|Institution||College of Medicine|
|Department||Microbiology and Immunology|
|Address||500 University Drive Hershey PA 17033|
Distinguished Professor of Microbiology and Immunology
GRADUATE PROGRAM AFFILIATIONS:
Biomedical Sciences, Molecular Medicine, and MD/PhD Degree Program
B.S., Brigham Young University, Provo, UT, 1982
M.S., Brigham Young University, Provo, UT, 1984
Ph.D., University of California, Los Angeles, CA, 1990
Postdoctoral Training, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 1990-1993
The central research goals of my laboratory are to study the differentiation-dependent life cycle of human papillomavirus (HPV) and HPV-associated oncogenesis. My studies follow six general research themes: (1) Investigation of the molecular biology and genetics of HPV morphogenesis and structure in native virus replicated under natural physiological differentiation conditions of the host tissue. The majority of the laboratories studying HPV morphogenesis and structure utilize synthetic particles such as virus-like particles (VLPs) or pseudoviral particles (PsV). Our studies have shown that the morphogenesis, maturation, and structure of native HPV differs in many significant characteristic from VLPs or PsV particles. (2) Investigation of the efficacy of disinfectants and microbicides on native HPV as compared to VLPs/PsV. Our results demonstrate that HPV is significantly more resistant to disinfectants and microbicides then our VLPs/PsV. This demonstrates the clinical importance of using native HPV for disinfectant and microbicide testing. (3) Determining the mechanism whereby cofactors such as tobacco carcinogens increase carcinogenic progression in HPV-associated cancers. We are dissecting the signaling pathways and cell cycle components that are impacted by the interaction of cofactors and HPV in host tissue. (4) Determining the interaction of highly active anti-retroviral drugs on oral tissues, HPV and HPV’s infection of oral tissue. (5) Development of population science and basic science interactions to monitor, understand and influence education and behavior as they relate to a risk for acquiring an HPV-associated infection. (6) Comparative analysis of HPV infection, life cycle, and oncogenesis at different anatomical sites. (7) Investigation of AAV2 oncolytic properties. Including determine the mechanisms induced by AAV2 causing cancer cells to undergo cell death and translating these findings to the clinic.
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