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Curtis Omiecinski

TitleProfessor of Veterinary and Biomedical Sciences, H. Thomas and Dorothy Willits Hallowell Chair
InstitutionCollege of Agricultural Sciences
DepartmentVeterinary and Biomedical Sciences
Address306D Life Sciences Bldg
University Park, PA 16802
Phone8148631625
Other Positions
TitleCo-chair of the Intercollege Graduate Degree Program in Molecular Toxicology
InstitutionHuck Institutes of the Life Sciences


 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Veterinary & Biomedical Sciences
H. Thomas and Dorothy Willits Hallowell Chair
Co-chair, Intercollege Graduate Degree Program in Molecular Toxicology

EDUCATION:

B.S. Biology, State Univeristy of New York at Albany, 1975
Ph.D. Pharmacology, University of Washington, Seattle, WA, 1980
Postdoctoral Fellow in Molecular Toxicology, University of Vermont, Burlington, VT, 1980-83

NARRATIVE:

Dr. Omiecinski's research focuses on the role of nuclear receptors, including the constitutive androstane receptor (CAR), as regulators of chemical metabolism, toxicology and liver cancer. His laboratory also studies the genetics, enzymology and transcriptional mechanisms of epoxide hydrolase in relation to lung cancer risk.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Takeda S, Ikeda E, Su S, Harada M, Okazaki H, Yoshioka Y, Nishimura H, Ishii H, Kakizoe K, Taniguchi A, Tokuyasu M, Himeno T, Watanabe K, Omiecinski CJ, Aramaki H. ?(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: Possible involvement of induced levels of PPARa in MDA-MB-231 breast cancer cells. Toxicology. 2014 Dec 4; 326:18-24.
    View in: PubMed
  2. Wahlang B, Falkner KC, Clair HB, Al-Eryani L, Prough RA, States JC, Coslo DM, Omiecinski CJ, Cave MC. Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci. 2014 Aug 1; 140(2):283-97.
    View in: PubMed
  3. Su S, Yang X, Omiecinski CJ. Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter. Biochim Biophys Acta. 2014 Jun; 1839(6):493-505.
    View in: PubMed
  4. Currie RA, Peffer RC, Goetz AK, Omiecinski CJ, Goodman JI. Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action. Toxicology. 2014 Jul 3; 321:80-8.
    View in: PubMed
  5. Chen T, Laurenzana EM, Coslo DM, Chen F, Omiecinski CJ. Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. Biochem J. 2014 Feb 15; 458(1):95-107.
    View in: PubMed
  6. Su S, Omiecinski CJ. Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter. Gene. 2014 Feb 15; 536(1):135-44.
    View in: PubMed
  7. Elcombe CR, Peffer RC, Wolf DC, Bailey J, Bars R, Bell D, Cattley RC, Ferguson SS, Geter D, Goetz A, Goodman JI, Hester S, Jacobs A, Omiecinski CJ, Schoeny R, Xie W, Lake BG. Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Crit Rev Toxicol. 2014 Jan; 44(1):64-82.
    View in: PubMed
  8. Chen F, Zamule SM, Coslo DM, Chen T, Omiecinski CJ. The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells. Dev Biol. 2013 Dec 15; 384(2):155-65.
    View in: PubMed
  9. Takeda S, Yoshida K, Nishimura H, Harada M, Okajima S, Miyoshi H, Okamoto Y, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H. ?(9)-tetrahydrocannabinol disrupts estrogen-signaling through up-regulation of estrogen receptor ß (ERß). Chem Res Toxicol. 2013 Jul 15; 26(7):1073-9.
    View in: PubMed
  10. Nguyen HL, Yang X, Omiecinski CJ. Expression of a novel mRNA transcript for human microsomal epoxide hydrolase (EPHX1) is regulated by short open reading frames within its 5'-untranslated region. RNA. 2013 Jun; 19(6):752-66.
    View in: PubMed
  11. Takeda S, Noguchi M, Matsuo K, Yamaguchi Y, Kudo T, Nishimura H, Okamoto Y, Amamoto T, Shindo M, Omiecinski CJ, Aramaki H. (-)-Xanthatin up-regulation of the GADD45? tumor suppressor gene in MDA-MB-231 breast cancer cells: role of topoisomerase IIa inhibition and reactive oxygen species. Toxicology. 2013 Mar 8; 305:1-9.
    View in: PubMed
  12. Takeda S, Harada M, Su S, Okajima S, Miyoshi H, Yoshida K, Nishimura H, Okamoto Y, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H. Induction of the fatty acid 2-hydroxylase (FA2H) gene by ?(9)-tetrahydrocannabinol in human breast cancer cells. J Toxicol Sci. 2013; 38(2):305-8.
    View in: PubMed
  13. Takeda S, Okajima S, Miyoshi H, Yoshida K, Okamoto Y, Okada T, Amamoto T, Watanabe K, Omiecinski CJ, Aramaki H. Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Toxicol Lett. 2012 Nov 15; 214(3):314-9.
    View in: PubMed
  14. Laurenzana EM, Chen T, Kannuswamy M, Sell BE, Strom SC, Li Y, Omiecinski CJ. The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3). Mol Pharmacol. 2012 Nov; 82(5):918-28.
    View in: PubMed
  15. Omiecinski CJ, Coslo DM, Chen T, Laurenzana EM, Peffer RC. Multi-species analyses of direct activators of the constitutive androstane receptor. Toxicol Sci. 2011 Oct; 123(2):550-62.
    View in: PubMed
  16. Takeda S, Matsuo K, Yaji K, Okajima-Miyazaki S, Harada M, Miyoshi H, Okamoto Y, Amamoto T, Shindo M, Omiecinski CJ, Aramaki H. (--)-Xanthatin selectively induces GADD45? and stimulates caspase-independent cell death in human breast cancer MDA-MB-231 cells. Chem Res Toxicol. 2011 Jun 20; 24(6):855-65.
    View in: PubMed
  17. Zamule SM, Coslo DM, Chen F, Omiecinski CJ. Differentiation of human embryonic stem cells along a hepatic lineage. Chem Biol Interact. 2011 Mar 15; 190(1):62-72.
    View in: PubMed
  18. DeKeyser JG, Laurenzana EM, Peterson EC, Chen T, Omiecinski CJ. Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor. Toxicol Sci. 2011 Apr; 120(2):381-91.
    View in: PubMed
  19. Takeda S, Hirayama A, Urata S, Mano N, Fukagawa K, Imamura M, Irii A, Kitajima S, Masuyama T, Nomiyama M, Tatei S, Tomita S, Kudo T, Noguchi M, Yamaguchi Y, Okamoto Y, Amamoto T, Fukunishi Y, Watanabe K, Omiecinski CJ, Aramaki H. Cannabidiol-2',6'-dimethyl ether as an effective protector of 15-lipoxygenase-mediated low-density lipoprotein oxidation in vitro. Biol Pharm Bull. 2011; 34(8):1252-6.
    View in: PubMed
  20. Stagliano MC, DeKeyser JG, Omiecinski CJ, Jones AD. Bioassay-directed fractionation for discovery of bioactive neutral lipids guided by relative mass defect filtering and multiplexed collision-induced dissociation. Rapid Commun Mass Spectrom. 2010 Dec 30; 24(24):3578-84.
    View in: PubMed
  21. Omiecinski CJ, Vanden Heuvel JP, Perdew GH, Peters JM. Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities. Toxicol Sci. 2011 Mar; 120 Suppl 1:S49-75.
    View in: PubMed
  22. DiNatale BC, Murray IA, Schroeder JC, Flaveny CA, Lahoti TS, Laurenzana EM, Omiecinski CJ, Perdew GH. Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol Sci. 2010 May; 115(1):89-97.
    View in: PubMed
  23. Schroeder JC, Dinatale BC, Murray IA, Flaveny CA, Liu Q, Laurenzana EM, Lin JM, Strom SC, Omiecinski CJ, Amin S, Perdew GH. The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor. Biochemistry. 2010 Jan 19; 49(2):393-400.
    View in: PubMed
  24. Olsavsky Goyak KM, Laurenzana EM, Omiecinski CJ. Hepatocyte differentiation. Methods Mol Biol. 2010; 640:115-38.
    View in: PubMed
  25. Moody DE, Fang WB, Lin SN, Weyant DM, Strom SC, Omiecinski CJ. Effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes. Drug Metab Dispos. 2009 Dec; 37(12):2323-9.
    View in: PubMed
  26. Yang X, Liang SH, Weyant DM, Lazarus P, Gallagher CJ, Omiecinski CJ. The expression of human microsomal epoxide hydrolase is predominantly driven by a genetically polymorphic far upstream promoter. J Pharmacol Exp Ther. 2009 Jul; 330(1):23-30.
    View in: PubMed
  27. DeKeyser JG, Stagliano MC, Auerbach SS, Prabhu KS, Jones AD, Omiecinski CJ. Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2. Mol Pharmacol. 2009 May; 75(5):1005-13.
    View in: PubMed
  28. Goyak KM, Johnson MC, Strom SC, Omiecinski CJ. Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures. Toxicol Appl Pharmacol. 2008 Sep 1; 231(2):216-24.
    View in: PubMed
  29. Zamule SM, Strom SC, Omiecinski CJ. Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes. Chem Biol Interact. 2008 Jun 17; 173(3):179-86.
    View in: PubMed
  30. Bogen KT, Benson JM, Yost GS, Morris JB, Dahl AR, Clewell HJ, Krishnan K, Omiecinski CJ. Naphthalene metabolism in relation to target tissue anatomy, physiology, cytotoxicity and tumorigenic mechanism of action. Regul Toxicol Pharmacol. 2008 Jul; 51(2 Suppl):S27-36.
    View in: PubMed
  31. Page JL, Strom SC, Omiecinski CJ. Regulation of the human cathepsin E gene by the constitutive androstane receptor. Arch Biochem Biophys. 2007 Nov 1; 467(1):132-8.
    View in: PubMed
  32. Patel RD, Hollingshead BD, Omiecinski CJ, Perdew GH. Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver. Hepatology. 2007 Jul; 46(1):209-18.
    View in: PubMed
  33. Olsavsky KM, Page JL, Johnson MC, Zarbl H, Strom SC, Omiecinski CJ. Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues. Toxicol Appl Pharmacol. 2007 Jul 1; 222(1):42-56.
    View in: PubMed
  34. Stoner MA, Auerbach SS, Zamule SM, Strom SC, Omiecinski CJ. Transactivation of a DR-1 PPRE by a human constitutive androstane receptor variant expressed from internal protein translation start sites. Nucleic Acids Res. 2007; 35(7):2177-90.
    View in: PubMed
  35. Page JL, Johnson MC, Olsavsky KM, Strom SC, Zarbl H, Omiecinski CJ. Gene expression profiling of extracellular matrix as an effector of human hepatocyte phenotype in primary cell culture. Toxicol Sci. 2007 Jun; 97(2):384-97.
    View in: PubMed
  36. Auerbach SS, Dekeyser JG, Stoner MA, Omiecinski CJ. CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics. Drug Metab Dispos. 2007 Mar; 35(3):428-39.
    View in: PubMed
  37. Faucette SR, Zhang TC, Moore R, Sueyoshi T, Omiecinski CJ, LeCluyse EL, Negishi M, Wang H. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. J Pharmacol Exp Ther. 2007 Jan; 320(1):72-80.
    View in: PubMed
  38. Auerbach SS, Stoner MA, Su S, Omiecinski CJ. Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3). Mol Pharmacol. 2005 Nov; 68(5):1239-53.
    View in: PubMed
  39. Abdel-Rahman SZ, Ammenheuser MM, Omiecinski CJ, Wickliffe JK, Rosenblatt JI, Ward JB. Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region of the microsomal epoxide hydrolase gene (EPHX1). Toxicol Sci. 2005 May; 85(1):624-31.
    View in: PubMed
  40. Hosagrahara VP, Rettie AE, Hassett C, Omiecinski CJ. Functional analysis of human microsomal epoxide hydrolase genetic variants. Chem Biol Interact. 2004 Nov 20; 150(2):149-59.
    View in: PubMed
  41. Liang SH, Hassett C, Omiecinski CJ. Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1). Mol Pharmacol. 2005 Jan; 67(1):220-30.
    View in: PubMed
  42. Sidhu JS, Liu F, Omiecinski CJ. Phenobarbital responsiveness as a uniquely sensitive indicator of hepatocyte differentiation status: requirement of dexamethasone and extracellular matrix in establishing the functional integrity of cultured primary rat hepatocytes. Exp Cell Res. 2004 Jan 15; 292(2):252-64.
    View in: PubMed
  43. Yamamoto M, Mise M, Matsumoto S, Ito S, Gohyama N, Ishida S, Sagara Y, Omiecinski CJ, Oguri K, Yamada H. Comparison of genomic and cDNA sequences of guinea pig CYP2B18 and rat CYP2B2: absence of a phenobarbital-responsive enhancer module in the upstream region of the CYP2B18 gene. J Biochem Mol Toxicol. 2004; 18(3):124-30.
    View in: PubMed
  44. Auerbach SS, Ramsden R, Stoner MA, Verlinde C, Hassett C, Omiecinski CJ. Alternatively spliced isoforms of the human constitutive androstane receptor. Nucleic Acids Res. 2003 Jun 15; 31(12):3194-207.
    View in: PubMed
  45. Farin FM, Janssen P, Quigley S, Abbott D, Hassett C, Smith-Weller T, Franklin GM, Swanson PD, Longstreth WT, Omiecinski CJ, Checkoway H. Genetic polymorphisms of microsomal and soluble epoxide hydrolase and the risk of Parkinson's disease. Pharmacogenetics. 2001 Nov; 11(8):703-8.
    View in: PubMed
  46. Sidhu JS, Liu F, Boyle SM, Omiecinski CJ. PI3K inhibitors reverse the suppressive actions of insulin on CYP2E1 expression by activating stress-response pathways in primary rat hepatocytes. Mol Pharmacol. 2001 May; 59(5):1138-46.
    View in: PubMed
  47. Fretland AJ, Omiecinski CJ. Epoxide hydrolases: biochemistry and molecular biology. Chem Biol Interact. 2000 Dec 1; 129(1-2):41-59.
    View in: PubMed
  48. Yamada H, Matsunaga H, Tsuji K, Matsumoto S, Yamamoto M, Ishii Y, Omiecinski CJ, Oguri K. Sequence analyses of CYP2B genes and catalytic profiles for P450s in Qdj:Sprague-dawley rats that lack response to the phenobarbital-mediated induction of CYP2B2. J Pharmacol Exp Ther. 2000 Dec; 295(3):986-93.
    View in: PubMed
  49. Sandberg M, Hassett C, Adman ET, Meijer J, Omiecinski CJ. Identification and functional characterization of human soluble epoxide hydrolase genetic polymorphisms. J Biol Chem. 2000 Sep 15; 275(37):28873-81.
    View in: PubMed
  50. Schilter B, Andersen MR, Acharya C, Omiecinski CJ. Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers. J Pharmacol Exp Ther. 2000 Sep; 294(3):916-22.
    View in: PubMed
  51. Beck NB, Sidhu JS, Omiecinski CJ. Baculovirus vectors repress phenobarbital-mediated gene induction and stimulate cytokine expression in primary cultures of rat hepatocytes. Gene Ther. 2000 Aug; 7(15):1274-83.
    View in: PubMed
  52. Krovat BC, Tracy JH, Omiecinski CJ. Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells. Toxicol Sci. 2000 Jun; 55(2):352-60.
    View in: PubMed
  53. Omiecinski CJ, Hassett C, Hosagrahara V. Epoxide hydrolase--polymorphism and role in toxicology. Toxicol Lett. 2000 Mar 15; 112-113:365-70.
    View in: PubMed
  54. Beck NB, Omiecinski CJ. Lack of modulation by phenobarbital of cyclic AMP levels or protein kinase A activity in rat primary hepatocytes. Biochem Pharmacol. 1999 Oct 1; 58(7):1109-14.
    View in: PubMed
  55. Weagant SD, Jagow JA, Jinneman KC, Omiecinski CJ, Kaysner CA, Hill WE. Development of digoxigenin-labeled PCR amplicon probes for use in the detection and identification of enteropathogenic Yersinia and Shiga toxin-producing Escherichia coli from foods. J Food Prot. 1999 May; 62(5):438-43.
    View in: PubMed
  56. Omiecinski CJ, Remmel RP, Hosagrahara VP. Concise review of the cytochrome P450s and their roles in toxicology. Toxicol Sci. 1999 Apr; 48(2):151-6.
    View in: PubMed
  57. Ramsden R, Beck NB, Sommer KM, Omiecinski CJ. Phenobarbital responsiveness conferred by the 5'-flanking region of the rat CYP2B2 gene in transgenic mice. Gene. 1999 Mar 4; 228(1-2):169-79.
    View in: PubMed
  58. Hulla JE, Miller MS, Taylor JA, Hein DW, Furlong CE, Omiecinski CJ, Kunkel TA. Symposium overview: the role of genetic polymorphism and repair deficiencies in environmental disease. Toxicol Sci. 1999 Feb; 47(2):135-43.
    View in: PubMed
  59. Sidhu JS, Omiecinski CJ. Insulin-mediated modulation of cytochrome P450 gene induction profiles in primary rat hepatocyte cultures. J Biochem Mol Toxicol. 1999; 13(1):1-9.
    View in: PubMed
  60. Morgan ET, Sewer MB, Iber H, Gonzalez FJ, Lee YH, Tukey RH, Okino S, Vu T, Chen YH, Sidhu JS, Omiecinski CJ. Physiological and pathophysiological regulation of cytochrome P450. Drug Metab Dispos. 1998 Dec; 26(12):1232-40.
    View in: PubMed
  61. Sado PN, Jinneman KC, Husby GJ, Sorg SM, Omiecinski CJ. Identification of Listeria monocytogenes from unpasteurized apple juice using rapid test kits. J Food Prot. 1998 Sep; 61(9):1199-202.
    View in: PubMed
  62. Laurenzana EM, Hassett C, Omiecinski CJ. Post-transcriptional regulation of human microsomal epoxide hydrolase. Pharmacogenetics. 1998 Apr; 8(2):157-67.
    View in: PubMed
  63. Hassett C, Laurenzana EM, Sidhu JS, Omiecinski CJ. Effects of chemical inducers on human microsomal epoxide hydrolase in primary hepatocyte cultures. Biochem Pharmacol. 1998 Apr 1; 55(7):1059-69.
    View in: PubMed
  64. Andersen MR, Farin FM, Omiecinski CJ. Quantification of multiple human cytochrome P450 mRNA molecules using competitive reverse transcriptase-PCR. DNA Cell Biol. 1998 Mar; 17(3):231-8.
    View in: PubMed
  65. Sidhu JS, Omiecinski CJ. Protein synthesis inhibitors exhibit a nonspecific effect on phenobarbital-inducible cytochome P450 gene expression in primary rat hepatocytes. J Biol Chem. 1998 Feb 20; 273(8):4769-75.
    View in: PubMed
  66. Hartsfield JK, Sutcliffe MJ, Everett ET, Hassett C, Omiecinski CJ, Saari JA. Assignment1 of microsomal epoxide hydrolase (EPHX1) to human chromosome 1q42.1 by in situ hybridization. Cytogenet Cell Genet. 1998; 83(1-2):44-5.
    View in: PubMed
  67. Sidhu JS, Marcus CB, Parkinson A, Omiecinski CJ. Differential induction of cytochrome P450 gene expression by 4n-alkyl-methylenedioxybenzenes in primary rat hepatocyte cultures. J Biochem Mol Toxicol. 1998; 12(5):253-62.
    View in: PubMed
  68. Sidhu JS, Omiecinski CJ. An okadaic acid-sensitive pathway involved in the phenobarbital-mediated induction of CYP2B gene expression in primary rat hepatocyte cultures. J Pharmacol Exp Ther. 1997 Aug; 282(2):1122-9.
    View in: PubMed
  69. Hassett C, Lin J, Carty CL, Laurenzana EM, Omiecinski CJ. Human hepatic microsomal epoxide hydrolase: comparative analysis of polymorphic expression. Arch Biochem Biophys. 1997 Jan 15; 337(2):275-83.
    View in: PubMed
  70. Villaroman C, Farin FM, Sidhu JS, Oda D, Omiecinski CJ. Detection of Cytochrome P450 mRNA in Tissue Sections and Cell Lines Using Enzyme-Labeled Fluorescence In Situ Hybridization. In Vitro Toxicol. 1997; 10(3):295-308.
    View in: PubMed
  71. Omiecinski CJ. Phenobarbital induction of cytochrome P450 genes in primary hepatocyte and transgenic models. J Toxicol Sci. 1996 Dec; 21(5):279-81.
    View in: PubMed
  72. Sommer KM, Ramsden R, Sidhu J, Costa P, Omiecinski CJ. Promoter region analysis of the rat CYP2B1 and CYP2B2 genes. Pharmacogenetics. 1996 Aug; 6(4):369-74.
    View in: PubMed
  73. Heinonen JT, Sidhu JS, Reilly MT, Farin FM, Omiecinski CJ, Eaton DL, Kavanagh TJ. Assessment of regional cytochrome P450 activities in rat liver slices using resorufin substrates and fluorescence confocal laser cytometry. Environ Health Perspect. 1996 May; 104(5):536-43.
    View in: PubMed
  74. Sidhu JS, Omiecinski CJ. Forskolin-mediated induction of CYP3A1 mRNA expression in primary rat hepatocytes is independent of elevated intracellular cyclic AMP. J Pharmacol Exp Ther. 1996 Jan; 276(1):238-45.
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  75. Richardson TH, Jung F, Griffin KJ, Wester M, Raucy JL, Kemper B, Bornheim LM, Hassett C, Omiecinski CJ, Johnson EF. A universal approach to the expression of human and rabbit cytochrome P450s of the 2C subfamily in Escherichia coli. Arch Biochem Biophys. 1995 Oct 20; 323(1):87-96.
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  76. Farin FM, Bigler LG, Oda D, McDougall JK, Omiecinski CJ. Expression of cytochrome P450 and microsomal exposide hydrolase in cervical and oral epithelial cells immortalized by human papillomavirus type 16 E6/E7 genes. Carcinogenesis. 1995 Jul; 16(7):1670.
    View in: PubMed
  77. Farin FM, Bigler LG, Oda D, McDougall JK, Omiecinski CJ. Expression of cytochrome P450 and microsomal epoxide hydrolase in cervical and oral epithelial cells immortalized by human papillomavirus type 16 E6/E7 genes. Carcinogenesis. 1995 Jun; 16(6):1391-401.
    View in: PubMed
  78. Sidhu JS, Omiecinski CJ. cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures. J Biol Chem. 1995 May 26; 270(21):12762-73.
    View in: PubMed
  79. Sidhu JS, Omiecinski CJ. Modulation of xenobiotic-inducible cytochrome P450 gene expression by dexamethasone in primary rat hepatocytes. Pharmacogenetics. 1995 Feb; 5(1):24-36.
    View in: PubMed
  80. Nims RW, Sidhu JS, Thomas PE, Mellini DW, Nelson VC, Omiecinski CJ, Lubet RA. Absence of enantioselectivity in the pharmacodynamics of P450 2B induction by 5-ethyl-5-phenylhydantoin in the male rat liver or in cultured rat hepatocytes. J Biochem Toxicol. 1994 Dec; 9(6):279-88.
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  81. Hassett C, Robinson KB, Beck NB, Omiecinski CJ. The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization. Genomics. 1994 Sep 15; 23(2):433-42.
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  82. Omiecinski CJ, Aicher L, Swenson L. Developmental expression of human microsomal epoxide hydrolase. J Pharmacol Exp Ther. 1994 Apr; 269(1):417-23.
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  83. Hassett C, Aicher L, Sidhu JS, Omiecinski CJ. Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Hum Mol Genet. 1994 Mar; 3(3):421-8.
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  84. Farin FM, Pohlman TH, Omiecinski CJ. Expression of cytochrome P450s and microsomal epoxide hydrolase in primary cultures of human umbilical vein endothelial cells. Toxicol Appl Pharmacol. 1994 Jan; 124(1):1-9.
    View in: PubMed
  85. Schilter B, Omiecinski CJ. Regional distribution and expression modulation of cytochrome P-450 and epoxide hydrolase mRNAs in the rat brain. Mol Pharmacol. 1993 Nov; 44(5):990-6.
    View in: PubMed
  86. Ramsden R, Sommer KM, Omiecinski CJ. Phenobarbital induction and tissue-specific expression of the rat CYP2B2 gene in transgenic mice. J Biol Chem. 1993 Oct 15; 268(29):21722-6.
    View in: PubMed
  87. Sidhu JS, Kavanagh TJ, Reilly MT, Omiecinski CJ. Direct determination of functional activity of cytochrome P-4501A1 and NADPH DT-diaphorase in hepatoma cell lines using noninvasive scanning laser cytometry. J Toxicol Environ Health. 1993 Oct-Nov; 40(2-3):177-94.
    View in: PubMed
  88. Farin FM, Omiecinski CJ. Regiospecific expression of cytochrome P-450s and microsomal epoxide hydrolase in human brain tissue. J Toxicol Environ Health. 1993 Oct-Nov; 40(2-3):317-35.
    View in: PubMed
  89. Omiecinski CJ, Aicher L, Holubkov R, Checkoway H. Human peripheral lymphocytes as indicators of microsomal epoxide hydrolase activity in liver and lung. Pharmacogenetics. 1993 Jun; 3(3):150-8.
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  90. Furlong CE, Costa LG, Hassett C, Richter RJ, Sundstrom JA, Adler DA, Disteche CM, Omiecinski CJ, Chapline C, Crabb JW, et al. Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification. Chem Biol Interact. 1993 Jun; 87(1-3):35-48.
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  91. Sidhu JS, Farin FM, Omiecinski CJ. Influence of extracellular matrix overlay on phenobarbital-mediated induction of CYP2B1, 2B2, and 3A1 genes in primary adult rat hepatocyte culture. Arch Biochem Biophys. 1993 Feb 15; 301(1):103-13.
    View in: PubMed
  92. Humbert R, Adler DA, Disteche CM, Hassett C, Omiecinski CJ, Furlong CE. The molecular basis of the human serum paraoxonase activity polymorphism. Nat Genet. 1993 Jan; 3(1):73-6.
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  93. Andersen MR, Omiecinski CJ. Direct extraction of bacterial plasmids from food for polymerase chain reaction amplification. Appl Environ Microbiol. 1992 Dec; 58(12):4080-2.
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  94. Omiecinski CJ, Ramsden R, Rampersaud A, Walz FG. Null phenotype for cytochrome P450 2B2 in the rat results from a deletion of its structural gene. Mol Pharmacol. 1992 Aug; 42(2):249-56.
    View in: PubMed
  95. Chen ZY, Farin F, Omiecinski CJ, Eaton DL. Association between growth stimulation by phenobarbital and expression of cytochromes P450 1A1, 1A2, 2B1/2 and 3A1 in hepatic hyperplastic nodules in male F344 rats. Carcinogenesis. 1992 Apr; 13(4):675-82.
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  96. Hassett C, Richter RJ, Humbert R, Chapline C, Crabb JW, Omiecinski CJ, Furlong CE. Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence. Biochemistry. 1991 Oct 22; 30(42):10141-9.
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  97. Hassett C, Ramsden R, Omiecinski CJ. Isolating cytochrome P450 cDNA and genomic clones: library screening with synthetic DNA oligomers. Methods Enzymol. 1991; 206:291-301.
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  98. Omiecinski CJ, Hassett C, Costa P. Developmental expression and in situ localization of the phenobarbital-inducible rat hepatic mRNAs for cytochromes CYP2B1, CYP2B2, CYP2C6, and CYP3A1. Mol Pharmacol. 1990 Oct; 38(4):462-70.
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  99. Omiecinski CJ, Redlich CA, Costa P. Induction and developmental expression of cytochrome P450IA1 messenger RNA in rat and human tissues: detection by the polymerase chain reaction. Cancer Res. 1990 Jul 15; 50(14):4315-21.
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  100. Hassett C, Omiecinski CJ. Sequence and gene expression of rabbit cytochrome P450 IIC16: comparison to highly related family members. Nucleic Acids Res. 1990 Mar 25; 18(6):1429-34.
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  101. Marcus CB, Wilson NM, Keith IM, Jefcoate CR, Omiecinski CJ. Selective expression of cytochrome P450 isozymes by 4-n-alkyl-methylenedioxybenzenes in rat lung cells. Arch Biochem Biophys. 1990 Feb 15; 277(1):17-25.
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  102. Marcus CB, Wilson NM, Jefcoate CR, Wilkinson CF, Omiecinski CJ. Selective induction of cytochrome P450 isozymes in rat liver by 4-n-alkyl-methylenedioxybenzenes. Arch Biochem Biophys. 1990 Feb 15; 277(1):8-16.
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  103. Wilson NM, Omiecinski CJ. Xenobiotic microsomal epoxide hydrolase: 5' sequence of the human gene. Biochim Biophys Acta. 1989 Aug 14; 1008(3):357-8.
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  104. Hassett C, Turnblom SM, DeAngeles A, Omiecinski CJ. Rabbit microsomal epoxide hydrolase: isolation and characterization of the xenobiotic metabolizing enzyme cDNA. Arch Biochem Biophys. 1989 Jun; 271(2):380-9.
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  105. Giachelli CM, Lin-Jones J, Omiecinski CJ. Isolation and characterization of rat cytochrome P-450IIB gene family members. Use of the polymerase chain reaction to detect expression of a novel P-450 mRNA. J Biol Chem. 1989 Apr 25; 264(12):7046-53.
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  106. Hassett C, Luchtel DL, Omiecinski CJ. Hepatic expression of rat P450 mRNA assessed by in situ hybridization to oligomer probes. DNA. 1989 Jan-Feb; 8(1):29-37.
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  107. Schuetz EG, Li D, Omiecinski CJ, Muller-Eberhard U, Kleinman HK, Elswick B, Guzelian PS. Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix. J Cell Physiol. 1988 Mar; 134(3):309-23.
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  108. Hassett C, Omiecinski CJ. Use of a conserved consensus oligomer in the identification of cytochrome P-450 mRNAs. Biochem Biophys Res Commun. 1987 Dec 16; 149(2):326-33.
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  109. Giachelli CM, Omiecinski CJ. Developmental regulation of cytochrome P-450 genes in the rat. Mol Pharmacol. 1987 May; 31(5):477-84.
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  110. Omiecinski CJ. Tissue-specific expression of rat mRNAs homologous to cytochromes P-450b and P-450e. Nucleic Acids Res. 1986 Feb 11; 14(3):1525-39.
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  111. Giachelli CM, Omiecinski CJ. Regulation of cytochrome P-450b and P-450e mRNA expression in the developing rat. Hybridization to synthetic oligodeoxyribonucleotide probes. J Biol Chem. 1986 Jan 25; 261(3):1359-63.
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  112. Omiecinski CJ, Walz FG, Vlasuk GP. Phenobarbital induction of rat liver cytochromes P-450b and P-450e. Quantitation of specific RNAs by hybridization to synthetic oligodeoxyribonucleotide probes. J Biol Chem. 1985 Mar 25; 260(6):3247-50.
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  113. Omiecinski CJ, Hines RN, Foldes RL, Levy JB, Bresnick E. Molecular induction by phenobarbital of a rat hepatic form of cytochrome P-450: expression of a 4-kilobase messenger RNA. Arch Biochem Biophys. 1983 Dec; 227(2):478-93.
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  114. Walz FG, Vlasuk GP, Omiecinski CJ, Bresnick E, Thomas PE, Ryan DE, Levin W. Multiple, immunoidentical forms of phenobarbital-induced rat liver cytochromes P-450 are encoded by different mRNAs. J Biol Chem. 1982 Apr 25; 257(8):4023-6.
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  115. Omiecinski CJ, Namkung MJ, Juchau MR. Substrate and position specificity of hematin-activated monooxygenation reactions. Biochem Pharmacol. 1981 Oct; 30(20):2837-45.
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  116. Chao ST, Omiecinski CJ, Namkung MJ, Nelson SD, Dvorchik BH, Juchau MR. Catechol estrogen formation in placental and fetal tissues of humans, macaques, rats and rabbits. Dev Pharmacol Ther. 1981; 2(1):1-16.
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  117. Juchau MR, Chao ST, Omiecinski CJ. Drug metabolism by the human fetus. Clin Pharmacokinet. 1980 Jul-Aug; 5(4):320-39.
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  118. Omiecinski CJ, Namkung MJ, Juchau MR. Mechanistic aspects of the hematin-mediated increases in brain monooxygenase activities. Mol Pharmacol. 1980 Mar; 17(2):255-32.
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  119. Omiecinski CJ, Chao ST, Juchau MR. Modulation of monooxygenase activities by hematin and 7,8-benzoflavone in fetal tissues of rats, rabbits, and humans. Dev Pharmacol Ther. 1980; 1(1):90-100.
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  120. Omiecinski CJ, Juchau MR. Activators of cytochrome P-450 dependent monooxygenation reactions. Proc West Pharmacol Soc. 1980; 23:9-10.
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  121. Bond JA, Omiecinski CJ, Juchau MR. Kinetics, activation, and induction of aortic mono-oxygenases--biotransformation of benzo[a]pyrene. Biochem Pharmacol. 1979; 28(2):305-11.
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  122. Omiecinski CJ, Bond JA, Juchau MR. Stimulation by hematin of monooxygenase activity in extra-hepatic tissues from rats, rabbits and chickens. Biochem Biophys Res Commun. 1978 Aug 14; 83(3):1004-11.
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