PSU Profiles
Keywords
Last Name
Institution

Alistair Barber

TitleAssociate Professor
InstitutionCollege of Medicine
DepartmentOphthalmology
Address500 University Drive Hershey PA 17033
Mailbox: H166
Phone7175315542

 Overview 
 overview
PREFERRED TITLE/ROLE:

Associate Professor of Ophthalmology and Cellular &Molecular Physiology

GRADUATE PROGRAM AFFILIATIONS:

Anatomy, Physiology, Cellular and Molecular Biology, Neuroscience

EDUCATION:

Ph.D. Open University, Milton Keynes, UK, 1990
Postdoctoral: University of Saskatchewan, 1990-1993
Postdoctoral: Pennsylvania State University College of Medicine, 1993-1995



 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Abcouwer SF, Lin CM, Shanmugam S, Muthusamy A, Barber AJ, Antonetti DA. Minocycline prevents retinal inflammation and vascular permeability following ischemia-reperfusion injury. J Neuroinflammation. 2013; 10(1):149.
    View in: PubMed
  2. Xu Z, Wei Y, Gong J, Cho H, Park JK, Sung ER, Huang H, Wu L, Eberhart C, Handa JT, Du Y, Kern TS, Thimmulappa R, Barber AJ, Biswal S, Duh EJ. NRF2 plays a protective role in diabetic retinopathy in mice. Diabetologia. 2014 Jan; 57(1):204-13.
    View in: PubMed
  3. Titchenell PM, Hollis Showalter HD, Pons JF, Barber AJ, Jin Y, Antonetti DA. Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors. Bioorg Med Chem Lett. 2013 May 15; 23(10):3034-8.
    View in: PubMed
  4. D'Cruz TS, Weibley BN, Kimball SR, Barber AJ. Post-translational processing of synaptophysin in the rat retina is disrupted by diabetes. PLoS One. 2012; 7(9):e44711.
    View in: PubMed
  5. Barber A. JOBDI special edition-introduction. J Ocul Biol Dis Infor. 2011 Jun; 4(1-2):1-2.
    View in: PubMed
  6. Fort PE, Losiewicz MK, Reiter CE, Singh RS, Nakamura M, Abcouwer SF, Barber AJ, Gardner TW. Differential roles of hyperglycemia and hypoinsulinemia in diabetes induced retinal cell death: evidence for retinal insulin resistance. PLoS One. 2011; 6(10):e26498.
    View in: PubMed
  7. Barber AJ, Gardner TW, Abcouwer SF. The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):1156-63.
    View in: PubMed
  8. Gardner TW, Abcouwer SF, Barber AJ, Jackson GR. An integrated approach to diabetic retinopathy research. Arch Ophthalmol. 2011 Feb; 129(2):230-5.
    View in: PubMed
  9. Jackson GR, Barber AJ. Visual dysfunction associated with diabetic retinopathy. Curr Diab Rep. 2010 Oct; 10(5):380-4.
    View in: PubMed
  10. Abcouwer SF, Lin CM, Wolpert EB, Shanmugam S, Schaefer EW, Freeman WM, Barber AJ, Antonetti DA. Effects of ischemic preconditioning and bevacizumab on apoptosis and vascular permeability following retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5920-33.
    View in: PubMed
  11. Freeman WM, Bixler GV, Brucklacher RM, Lin CM, Patel KM, VanGuilder HD, LaNoue KF, Kimball SR, Barber AJ, Antonetti DA, Gardner TW, Bronson SK. A multistep validation process of biomarkers for preclinical drug development. Pharmacogenomics J. 2010 Oct; 10(5):385-95.
    View in: PubMed
  12. Paralikar KJ, Neuberger T, Matsui JT, Barber AJ, Webb A, Clement RS. Feasibility and safety of longitudinal magnetic resonance imaging in a rodent model with intracortical microwire implants. J Neural Eng. 2009 Jun; 6(3):034001.
    View in: PubMed
  13. Hirschler-Laszkiewicz I, Tong Q, Conrad K, Zhang W, Flint WW, Barber AJ, Barber DL, Cheung JY, Miller BA. TRPC3 activation by erythropoietin is modulated by TRPC6. J Biol Chem. 2009 Feb 13; 284(7):4567-81.
    View in: PubMed
  14. Abcouwer SF, Shanmugam S, Gomez PF, Shushanov S, Barber AJ, Lanoue KF, Quinn PG, Kester M, Gardner TW. Effect of IL-1beta on survival and energy metabolism of R28 and RGC-5 retinal neurons. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5581-92.
    View in: PubMed
  15. VanGuilder HD, Brucklacher RM, Patel K, Ellis RW, Freeman WM, Barber AJ. Diabetes downregulates presynaptic proteins and reduces basal synapsin I phosphorylation in rat retina. Eur J Neurosci. 2008 Jul; 28(1):1-11.
    View in: PubMed
  16. Kern TS, Barber AJ. Retinal ganglion cells in diabetes. J Physiol. 2008 Sep 15; 586(Pt 18):4401-8.
    View in: PubMed
  17. Brucklacher RM, Patel KM, VanGuilder HD, Bixler GV, Barber AJ, Antonetti DA, Lin CM, LaNoue KF, Gardner TW, Bronson SK, Freeman WM. Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response. BMC Med Genomics. 2008; 1:26.
    View in: PubMed
  18. Gastinger MJ, Kunselman AR, Conboy EE, Bronson SK, Barber AJ. Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice. Invest Ophthalmol Vis Sci. 2008 Jun; 49(6):2635-42.
    View in: PubMed
  19. Xu Y, Ola MS, Berkich DA, Gardner TW, Barber AJ, Palmieri F, Hutson SM, LaNoue KF. Energy sources for glutamate neurotransmission in the retina: absence of the aspartate/glutamate carrier produces reliance on glycolysis in glia. J Neurochem. 2007 Apr; 101(1):120-31.
    View in: PubMed
  20. Antonetti DA, Barber AJ, Bronson SK, Freeman WM, Gardner TW, Jefferson LS, Kester M, Kimball SR, Krady JK, LaNoue KF, Norbury CC, Quinn PG, Sandirasegarane L, Simpson IA. Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes. 2006 Sep; 55(9):2401-11.
    View in: PubMed
  21. Santiago AR, Rosa SC, Santos PF, Cristóvão AJ, Barber AJ, Ambrósio AF. Elevated glucose changes the expression of ionotropic glutamate receptor subunits and impairs calcium homeostasis in retinal neural cells. Invest Ophthalmol Vis Sci. 2006 Sep; 47(9):4130-7.
    View in: PubMed
  22. Gastinger MJ, Singh RS, Barber AJ. Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):3143-50.
    View in: PubMed
  23. Gastinger MJ, Barber AJ, Vardi N, Marshak DW. Histamine receptors in mammalian retinas. J Comp Neurol. 2006 Apr 20; 495(6):658-67.
    View in: PubMed
  24. Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK. The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci. 2005 Jun; 46(6):2210-8.
    View in: PubMed
  25. Barber AJ, Antonetti DA. Mapping the blood vessels with paracellular permeability in the retinas of diabetic rats. Invest Ophthalmol Vis Sci. 2003 Dec; 44(12):5410-6.
    View in: PubMed
  26. Reiter CE, Sandirasegarane L, Wolpert EB, Klinger M, Simpson IA, Barber AJ, Antonetti DA, Kester M, Gardner TW. Characterization of insulin signaling in rat retina in vivo and ex vivo. Am J Physiol Endocrinol Metab. 2003 Oct; 285(4):E763-74.
    View in: PubMed
  27. Barber AJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Apr; 27(2):283-90.
    View in: PubMed
  28. Harhaj NS, Barber AJ, Antonetti DA. Platelet-derived growth factor mediates tight junction redistribution and increases permeability in MDCK cells. J Cell Physiol. 2002 Dec; 193(3):349-64.
    View in: PubMed
  29. Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Levison SW. Diabetic retinopathy: more than meets the eye. Surv Ophthalmol. 2002 Dec; 47 Suppl 2:S253-62.
    View in: PubMed
  30. LaNoue KF, Berkich DA, Conway M, Barber AJ, Hu LY, Taylor C, Hutson S. Role of specific aminotransferases in de novo glutamate synthesis and redox shuttling in the retina. J Neurosci Res. 2001 Dec 1; 66(5):914-22.
    View in: PubMed
  31. Gastinger MJ, Barber AJ, Khin SA, McRill CS, Gardner TW, Marshak DW. Abnormal centrifugal axons in streptozotocin-diabetic rat retinas. Invest Ophthalmol Vis Sci. 2001 Oct; 42(11):2679-85.
    View in: PubMed
  32. Nakamura M, Barber AJ, Antonetti DA, LaNoue KF, Robinson KA, Buse MG, Gardner TW. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. J Biol Chem. 2001 Nov 23; 276(47):43748-55.
    View in: PubMed
  33. Barber AJ, Nakamura M, Wolpert EB, Reiter CE, Seigel GM, Antonetti DA, Gardner TW. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. J Biol Chem. 2001 Aug 31; 276(35):32814-21.
    View in: PubMed
  34. Barber AJ, Antonetti DA, Gardner TW. Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group. Invest Ophthalmol Vis Sci. 2000 Oct; 41(11):3561-8.
    View in: PubMed
  35. Lieth E, Gardner TW, Barber AJ, Antonetti DA. Retinal neurodegeneration: early pathology in diabetes. Clin Experiment Ophthalmol. 2000 Feb; 28(1):3-8.
    View in: PubMed
  36. Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Nakamura M. New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets. Diabetes Technol Ther. 2000; 2(4):601-8.
    View in: PubMed
  37. Antonetti DA, Lieth E, Barber AJ, Gardner TW. Molecular mechanisms of vascular permeability in diabetic retinopathy. Semin Ophthalmol. 1999 Dec; 14(4):240-8.
    View in: PubMed
  38. Antonetti DA, Barber AJ, Hollinger LA, Wolpert EB, Gardner TW. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J Biol Chem. 1999 Aug 13; 274(33):23463-7.
    View in: PubMed
  39. Gardner TW, Antonetti DA, Barber AJ, Lieth E, Tarbell JA. The molecular structure and function of the inner blood-retinal barrier. Penn State Retina Research Group. Doc Ophthalmol. 1999; 97(3-4):229-37.
    View in: PubMed
  40. Antonetti DA, Barber AJ, Khin S, Lieth E, Tarbell JM, Gardner TW. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. Diabetes. 1998 Dec; 47(12):1953-9.
    View in: PubMed
  41. Barber AJ, Lieth E, Khin SA, Antonetti DA, Buchanan AG, Gardner TW. Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J Clin Invest. 1998 Aug 15; 102(4):783-91.
    View in: PubMed
  42. Lieth E, Barber AJ, Xu B, Dice C, Ratz MJ, Tanase D, Strother JM. Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group. Diabetes. 1998 May; 47(5):815-20.
    View in: PubMed
  43. Gardner TW, Lieth E, Khin SA, Barber AJ, Bonsall DJ, Lesher T, Rice K, Brennan WA. Astrocytes increase barrier properties and ZO-1 expression in retinal vascular endothelial cells. Invest Ophthalmol Vis Sci. 1997 Oct; 38(11):2423-7.
    View in: PubMed
  44. Barber AJ, Lieth E. Agrin accumulates in the brain microvascular basal lamina during development of the blood-brain barrier. Dev Dyn. 1997 Jan; 208(1):62-74.
    View in: PubMed
  45. Gardner TW, Lesher T, Khin S, Vu C, Barber AJ, Brennan WA. Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells. Biochem J. 1996 Dec 15; 320 ( Pt 3):717-21.
    View in: PubMed
Barber's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_