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Chunhua Song

TitleAssociate Professor
InstitutionCollege of Medicine
DepartmentPediatrics
Address500 University Drive Hershey PA 17033
Mailbox: H085
Phone7175316700
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    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Associate Professor of Pediatrics


    EDUCATION:

    Ph.D., M.D.

    Graduated from Medical School in China and got Ph.D. on Molecular and Cellular Biology in Kobe University School of Medicine, Japan. Postdoctoral fellow at Department of Pharmacology , Research Scientist at Department of Pediatrics, University of Wisconsin-Madison, USA.

    NARRATIVE

    The goal of my research is to understand the epigenetic and transcriptional regulation of cancer and develop novel therapy for cancer. My contributions to science include transcriptional and epigenetic regulation in Leukemia and CK2 inhibitor for leukemia therapy, identification of novel poly A polymerase regulated by phospholipid (Star-PAP), discovery of a novel phospholipase C (PLCepsilon) regulated by Ras, identification of biomarkers in cancer, anti-tumor effect of potential new drugs, and work on ion channels, metabolism and hepatitis infection.

    Currently,my research focus on leukemia, particularly identification of genome-wide chromatin state of Ikaros and HDAC1 targets in primary human leukemia cells. We found that targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrated therapeutic efficacy in High-Risk leukemia. By collaboration with other researchers, I also identified miR-215 is a bio-marker in human glioma, Ikaros, c-MYC, LEF1, WDR5 and CRLF2 in human leukemia.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. He X, Li X, Guo Y, Zhao Y, Dong H, Dong J, Zhong L, Shi Z, Zhang Y, Soliman M, Song C, Zhao Z. Newborn Screening of Genetic Mutations in Common Deafness Genes With Bloodspot-Based Gene Chip Array. Am J Audiol. 2017 Dec 12; 1-10. PMID: 29234782.
      View in: PubMed
    2. Ge Z, Gu Y, Han Q, Sloane J, Ge Q, Gao G, Ma J, Song H, Hu J, Chen B, Dovat S, Song C. Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia. Epigenomics. 2018 Jan; 10(1):59-69. PMID: 28994305.
      View in: PubMed
    3. Zhou X, Gu Y, Han Q, Soliman M, Song C, Ge Z. Coexistence of EZH2, NOTCH1, IL7R, and PHF6 Mutations in Adult T-cell Acute Lymphoblastic Leukemia. Turk J Haematol. 2017 Dec 01; 34(4):366-368. PMID: 28747286.
      View in: PubMed
    4. Ge Z, Zhou X, Gu Y, Han Q, Li J, Chen B, Ge Q, Dovat E, Payne JL, Sun T, Song C, Dovat S. Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia. Oncotarget. 2017 Jan 31; 8(5):8022-8034. PMID: 28030830.
      View in: PubMed
    5. Yoshida N, Sakaguchi H, Muramatsu H, Okuno Y, Song C, Dovat S, Shimada A, Ozeki M, Ohnishi H, Teramoto T, Fukao T, Kondo N, Takahashi Y, Matsumoto K, Kato K, Kojima S. Germline IKAROS mutation associated with primary immunodeficiency that progressed to T-cell acute lymphoblastic leukemia. Leukemia. 2017 May; 31(5):1221-1223. PMID: 28096536.
      View in: PubMed
    6. Ge Z, Gu Y, Han Q, Zhao G, Li M, Li J, Chen B, Sun T, Dovat S, Gale RP, Song C. Corrigendum: Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia. Sci Rep. 2017 Jan 11; 7:40457. PMID: 28074872.
      View in: PubMed
    7. Gowda C, Sachdev M, Muthusami S, Kapadia M, Petrovic-Dovat L, Hartman M, Ding Y, Song C, Payne JL, Tan BH, Dovat S. Casein Kinase II (CK2) as a Therapeutic Target for Hematological Malignancies. Curr Pharm Des. 2017; 23(1):95-107. PMID: 27719640.
      View in: PubMed
    8. Ge Z, Gu Y, Han Q, Zhao G, Li M, Li J, Chen B, Sun T, Dovat S, Gale RP, Song C. Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia. Sci Rep. 2016 Nov 25; 6:38004. PMID: 27885263.
      View in: PubMed
    9. Gowda C, Song C, Kapadia M, Payne JL, Hu T, Ding Y, Dovat S. Regulation of cellular proliferation in acute lymphoblastic leukemia by Casein Kinase II (CK2) and Ikaros. Adv Biol Regul. 2017 Jan; 63:71-80. PMID: 27666503.
      View in: PubMed
    10. Ge Z, Li M, Zhao G, Xiao L, Gu Y, Zhou X, Yu MD, Li J, Dovat S, Song C. Novel dynamin 2 mutations in adult T-cell acute lymphoblastic leukemia. Oncol Lett. 2016 Oct; 12(4):2746-2751. PMID: 27698851.
      View in: PubMed
    11. Ge Z, Gu Y, Zhao G, Li J, Chen B, Han Q, Guo X, Liu J, Li H, Yu MD, Olson J, Steffens S, Payne KJ, Song C, Dovat S. High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement. Oncotarget. 2016 Aug 02; 7(31):49722-49732. PMID: 27391346.
      View in: PubMed
    12. Tong Y, Liu B, Liu H, Zheng H, Gu J, Liu H, Lin M, Ding Y, Song C, Li Y. New universal primers for genotyping and resistance detection of low HBV DNA levels. Medicine (Baltimore). 2016 Aug; 95(33):e4618. PMID: 27537600.
      View in: PubMed
    13. Ge Z, Gu Y, Xiao L, Han Q, Li J, Chen B, Yu J, Kawasawa YI, Payne KJ, Dovat S, Song C. Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction. Oncotarget. 2016 Jul 19; 7(29):46014-46027. PMID: 27322554.
      View in: PubMed
    14. Y Tong, B Liu, H Liu, H Zheng, J Gu, H Liu, Y Ding, C Song, Y Li. Comparison of pyrosequencing and sanger sequencing for HBV DNA genotyping and resistance mutations. Int J Clin Exp Med. 2016; 9(7):14283-14293.
    15. Ge Z, Song EJ, Kawasawa YI, Li J, Dovat S, Song C. WDR5 high expression and its effect on tumorigenesis in leukemia. Oncotarget. 2016 Jun 21; 7(25):37740-37754. PMID: 27192115.
      View in: PubMed
    16. Li M, Xiao L, Xu J, Zhang R, Guo J, Olson J, Wu Y, Li J, Song C, Ge Z. Co-existence of PHF6 and NOTCH1 mutations in adult T-cell acute lymphoblastic leukemia. Oncol Lett. 2016 Jul; 12(1):16-22. PMID: 27347093.
      View in: PubMed
    17. Xiang M, Su H, Shu G, Wan D, He F, Loaec M, Ding Y, Li J, Dovat S, Yang G, Song C. Amplexicaule A exerts anti-tumor effects by inducing apoptosis in human breast cancer. Oncotarget. 2016 Apr 05; 7(14):18521-30. PMID: 26943775; PMCID: PMC4951306.
    18. Gowda CS, Song C, Ding Y, Kapadia M, Dovat S. Protein signaling and regulation of gene transcription in leukemia: role of the Casein Kinase II-Ikaros axis. J Investig Med. 2016 Mar; 64(3):735-9. PMID: 26912004.
      View in: PubMed
    19. Wang H, Song C, Ding Y, Pan X, Ge Z, Tan BH, Gowda C, Sachdev M, Muthusami S, Ouyang H, Lai L, Francis OL, Morris CL, Abdel-Azim H, Dorsam G, Xiang M, Payne KJ, Dovat S. Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia. J Biol Chem. 2016 Feb 19; 291(8):4004-18. PMID: 26655717; PMCID: PMC4759178 [Available on 02/19/17].
    20. Ge Z, Guo X, Li J, Hartman M, Kawasawa YI, Dovat S, Song C. Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia. Oncotarget. 2015 Dec 08; 6(39):42300-11. PMID: 26517351; PMCID: PMC4747226.
    21. Song C, Pan X, Ge Z, Gowda C, Ding Y, Li H, Li Z, Yochum G, Muschen M, Li Q, Payne KJ, Dovat S. Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia. Leukemia. 2016 Jun; 30(6):1436-40. PMID: 26639180; PMCID: PMC4889471.
    22. Francis OL, Milford TA, Martinez SR, Baez I, Coats JS, Mayagoitia K, Concepcion KR, Ginelli E, Beldiman C, Benitez A, Weldon AJ, Arogyaswamy K, Shiraz P, Fisher R, Morris CL, Zhang XB, Filippov V, Van Handel B, Ge Z, Song C, Dovat S, Su RJ, Payne KJ. A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis. Haematologica. 2016 Apr; 101(4):417-26. PMID: 26611474; PMCID: PMC5004401.
    23. Tong YQ, Liu B, Zheng HY, Gu J, Liu H, Li F, Tan BH, Hartman M, Song C, Li Y. MiR-215, an activator of the CTNNBIP1/ß-catenin pathway, is a marker of poor prognosis in human glioma. Oncotarget. 2015 Sep 22; 6(28):25024-33. PMID: 26317904; PMCID: PMC4694812.
    24. Song C, Gowda C, Pan X, Ding Y, Tong Y, Tan BH, Wang H, Muthusami S, Ge Z, Sachdev M, Amin SG, Desai D, Gowda K, Gowda R, Robertson GP, Schjerven H, Muschen M, Payne KJ, Dovat S. Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia. Blood. 2015 Oct 08; 126(15):1813-22. PMID: 26219304; PMCID: PMC4600018.
    25. Tong YQ, Liu B, Liu H, Zheng HY, Gu J, Liu H, Song EJ, Song C, Li Y. Accurate genotyping of hepatitis C virus through nucleotide sequencing and identification of new HCV subtypes in China population. Clin Microbiol Infect. 2015 Sep; 21(9):874.e9-874.e21. PMID: 26055416.
      View in: PubMed
    26. Guo X, Zhang R, Liu J, Li M, Song C, Dovat S, Li J, Ge Z. Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia. PLoS One. 2015; 10(5):e0125429. PMID: 25942645; PMCID: PMC4420493.
    27. Hu RM, Tan BH, Tester DJ, Song C, He Y, Dovat S, Peterson BZ, Ackerman MJ, Makielski JC. Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis. PLoS One. 2015; 10(4):e0124921. PMID: 25923670; PMCID: PMC4414567.
    28. Lv B, Song C, Wu L, Zhang Q, Hou D, Chen P, Yu S, Wang Z, Chu Y, Zhang J, Yang D, Liu J. Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer. Oncotarget. 2015; 6(12):9794-806. PMID: 25909166; PMCID: PMC4496398.
    29. Wang H, Song C, Gurel Z, Song N, Ma J, Ouyang H, Lai L, Payne KJ, Dovat S. Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia. Pediatr Blood Cancer. 2014 Dec; 61(12):2230-5. PMID: 25214003; PMCID: PMC4205270.
    30. Pandey MK, Kale VP, Song C, Sung SS, Sharma AK, Talamo G, Dovat S, Amin SG. Gambogic acid inhibits multiple myeloma mediated osteoclastogenesis through suppression of chemokine receptor CXCR4 signaling pathways. Exp Hematol. 2014 Oct; 42(10):883-96. PMID: 25034231.
      View in: PubMed
    31. Ma Y, Zhang J, Zhang Q, Chen P, Song J, Yu S, Liu H, Liu F, Song C, Yang D, Liu J. Adenosine induces apoptosis in human liver cancer cells through ROS production and mitochondrial dysfunction. Biochem Biophys Res Commun. 2014 May 23; 448(1):8-14. PMID: 24727456.
      View in: PubMed
    32. Yang D, Song J, Wu L, Ma Y, Song C, Dovat S, Nishizaki T, Liu J. Induction of senescence by adenosine suppressing the growth of lung cancer cells. Biochem Biophys Res Commun. 2013 Oct 11; 440(1):62-7. PMID: 24051088.
      View in: PubMed
    33. Vaidyanathan R, Vega AL, Song C, Zhou Q, Tan BH, Tan B, Berger S, Makielski JC, Eckhardt LL. The interaction of caveolin 3 protein with the potassium inward rectifier channel Kir2.1: physiology and pathology related to long qt syndrome 9 (LQT9). J Biol Chem. 2013 Jun 14; 288(24):17472-80. PMID: 23640888; PMCID: PMC3682547.
    34. Li Z, Song C, Ouyang H, Lai L, Payne KJ, Dovat S. Cell cycle-specific function of Ikaros in human leukemia. Pediatr Blood Cancer. 2012 Jul 15; 59(1):69-76. PMID: 22106042; PMCID: PMC3292658.
    35. Tester DJ, Tan BH, Medeiros-Domingo A, Song C, Makielski JC, Ackerman MJ. Loss-of-function mutations in the KCNJ8-encoded Kir6.1 K(ATP) channel and sudden infant death syndrome. Circ Cardiovasc Genet. 2011 Oct; 4(5):510-5. PMID: 21836131; PMCID: PMC3281577.
    36. Dovat S, Song C, Payne KJ, Li Z. Ikaros, CK2 kinase, and the road to leukemia. Mol Cell Biochem. 2011 Oct; 356(1-2):201-7. PMID: 21750978; PMCID: PMC3665334.
    37. Song C, Li Z, Erbe AK, Savic A, Dovat S. Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1. World J Biol Chem. 2011 Jun 26; 2(6):126-31. PMID: 21765978; PMCID: PMC3135859.
    38. Li Z, Perez-Casellas LA, Savic A, Song C, Dovat S. Ikaros isoforms: The saga continues. World J Biol Chem. 2011 Jun 26; 2(6):140-5. PMID: 21765980; PMCID: PMC3135861.
    39. Yang D, Yaguchi T, Nagata T, Gotoh A, Dovat S, Song C, Nishizaki T. AMID mediates adenosine-induced caspase-independent HuH-7 cell apoptosis. Cell Physiol Biochem. 2011; 27(1):37-44. PMID: 21325820; PMCID: PMC3221265.
    40. Medeiros-Domingo A, Tan BH, Crotti L, Tester DJ, Eckhardt L, Cuoretti A, Kroboth SL, Song C, Zhou Q, Kopp D, Schwartz PJ, Makielski JC, Ackerman MJ. Gain-of-function mutation S422L in the KCNJ8-encoded cardiac K(ATP) channel Kir6.1 as a pathogenic substrate for J-wave syndromes. Heart Rhythm. 2010 Oct; 7(10):1466-71. PMID: 20558321; PMCID: PMC3049900.
    41. Mellman DL, Gonzales ML, Song C, Barlow CA, Wang P, Kendziorski C, Anderson RA. A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. Nature. 2008 Feb 21; 451(7181):1013-7. PMID: 18288197.
      View in: PubMed
    42. Tan BH, Valdivia CR, Song C, Makielski JC. Partial expression defect for the SCN5A missense mutation G1406R depends on splice variant background Q1077 and rescue by mexiletine. Am J Physiol Heart Circ Physiol. 2006 Oct; 291(4):H1822-8. PMID: 16632547.
      View in: PubMed
    43. Kisseleva M, Feng Y, Ward M, Song C, Anderson RA, Longmore GD. The LIM protein Ajuba regulates phosphatidylinositol 4,5-bisphosphate levels in migrating cells through an interaction with and activation of PIPKI alpha. Mol Cell Biol. 2005 May; 25(10):3956-66. PMID: 15870270; PMCID: PMC1087706.
    44. Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T. Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. Oncogene. 2002 Nov 21; 21(53):8105-13. PMID: 12444546.
      View in: PubMed
    45. Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T. Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras. J Biol Chem. 2001 Nov 09; 276(45):42219-25. PMID: 11524421.
      View in: PubMed
    46. Jin TG, Satoh T, Liao Y, Song C, Gao X, Kariya K, Hu CD, Kataoka T. Role of the CDC25 homology domain of phospholipase Cepsilon in amplification of Rap1-dependent signaling. J Biol Chem. 2001 Aug 10; 276(32):30301-7. PMID: 11395506.
      View in: PubMed
    47. Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T. Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. J Biol Chem. 2001 Jan 26; 276(4):2752-7. PMID: 11022048.
      View in: PubMed
    48. Sendoh H, Hu CD, Wu D, Song C, Yamawaki-Kataoka Y, Kotani J, Okada T, Shima F, Kariya K, Kataoka T. Role of Raf-1 conserved region 2 in regulation of Ras-dependent Raf-1 activation. Biochem Biophys Res Commun. 2000 May 19; 271(3):596-602. PMID: 10814507.
      View in: PubMed
    49. Hu CD, Kariya K, Okada T, Qi X, Song C, Kataoka T. Effect of phosphorylation on activities of Rap1A to interact with Raf-1 and to suppress Ras-dependent Raf-1 activation. J Biol Chem. 1999 Jan 01; 274(1):48-51. PMID: 9867809.
      View in: PubMed
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