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Craig Meyers

TitleProfessor
InstitutionCollege of Medicine
DepartmentMicrobiology and Immunology
Address500 University Drive Hershey PA 17033
Mailbox: H107
Phone7175316240
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    Collapse Biography 
    Collapse awards and honors
    2010Postdoctoral Mentorship Award, Penn State College of Medicine
    2013Alumni Achievement Award, Brigham Young University

    Collapse Overview 
    Collapse overview
    PREFERRED TITLE/ROLE:

    Distinguished Professor of Microbiology and Immunology

    GRADUATE PROGRAM AFFILIATIONS:

    Biomedical Sciences, Molecular Medicine, and MD/PhD Degree Program

    EDUCATION:

    B.S., Brigham Young University, Provo, UT, 1982
    M.S., Brigham Young University, Provo, UT, 1984
    Ph.D., University of California, Los Angeles, CA, 1990
    Postdoctoral Training, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 1990-1993


    NARRATIVE:

    The central research goals of my laboratory are to study the differentiation-dependent life cycle of human papillomavirus (HPV) and HPV-associated oncogenesis. My studies follow six general research themes: (1) Investigation of the molecular biology and genetics of HPV morphogenesis and structure in native virus replicated under natural physiological differentiation conditions of the host tissue. The majority of the laboratories studying HPV morphogenesis and structure utilize synthetic particles such as virus-like particles (VLPs) or pseudoviral particles (PsV). Our studies have shown that the morphogenesis, maturation, and structure of native HPV differs in many significant characteristic from VLPs or PsV particles. (2) Investigation of the efficacy of disinfectants and microbicides on native HPV as compared to VLPs/PsV. Our results demonstrate that HPV is significantly more resistant to disinfectants and microbicides then our VLPs/PsV. This demonstrates the clinical importance of using native HPV for disinfectant and microbicide testing. (3) Determining the mechanism whereby cofactors such as tobacco carcinogens increase carcinogenic progression in HPV-associated cancers. We are dissecting the signaling pathways and cell cycle components that are impacted by the interaction of cofactors and HPV in host tissue. (4) Determining the interaction of highly active anti-retroviral drugs on oral tissues, HPV and HPV’s infection of oral tissue. (5) Development of population science and basic science interactions to monitor, understand and influence education and behavior as they relate to a risk for acquiring an HPV-associated infection. (6) Comparative analysis of HPV infection, life cycle, and oncogenesis at different anatomical sites. (7) Investigation of AAV2 oncolytic properties. Including determine the mechanisms induced by AAV2 causing cancer cells to undergo cell death and translating these findings to the clinic.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chiang C, Pauli EK, Biryukov J, Feister KF, Meng M, White EA, Münger K, Howley PM, Meyers C, Gack MU. The human papillomavirus E6 oncoprotein targets USP15 and TRIM25 to suppress RIG-I-mediated innate immune signaling. J Virol. 2017 Dec 20. PMID: 29263274.
      View in: PubMed
    2. Biryukov J, Myers JC, McLaughlin-Drubin ME, Griffin HM, Milici J, Doorbar J, Meyers C. Mutations in HPV18 E1^E4 Impact Virus Capsid Assembly, Infectivity Competence, and Maturation. Viruses. 2017 Dec 19; 9(12). PMID: 29257050.
      View in: PubMed
    3. Bywaters SM, Brendle SA, Tossi KP, Biryukov J, Meyers C, Christensen ND. Antibody Competition Reveals Surface Location of HPV L2 Minor Capsid Protein Residues 17-36. Viruses. 2017 Nov 10; 9(11). PMID: 29125554.
      View in: PubMed
    4. Meyers C, Milici J, Robison R. UVC radiation as an effective disinfectant method to inactivate human papillomaviruses. PLoS One. 2017; 12(10):e0187377. PMID: 29088277.
      View in: PubMed
    5. Tang X, Loc WS, Dong C, Matters GL, Butler PJ, Kester M, Meyers C, Jiang Y, Adair JH. The use of nanoparticulates to treat breast cancer. Nanomedicine (Lond). 2017 Oct; 12(19):2367-2388. PMID: 28868970.
      View in: PubMed
    6. Wang X, Liu H, Ge H, Ajiro M, Sharma NR, Meyers C, Morozov P, Tuschl T, Klar A, Court D, Zheng ZM. Viral DNA Replication Orientation and hnRNPs Regulate Transcription of the Human Papillomavirus 18 Late Promoter. MBio. 2017 May 30; 8(3). PMID: 28559488.
      View in: PubMed
    7. Temple RM, Meyers C, Sample CE. Generation and Infection of Organotypic Cultures with Epstein-Barr Virus. Methods Mol Biol. 2017; 1532:65-78. PMID: 27873267.
      View in: PubMed
    8. Ma W, Tummers B, van Esch EM, Goedemans R, Melief CJ, Meyers C, Boer JM, van der Burg SH. Human Papillomavirus Downregulates the Expression of IFITM1 and RIPK3 to Escape from IFN?- and TNFa-Mediated Antiproliferative Effects and Necroptosis. Front Immunol. 2016; 7:496. PMID: 27920775.
      View in: PubMed
    9. Wang X, Liu H, Wang HK, Meyers C, Chow L, Zheng ZM. HPV18 DNA replication inactivates the early promoter P55 activity and prevents viral E6 expression. Virol Sin. 2016 Oct; 31(5):437-440. PMID: 27822719.
      View in: PubMed
    10. Israr M, Biryukov J, Ryndock EJ, Alam S, Meyers C. Comparison of human papillomavirus type 16 replication in tonsil and foreskin epithelia. Virology. 2016 12; 499:82-90. PMID: 27639574.
      View in: PubMed
    11. Sharma NR, Wang X, Majerciak V, Ajiro M, Kruhlak M, Meyers C, Zheng ZM. Cell Type- and Tissue Context-dependent Nuclear Distribution of Human Ago2. J Biol Chem. 2016 Jan 29; 291(5):2302-9. PMID: 26699195; PMCID: PMC4732213 [Available on 01/29/17].
    12. Ryndock E, Robison R, Meyers C. Susceptibility of HPV16 and 18 to high level disinfectants indicated for semi-critical ultrasound probes. J Med Virol. 2016 Jun; 88(6):1076-80. PMID: 26519866.
      View in: PubMed
    13. Cruz L, Biryukov J, Conway MJ, Meyers C. Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection. Viruses. 2015 Nov 11; 7(11):5813-30. PMID: 26569287; PMCID: PMC4664983.
    14. Du P, Camacho F, McCall-Hosenfeld J, Lengerich E, Meyers CM, Christensen ND. Human Papillomavirus Vaccination Among Adults and Children in 5 US States. J Public Health Manag Pract. 2015 Nov-Dec; 21(6):573-83. PMID: 26035648; PMCID: PMC4666808 [Available on 11/01/16].
    15. Biryukov J, Meyers C. Papillomavirus Infectious Pathways: A Comparison of Systems. Viruses. 2015 Aug 04; 7(8):4303-25. PMID: 26247955; PMCID: PMC4576184.
    16. Tummers B, Goedemans R, Pelascini LP, Jordanova ES, van Esch EM, Meyers C, Melief CJ, Boer JM, van der Burg SH. The interferon-related developmental regulator 1 is used by human papillomavirus to suppress NF?B activation. Nat Commun. 2015 Mar 13; 6:6537. PMID: 26055519; PMCID: PMC4382698.
    17. Du P, Brendle S, Milici J, Camacho F, Zurlo J, Christensen N, Meyers C. Comparisons of VLP-Based ELISA, Neutralization Assays with Native HPV, and Neutralization Assays with PsV in Detecting HPV Antibody Responses in HIV-Infected Women. J AIDS Clin Res. 2015 Mar; 6(3). PMID: 26085957.
      View in: PubMed
    18. Biryukov J, Cruz L, Ryndock EJ, Meyers C. Native human papillomavirus production, quantification, and infectivity analysis. Methods Mol Biol. 2015; 1249:317-31. PMID: 25348317.
      View in: PubMed
    19. Ryndock EJ, Biryukov J, Meyers C. Replication of human papillomavirus in culture. Methods Mol Biol. 2015; 1249:39-52. PMID: 25348296.
      View in: PubMed
    20. Temple RM, Zhu J, Budgeon L, Christensen ND, Meyers C, Sample CE. Efficient replication of Epstein-Barr virus in stratified epithelium in vitro. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16544-9. PMID: 25313069; PMCID: PMC4246336.
    21. Ryndock EJ, Meyers C. A risk for non-sexual transmission of human papillomavirus? Expert Rev Anti Infect Ther. 2014 Oct; 12(10):1165-70. PMID: 25199987.
      View in: PubMed
    22. Tummers B, Goedemans R, Jha V, Meyers C, Melief CJM, van der Burg SH, Boer JM. CD40-mediated amplification of local immunity by epithelial cells is impaired by HPV. J Invest Dermatol. 2014 Dec; 134(12):2918-2927. PMID: 24945092; PMCID: PMC4227541.
    23. Ryndock EJ, Conway MJ, Alam S, Gul S, Murad S, Christensen ND, Meyers C. Roles for human papillomavirus type 16 l1 cysteine residues 161, 229, and 379 in genome encapsidation and capsid stability. PLoS One. 2014; 9(6):e99488. PMID: 24918586; PMCID: PMC4053435.
    24. Alam S, Bowser BS, Israr M, Conway MJ, Meyers C. Adeno-associated virus type 2 infection of nude mouse human breast cancer xenograft induces necrotic death and inhibits tumor growth. Cancer Biol Ther. 2014 Aug; 15(8):1013-28. PMID: 24834917; PMCID: PMC4119069.
    25. Wang X, Wang HK, Li Y, Hafner M, Banerjee NS, Tang S, Briskin D, Meyers C, Chow LT, Xie X, Tuschl T, Zheng ZM. microRNAs are biomarkers of oncogenic human papillomavirus infections. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4262-7. PMID: 24591631; PMCID: PMC3964092.
    26. Meyers J, Ryndock E, Conway MJ, Meyers C, Robison R. Susceptibility of high-risk human papillomavirus type 16 to clinical disinfectants. J Antimicrob Chemother. 2014 Jun; 69(6):1546-50. PMID: 24500190; PMCID: PMC4019329.
    27. Mitchell D, Israr M, Alam S, Dinello D, Kishel J, Jia R, Meyers C. HIV nucleoside reverse transcriptase inhibitors efavirenz and tenofovir change the growth and differentiation of primary gingival epithelium. HIV Med. 2014 Apr; 15(4):196-202. PMID: 24580719; PMCID: PMC3942794.
    28. Cruz L, Meyers C. Differential dependence on host cell glycosaminoglycans for infection of epithelial cells by high-risk HPV types. PLoS One. 2013; 8(7):e68379. PMID: 23861898; PMCID: PMC3701689.
    29. Karim R, Tummers B, Meyers C, Biryukov JL, Alam S, Backendorf C, Jha V, Offringa R, van Ommen GJ, Melief CJ, Guardavaccaro D, Boer JM, van der Burg SH. Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response. PLoS Pathog. 2013; 9(5):e1003384. PMID: 23717208; PMCID: PMC3662672.
    30. Trushin N, Alam S, El-Bayoumy K, Krzeminski J, Amin SG, Gullett J, Meyers C, Prokopczyk B. Comparative metabolism of benzo[a]pyrene by human keratinocytes infected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes. J Carcinog. 2012; 11:1. PMID: 22368516; PMCID: PMC3284083.
    31. Mitchell D, Israr M, Alam S, Kishel J, Dinello D, Meyers C. Effect of the HIV nucleoside reverse transcriptase inhibitor zidovudine on the growth and differentiation of primary gingival epithelium. HIV Med. 2012 May; 13(5):276-90. PMID: 22276657; PMCID: PMC3319519.
    32. Alam S, Bowser BS, Conway MJ, Israr M, Tandon A, Meyers C. Adeno-associated virus type 2 infection activates caspase dependent and independent apoptosis in multiple breast cancer lines but not in normal mammary epithelial cells. Mol Cancer. 2011 Aug 09; 10:97. PMID: 21827643; PMCID: PMC3199901.
    33. Conway MJ, Cruz L, Alam S, Christensen ND, Meyers C. Differentiation-dependent interpentameric disulfide bond stabilizes native human papillomavirus type 16. PLoS One. 2011; 6(7):e22427. PMID: 21811610; PMCID: PMC3139651.
    34. Bowser BS, Chen HS, Conway MJ, Christensen ND, Meyers C. Human papillomavirus type 18 chimeras containing the L2/L1 capsid genes from evolutionarily diverse papillomavirus types generate infectious virus. Virus Res. 2011 Sep; 160(1-2):246-55. PMID: 21762735; PMCID: PMC3163805.
    35. Bodily JM, Mehta KP, Cruz L, Meyers C, Laimins LA. The E7 open reading frame acts in cis and in trans to mediate differentiation-dependent activities in the human papillomavirus type 16 life cycle. J Virol. 2011 Sep; 85(17):8852-62. PMID: 21697473; PMCID: PMC3165838.
    36. Wang X, Meyers C, Wang HK, Chow LT, Zheng ZM. Construction of a full transcription map of human papillomavirus type 18 during productive viral infection. J Virol. 2011 Aug; 85(16):8080-92. PMID: 21680515; PMCID: PMC3147953.
    37. Karim R, Meyers C, Backendorf C, Ludigs K, Offringa R, van Ommen GJ, Melief CJ, van der Burg SH, Boer JM. Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes. PLoS One. 2011 Mar 14; 6(3):e17848. PMID: 21423754; PMCID: PMC3056770.
    38. Bowser BS, Alam S, Meyers C. Treatment of a human papillomavirus type 31b-positive cell line with benzo[a]pyrene increases viral titer through activation of the Erk1/2 signaling pathway. J Virol. 2011 May; 85(10):4982-92. PMID: 21367897; PMCID: PMC3126175.
    39. Wang X, Meyers C, Guo M, Zheng ZM. Upregulation of p18Ink4c expression by oncogenic HPV E6 via p53-miR-34a pathway. Int J Cancer. 2011 Sep 15; 129(6):1362-72. PMID: 21128241; PMCID: PMC3086996.
    40. Chen HS, Conway MJ, Christensen ND, Alam S, Meyers C. Papillomavirus capsid proteins mutually impact structure. Virology. 2011 Apr 10; 412(2):378-83. PMID: 21329956; PMCID: PMC3060953.
    41. Conway MJ, Cruz L, Alam S, Christensen ND, Meyers C. Cross-neutralization potential of native human papillomavirus N-terminal L2 epitopes. PLoS One. 2011 Feb 08; 6(2):e16405. PMID: 21346798; PMCID: PMC3035607.
    42. Nguyen N, Sharma A, Nguyen N, Sharma AK, Desai D, Huh SJ, Amin S, Meyers C, Robertson GP. Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4. Cancer Prev Res (Phila). 2011 Feb; 4(2):248-58. PMID: 21097713; PMCID: PMC3210697.
    43. Israr M, Mitchell D, Alam S, Dinello D, Kishel JJ, Meyers C. The HIV protease inhibitor lopinavir/ritonavir (Kaletra) alters the growth, differentiation and proliferation of primary gingival epithelium. HIV Med. 2011 Mar; 12(3):145-56. PMID: 20722750; PMCID: PMC3024444.
    44. Chen HS, Bromberg-White J, Conway MJ, Alam S, Meyers C. Study of infectious virus production from HPV18/16 capsid chimeras. Virology. 2010 Sep 30; 405(2):289-99. PMID: 20598725; PMCID: PMC2923236.
    45. Chapman S, Liu X, Meyers C, Schlegel R, McBride AA. Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor. J Clin Invest. 2010 Jul; 120(7):2619-26. PMID: 20516646; PMCID: PMC2898606.
    46. Du P, Lemkin A, Kluhsman B, Chen J, Roth RE, MacEachren A, Meyers C, Zurlo JJ, Lengerich EJ. The roles of social domains, behavioral risk, health care resources, and chlamydia in spatial clusters of US cervical cancer mortality: not all the clusters are the same. Cancer Causes Control. 2010 Oct; 21(10):1669-83. PMID: 20532608.
      View in: PubMed
    47. Alam S, Bowser BS, Conway MJ, Israr M, Ryndock EJ, Xi LF, Meyers C. Downregulation of Cdc2/CDK1 kinase activity induces the synthesis of noninfectious human papillomavirus type 31b virions in organotypic tissues exposed to benzo[a]pyrene. J Virol. 2010 May; 84(9):4630-45. PMID: 20181698; PMCID: PMC2863740.
    48. Israr M, Mitchell D, Alam S, Dinello D, Kishel JJ, Meyers C. Effect of the HIV protease inhibitor amprenavir on the growth and differentiation of primary gingival epithelium. Antivir Ther. 2010; 15(2):253-65. PMID: 20386081; PMCID: PMC3678718.
    49. Xi LF, Koutsky LA, Castle PE, Edelstein ZR, Meyers C, Ho J, Schiffman M. Relationship between cigarette smoking and human papilloma virus types 16 and 18 DNA load. Cancer Epidemiol Biomarkers Prev. 2009 Dec; 18(12):3490-6. PMID: 19959700; PMCID: PMC2920639.
    50. Conway MJ, Alam S, Christensen ND, Meyers C. Overlapping and independent structural roles for human papillomavirus type 16 L2 conserved cysteines. Virology. 2009 Oct 25; 393(2):295-303. PMID: 19733888; PMCID: PMC2763999.
    51. Xi LF, Edelstein ZR, Meyers C, Ho J, Cherne SL, Schiffman M. Human papillomavirus types 16 and 18 DNA load in relation to coexistence of other types, particularly those in the same species. Cancer Epidemiol Biomarkers Prev. 2009 Sep; 18(9):2507-12. PMID: 19690188; PMCID: PMC2745080.
    52. Conway MJ, Alam S, Ryndock EJ, Cruz L, Christensen ND, Roden RB, Meyers C. Tissue-spanning redox gradient-dependent assembly of native human papillomavirus type 16 virions. J Virol. 2009 Oct; 83(20):10515-26. PMID: 19656879; PMCID: PMC2753102.
    53. Alam S, Meyers C. Adeno-associated virus type 2 induces apoptosis in human papillomavirus-infected cell lines but not in normal keratinocytes. J Virol. 2009 Oct; 83(19):10286-92. PMID: 19625406; PMCID: PMC2748052.
    54. Conway MJ, Meyers C. Replication and assembly of human papillomaviruses. J Dent Res. 2009 Apr; 88(4):307-17. PMID: 19407149; PMCID: PMC3317948.
    55. Wang X, Wang HK, McCoy JP, Banerjee NS, Rader JS, Broker TR, Meyers C, Chow LT, Zheng ZM. Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6. RNA. 2009 Apr; 15(4):637-47. PMID: 19258450; PMCID: PMC2661824.
    56. Lin Z, Yemelyanova AV, Gambhira R, Jagu S, Meyers C, Kirnbauer R, Ronnett BM, Gravitt PE, Roden RB. Expression pattern and subcellular localization of human papillomavirus minor capsid protein L2. Am J Pathol. 2009 Jan; 174(1):136-43. PMID: 19095951; PMCID: PMC2631326.
    57. Jia R, Liu X, Tao M, Kruhlak M, Guo M, Meyers C, Baker CC, Zheng ZM. Control of the papillomavirus early-to-late switch by differentially expressed SRp20. J Virol. 2009 Jan; 83(1):167-80. PMID: 18945760; PMCID: PMC2612334.
    58. Wang X, Tang S, Le SY, Lu R, Rader JS, Meyers C, Zheng ZM. Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One. 2008 Jul 02; 3(7):e2557. PMID: 18596939; PMCID: PMC2438475.
    59. Alam S, Conway MJ, Chen HS, Meyers C. The cigarette smoke carcinogen benzo[a]pyrene enhances human papillomavirus synthesis. J Virol. 2008 Jan; 82(2):1053-8. PMID: 17989183; PMCID: PMC2224590.
    60. Schweinfurth JM, Meyers C. Organotypic (raft) culture of biopsy-derived upper respiratory epithelium. Laryngoscope. 2006 Sep; 116(9):1600-2. PMID: 16954987.
      View in: PubMed
    61. Alam S, Sen E, Brashear H, Meyers C. Adeno-associated virus type 2 increases proteosome-dependent degradation of p21WAF1 in a human papillomavirus type 31b-positive cervical carcinoma line. J Virol. 2006 May; 80(10):4927-39. PMID: 16641284; PMCID: PMC1472069.
    62. Drubin DA, McLaughlin-Drubin ME, Clawson GA, Meyers C. A protease inhibitor specifically inhibits growth of HPV-infected keratinocytes. Mol Ther. 2006 Jun; 13(6):1142-8. PMID: 16564747.
      View in: PubMed
    63. Bodily JM, Alam S, Meyers C. Regulation of human papillomavirus type 31 late promoter activation and genome amplification by protein kinase C. Virology. 2006 May 10; 348(2):328-40. PMID: 16500689.
      View in: PubMed
    64. Fang L, Meyers C, Budgeon LR, Howett MK. Induction of productive human papillomavirus type 11 life cycle in epithelial cells grown in organotypic raft cultures. Virology. 2006 Mar 30; 347(1):28-35. PMID: 16460777.
      View in: PubMed
    65. Bodily, J.M., Alam, S., Chen, H.S., and Meyers, C. Papillomavirus Research: From Natural History To Vaccines and Beyond (Campo, M.S. ed.). Organotypic raft cultures and the study of the ntural history of papillomavirus. 2006.
    66. McLaughlin-Drubin ME, Bromberg-White JL, Meyers C. The role of the human papillomavirus type 18 E7 oncoprotein during the complete viral life cycle. Virology. 2005 Jul 20; 338(1):61-8. PMID: 15921717.
      View in: PubMed
    67. Sen E, McLaughlin-Drubin M, Meyers C. Efficacy of two commercial preparations of interferon-alpha on human papillomavirus replication. Anticancer Res. 2005 Mar-Apr; 25(2A):1091-100. PMID: 15868951.
      View in: PubMed
    68. Bodily JM, Meyers C. Genetic analysis of the human papillomavirus type 31 differentiation-dependent late promoter. J Virol. 2005 Mar; 79(6):3309-21. PMID: 15731225; PMCID: PMC1075705.
    69. Alam S, Bromberg-White J, McLaughlin-Drubin M, Sen E, Bodily JM, Meyers C. Activity and therapeutic potential of ORI-1001 antisense oligonucleotide on human papillomavirus replication utilizing a model of dysplastic human epithelium. Anticancer Res. 2005 Mar-Apr; 25(2A):765-77. PMID: 15868908.
      View in: PubMed
    70. McLaughlin-Drubin ME, Meyers C. Propagation of infectious, high-risk HPV in organotypic "raft" culture. Methods Mol Med. 2005; 119:171-86. PMID: 16350404.
      View in: PubMed
    71. Bodily JM, Meyers C. Analysis of HPV transcription by RPA. Methods Mol Med. 2005; 119:279-90. PMID: 16350407.
      View in: PubMed
    72. McLaughlin-Drubin ME, Christensen ND, Meyers C. Propagation, infection, and neutralization of authentic HPV16 virus. Virology. 2004 May 01; 322(2):213-9. PMID: 15110519.
      View in: PubMed
    73. McLaughlin-Drubin ME, Meyers C. Evidence for the coexistence of two genital HPV types within the same host cell in vitro. Virology. 2004 Apr 10; 321(2):173-80. PMID: 15051378.
      View in: PubMed
    74. Sen E, Alam S, Meyers C. Genetic and biochemical analysis of cis regulatory elements within the keratinocyte enhancer region of the human papillomavirus type 31 upstream regulatory region during different stages of the viral life cycle. J Virol. 2004 Jan; 78(2):612-29. PMID: 14694093; PMCID: PMC368763.
    75. Bromberg-White, J.L. and Meyers, C. Current Topics in Virol. The role of steroid hormones in human papilomavirus-induced cervical carcinogenesis. 2004; 3:183-199.
    76. Meyers C, Andreansky SS, Courtney RJ. Replication and interaction of herpes simplex virus and human papillomavirus in differentiating host epithelial tissue. Virology. 2003 Oct 10; 315(1):43-55. PMID: 14592758.
      View in: PubMed
    77. Bromberg-White JL, Sen E, Alam S, Bodily JM, Meyers C. Induction of the upstream regulatory region of human papillomavirus type 31 by dexamethasone is differentiation dependent. J Virol. 2003 Oct; 77(20):10975-83. PMID: 14512546; PMCID: PMC225009.
    78. Prasad CK, Meyers C, Zhan DJ, You H, Chiriva-Internati M, Mehta JL, Liu Y, Hermonat PL. The adeno-associated virus major regulatory protein Rep78-c-Jun-DNA motif complex modulates AP-1 activity. Virology. 2003 Sep 15; 314(1):423-31. PMID: 14517094.
      View in: PubMed
    79. McLaughlin-Drubin ME, Wilson S, Mullikin B, Suzich J, Meyers C. Human papillomavirus type 45 propagation, infection, and neutralization. Virology. 2003 Jul 20; 312(1):1-7. PMID: 12890615.
      View in: PubMed
    80. Bromberg-White JL, Meyers C. Comparison of the basal and glucocorticoid-inducible activities of the upstream regulatory regions of HPV18 and HPV31 in multiple epithelial cell lines. Virology. 2003 Feb 15; 306(2):197-202. PMID: 12642092.
      View in: PubMed
    81. Bromberg-White JL, Meyers C. The upstream regulatory region of human papillomavirus type 31 is insensitive to glucocorticoid induction. J Virol. 2002 Oct; 76(19):9702-15. PMID: 12208949; PMCID: PMC136493.
    82. Steele BK, Meyers C, Ozbun MA. Variable expression of some "housekeeping" genes during human keratinocyte differentiation. Anal Biochem. 2002 Aug 15; 307(2):341-7. PMID: 12202253.
      View in: PubMed
    83. Sen E, Bromberg-White JL, Meyers C. Genetic analysis of cis regulatory elements within the 5' region of the human papillomavirus type 31 upstream regulatory region during different stages of the viral life cycle. J Virol. 2002 May; 76(10):4798-809. PMID: 11967297; PMCID: PMC136139.
    84. Meyers C, Bromberg-White JL, Zhang J, Kaupas ME, Bryan JT, Lowe RS, Jansen KU. Infectious virions produced from a human papillomavirus type 18/16 genomic DNA chimera. J Virol. 2002 May; 76(10):4723-33. PMID: 11967289; PMCID: PMC136126.
    85. Meyers, C. Methods in Tissue Engineering (Atala, A. and Lanza, R. eds. Three-dimensional cervical epithelial culture system. 2002.
    86. Meyers C, Alam S, Mane M, Hermonat PL. Altered biology of adeno-associated virus type 2 and human papillomavirus during dual infection of natural host tissue. Virology. 2001 Aug 15; 287(1):30-9. PMID: 11504539.
      View in: PubMed
    87. Southern SA, Noya F, Meyers C, Broker TR, Chow LT, Herrington CS. Tetrasomy is induced by human papillomavirus type 18 E7 gene expression in keratinocyte raft cultures. Cancer Res. 2001 Jun 15; 61(12):4858-63. PMID: 11406563.
      View in: PubMed
    88. Meyers C, Mane M, Kokorina N, Alam S, Hermonat PL. Ubiquitous human adeno-associated virus type 2 autonomously replicates in differentiating keratinocytes of a normal skin model. Virology. 2000 Jul 05; 272(2):338-46. PMID: 10873777.
      View in: PubMed
    89. Mayer, T.J., Frauenhoffer, E., and Meyers, C. In Vitro. Expression of epidermal growth factor receptor and platelet-derived growth factor receptor during cervical carcinogenesis. 2000; 36:667-676.
    90. Shier MK, Neely EB, Ward MG, Meyers C, Howett MK. Transforming growth factor beta 1 (TGF beta 1) down-regulates expression and function of proliferation-inducing molecules in HPV-transformed cells. Anticancer Res. 1999 Nov-Dec; 19(6B):4977-82. PMID: 10697499.
      View in: PubMed
    91. Shier MK, Neely EB, Ward MG, Richards ME, Manders EC, Meyers C, Howett MK. Correlation of TGF beta 1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts. Anticancer Res. 1999 Nov-Dec; 19(6B):4969-76. PMID: 10697498.
      View in: PubMed
    92. Zhan D, Santin AD, Liu Y, Parham GP, Li C, Meyers C, Hermonat PL. Binding of the human papillomavirus type 16 p97 promoter by the adeno-associated virus Rep78 major regulatory protein correlates with inhibition. J Biol Chem. 1999 Oct 29; 274(44):31619-24. PMID: 10531369.
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    93. Ozbun MA, Meyers C. Two novel promoters in the upstream regulatory region of human papillomavirus type 31b are negatively regulated by epithelial differentiation. J Virol. 1999 Apr; 73(4):3505-10. PMID: 10074210; PMCID: PMC104120.
    94. Ozbun, M.A. and Meyers, C. Current Topics in Virol. Human papillomavirus type 31b transcription during the differentiation-dependent viral life cycle. 1999; 1:203-217.
    95. Ozbun MA, Meyers C. Human papillomavirus type 31b E1 and E2 transcript expression correlates with vegetative viral genome amplification. Virology. 1998 Sep 01; 248(2):218-30. PMID: 9721231; PMCID: PMC3600430.
    96. Mayer TJ, Meyers C. Temporal and spatial expression of the E5a protein during the differentiation-dependent life cycle of human papillomavirus type 31b. Virology. 1998 Sep 01; 248(2):208-17. PMID: 9721230.
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    97. Hermonat PL, Meyers C, Parham GP, Santin AD. Inhibition/stimulation of bovine papillomavirus by adeno-associated virus is time as well as multiplicity dependent. Virology. 1998 Aug 01; 247(2):240-50. PMID: 9705917.
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    98. Ozbun MA, Meyers C. Temporal usage of multiple promoters during the life cycle of human papillomavirus type 31b. J Virol. 1998 Apr; 72(4):2715-22. PMID: 9525589; PMCID: PMC109714.
    99. Meyers, C., Frattini, M.G., and Laimins, L.A. Cell Biology: A laboratory Handbook (Celis, J.E. ed.). Tissue culture techniques for the study of human papillomaviruses in stratified epihtelia. 1998.
    100. Meyers, C., Frattini, M.G., and Laimins, L.A. Cell Biology: A Laboratory Handbook. Tissue culture techniques for the study of human papillomaviruses in stratified epithelia. 1998; 513-520.
    101. Meyers C, Mayer TJ, Ozbun MA. Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA. J Virol. 1997 Oct; 71(10):7381-6. PMID: 9311816; PMCID: PMC192083.
    102. Ozbun MA, Meyers C. Characterization of late gene transcripts expressed during vegetative replication of human papillomavirus type 31b. J Virol. 1997 Jul; 71(7):5161-72. PMID: 9188583; PMCID: PMC191751.
    103. Visalli RJ, Courtney RJ, Meyers C. Infection and replication of herpes simplex virus type 1 in an organotypic epithelial culture system. Virology. 1997 Apr 14; 230(2):236-43. PMID: 9143279.
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    104. Ozbun MA, Meyers C. Transforming growth factor beta1 induces differentiation in human papillomavirus-positive keratinocytes. J Virol. 1996 Aug; 70(8):5437-46. PMID: 8764055; PMCID: PMC190501.
    105. Meyers, C. Methods in Cell Science. Organotypic (raft) epithelial culture system for the study of the differentiation-dependent replication of papillomavirus. 1996; 18:201-210.
    106. Meyers C, Laimins LA. In vitro systems for the study and propagation of human papillomaviruses. Curr Top Microbiol Immunol. 1994; 186:199-215. PMID: 8205842.
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    107. Wagner AJ, Meyers C, Laimins LA, Hay N. c-Myc induces the expression and activity of ornithine decarboxylase. Cell Growth Differ. 1993 Nov; 4(11):879-83. PMID: 8297793.
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    108. Meyers C, Frattini MG, Hudson JB, Laimins LA. Biosynthesis of human papillomavirus from a continuous cell line upon epithelial differentiation. Science. 1992 Aug 14; 257(5072):971-3. PMID: 1323879.
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    109. Meyers C, Harry J, Lin YL, Wettstein FO. Identification of three transforming proteins encoded by cottontail rabbit papillomavirus. J Virol. 1992 Mar; 66(3):1655-64. PMID: 1310771; PMCID: PMC240904.
    110. Meyers, C. and Laimins, L.A. Papillomavirus Reports. In vitro model systems for the study of HPV-induced neoplasia. 1992; 3:1-3.
    111. Meyers C, Wettstein FO. The late region differentially regulates the in vitro transformation by cottontail rabbit papillomavirus DNA in different cell types. Virology. 1991 Apr; 181(2):637-46. PMID: 1849681.
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    112. Gage JR, Meyers C, Wettstein FO. The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties. J Virol. 1990 Feb; 64(2):723-30. PMID: 2153238; PMCID: PMC249166.
    113. Nasseri M, Meyers C, Wettstein FO. Genetic analysis of CRPV pathogenesis: the L1 open reading frame is dispensable for cellular transformation but is required for papilloma formation. Virology. 1989 May; 170(1):321-5. PMID: 2541552.
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    114. Jensen MM, Downs WC, Morrey JD, Nicoll TR, LeFevre SD, Meyers CM. Staphylococcosis of turkeys. 1. Portal of entry and tissue colonization. Avian Dis. 1987 Jan-Mar; 31(1):64-9. PMID: 3579796.
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    115. Meyers CM, Jensen MM. Staphylococcosis of turkeys. 3. Bacterial interference as a possible means of control. Avian Dis. 1987 Jan-Mar; 31(1):74-9. PMID: 3579798.
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    116. Jensen, M.M. and Meyers, C.M. The Staphylococci. J. Jeljaszewicz (Ed.). Pathogenesis of Staphylococcosis in turkeys and its control by colonization with avirulent staphylococcin-producing Staphylococci. 1985.
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