73(1):47-55. PMID: 853061; PMCID: PMC2109888.
    228. Topp W, Hall JD, Marsden M, Teresky AK, Rifkin D, Levine AJ, Pollack R. In vitro differentiation of teratomas and the distribution of creatine phosphokinase and plasminogen activator in teratocarcinoma-derived cells. Cancer Res. 1976 Nov; 36(11 Pt. 2):4217-23. PMID: 184930.
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    229. Pollack R, Risser R, Conlon S, Rifkin D. Plasminogen activator production accompanies loss of anchorage regulation in transformation of primary rat embryo cells by simian virus 40. Proc Natl Acad Sci U S A. 1974 Dec; 71(12):4792-6. PMID: 4373730; PMCID: PMC433983.
    230. Rifkin DB, Loeb JN, Moore G, Reich E. Properties of plasminogen activators formed by neoplastic human cell cultures. J Exp Med. 1974 May 01; 139(5):1317-28. PMID: 4207624; PMCID: PMC2139652.
    231. Ossowski L, Unkeless JC, Tobia A, Quigley JP, Rifkin DB, Reich E. An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. II. Mammalian fibroblast cultures transformed by DNA and RNA tumor viruses. J Exp Med. 1973 Jan 01; 137(1):112-26. PMID: 4347288; PMCID: PMC2139367.
    232. Unkeless JC, Tobia A, Ossowski L, Quigley JP, Rifkin DB, Reich E. An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. I. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses. J Exp Med. 1973 Jan 01; 137(1):85-111. PMID: 4347290; PMCID: PMC2139356.
    233. Brdar B, Rifkin DB, Reich E. Specificity of Rous sarcoma virus synthesis. FEBS Lett. 1972 Aug 15; 24(3):347-350. PMID: 11946704.
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    234. Quigley JP, Rifkin DB, Einhorn MH. Determination of phospholipid composition of RNA tumor viruses by 32 P labeling of infected cell cultures. Anal Biochem. 1972 Jun; 47(2):614-9. PMID: 4338619.
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