|Institution||College of Medicine|
|Address||500 University Drive Hershey PA 17033|
Physician, Professor of Dermatology
GRADUATE PROGRAM AFFILIATIONS:
Molecular Medicine, Biomedical Sciences
M.D., Penn State Hershey College of Medicine (1988)
Internship, Penn State Milton S. Hershey Medical Center
Residency, Dermatology, Penn State Milton S. Hershey Medical Center (1992)
Retinoids in cellular apoptosis
The goal of our research (Diane Thiboutot/Amanda Nelson) is to determine the mechanisms by which retinoids induce apoptosis in cancer cells and human sebaceous glands. We have identified a protein mediator of the apoptotic cascade and are examining alternative ways to induce this protein without the use of retinoids. We are also interested in mechanisms of skin cancer migration through tissue particularly with regard to the role of innate immune signaling. Our translational studies use both cell culture and samples from patients and utilize the expertise of the group in gene array expression analysis, microscopy, protein and RNA expression, innate immune signaling in skin cells as well as various aspects of human subjects research.
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