PSU Profiles
Keywords
Last Name
Institution

Patrick James Drew

TitleAssistant Professor
InstitutionCollege of Engineering
DepartmentEngineering Science and Mechanics
AddressW317 Millennium Science Cmplx
University Park, PA 16802
Phone8148631473
Other Positions
InstitutionHuck Institutes of the Life Sciences

TitleAssistant Professor
InstitutionCollege of Medicine
DepartmentNeurosurgery


 Overview 
 overview
PREFERRED TITLE/ROLE:

Assistant Professor of Engineering Science and Mechanics
Assistant Professor of Neurosurgery

GRADUATE PROGRAM AFFILIATIONS:

Cell and Developmental Biology, Neuroscience, Physiology

NARRATIVE:

Dr. Drew's research focuses on understanding the neural circuits and signaling pathways that dynamically route the brain's blood supply to active areas — specifically the relationship between changes in neural activity and the corresponding changes in blood flow — by using optical methods such as two-photon laser-scanning microscopy and intrinsic imaging, as well as electrophysiology, in the awake, behaving mouse.

Lab webpage


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Gao YR, Greene SE, Drew PJ. Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response. Neuroimage. 2015 Jul 15; 115:162-76.
    View in: PubMed
  2. Shih AY, Rühlmann C, Blinder P, Devor A, Drew PJ, Friedman B, Knutsen PM, Lyden PD, Matéo C, Mellander L, Nishimura N, Schaffer CB, Tsai PS, Kleinfeld D. Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture. Microcirculation. 2015 Apr; 22(3):204-18.
    View in: PubMed
  3. Letourneur A, Chen V, Waterman G, Drew PJ. A method for longitudinal, transcranial imaging of blood flow and remodeling of the cerebral vasculature in postnatal mice. Physiol Rep. 2014 Dec 1; 2(12).
    View in: PubMed
  4. Huo BX, Gao YR, Drew PJ. Quantitative separation of arterial and venous cerebral blood volume increases during voluntary locomotion. Neuroimage. 2015 Jan 15; 105:369-79.
    View in: PubMed
  5. Huo BX, Smith JB, Drew PJ. Neurovascular coupling and decoupling in the cortex during voluntary locomotion. J Neurosci. 2014 Aug 13; 34(33):10975-81.
    View in: PubMed
  6. Gao YR, Drew PJ. Determination of vessel cross-sectional area by thresholding in Radon space. J Cereb Blood Flow Metab. 2014 Jul; 34(7):1180-7.
    View in: PubMed
  7. Driscoll JD, Shih AY, Drew PJ, Cauwenberghs G, Kleinfeld D. Two-photon imaging of blood flow in the rat cortex. Cold Spring Harb Protoc. 2013 Aug; 2013(8):759-67.
    View in: PubMed
  8. Shih AY, Mateo C, Drew PJ, Tsai PS, Kleinfeld D. A polished and reinforced thinned-skull window for long-term imaging of the mouse brain. J Vis Exp. 2012; (61).
    View in: PubMed
  9. Shih AY, Driscoll JD, Drew PJ, Nishimura N, Schaffer CB, Kleinfeld D. Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain. J Cereb Blood Flow Metab. 2012 Jul; 32(7):1277-309.
    View in: PubMed
  10. Drew PJ, Shih AY, Kleinfeld D. Fluctuating and sensory-induced vasodynamics in rodent cortex extend arteriole capacity. Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8473-8.
    View in: PubMed
  11. Kleinfeld D, Blinder P, Drew PJ, Driscoll JD, Muller A, Tsai PS, Shih AY. A guide to delineate the logic of neurovascular signaling in the brain. Front Neuroenergetics. 2011; 3:1.
    View in: PubMed
  12. Drew PJ, Shih AY, Driscoll JD, Knutsen PM, Blinder P, Davalos D, Akassoglou K, Tsai PS, Kleinfeld D. Chronic optical access through a polished and reinforced thinned skull. Nat Methods. 2010 Dec; 7(12):981-4.
    View in: PubMed
  13. Li L, Bender KJ, Drew PJ, Jadhav SP, Sylwestrak E, Feldman DE. Endocannabinoid signaling is required for development and critical period plasticity of the whisker map in somatosensory cortex. Neuron. 2009 Nov 25; 64(4):537-49.
    View in: PubMed
  14. Tsai PS, Kaufhold JP, Blinder P, Friedman B, Drew PJ, Karten HJ, Lyden PD, Kleinfeld D. Correlations of neuronal and microvascular densities in murine cortex revealed by direct counting and colocalization of nuclei and vessels. J Neurosci. 2009 Nov 18; 29(46):14553-70.
    View in: PubMed
  15. Drew PJ, Blinder P, Cauwenberghs G, Shih AY, Kleinfeld D. Rapid determination of particle velocity from space-time images using the Radon transform. J Comput Neurosci. 2010 Aug; 29(1-2):5-11.
    View in: PubMed
  16. Shih AY, Friedman B, Drew PJ, Tsai PS, Lyden PD, Kleinfeld D. Active dilation of penetrating arterioles restores red blood cell flux to penumbral neocortex after focal stroke. J Cereb Blood Flow Metab. 2009 Apr; 29(4):738-51.
    View in: PubMed
  17. Drew PJ, Duyn JH, Golanov E, Kleinfeld D. Finding coherence in spontaneous oscillations. Nat Neurosci. 2008 Sep; 11(9):991-3.
    View in: PubMed
  18. Wolfe J, Hill DN, Pahlavan S, Drew PJ, Kleinfeld D, Feldman DE. Texture coding in the rat whisker system: slip-stick versus differential resonance. PLoS Biol. 2008 Aug 26; 6(8):e215.
    View in: PubMed
  19. Drew PJ, Feldman DE. Intrinsic signal imaging of deprivation-induced contraction of whisker representations in rat somatosensory cortex. Cereb Cortex. 2009 Feb; 19(2):331-48.
    View in: PubMed
  20. Drew PJ, Feldman DE. Representation of moving wavefronts of whisker deflection in rat somatosensory cortex. J Neurophysiol. 2007 Sep; 98(3):1566-80.
    View in: PubMed
  21. Drew PJ, Abbott LF. Extending the effects of spike-timing-dependent plasticity to behavioral timescales. Proc Natl Acad Sci U S A. 2006 Jun 6; 103(23):8876-81.
    View in: PubMed
  22. Drew PJ, Abbott LF. Models and properties of power-law adaptation in neural systems. J Neurophysiol. 2006 Aug; 96(2):826-33.
    View in: PubMed
  23. Fusi S, Drew PJ, Abbott LF. Cascade models of synaptically stored memories. Neuron. 2005 Feb 17; 45(4):599-611.
    View in: PubMed
  24. Drew PJ, Abbott LF. Model of song selectivity and sequence generation in area HVc of the songbird. J Neurophysiol. 2003 May; 89(5):2697-706.
    View in: PubMed
Drew's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Similar People
_
Same Department
Physical Neighbors
_