PSU Profiles
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Last Name
Institution

Douglas Cavener

TitleDepartment Head and Professor of Biology
InstitutionEberly College of Science
DepartmentBiology
Address110 Life Sciences Bldg
University Park, PA 16802
Phone8148654562
Other Positions
InstitutionHuck Institutes of the Life Sciences


 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor and Head of Biology

GRADUATE PROGRAM AFFILIATIONS:

Cell and Developmental Biology, Genetics, Molecular Medicine, Neuroscience, Physiology

EDUCATION:

B.A., Pasadena College, 1973
M.S., Brown University, 1977
Ph.D., University of Georgia, 1980

NARRATIVE:

Dr. Cavener's research focuses on the genetic regulatory pathways that dynamically control developmental and physiological processes to adapt to internal or external perturbations. Currently, his research group is focused on regulation of metabolic and neurological processes that are particularly prone to maladaptations that lead to diseases such as diabetes, metabolic syndrome, and neurodegenerative diseases.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Liu X, Kwak D, Lu Z, Xu X, Fassett J, Wang H, Wei Y, Cavener DR, Hu X, Hall J, Bache RJ, Chen Y. Endoplasmic reticulum stress sensor protein kinase R-like endoplasmic reticulum kinase (PERK) protects against pressure overload-induced heart failure and lung remodeling. Hypertension. 2014 Oct; 64(4):738-44.
    View in: PubMed
  2. Wang R, Munoz EE, Zhu S, McGrath BC, Cavener DR. Perk gene dosage regulates glucose homeostasis by modulating pancreatic ß-cell functions. PLoS One. 2014; 9(6):e99684.
    View in: PubMed
  3. Trinh MA, Ma T, Kaphzan H, Bhattacharya A, Antion MD, Cavener DR, Hoeffer CA, Klann E. The eIF2a kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learn Mem. 2014 May; 21(5):298-304.
    View in: PubMed
  4. Hussien Y, Cavener DR, Popko B. Genetic inactivation of PERK signaling in mouse oligodendrocytes: normal developmental myelination with increased susceptibility to inflammatory demyelination. Glia. 2014 May; 62(5):680-91.
    View in: PubMed
  5. Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK. 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. J Biol Chem. 2013 Dec 13; 288(50):35812-23.
    View in: PubMed
  6. Wang R, McGrath BC, Kopp RF, Roe MW, Tang X, Chen G, Cavener DR. Insulin secretion and Ca2+ dynamics in ß-cells are regulated by PERK (EIF2AK3) in concert with calcineurin. J Biol Chem. 2013 Nov 22; 288(47):33824-36.
    View in: PubMed
  7. Xu X, Hu J, McGrath BC, Cavener DR. GCN2 in the brain programs PPAR?2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat. PLoS One. 2013; 8(10):e75917.
    View in: PubMed
  8. Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E. Suppression of eIF2a kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci. 2013 Sep; 16(9):1299-305.
    View in: PubMed
  9. Xu X, Hu J, McGrath BC, Cavener DR. GCN2 regulates the CCAAT enhancer binding protein beta and hepatic gluconeogenesis. Am J Physiol Endocrinol Metab. 2013 Oct 15; 305(8):E1007-17.
    View in: PubMed
  10. Trinh MA, Kaphzan H, Wek RC, Pierre P, Cavener DR, Klann E. Brain-specific disruption of the eIF2a kinase PERK decreases ATF4 expression and impairs behavioral flexibility. Cell Rep. 2012 Jun 28; 1(6):676-88.
    View in: PubMed
  11. Xu X, Gupta S, Hu W, McGrath BC, Cavener DR. Hyperthermia induces the ER stress pathway. PLoS One. 2011; 6(8):e23740.
    View in: PubMed
  12. Saito A, Ochiai K, Kondo S, Tsumagari K, Murakami T, Cavener DR, Imaizumi K. Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2. J Biol Chem. 2011 Feb 11; 286(6):4809-18.
    View in: PubMed
  13. Cavener DR, Gupta S, McGrath BC. PERK in beta cell biology and insulin biogenesis. Trends Endocrinol Metab. 2010 Dec; 21(12):714-21.
    View in: PubMed
  14. Gupta S, McGrath B, Cavener DR. PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway. Diabetes. 2010 Aug; 59(8):1937-47.
    View in: PubMed
  15. Bobrovnikova-Marjon E, Grigoriadou C, Pytel D, Zhang F, Ye J, Koumenis C, Cavener D, Diehl JA. PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage. Oncogene. 2010 Jul 8; 29(27):3881-95.
    View in: PubMed
  16. Gupta S, McGrath B, Cavener DR. PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice. PLoS One. 2009; 4(11):e8008.
    View in: PubMed
  17. Bunpo P, Dudley A, Cundiff JK, Cavener DR, Wek RC, Anthony TG. GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase. J Biol Chem. 2009 Nov 20; 284(47):32742-9.
    View in: PubMed
  18. Feng D, Wei J, Gupta S, McGrath BC, Cavener DR. Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation. BMC Cell Biol. 2009; 10:61.
    View in: PubMed
  19. Dang Do AN, Kimball SR, Cavener DR, Jefferson LS. eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. Physiol Genomics. 2009 Aug 7; 38(3):328-41.
    View in: PubMed
  20. Cavener DR. Sleeping Beauty, awake! Regulation of insulin gene expression by methylation of histone H3. Diabetes. 2009 Jan; 58(1):28-9.
    View in: PubMed
  21. Wei J, Sheng X, Feng D, McGrath B, Cavener DR. PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation. J Cell Physiol. 2008 Dec; 217(3):693-707.
    View in: PubMed
  22. Bobrovnikova-Marjon E, Hatzivassiliou G, Grigoriadou C, Romero M, Cavener DR, Thompson CB, Diehl JA. PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16314-9.
    View in: PubMed
  23. Kimball SR, Do AN, Kutzler L, Cavener DR, Jefferson LS. Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem. 2008 Feb 8; 283(6):3465-75.
    View in: PubMed
  24. Wek RC, Cavener DR. Translational control and the unfolded protein response. Antioxid Redox Signal. 2007 Dec; 9(12):2357-71.
    View in: PubMed
  25. Iida K, Li Y, McGrath BC, Frank A, Cavener DR. PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice. BMC Cell Biol. 2007; 8:38.
    View in: PubMed
  26. Iida K, Cox-Foster DL, Yang X, Ko WY, Cavener DR. Expansion and evolution of insect GMC oxidoreductases. BMC Evol Biol. 2007; 7:75.
    View in: PubMed
  27. Guo F, Cavener DR. The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab. 2007 Feb; 5(2):103-14.
    View in: PubMed
  28. Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR. PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab. 2006 Dec; 4(6):491-7.
    View in: PubMed
  29. Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Fioretti MC, Puccetti P. Tryptophan catabolism generates autoimmune-preventive regulatory T cells. Transpl Immunol. 2006 Dec; 17(1):58-60.
    View in: PubMed
  30. Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Santamaria P, Fioretti MC, Puccetti P. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol. 2006 Jun 1; 176(11):6752-61.
    View in: PubMed
  31. Senée V, Chelala C, Duchatelet S, Feng D, Blanc H, Cossec JC, Charon C, Nicolino M, Boileau P, Cavener DR, Bougnères P, Taha D, Julier C. Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. Nat Genet. 2006 Jun; 38(6):682-7.
    View in: PubMed
  32. Liang SH, Zhang W, McGrath BC, Zhang P, Cavener DR. PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis. Biochem J. 2006 Jan 1; 393(Pt 1):201-9.
    View in: PubMed
  33. Owen CR, Kumar R, Zhang P, McGrath BC, Cavener DR, Krause GS. PERK is responsible for the increased phosphorylation of eIF2alpha and the severe inhibition of protein synthesis after transient global brain ischemia. J Neurochem. 2005 Sep; 94(5):1235-42.
    View in: PubMed
  34. Hao S, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, Wek RC, Cavener DR, McGrath BC, Rudell JB, Koehnle TJ, Gietzen DW. Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science. 2005 Mar 18; 307(5716):1776-8.
    View in: PubMed
  35. Liu M, Li Y, Cavener D, Arvan P. Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum. J Biol Chem. 2005 Apr 8; 280(14):13209-12.
    View in: PubMed
  36. Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC. Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem. 2004 Aug 27; 279(35):36553-61.
    View in: PubMed
  37. Iida K, Cavener DR. Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster. J Exp Biol. 2004 Feb; 207(Pt 4):675-81.
    View in: PubMed
  38. Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC. Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol. 2004 Feb; 24(3):1365-77.
    View in: PubMed
  39. Li Y, Iida K, O'Neil J, Zhang P, Li S, Frank A, Gabai A, Zambito F, Liang SH, Rosen CJ, Cavener DR. PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Endocrinology. 2003 Aug; 144(8):3505-13.
    View in: PubMed
  40. Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR, Wek RC. Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol. 2003 Aug; 23(16):5651-63.
    View in: PubMed
  41. Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol. 2002 Oct; 22(19):6681-8.
    View in: PubMed
  42. Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol. 2002 Jun; 22(11):3864-74.
    View in: PubMed
  43. Whetten R, Organ E, Krasney P, Cox-Foster D, Cavener D. Molecular structure and transformation of the glucose dehydrogenase gene in Drosophila melanogaster. Genetics. 1988 Oct; 120(2):475-84.
    View in: PubMed
  44. Cavener D. Preference for ethanol in Drosophila melanogaster associated with the alcohol dehydrogenase polymorphism. Behav Genet. 1979 Sep; 9(5):359-65.
    View in: PubMed
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