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Last Name
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Daniel Notterman

TitleProfessor and Vice Dean for Research and Graduate Studies
InstitutionCollege of Medicine
DepartmentPediatrics
Address500 University Drive Hershey PA 17033
Mailbox: H175
Phone7175317199
Other Positions
TitleProfessor
InstitutionCollege of Medicine
DepartmentBiochemistry and Molecular Biology


 Overview 
 overview
PREFERRED TITLE/ROLE:
Professor of Pediatrics and Biochemistry and Molecular Biology
Vice Dean for Research and Graduate Studies, Penn State College of Medicine
Associate Vice President for Research, Penn State University


EDUCATION:
Post-doctoral fellowship, Molecular Biology, Princeton University (1993-1996)
Post-doctoral fellowship, Clinical Pharmacology, Cornell Medical College (1983-84)
Residency, Pediatrics, Bellevue Hospital Center, New York University (1982)
M.D., New York University School of Medicine, New York City (1978)
M.A, Tufts University, Philosophy (1978)
A.B. Cornell University, College Scholar Program (1973)


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mitchell C, McLanahan S, Brooks-Gunn J, Garfinkel I, Hobcraft J, Notterman D. Genetic differential sensitivity to social environments: implications for research. Am J Public Health. 2013 Oct; 103 Suppl 1:S102-10.
    View in: PubMed
  2. Lee D, Brooks-Gunn J, McLanahan SS, Notterman D, Garfinkel I. The Great Recession, genetic sensitivity, and maternal harsh parenting. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13780-4.
    View in: PubMed
  3. Giacobbe A, Bongiorno-Borbone L, Bernassola F, Terrinoni A, Markert EK, Levine AJ, Feng Z, Agostini M, Zolla L, Agrò AF, Notterman DA, Melino G, Peschiaroli A. p63 regulates glutaminase 2 expression. Cell Cycle. 2013 May 1; 12(9):1395-405.
    View in: PubMed
  4. Mitchell C, Notterman D, Brooks-Gunn J, Hobcraft J, Garfinkel I, Jaeger K, Kotenko I, McLanahan S. Role of mother's genes and environment in postpartum depression. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8189-93.
    View in: PubMed
  5. Postel EH, Zou X, Notterman DA, La Perle KM. Double knockout Nme1/Nme2 mouse model suggests a critical role for NDP kinases in erythroid development. Mol Cell Biochem. 2009 Sep; 329(1-2):45-50.
    View in: PubMed
  6. Sheffer M, Bacolod MD, Zuk O, Giardina SF, Pincas H, Barany F, Paty PB, Gerald WL, Notterman DA, Domany E. Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7131-6.
    View in: PubMed
  7. Postel EH, Wohlman I, Zou X, Juan T, Sun N, D'Agostin D, Cuellar M, Choi T, Notterman DA, La Perle KM. Targeted deletion of Nm23/nucleoside diphosphate kinase A and B reveals their requirement for definitive erythropoiesis in the mouse embryo. Dev Dyn. 2009 Mar; 238(3):775-87.
    View in: PubMed
  8. Bacolod MD, Schemmann GS, Giardina SF, Paty P, Notterman DA, Barany F. Emerging paradigms in cancer genetics: some important findings from high-density single nucleotide polymorphism array studies. Cancer Res. 2009 Feb 1; 69(3):723-7.
    View in: PubMed
  9. Meng RD, Shelton CC, Li YM, Qin LX, Notterman D, Paty PB, Schwartz GK. gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res. 2009 Jan 15; 69(2):573-82.
    View in: PubMed
  10. Cheng YW, Pincas H, Bacolod MD, Schemmann G, Giardina SF, Huang J, Barral S, Idrees K, Khan SA, Zeng Z, Rosenberg S, Notterman DA, Ott J, Paty P, Barany F. CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer. Clin Cancer Res. 2008 Oct 1; 14(19):6005-13.
    View in: PubMed
  11. Puca R, Nardinocchi L, Gal H, Rechavi G, Amariglio N, Domany E, Notterman DA, Scarsella M, Leonetti C, Sacchi A, Blandino G, Givol D, D'Orazi G. Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown. Cancer Res. 2008 May 15; 68(10):3707-14.
    View in: PubMed
  12. Bacolod MD, Schemmann GS, Wang S, Shattock R, Giardina SF, Zeng Z, Shia J, Stengel RF, Gerry N, Hoh J, Kirchhoff T, Gold B, Christman MF, Offit K, Gerald WL, Notterman DA, Ott J, Paty PB, Barany F. The signatures of autozygosity among patients with colorectal cancer. Cancer Res. 2008 Apr 15; 68(8):2610-21.
    View in: PubMed
  13. Forslund A, Zeng Z, Qin LX, Rosenberg S, Ndubuisi M, Pincas H, Gerald W, Notterman DA, Barany F, Paty PB. MDM2 gene amplification is correlated to tumor progression but not to the presence of SNP309 or TP53 mutational status in primary colorectal cancers. Mol Cancer Res. 2008 Feb; 6(2):205-11.
    View in: PubMed
  14. Gavert N, Sheffer M, Raveh S, Spaderna S, Shtutman M, Brabletz T, Barany F, Paty P, Notterman D, Domany E, Ben-Ze'ev A. Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. Cancer Res. 2007 Aug 15; 67(16):7703-12.
    View in: PubMed
  15. Li X, Liu H, Qin L, Tamasi J, Bergenstock M, Shapses S, Feyen JH, Notterman DA, Partridge NC. Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis. J Biol Chem. 2007 Nov 9; 282(45):33086-97.
    View in: PubMed
  16. Hertzberg L, Betts DR, Raimondi SC, Schäfer BW, Notterman DA, Domany E, Izraeli S. Prediction of chromosomal aneuploidy from gene expression data. Genes Chromosomes Cancer. 2007 Jan; 46(1):75-86.
    View in: PubMed
  17. Wen Y, Giardina SF, Hamming D, Greenman J, Zachariah E, Bacolod MD, Liu H, Shia J, Amenta PS, Barany F, Paty P, Gerald W, Notterman D. GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1. Clin Cancer Res. 2006 Oct 15; 12(20 Pt 1):5951-9.
    View in: PubMed
  18. Lee HJ, Liu H, Goodman C, Ji Y, Maehr H, Uskokovic M, Notterman D, Reiss M, Suh N. Gene expression profiling changes induced by a novel Gemini Vitamin D derivative during the progression of breast cancer. Biochem Pharmacol. 2006 Jul 28; 72(3):332-43.
    View in: PubMed
  19. Baden HP, Zimmerman JJ, Brilli RJ, Wong H, Wetzel RC, Burns JP, Nadkarni V, Checchia PA, Dalton HJ, Berger J, Pollack M, Notterman D, Green TP, Blumer J, Dean M. Intensivist-led team approach to critical care of children with heart disease. Pediatrics. 2006 May; 117(5):1854-6; author reply 1856-7.
    View in: PubMed
  20. Tsafrir D, Bacolod M, Selvanayagam Z, Tsafrir I, Shia J, Zeng Z, Liu H, Krier C, Stengel RF, Barany F, Gerald WL, Paty PB, Domany E, Notterman DA. Relationship of gene expression and chromosomal abnormalities in colorectal cancer. Cancer Res. 2006 Feb 15; 66(4):2129-37.
    View in: PubMed
  21. Stevens J, Notterman D. Personalizing medicine: the single nucleotide polymorphism and the treatment of status asthmaticus. Pediatr Crit Care Med. 2006 Jan; 7(1):87-9.
    View in: PubMed
  22. Cheng YW, Shawber C, Notterman D, Paty P, Barany F. Multiplexed profiling of candidate genes for CpG island methylation status using a flexible PCR/LDR/Universal Array assay. Genome Res. 2006 Feb; 16(2):282-9.
    View in: PubMed
  23. Schaar DG, Liu H, Sharma S, Ting Y, Martin J, Krier C, Ciardella M, Osman M, Goodell L, Notterman DA, Strair RK. 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced dual-specificity phosphatase expression and AML cell survival. Leuk Res. 2005 Oct; 29(10):1171-9.
    View in: PubMed
  24. Tsafrir D, Tsafrir I, Ein-Dor L, Zuk O, Notterman DA, Domany E. Sorting points into neighborhoods (SPIN): data analysis and visualization by ordering distance matrices. Bioinformatics. 2005 May 15; 21(10):2301-8.
    View in: PubMed
  25. Getz G, Gal H, Kela I, Notterman DA, Domany E. Coupled two-way clustering analysis of breast cancer and colon cancer gene expression data. Bioinformatics. 2003 Jun 12; 19(9):1079-89.
    View in: PubMed
  26. Yagiela JA, Coté CJ, Notterman DA, Karl HW, Weinberg JA, McCloskey C. Adverse sedation events in pediatrics. Pediatrics. 2001 Jun; 107(6):1494.
    View in: PubMed
  27. Notterman DA, Alon U, Sierk AJ, Levine AJ. Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays. Cancer Res. 2001 Apr 1; 61(7):3124-30.
    View in: PubMed
  28. Coté CJ, Karl HW, Notterman DA, Weinberg JA, McCloskey C. Adverse sedation events in pediatrics: analysis of medications used for sedation. Pediatrics. 2000 Oct; 106(4):633-44.
    View in: PubMed
  29. Sohn LL, Saleh OA, Facer GR, Beavis AJ, Allan RS, Notterman DA. Capacitance cytometry: measuring biological cells one by one. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10687-90.
    View in: PubMed
  30. Zhao R, Gish K, Murphy M, Yin Y, Notterman D, Hoffman WH, Tom E, Mack DH, Levine AJ. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev. 2000 Apr 15; 14(8):981-93.
    View in: PubMed
  31. Coté CJ, Notterman DA, Karl HW, Weinberg JA, McCloskey C. Adverse sedation events in pediatrics: a critical incident analysis of contributing factors. Pediatrics. 2000 Apr; 105(4 Pt 1):805-14.
    View in: PubMed
  32. Zhao R, Gish K, Murphy M, Yin Y, Notterman D, Hoffman WH, Tom E, Mack DH, Levine AJ. The transcriptional program following p53 activation. Cold Spring Harb Symp Quant Biol. 2000; 65:475-82.
    View in: PubMed
  33. Alon U, Barkai N, Notterman DA, Gish K, Ybarra S, Mack D, Levine AJ. Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays. Proc Natl Acad Sci U S A. 1999 Jun 8; 96(12):6745-50.
    View in: PubMed
  34. Bojko T, Notterman DA. Reversal of fortune? Respiratory failure after bone marrow transplantation. Crit Care Med. 1999 Jun; 27(6):1061-2.
    View in: PubMed
  35. Notterman D, Young S, Wainger B, Levine AJ. Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity. Oncogene. 1998 Nov 26; 17(21):2743-51.
    View in: PubMed
  36. Bullions LC, Notterman DA, Chung LS, Levine AJ. Expression of wild-type alpha-catenin protein in cells with a mutant alpha-catenin gene restores both growth regulation and tumor suppressor activities. Mol Cell Biol. 1997 Aug; 17(8):4501-8.
    View in: PubMed
  37. Notterman DA. Sedation with intravenous midazolam in the pediatric intensive care unit. Clin Pediatr (Phila). 1997 Aug; 36(8):449-54.
    View in: PubMed
  38. Ushay HM, Notterman DA. Pharmacology of pediatric resuscitation. Pediatr Clin North Am. 1997 Feb; 44(1):207-33.
    View in: PubMed
  39. Steinberg C, Notterman DA. Hemodynamic effects of carcinine in the anesthetized, instrumented, open-chest rat. Crit Care Med. 1996 Dec; 24(12):2042-5.
    View in: PubMed
  40. Nehama J, Pass R, Bechtler-Karsch A, Steinberg C, Notterman DA. Continuous ketamine infusion for the treatment of refractory asthma in a mechanically ventilated infant: case report and review of the pediatric literature. Pediatr Emerg Care. 1996 Aug; 12(4):294-7.
    View in: PubMed
  41. Notterman DA. Acquired immunodeficiency syndrome, Pneumocystis carinii pneumonia, and futility. Crit Care Med. 1996 Jun; 24(6):907-9.
    View in: PubMed
  42. Weiss I, Ushay HM, DeBruin W, O'Loughlin J, Rosner I, Notterman D. Respiratory and cardiac function in children after acute hypoxemic respiratory failure. Crit Care Med. 1996 Jan; 24(1):148-54.
    View in: PubMed
  43. Fong J, Johnston S, Valentino T, Notterman D. Length/serum creatinine ratio does not predict measured creatinine clearance in critically ill children. Clin Pharmacol Ther. 1995 Aug; 58(2):192-7.
    View in: PubMed
  44. Pon S, Notterman DA. Aerosolized ribavirin in mechanically ventilated children with respiratory syncytial virus lower respiratory tract disease. Crit Care Med. 1995 Apr; 23(4):787-8.
    View in: PubMed
  45. Bojko T, Notterman DA, Greenwald BM, De Bruin WJ, Magid MS, Godwin T. Acute hypoxemic respiratory failure in children following bone marrow transplantation: an outcome and pathologic study. Crit Care Med. 1995 Apr; 23(4):755-9.
    View in: PubMed
  46. Greenwald BM, Ghajar J, Notterman DA. Critical care of children with acute brain injury. Adv Pediatr. 1995; 42:47-89.
    View in: PubMed
  47. Axelrod FB, Krey L, Glickstein JS, Friedman D, Weider J, Metakis LJ, Porges VM, Mineo M, Notterman D. Atrial natriuretic peptide response to postural change and medication in familial dysautonomia. Clin Auton Res. 1994 Dec; 4(6):311-8.
    View in: PubMed
  48. Steinberg C, Notterman DA. Pharmacokinetics of cardiovascular drugs in children. Inotropes and vasopressors. Clin Pharmacokinet. 1994 Nov; 27(5):345-67.
    View in: PubMed
  49. Levine AJ, Chang A, Dittmer D, Notterman DA, Silver A, Thorn K, Welsh D, Wu M. The p53 tumor suppressor gene. J Lab Clin Med. 1994 Jun; 123(6):817-23.
    View in: PubMed
  50. Notterman DA. Pediatric AIDS and critical care. Crit Care Med. 1993 Sep; 21(9 Suppl):S319-21.
    View in: PubMed
  51. Notterman DA. A new PAGE in mechanical ventilation? Crit Care Med. 1993 Sep; 21(9):1257-9.
    View in: PubMed
  52. Pon S, Notterman DA, Martin K. Pediatric critical care and hospital costs under reimbursement by diagnosis-related group: effect of clinical and demographic characteristics. J Pediatr. 1993 Sep; 123(3):355-64.
    View in: PubMed
  53. Platt SL, Notterman DA, Winchester P. Fungal osteomyelitis and sepsis from intraosseous infusion. Pediatr Emerg Care. 1993 Jun; 9(3):149-50.
    View in: PubMed
  54. Singh M, Notterman DA, Metakis L. Tumor necrosis factor produces homologous desensitization of lymphocyte beta 2-adrenergic responses. Circ Shock. 1993 Apr; 39(4):275-8.
    View in: PubMed
  55. Pon S, Notterman DA. The organization of a pediatric critical care transport program. Pediatr Clin North Am. 1993 Apr; 40(2):241-61.
    View in: PubMed
  56. Steinberg C, Weinstock DJ, Gold JP, Notterman DA. Measurements of central blood vessels in infants and children: normal values. Cathet Cardiovasc Diagn. 1992 Nov; 27(3):197-201.
    View in: PubMed
  57. DeBruin W, Notterman DA, Magid M, Godwin T, Johnston S. Acute hypoxemic respiratory failure in infants and children: clinical and pathologic characteristics. Crit Care Med. 1992 Sep; 20(9):1223-34.
    View in: PubMed
  58. De Bruin WJ, Greenwald BM, Notterman DA. Fluid resuscitation in pediatrics. Crit Care Clin. 1992 Apr; 8(2):423-38.
    View in: PubMed
  59. Day S, McCloskey K, Orr R, Bolte R, Notterman D, Hackel A. Pediatric interhospital critical care transport: consensus of a national leadership conference. Pediatrics. 1991 Oct; 88(4):696-704.
    View in: PubMed
  60. Notterman DA. Inotropic agents. Catecholamines, digoxin, amrinone. Crit Care Clin. 1991 Jul; 7(3):583-613.
    View in: PubMed
  61. Greenwald BM, Notterman DA, DeBruin WJ, McCready M. Percutaneous axillary artery catheterization in critically ill infants and children. J Pediatr. 1990 Sep; 117(3):442-4.
    View in: PubMed
  62. Notterman DA, Greenwald BM, Moran F, DiMaio-Hunter A, Metakis L, Reidenberg MM. Dopamine clearance in critically ill infants and children: effect of age and organ system dysfunction. Clin Pharmacol Ther. 1990 Aug; 48(2):138-47.
    View in: PubMed
  63. Notterman DA, Greenwald BM, Di Maio-Hunter A, Wilkinson JD, Krasinski K, Borkowsky W. Outcome after assisted ventilation in children with acquired immunodeficiency syndrome. Crit Care Med. 1990 Jan; 18(1):18-20.
    View in: PubMed
  64. Notterman DA, Castello FV, Steinberg C, Greenwald BM, O'Loughlin JE, Gold JP. A comparison of thermodilution and pulsed Doppler cardiac output measurement in critically ill children. J Pediatr. 1989 Oct; 115(4):554-60.
    View in: PubMed
  65. Notterman DA, Drayer DE, Metakis L, Reidenberg MM. Stereoselective renal tubular secretion of quinidine and quinine. Clin Pharmacol Ther. 1986 Nov; 40(5):511-7.
    View in: PubMed
  66. Notterman DA, Nardi M, Saslow JG. Effect of dose formulation on isoniazid absorption in two young children. Pediatrics. 1986 Jun; 77(6):850-2.
    View in: PubMed
  67. Wald P, Wortzman D, Notterman D. Salicylate-induced pulmonary edema. Am J Emerg Med. 1985 Sep; 3(5):481-2.
    View in: PubMed
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