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Christopher Lynch

TitleProfessor
InstitutionCollege of Medicine
DepartmentCellular and Molecular Physiology
Address500 University Drive Hershey PA 17033
Mailbox: H166
Phone7175315170

 Overview 
 overview
PREFERRED TITLE/ROLE:
Professor and Vice Chair of Cellular and Molecular Physiology

GRADUATE PROGRAM AFFILIATIONS:
MD/PhD Degree Program, Physiology (Integrative Biolsciences), Molecular Medicine (Integrative Biolsciences), Biomedical Sciences Graduate program

EDUCATION:
Ph.D., Northeastern University, 1983
Postdoctoral Training, Howard Hughes Medical Institute, Vanderbilt University Medical School, 1983-1988

LAB WEB SITE:
http://www2.med.psu.edu/lynchlab/

NARRATIVE:
Our laboratory is dedicated to developing cures for metabolic diseases like Obesity, Diabetes and MSUD. We have several projects:
Project 1: How Antipsychotic Drugs Exert Obesity and Metabolic Disease Side effects
Project 2: Impact of Branched Chain Amino Acid (BCAA) signaling and metabolism in obesity and diabetes.
Project 3: Adipose tissue transplant as a treatment for Maple Syrup Urine Disease.
Project 4: How Gastric Bypass Surgery Provides A Rapid Cure For Diabetes And Other Obesity Co-Morbidities Like Hypertension
Project 5: Novel Mechanism Of Action Of Cannabinoid Receptor 1 Blockers For Improvement Of Diabetes



 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zimmerman HA, Olson KC, Chen G, Lynch CJ. Adipose transplant for inborn errors of branched chain amino acid metabolism in mice. Mol Genet Metab. 2013 Aug; 109(4):345-53.
    View in: PubMed
  2. Olson KC, Chen G, Lynch CJ. Quantification of branched-chain keto acids in tissue by ultra fast liquid chromatography-mass spectrometry. Anal Biochem. 2013 Aug 15; 439(2):116-22.
    View in: PubMed
  3. She P, Olson KC, Kadota Y, Inukai A, Shimomura Y, Hoppel CL, Adams SH, Kawamata Y, Matsumoto H, Sakai R, Lang CH, Lynch CJ. Leucine and protein metabolism in obese Zucker rats. PLoS One. 2013; 8(3):e59443.
    View in: PubMed
  4. Lackey DE, Lynch CJ, Olson KC, Mostaedi R, Ali M, Smith WH, Karpe F, Humphreys S, Bedinger DH, Dunn TN, Thomas AP, Oort PJ, Kieffer DA, Amin R, Bettaieb A, Haj FG, Permana P, Anthony TG, Adams SH. Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity. Am J Physiol Endocrinol Metab. 2013 Jun 1; 304(11):E1175-87.
    View in: PubMed
  5. Carr TD, DiGiovanni J, Lynch CJ, Shantz LM. Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival. Cancer Prev Res (Phila). 2012 Dec; 5(12):1394-404.
    View in: PubMed
  6. Lynch CJ, Zhou Q, Shyng SL, Heal DJ, Cheetham SC, Dickinson K, Gregory P, Firnges M, Nordheim U, Goshorn S, Reiche D, Turski L, Antel J. Some cannabinoid receptor ligands and their distomers are direct-acting openers of SUR1 K(ATP) channels. Am J Physiol Endocrinol Metab. 2012 Mar 1; 302(5):E540-51.
    View in: PubMed
  7. Albaugh VL, Singareddy R, Mauger D, Lynch CJ. A double blind, placebo-controlled, randomized crossover study of the acute metabolic effects of olanzapine in healthy volunteers. PLoS One. 2011; 6(8):e22662.
    View in: PubMed
  8. She P, Zhang Z, Marchionini D, Diaz WC, Jetton TJ, Kimball SR, Vary TC, Lang CH, Lynch CJ. Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease. Am J Physiol Endocrinol Metab. 2011 Jul; 301(1):E49-61.
    View in: PubMed
  9. Fogle RL, Hollenbeak CS, Stanley BA, Vary TC, Kimball SR, Lynch CJ. Functional proteomic analysis reveals sex-dependent differences in structural and energy-producing myocardial proteins in rat model of alcoholic cardiomyopathy. Physiol Genomics. 2011 Apr 12; 43(7):346-56.
    View in: PubMed
  10. Zhou Y, Jetton TL, Goshorn S, Lynch CJ, She P. Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion. J Biol Chem. 2010 Oct 29; 285(44):33718-26.
    View in: PubMed
  11. Agostino NM, Chinchilli VM, Lynch CJ, Koszyk-Szewczyk A, Gingrich R, Sivik J, Drabick JJ. Effect of the tyrosine kinase inhibitors (sunitinib, sorafenib, dasatinib, and imatinib) on blood glucose levels in diabetic and nondiabetic patients in general clinical practice. J Oncol Pharm Pract. 2011 Sep; 17(3):197-202.
    View in: PubMed
  12. Li J, Romestaing C, Han X, Li Y, Hao X, Wu Y, Sun C, Liu X, Jefferson LS, Xiong J, Lanoue KF, Chang Z, Lynch CJ, Wang H, Shi Y. Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity. Cell Metab. 2010 Aug 4; 12(2):154-65.
    View in: PubMed
  13. Culnan DM, Albaugh V, Sun M, Lynch CJ, Lang CH, Cooney RN. Ileal interposition improves glucose tolerance and insulin sensitivity in the obese Zucker rat. Am J Physiol Gastrointest Liver Physiol. 2010 Sep; 299(3):G751-60.
    View in: PubMed
  14. Hajnal A, Kovacs P, Ahmed T, Meirelles K, Lynch CJ, Cooney RN. Gastric bypass surgery alters behavioral and neural taste functions for sweet taste in obese rats. Am J Physiol Gastrointest Liver Physiol. 2010 Oct; 299(4):G967-79.
    View in: PubMed
  15. Lang CH, Lynch CJ, Vary TC. BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice. Am J Physiol Regul Integr Comp Physiol. 2010 Sep; 299(3):R935-44.
    View in: PubMed
  16. Albaugh VL, Vary TC, Ilkayeva O, Wenner BR, Maresca KP, Joyal JL, Breazeale S, Elich TD, Lang CH, Lynch CJ. Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents. Schizophr Bull. 2012 Jan; 38(1):153-66.
    View in: PubMed
  17. Fogle RL, Lynch CJ, Palopoli M, Deiter G, Stanley BA, Vary TC. Impact of chronic alcohol ingestion on cardiac muscle protein expression. Alcohol Clin Exp Res. 2010 Jul; 34(7):1226-34.
    View in: PubMed
  18. Lang CH, Frost RA, Bronson SK, Lynch CJ, Vary TC. Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. Am J Physiol Endocrinol Metab. 2010 Jun; 298(6):E1283-94.
    View in: PubMed
  19. Albaugh VL, Judson JG, She P, Lang CH, Maresca KP, Joyal JL, Lynch CJ. Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis. Mol Psychiatry. 2011 May; 16(5):569-81.
    View in: PubMed
  20. Lang CH, Lynch CJ, Vary TC. Alcohol-induced IGF-I resistance is ameliorated in mice deficient for mitochondrial branched-chain aminotransferase. J Nutr. 2010 May; 140(5):932-8.
    View in: PubMed
  21. She P, Zhou Y, Zhang Z, Griffin K, Gowda K, Lynch CJ. Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance. J Appl Physiol (1985). 2010 Apr; 108(4):941-9.
    View in: PubMed
  22. Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB. Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem. 2010 Apr 9; 285(15):11348-56.
    View in: PubMed
  23. Li P, Knabe DA, Kim SW, Lynch CJ, Hutson SM, Wu G. Lactating porcine mammary tissue catabolizes branched-chain amino acids for glutamine and aspartate synthesis. J Nutr. 2009 Aug; 139(8):1502-9.
    View in: PubMed
  24. Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. 2009 Jun; 119(6):1678-87.
    View in: PubMed
  25. Nairizi A, She P, Vary TC, Lynch CJ. Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice. J Nutr. 2009 Apr; 139(4):715-9.
    View in: PubMed
  26. Meirelles K, Ahmed T, Culnan DM, Lynch CJ, Lang CH, Cooney RN. Mechanisms of glucose homeostasis after Roux-en-Y gastric bypass surgery in the obese, insulin-resistant Zucker rat. Ann Surg. 2009 Feb; 249(2):277-85.
    View in: PubMed
  27. Culnan DM, Cooney RN, Stanley B, Lynch CJ. Apolipoprotein A-IV, a putative satiety/antiatherogenic factor, rises after gastric bypass. Obesity (Silver Spring). 2009 Jan; 17(1):46-52.
    View in: PubMed
  28. She P, Van Horn C, Reid T, Hutson SM, Cooney RN, Lynch CJ. Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1552-63.
    View in: PubMed
  29. She P, Reid TM, Bronson SK, Vary TC, Hajnal A, Lynch CJ, Hutson SM. Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab. 2007 Sep; 6(3):181-94.
    View in: PubMed
  30. Vary TC, Lynch CJ. Nutrient signaling components controlling protein synthesis in striated muscle. J Nutr. 2007 Aug; 137(8):1835-43.
    View in: PubMed
  31. Vary TC, Deiter G, Lynch CJ. Rapamycin limits formation of active eukaryotic initiation factor 4F complex following meal feeding in rat hearts. J Nutr. 2007 Aug; 137(8):1857-62.
    View in: PubMed
  32. Vary TC, Anthony JC, Jefferson LS, Kimball SR, Lynch CJ. Rapamycin blunts nutrient stimulation of eIF4G, but not PKCepsilon phosphorylation, in skeletal muscle. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E188-96.
    View in: PubMed
  33. Vary TC, Lynch CJ. Meal feeding stimulates phosphorylation of multiple effector proteins regulating protein synthetic processes in rat hearts. J Nutr. 2006 Sep; 136(9):2284-90.
    View in: PubMed
  34. Lynch CJ, Gern B, Lloyd C, Hutson SM, Eicher R, Vary TC. Leucine in food mediates some of the postprandial rise in plasma leptin concentrations. Am J Physiol Endocrinol Metab. 2006 Sep; 291(3):E621-30.
    View in: PubMed
  35. Albaugh VL, Henry CR, Bello NT, Hajnal A, Lynch SL, Halle B, Lynch CJ. Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents. Obesity (Silver Spring). 2006 Jan; 14(1):36-51.
    View in: PubMed
  36. Vary TC, Lynch CJ. Meal feeding enhances formation of eIF4F in skeletal muscle: role of increased eIF4E availability and eIF4G phosphorylation. Am J Physiol Endocrinol Metab. 2006 Apr; 290(4):E631-42.
    View in: PubMed
  37. Vary TC, Goodman S, Kilpatrick LE, Lynch CJ. Nutrient regulation of PKCepsilon is mediated by leucine, not insulin, in skeletal muscle. Am J Physiol Endocrinol Metab. 2005 Oct; 289(4):E684-94.
    View in: PubMed
  38. Vary TC, Lynch CJ. Biochemical approaches for nutritional support of skeletal muscle protein metabolism during sepsis. Nutr Res Rev. 2004 Jun; 17(1):77-88.
    View in: PubMed
  39. Lynch CJ, Halle B, Fujii H, Vary TC, Wallin R, Damuni Z, Hutson SM. Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR. Am J Physiol Endocrinol Metab. 2003 Oct; 285(4):E854-63.
    View in: PubMed
  40. Lynch CJ, Hutson SM, Patson BJ, Vaval A, Vary TC. Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats. Am J Physiol Endocrinol Metab. 2002 Oct; 283(4):E824-35.
    View in: PubMed
  41. Lynch CJ, Patson BJ, Anthony J, Vaval A, Jefferson LS, Vary TC. Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue. Am J Physiol Endocrinol Metab. 2002 Sep; 283(3):E503-13.
    View in: PubMed
  42. Vary TC, Lynch CJ, Lang CH. Effects of chronic alcohol consumption on regulation of myocardial protein synthesis. Am J Physiol Heart Circ Physiol. 2001 Sep; 281(3):H1242-51.
    View in: PubMed
  43. Lynch CJ, Patson BJ, Goodman SA, Trapolsi D, Kimball SR. Zinc stimulates the activity of the insulin- and nutrient-regulated protein kinase mTOR. Am J Physiol Endocrinol Metab. 2001 Jul; 281(1):E25-34.
    View in: PubMed
  44. Lynch CJ. Role of leucine in the regulation of mTOR by amino acids: revelations from structure-activity studies. J Nutr. 2001 Mar; 131(3):861S-865S.
    View in: PubMed
  45. Pham PT, Heydrick SJ, Fox HL, Kimball SR, Jefferson LS, Lynch CJ. Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes. J Cell Biochem. 2000 Sep 7; 79(3):427-41.
    View in: PubMed
  46. Lynch CJ, Fox HL, Vary TC, Jefferson LS, Kimball SR. Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes. J Cell Biochem. 2000 Mar; 77(2):234-51.
    View in: PubMed
  47. Miller BA, Zhang MY, Gocke CD, De Souza C, Osmani AH, Lynch C, Davies J, Bell L, Osmani SA. A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. Exp Hematol. 1999 Apr; 27(4):742-50.
    View in: PubMed
  48. Fox HL, Pham PT, Kimball SR, Jefferson LS, Lynch CJ. Amino acid effects on translational repressor 4E-BP1 are mediated primarily by L-leucine in isolated adipocytes. Am J Physiol. 1998 Nov; 275(5 Pt 1):C1232-8.
    View in: PubMed
  49. Fox HL, Kimball SR, Jefferson LS, Lynch CJ. Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters. Am J Physiol. 1998 Jan; 274(1 Pt 1):C206-13.
    View in: PubMed
  50. Gamberino WC, Berkich DA, Lynch CJ, Xu B, LaNoue KF. Role of pyruvate carboxylase in facilitation of synthesis of glutamate and glutamine in cultured astrocytes. J Neurochem. 1997 Dec; 69(6):2312-25.
    View in: PubMed
  51. Brown LM, Fox HL, Hazen SA, LaNoue KF, Rannels SR, Lynch CJ. Role of the matrixin MMP-2 in multicellular organization of adipocytes cultured in basement membrane components. Am J Physiol. 1997 Mar; 272(3 Pt 1):C937-49.
    View in: PubMed
  52. Hazen SA, Waheed A, Sly WS, LaNoue KF, Lynch CJ. Effect of carbonic anhydrase inhibition and acetoacetate on anaplerotic pyruvate carboxylase activity in cultured rat astrocytes. Dev Neurosci. 1997; 19(2):162-71.
    View in: PubMed
  53. Hazen SA, Waheed A, Sly WS, LaNoue KF, Lynch CJ. Differentiation-dependent expression of CA V and the role of carbonic anhydrase isozymes in pyruvate carboxylation in adipocytes. FASEB J. 1996 Mar; 10(4):481-90.
    View in: PubMed
  54. Lynch CJ, McCall KM, Ng YC, Hazen SA. Glucagon stimulation of hepatic Na(+)-pump activity and alpha-subunit phosphorylation in rat hepatocytes. Biochem J. 1996 Feb 1; 313 ( Pt 3):983-9.
    View in: PubMed
  55. Lynch CJ, Fox H, Hazen SA, Stanley BA, Dodgson S, Lanoue KF. Role of hepatic carbonic anhydrase in de novo lipogenesis. Biochem J. 1995 Aug 15; 310 ( Pt 1):197-202.
    View in: PubMed
  56. Hazen SA, Rowe WA, Lynch CJ. Monolayer cell culture of freshly isolated adipocytes using extracellular basement membrane components. J Lipid Res. 1995 Apr; 36(4):868-75.
    View in: PubMed
  57. Miller BA, Bell LL, Lynch CJ, Cheung JY. Erythropoietin modulation of intracellular calcium: a role for tyrosine phosphorylation. Cell Calcium. 1994 Dec; 16(6):481-90.
    View in: PubMed
  58. Lynch CJ, Mader AC, McCall KM, Ng YC, Hazen SA. Okadaic acid stimulates ouabain-sensitive 86Rb(+)-uptake and phosphorylation of the Na+/K(+)-ATPase alpha-subunit in rat hepatocytes. FEBS Lett. 1994 Nov 28; 355(2):157-62.
    View in: PubMed
  59. Owens EL, Lynch CJ, McCall KM, Carter ND, Vary TC. Altered expression of skeletal muscle proteins during sepsis. Shock. 1994 Sep; 2(3):171-8.
    View in: PubMed
  60. Vary TC, Nairn A, Lynch CJ. Role of elongation factor 2 in regulating peptide-chain elongation in the heart. Am J Physiol. 1994 Apr; 266(4 Pt 1):E628-34.
    View in: PubMed
  61. Lynch CJ, Hazen SA, Horetsky RL, Carter ND, Dodgson SJ. Differentiation-dependent expression of carbonic anhydrase II and III in 3T3 adipocytes. Am J Physiol. 1993 Jul; 265(1 Pt 1):C234-43.
    View in: PubMed
  62. Lynch CJ, Brennan WA, Vary TC, Carter N, Dodgson SJ. Carbonic anhydrase III in obese Zucker rats. Am J Physiol. 1993 Apr; 264(4 Pt 1):E621-30.
    View in: PubMed
  63. Lynch CJ, McCall KM, Billingsley ML, Bohlen LM, Hreniuk SP, Martin LF, Witters LA, Vannucci SJ. Pyruvate carboxylase in genetic obesity. Am J Physiol. 1992 May; 262(5 Pt 1):E608-18.
    View in: PubMed
  64. Lynch CJ, Blackmore PF, Johnson EH, Wange RL, Krone PK, Exton JH. Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides. J Clin Invest. 1989 Jun; 83(6):2050-62.
    View in: PubMed
  65. Bouscarel B, Wilson PB, Blackmore PF, Lynch CJ, Exton JH. Agonist-induced down-regulation of the angiotensin II receptor in primary cultures of rat hepatocytes. J Biol Chem. 1988 Oct 15; 263(29):14920-4.
    View in: PubMed
  66. Lynch CJ, Taylor SJ, Smith JA, Exton JH. Formation of the high-affinity agonist state of the alpha 1-adrenergic receptor at cold temperatures does not require a G-protein. FEBS Lett. 1988 Feb 29; 229(1):54-8.
    View in: PubMed
  67. Blackmore PF, Lynch CJ, Uhing RJ, Fitzgerald T, Bocckino SB, Exton JH. Role of guanine nucleotide regulatory proteins and inositol phosphates in the hormone induced mobilization of hepatocyte calcium. Adv Exp Med Biol. 1988; 232:169-82.
    View in: PubMed
  68. Blackmore PF, Exton JH. Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate. J Biol Chem. 1986 Aug 25; 261(24):11056-63.
    View in: PubMed
  69. Lynch CJ, Morbach L, Blackmore PF, Exton JH. Alpha-subunits of Ns are released from the plasma membrane following cholera toxin activation. FEBS Lett. 1986 May 12; 200(2):333-6.
    View in: PubMed
  70. Lynch CJ, Prpic V, Blackmore PF, Exton JH. Effect of islet-activating pertussis toxin on the binding characteristics of Ca2+-mobilizing hormones and on agonist activation of phosphorylase in hepatocytes. Mol Pharmacol. 1986 Feb; 29(2):196-203.
    View in: PubMed
  71. Lynch CJ, Sobo GE, Exton JH. An endogenous Ca2+-sensitive proteinase converts the hepatic alpha 1-adrenergic receptor to guanine nucleotide-insensitive forms. Biochim Biophys Acta. 1986 Jan 23; 885(1):110-20.
    View in: PubMed
  72. Lynch CJ, Blackmore PF, Charest R, Exton JH. The relationships between receptor binding capacity for norepinephrine, angiotensin II, and vasopressin and release of inositol trisphosphate, Ca2+ mobilization, and phosphorylase activation in rat liver. Mol Pharmacol. 1985 Aug; 28(2):93-9.
    View in: PubMed
  73. Lynch CJ, Charest R, Bocckino SB, Exton JH, Blackmore PF. Inhibition of hepatic alpha 1-adrenergic effects and binding by phorbol myristate acetate. J Biol Chem. 1985 Mar 10; 260(5):2844-51.
    View in: PubMed
  74. Lynch CJ, Steer ML, Connors MR, Schatz RA, Deth RC. Evidence for a decrease in the efficiency of beta-receptor coupling to adenylate cyclase in liver membranes from sucrose-fed rats. Biochem Pharmacol. 1985 Mar 1; 34(5):623-9.
    View in: PubMed
  75. Lynch CJ, Charest R, Blackmore PF, Exton JH. Studies on the hepatic alpha 1-adrenergic receptor. Modulation of guanine nucleotide effects by calcium, temperature, and age. J Biol Chem. 1985 Feb 10; 260(3):1593-600.
    View in: PubMed
  76. Lynch CJ, Guarino JJ, Deth RC, Steer ML. Effect of sucrose feeding on alpha 1-adrenergic responses in rat liver. Am J Physiol. 1984 Apr; 246(4 Pt 1):E344-9.
    View in: PubMed
  77. MacIntyre DE, Hoover RL, Smith M, Steer M, Lynch C, Karnovsky MJ, Salzman EW. Inhibition of platelet function by cis-unsaturated fatty acids. Blood. 1984 Apr; 63(4):848-57.
    View in: PubMed
  78. Lynch CJ, Deth RC. Release of a common source of intracellular Ca2+ by alpha-adrenergic agonists and dinitrophenol in rat liver slices. Pharmacology. 1984; 28(2):74-85.
    View in: PubMed
  79. Awad R, Payne R, Deth RC. Alpha adrenergic receptor subtype associated with receptor binding, Ca++ influx, Ca++ release and contractile events in the rabbit aorta. J Pharmacol Exp Ther. 1983 Oct; 227(1):60-7.
    View in: PubMed
  80. Lynch CJ, Deth RC, Steer ML. Simultaneous loss and reappearance of alpha 1-adrenergic responses and [3H]prazosin binding sites in rat liver after irreversible blockade by phenoxybenzamine. Biochim Biophys Acta. 1983 May 25; 757(2):156-63.
    View in: PubMed
  81. Deth RC, Lynch CJ. Mobilization of a common source of smooth muscle Ca2+ by norepinephrine and methylxanthines. Am J Physiol. 1981 May; 240(5):C239-47.
    View in: PubMed
  82. Deth R, Lynch C. Inhibition of alpha-receptor-induced Ca2+ release and Ca2+ influx by Mn2+ and La3+. Eur J Pharmacol. 1981 Apr 24; 71(1):1-11.
    View in: PubMed
  83. Lynch CJ, Steer ML. Evidence for high and low affinity alpha 2-receptors. Comparison of [3H]norepinephrine and [3H]phentolamine binding to human platelet membranes. J Biol Chem. 1981 Apr 10; 256(7):3298-303.
    View in: PubMed
  84. Deth RC, Lynch CJ. The binding of 3H-ouabain to Na+-K+ ATPase sites in arterial smooth muscle. Pharmacology. 1980; 21(1):29-37.
    View in: PubMed
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