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Christopher Yengo

TitleAssociate Professor
InstitutionCollege of Medicine
DepartmentCellular and Molecular Physiology
Address500 University Drive Hershey PA 17033
Mailbox: H166
Phone7175318575

 Overview 
 overview
PREFERRED TITLE/ROLE:



Associate Professor of Cellular and Molecular Physiology



SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):



The Huck Institute of the Life Sciences



GRADUATE PROGRAM AFFILIATIONS:



Biomedical Sciences, Physiology, Cell and Developmental Biology, Molecular Medicine, Anatomy



EDUCATION:



Postdoctoral Training, University of Pennsylvania School of Medicine, 2000-2003

Ph.D., University of Vermont College of Medicine, 2000



NARRATIVE:



My research group studies the structural, biochemical, and physiological properties of molecular motor and cytoskeletal proteins. We examine the structural mechanism of energy transduction in myosin motor proteins using spectroscopic, enzymatic, and biophysical methods. In addition, studies of uncharacterized non-muscle myosin proteins that function in vision, hearing, intracellular transport, and contractility are in progress. Defects in the myosin motors under investigation are associated with many different genetic diseases such as cardiomyopathies, cancer, deafness, and retinal degeneration. Other ongoing projects are focused on myosin-based regulation of the actin cytoskeleton in alveolar macrophages, inner ear hair cells, and photoreceptors.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Swenson AM, Trivedi DV, Rauscher AA, Wang Y, Takagi Y, Palmer BM, Málnási-Csizmadia A, Debold EP, Yengo CM. Magnesium modulates actin binding and ADP release in myosin motors. J Biol Chem. 2014 Aug 22; 289(34):23977-91.
    View in: PubMed
  2. Quintero OA, Unrath WC, Stevens SM, Manor U, Kachar B, Yengo CM. Myosin 3A kinase activity is regulated by phosphorylation of the kinase domain activation loop. J Biol Chem. 2013 Dec 27; 288(52):37126-37.
    View in: PubMed
  3. Trivedi DV, Muretta JM, Swenson AM, Thomas DD, Yengo CM. Magnesium impacts myosin V motor activity by altering key conformational changes in the mechanochemical cycle. Biochemistry. 2013 Jul 9; 52(27):4710-22.
    View in: PubMed
  4. Adikes RC, Unrath WC, Yengo CM, Quintero OA. Biochemical and bioinformatic analysis of the myosin-XIX motor domain. Cytoskeleton (Hoboken). 2013 May; 70(5):281-95.
    View in: PubMed
  5. Quintero OA, Yengo CM. Myosin X dimerization and its impact on cellular functions. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17313-4.
    View in: PubMed
  6. Manor U, Grati M, Yengo CM, Kachar B, Gov NS. Competition and compensation: dissecting the biophysical and functional differences between the class 3 myosin paralogs, myosins 3a and 3b. Bioarchitecture. 2012 Sep-Oct; 2(5):171-4.
    View in: PubMed
  7. Yengo CM, Takagi Y, Sellers JR. Temperature dependent measurements reveal similarities between muscle and non-muscle myosin motility. J Muscle Res Cell Motil. 2012 Dec; 33(6):385-94.
    View in: PubMed
  8. Trivedi DV, David C, Jacobs DJ, Yengo CM. Switch II mutants reveal coupling between the nucleotide- and actin-binding regions in myosin V. Biophys J. 2012 Jun 6; 102(11):2545-55.
    View in: PubMed
  9. Yengo CM, Zimmerman SD, McCormick RJ, Thomas DP. Exercise training post-MI favorably modifies heart extracellular matrix in the rat. Med Sci Sports Exerc. 2012 Jun; 44(6):1005-12.
    View in: PubMed
  10. Merritt RC, Manor U, Salles FT, Grati M, Dose AC, Unrath WC, Quintero OA, Yengo CM, Kachar B. Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Curr Biol. 2012 Feb 21; 22(4):320-5.
    View in: PubMed
  11. Phelps DS, Umstead TM, Quintero OA, Yengo CM, Floros J. In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement. Proteome Sci. 2011; 9:67.
    View in: PubMed
  12. Moore CC, Lakner AM, Yengo CM, Schrum LW. Nonmuscle myosin II regulates migration but not contraction in rat hepatic stellate cells. World J Hepatol. 2011 Jul 27; 3(7):184-97.
    View in: PubMed
  13. Jacobs DJ, Trivedi D, David C, Yengo CM. Kinetics and thermodynamics of the rate-limiting conformational change in the actomyosin V mechanochemical cycle. J Mol Biol. 2011 Apr 15; 407(5):716-30.
    View in: PubMed
  14. Yengo CM, Berger CL. Fluorescence anisotropy and resonance energy transfer: powerful tools for measuring real time protein dynamics in a physiological environment. Curr Opin Pharmacol. 2010 Dec; 10(6):731-7.
    View in: PubMed
  15. Quintero OA, Moore JE, Unrath WC, Manor U, Salles FT, Grati M, Kachar B, Yengo CM. Intermolecular autophosphorylation regulates myosin IIIa activity and localization in parallel actin bundles. J Biol Chem. 2010 Nov 12; 285(46):35770-82.
    View in: PubMed
  16. Jasuja R, Ulloor J, Yengo CM, Choong K, Istomin AY, Livesay DR, Jacobs DJ, Swerdloff RS, Miksovská J, Larsen RW, Bhasin S. Kinetic and thermodynamic characterization of dihydrotestosterone-induced conformational perturbations in androgen receptor ligand-binding domain. Mol Endocrinol. 2009 Aug; 23(8):1231-41.
    View in: PubMed
  17. Sefton JM, Hicks-Little CA, Hubbard TJ, Clemens MG, Yengo CM, Koceja DM, Cordova ML. Sensorimotor function as a predictor of chronic ankle instability. Clin Biomech (Bristol, Avon). 2009 Jun; 24(5):451-8.
    View in: PubMed
  18. Salles FT, Merritt RC, Manor U, Dougherty GW, Sousa AD, Moore JE, Yengo CM, Dosé AC, Kachar B. Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments. Nat Cell Biol. 2009 Apr; 11(4):443-50.
    View in: PubMed
  19. Sefton JM, Hicks-Little CA, Hubbard TJ, Clemens MG, Yengo CM, Koceja DM, Cordova ML. Segmental spinal reflex adaptations associated with chronic ankle instability. Arch Phys Med Rehabil. 2008 Oct; 89(10):1991-5.
    View in: PubMed
  20. Sun M, Rose MB, Ananthanarayanan SK, Jacobs DJ, Yengo CM. Characterization of the pre-force-generation state in the actomyosin cross-bridge cycle. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8631-6.
    View in: PubMed
  21. Dosé AC, Ananthanarayanan S, Moore JE, Corsa AC, Burnside B, Yengo CM. The kinase domain alters the kinetic properties of the myosin IIIA motor. Biochemistry. 2008 Feb 26; 47(8):2485-96.
    View in: PubMed
  22. Yengo CM, Ananthanarayanan SK, Brosey CA, Mao S, Tyska MJ. Human deafness mutation E385D disrupts the mechanochemical coupling and subcellular targeting of myosin-1a. Biophys J. 2008 Jan 15; 94(2):L5-7.
    View in: PubMed
  23. Juncadella IJ, Garg R, Ananthnarayanan SK, Yengo CM, Anguita J. T-cell signaling pathways inhibited by the tick saliva immunosuppressor, Salp15. FEMS Immunol Med Microbiol. 2007 Apr; 49(3):433-8.
    View in: PubMed
  24. Garg R, Juncadella IJ, Ramamoorthi N. Cutting edge: CD4 is the receptor for the tick saliva immunosuppressor, Salp15. J Immunol. 2006 Nov 15; 177(10):6579-83.
    View in: PubMed
  25. Dosé AC, Ananthanarayanan S, Moore JE, Burnside B, Yengo CM. Kinetic mechanism of human myosin IIIA. J Biol Chem. 2007 Jan 5; 282(1):216-31.
    View in: PubMed
  26. Sun M, Oakes JL, Ananthanarayanan SK, Hawley KH, Tsien RY, Adams SR, Yengo CM. Dynamics of the upper 50-kDa domain of myosin V examined with fluorescence resonance energy transfer. J Biol Chem. 2006 Mar 3; 281(9):5711-7.
    View in: PubMed
  27. Ménétrey J, Bahloul A, Wells AL, Yengo CM, Morris CA, Sweeney HL, Houdusse A. The structure of the myosin VI motor reveals the mechanism of directionality reversal. Nature. 2005 Jun 9; 435(7043):779-85.
    View in: PubMed
  28. Wallace KN, Dolan AC, Seiler C, Smith EM, Yusuff S, Chaille-Arnold L, Judson B, Sierk R, Yengo C, Sweeney HL, Pack M. Mutation of smooth muscle myosin causes epithelial invasion and cystic expansion of the zebrafish intestine. Dev Cell. 2005 May; 8(5):717-26.
    View in: PubMed
  29. Ramamurthy B, Yengo CM, Straight AF, Mitchison TJ, Sweeney HL. Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. Biochemistry. 2004 Nov 23; 43(46):14832-9.
    View in: PubMed
  30. Yengo CM, Sweeney HL. Functional role of loop 2 in myosin V. Biochemistry. 2004 Mar 9; 43(9):2605-12.
    View in: PubMed
  31. Chakrabarty T, Yengo C, Baldacchino C, Chen LQ, Sweeney HL, Selvin PR. Does the S2 rod of myosin II uncoil upon two-headed binding to actin? A leucine-zippered HMM study. Biochemistry. 2003 Nov 11; 42(44):12886-92.
    View in: PubMed
  32. Coureux PD, Wells AL, Ménétrey J, Yengo CM, Morris CA, Sweeney HL, Houdusse A. A structural state of the myosin V motor without bound nucleotide. Nature. 2003 Sep 25; 425(6956):419-23.
    View in: PubMed
  33. Yengo CM, De la Cruz EM, Safer D, Ostap EM, Sweeney HL. Kinetic characterization of the weak binding states of myosin V. Biochemistry. 2002 Jul 2; 41(26):8508-17.
    View in: PubMed
  34. Yengo CM, De La Cruz EM, Chrin LR, Gaffney DP, Berger CL. Actin-induced closure of the actin-binding cleft of smooth muscle myosin. J Biol Chem. 2002 Jul 5; 277(27):24114-9.
    View in: PubMed
  35. Yengo CM, Berger CL. Fluorescence resonance energy transfer in acto-myosin complexes. Results Probl Cell Differ. 2002; 36:21-30.
    View in: PubMed
  36. Yengo CM, Chrin LR, Berger CL. Interaction of myosin LYS-553 with the C-terminus and DNase I-binding loop of actin examined by fluorescence resonance energy transfer. J Struct Biol. 2000 Sep; 131(3):187-96.
    View in: PubMed
  37. Yengo CM, Chrin LR, Rovner AS, Berger CL. Tryptophan 512 is sensitive to conformational changes in the rigid relay loop of smooth muscle myosin during the MgATPase cycle. J Biol Chem. 2000 Aug 18; 275(33):25481-7.
    View in: PubMed
  38. Yengo CM, Chrin L, Rovner AS, Berger CL. Intrinsic tryptophan fluorescence identifies specific conformational changes at the actomyosin interface upon actin binding and ADP release. Biochemistry. 1999 Nov 2; 38(44):14515-23.
    View in: PubMed
  39. Yengo CM, Fagnant PM, Chrin L, Rovner AS, Berger CL. Smooth muscle myosin mutants containing a single tryptophan reveal molecular interactions at the actin-binding interface. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):12944-9.
    View in: PubMed
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