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Curtis Omiecinski

TitleProfessor of Veterinary and Biomedical Sciences, H. Thomas and Dorothy Willits Hallowell Chair
InstitutionCollege of Agricultural Sciences
DepartmentVeterinary and Biomedical Sciences
Address306D Life Sciences Bldg
University Park, PA 16802
Phone8148631625
Other Positions
TitleCo-chair of the Intercollege Graduate Degree Program in Molecular Toxicology
InstitutionHuck Institutes of the Life Sciences


 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Veterinary & Biomedical Sciences
H. Thomas and Dorothy Willits Hallowell Chair
Co-chair, Intercollege Graduate Degree Program in Molecular Toxicology

EDUCATION:

B.S. Biology, State Univeristy of New York at Albany, 1975
Ph.D. Pharmacology, University of Washington, Seattle, WA, 1980
Postdoctoral Fellow in Molecular Toxicology, University of Vermont, Burlington, VT, 1980-83

NARRATIVE:

Dr. Omiecinski's research focuses on the role of nuclear receptors, including the constitutive androstane receptor (CAR), as regulators of chemical metabolism, toxicology and liver cancer. His laboratory also studies the genetics, enzymology and transcriptional mechanisms of epoxide hydrolase in relation to lung cancer risk.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Takeda S, Ikeda E, Su S, Harada M, Okazaki H, Yoshioka Y, Nishimura H, Ishii H, Kakizoe K, Taniguchi A, Tokuyasu M, Himeno T, Watanabe K, Omiecinski CJ, Aramaki H. ?(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: Possible involvement of induced levels of PPARa in MDA-MB-231 breast cancer cells. Toxicology. 2014 Dec 4; 326:18-24.
    View in: PubMed
  2. Wahlang B, Falkner KC, Clair HB, Al-Eryani L, Prough RA, States JC, Coslo DM, Omiecinski CJ, Cave MC. Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci. 2014 Aug 1; 140(2):283-97.
    View in: PubMed
  3. Su S, Yang X, Omiecinski CJ. Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter. Biochim Biophys Acta. 2014 Jun; 1839(6):493-505.
    View in: PubMed
  4. Currie RA, Peffer RC, Goetz AK, Omiecinski CJ, Goodman JI. Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action. Toxicology. 2014 Jul 3; 321:80-8.
    View in: PubMed
  5. Chen T, Laurenzana EM, Coslo DM, Chen F, Omiecinski CJ. Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. Biochem J. 2014 Feb 15; 458(1):95-107.
    View in: PubMed
  6. Su S, Omiecinski CJ. Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter. Gene. 2014 Feb 15; 536(1):135-44.
    View in: PubMed
  7. Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Crit Rev Toxicol. 2014 Jan; 44(1):64-82.
    View in: PubMed
  8. Chen F, Zamule SM, Coslo DM, Chen T, Omiecinski CJ. The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells. Dev Biol. 2013 Dec 15; 384(2):155-65.
    View in: PubMed
  9. Takeda S, Yoshida K, Nishimura H, Harada M, Okajima S, Miyoshi H, Okamoto Y, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H. ?(9)-tetrahydrocannabinol disrupts estrogen-signaling through up-regulation of estrogen receptor ß (ERß). Chem Res Toxicol. 2013 Jul 15; 26(7):1073-9.
    View in: PubMed
  10. Nguyen HL, Yang X, Omiecinski CJ. Expression of a novel mRNA transcript for human microsomal epoxide hydrolase (EPHX1) is regulated by short open reading frames within its 5'-untranslated region. RNA. 2013 Jun; 19(6):752-66.
    View in: PubMed
  11. Takeda S, Noguchi M, Matsuo K, Yamaguchi Y, Kudo T, Nishimura H, Okamoto Y, Amamoto T, Shindo M, Omiecinski CJ, Aramaki H. (-)-Xanthatin up-regulation of the GADD45? tumor suppressor gene in MDA-MB-231 breast cancer cells: role of topoisomerase IIa inhibition and reactive oxygen species. Toxicology. 2013 Mar 8; 305:1-9.
    View in: PubMed
  12. Takeda S, Harada M, Su S, Okajima S, Miyoshi H, Yoshida K, Nishimura H, Okamoto Y, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H. Induction of the fatty acid 2-hydroxylase (FA2H) gene by ?(9)-tetrahydrocannabinol in human breast cancer cells. J Toxicol Sci. 2013; 38(2):305-8.
    View in: PubMed
  13. Takeda S, Okajima S, Miyoshi H, Yoshida K, Okamoto Y, Okada T, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H. Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Toxicol Lett. 2012 Nov 15; 214(3):314-9.
    View in: PubMed
  14. Laurenzana EM, Chen T, Kannuswamy M, Sell BE, Strom SC, Li Y, Omiecinski CJ. The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3). Mol Pharmacol. 2012 Nov; 82(5):918-28.
    View in: PubMed
  15. Omiecinski CJ, Coslo DM, Chen T, Laurenzana EM, Peffer RC. Multi-species analyses of direct activators of the constitutive androstane receptor. Toxicol Sci. 2011 Oct; 123(2):550-62.
    View in: PubMed
  16. Takeda S, Matsuo K, Yaji K, Okajima-Miyazaki S, Harada M, Miyoshi H, Okamoto Y, Amamoto T, Shindo M, Omiecinski CJ, Aramaki H. (--)-Xanthatin selectively induces GADD45? and stimulates caspase-independent cell death in human breast cancer MDA-MB-231 cells. Chem Res Toxicol. 2011 Jun 20; 24(6):855-65.
    View in: PubMed
  17. Zamule SM, Coslo DM, Chen F, Omiecinski CJ. Differentiation of human embryonic stem cells along a hepatic lineage. Chem Biol Interact. 2011 Mar 15; 190(1):62-72.
    View in: PubMed
  18. DeKeyser JG, Laurenzana EM, Peterson EC, Chen T, Omiecinski CJ. Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor. Toxicol Sci. 2011 Apr; 120(2):381-91.
    View in: PubMed
  19. Takeda S, Hirayama A, Urata S, Mano N, Fukagawa K, Imamura M, Irii A, Kitajima S, Masuyama T, Nomiyama M, Tatei S, Tomita S, Kudo T, Noguchi M, Yamaguchi Y, Okamoto Y, Amamoto T, Fukunishi Y, Watanabe K, Omiecinski CJ, Aramaki H. Cannabidiol-2',6'-dimethyl ether as an effective protector of 15-lipoxygenase-mediated low-density lipoprotein oxidation in vitro. Biol Pharm Bull. 2011; 34(8):1252-6.
    View in: PubMed
  20. Stagliano MC, DeKeyser JG, Omiecinski CJ, Jones AD. Bioassay-directed fractionation for discovery of bioactive neutral lipids guided by relative mass defect filtering and multiplexed collision-induced dissociation. Rapid Commun Mass Spectrom. 2010 Dec 30; 24(24):3578-84.
    View in: PubMed
  21. Omiecinski CJ, Vanden Heuvel JP, Perdew GH, Peters JM. Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities. Toxicol Sci. 2011 Mar; 120 Suppl 1:S49-75.
    View in: PubMed
  22. DiNatale BC, Murray IA, Schroeder JC, Flaveny CA, Lahoti TS, Laurenzana EM, Omiecinski CJ, Perdew GH. Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol Sci. 2010 May; 115(1):89-97.
    View in: PubMed
  23. Schroeder JC, Dinatale BC, Murray IA, Flaveny CA, Liu Q, Laurenzana EM, Lin JM, Strom SC, Omiecinski CJ, Amin S, Perdew GH. The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor. Biochemistry. 2010 Jan 19; 49(2):393-400.
    View in: PubMed
  24. Olsavsky Goyak KM, Laurenzana EM, Omiecinski CJ. Hepatocyte differentiation. Methods Mol Biol. 2010; 640:115-38.
    View in: PubMed
  25. Moody DE, Fang WB, Lin SN, Weyant DM, Strom SC, Omiecinski CJ. Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes. Drug Metab Dispos. 2009 Dec; 37(12):2323-9.
    View in: PubMed
  26. Yang X, Liang SH, Weyant DM, Lazarus P, Gallagher CJ, Omiecinski CJ. The expression of human microsomal epoxide hydrolase is predominantly driven by a genetically polymorphic far upstream promoter. J Pharmacol Exp Ther. 2009 Jul; 330(1):23-30.
    View in: PubMed
  27. DeKeyser JG, Stagliano MC, Auerbach SS, Prabhu KS, Jones AD, Omiecinski CJ. Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2. Mol Pharmacol. 2009 May; 75(5):1005-13.
    View in: PubMed
  28. Goyak KM, Johnson MC, Strom SC, Omiecinski CJ. Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures. Toxicol Appl Pharmacol. 2008 Sep 1; 231(2):216-24.
    View in: PubMed
  29. Zamule SM, Strom SC, Omiecinski CJ. Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes. Chem Biol Interact. 2008 Jun 17; 173(3):179-86.
    View in: PubMed
  30. Bogen KT, Benson JM, Yost GS, Morris JB, Dahl AR, Clewell HJ, Krishnan K, Omiecinski CJ. Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action. Regul Toxicol Pharmacol. 2008 Jul; 51(2 Suppl):S27-36.
    View in: PubMed
  31. Page JL, Strom SC, Omiecinski CJ. Regulation of the human cathepsin E gene by the constitutive androstane receptor. Arch Biochem Biophys. 2007 Nov 1; 467(1):132-8.
    View in: PubMed
  32. Patel RD, Hollingshead BD, Omiecinski CJ, Perdew GH. Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver. Hepatology. 2007 Jul; 46(1):209-18.
    View in: PubMed
  33. Olsavsky KM, Page JL, Johnson MC, Zarbl H, Strom SC, Omiecinski CJ. Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues. Toxicol Appl Pharmacol. 2007 Jul 1; 222(1):42-56.
    View in: PubMed
  34. Stoner MA, Auerbach SS, Zamule SM, Strom SC, Omiecinski CJ. Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites. Nucleic Acids Res. 2007; 35(7):2177-90.
    View in: PubMed
  35. Page JL, Johnson MC, Olsavsky KM, Strom SC, Zarbl H, Omiecinski CJ. Gene expression profiling of extracellular matrix as an effector of human hepatocyte phenotype in primary cell culture. Toxicol Sci. 2007 Jun; 97(2):384-97.
    View in: PubMed
  36. Auerbach SS, Dekeyser JG, Stoner MA, Omiecinski CJ. CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics. Drug Metab Dispos. 2007 Mar; 35(3):428-39.
    View in: PubMed
  37. Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. J Pharmacol Exp Ther. 2007 Jan; 320(1):72-80.
    View in: PubMed
  38. Auerbach SS, Stoner MA, Su S, Omiecinski CJ. Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3). Mol Pharmacol. 2005 Nov; 68(5):1239-53.
    View in: PubMed
  39. Abdel-Rahman SZ, Ammenheuser MM, Omiecinski CJ, Wickliffe JK, Rosenblatt JI, Ward JB. Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region of the microsomal epoxide hydrolase gene (EPHX1). Toxicol Sci. 2005 May; 85(1):624-31.
    View in: PubMed
  40. Hosagrahara VP, Rettie AE, Hassett C, Omiecinski CJ. Functional analysis of human microsomal epoxide hydrolase genetic variants. Chem Biol Interact. 2004 Nov 20; 150(2):149-59.
    View in: PubMed
  41. Liang SH, Hassett C, Omiecinski CJ. Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1). Mol Pharmacol. 2005 Jan; 67(1):220-30.
    View in: PubMed
  42. Sidhu JS, Liu F, Omiecinski CJ. Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes. Exp Cell Res. 2004 Jan 15; 292(2):252-64.
    View in: PubMed
  43. Yamamoto M, Mise M, Matsumoto S, Ito S, Gohyama N, Ishida S, Sagara Y, Omiecinski CJ, Oguri K, Yamada H. Comparison of genomic and cDNA sequences of guinea pig CYP2B18 and rat CYP2B2: absence of a phenobarbital-responsive enhancer module in the upstream region of the CYP2B18 gene. J Biochem Mol Toxicol. 2004; 18(3):124-30.
    View in: PubMed
  44. Auerbach SS, Ramsden R, Stoner MA, Verlinde C, Hassett C, Omiecinski CJ. Alternatively spliced isoforms of the human constitutive androstane receptor. Nucleic Acids Res. 2003 Jun 15; 31(12):3194-207.
    View in: PubMed
  45. Villaroman C, Farin FM, Sidhu JS, Oda D, Omiecinski CJ. Detection of Cytochrome P450 mRNA in Tissue Sections and Cell Lines Using Enzyme-Labeled Fluorescence In Situ Hybridization. In Vitro Toxicol. 1997; 10(3):295-308.
    View in: PubMed
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