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Melissa Rolls

Title
InstitutionEberly College of Science
DepartmentBiochemistry and Molecular Biology
Address118 Life Sciences Bldg
University Park, PA 16802
Phone8148671395
Other Positions
TitleDirector of the Center for Cellular Dynamics
InstitutionHuck Institutes of the Life Sciences


 Overview 
 overview
PREFERRED TITLE/ ROLE:

Assistant Professor of Biochemistry and Molecular Biology
Director, Center for Cellular Dynamics

NARRATIVE:

Dr. Rolls' research focuses on subcellular compartmentalization of neurons, using live imaging and Drosophila genetics to investigate neuron polarity — focusing on microtubule polarity — and neuronal responses to injury, including degeneration and regeneration.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Rolls MM, Jegla TJ. Neuronal polarity: an evolutionary perspective. J Exp Biol. 2015 Feb 15; 218(Pt 4):572-80.
    View in: PubMed
  2. Nguyen MM, McCracken CJ, Milner ES, Goetschius DJ, Weiner AT, Long MK, Michael NL, Munro S, Rolls MM. G-tubulin controls neuronal microtubule polarity independently of Golgi outposts. Mol Biol Cell. 2014 Jul 1; 25(13):2039-50.
    View in: PubMed
  3. Chen Y, Rolls MM, Hancock WO. An EB1-kinesin complex is sufficient to steer microtubule growth in vitro. Curr Biol. 2014 Feb 3; 24(3):316-21.
    View in: PubMed
  4. Stone MC, Albertson RM, Chen L, Rolls MM. Dendrite injury triggers DLK-independent regeneration. Cell Rep. 2014 Jan 30; 6(2):247-53.
    View in: PubMed
  5. Zhou K, Rolls MM, Hanna-Rose W. A postmitotic function and distinct localization mechanism for centralspindlin at a stable intercellular bridge. Dev Biol. 2013 Apr 1; 376(1):13-22.
    View in: PubMed
  6. Stone MC, Rao K, Gheres KW, Kim S, Tao J, La Rochelle C, Folker CT, Sherwood NT, Rolls MM. Normal spastin gene dosage is specifically required for axon regeneration. Cell Rep. 2012 Nov 29; 2(5):1340-50.
    View in: PubMed
  7. Hill SE, Parmar M, Gheres KW, Guignet MA, Huang Y, Jackson FR, Rolls MM. Development of dendrite polarity in Drosophila neurons. Neural Dev. 2012; 7:34.
    View in: PubMed
  8. Stewart A, Tsubouchi A, Rolls MM, Tracey WD, Sherwood NT. Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila. J Neurosci. 2012 Aug 22; 32(34):11631-42.
    View in: PubMed
  9. Chen L, Rolls MM. Microtubule deacetylation sets the stage for successful axon regeneration. EMBO J. 2012 Jul 18; 31(14):3033-5.
    View in: PubMed
  10. Chen L, Stone MC, Tao J, Rolls MM. Axon injury and stress trigger a microtubule-based neuroprotective pathway. Proc Natl Acad Sci U S A. 2012 Jul 17; 109(29):11842-7.
    View in: PubMed
  11. Nguyen MM, Stone MC, Rolls MM. Microtubules are organized independently of the centrosome in Drosophila neurons. Neural Dev. 2011; 6:38.
    View in: PubMed
  12. Rolls M. Science stories: flies, planes, worms, and lasers. Mol Biol Cell. 2011 Nov; 22(21):3921-2.
    View in: PubMed
  13. Rolls MM. Neuronal polarity in Drosophila: sorting out axons and dendrites. Dev Neurobiol. 2011 Jun; 71(6):419-29.
    View in: PubMed
  14. Tao J, Rolls MM. Dendrites have a rapid program of injury-induced degeneration that is molecularly distinct from developmental pruning. J Neurosci. 2011 Apr 6; 31(14):5398-405.
    View in: PubMed
  15. Mattie FJ, Stackpole MM, Stone MC, Clippard JR, Rudnick DA, Qiu Y, Tao J, Allender DL, Parmar M, Rolls MM. Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites. Curr Biol. 2010 Dec 21; 20(24):2169-77.
    View in: PubMed
  16. Stone MC, Nguyen MM, Tao J, Allender DL, Rolls MM. Global up-regulation of microtubule dynamics and polarity reversal during regeneration of an axon from a dendrite. Mol Biol Cell. 2010 Mar 1; 21(5):767-77.
    View in: PubMed
  17. Minn IL, Rolls MM, Hanna-Rose W, Malone CJ. SUN-1 and ZYG-12, mediators of centrosome-nucleus attachment, are a functional SUN/KASH pair in Caenorhabditis elegans. Mol Biol Cell. 2009 Nov; 20(21):4586-95.
    View in: PubMed
  18. Zhou K, Rolls MM, Hall DH, Malone CJ, Hanna-Rose W. A ZYG-12-dynein interaction at the nuclear envelope defines cytoskeletal architecture in the C. elegans gonad. J Cell Biol. 2009 Jul 27; 186(2):229-41.
    View in: PubMed
  19. Satoh D, Sato D, Tsuyama T, Saito M, Ohkura H, Rolls MM, Ishikawa F, Uemura T. Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes. Nat Cell Biol. 2008 Oct; 10(10):1164-71.
    View in: PubMed
  20. Stone MC, Roegiers F, Rolls MM. Microtubules have opposite orientation in axons and dendrites of Drosophila neurons. Mol Biol Cell. 2008 Oct; 19(10):4122-9.
    View in: PubMed
  21. Rolls MM, Satoh D, Clyne PJ, Henner AL, Uemura T, Doe CQ. Polarity and intracellular compartmentalization of Drosophila neurons. Neural Dev. 2007; 2:7.
    View in: PubMed
  22. Rolls MM, Doe CQ. Baz, Par-6 and aPKC are not required for axon or dendrite specification in Drosophila. Nat Neurosci. 2004 Dec; 7(12):1293-5.
    View in: PubMed
  23. Rolls MM, Albertson R, Shih HP, Lee CY, Doe CQ. Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia. J Cell Biol. 2003 Dec 8; 163(5):1089-98.
    View in: PubMed
  24. Rolls MM, Doe CQ. Cell polarity: From embryo to axon. Nature. 2003 Feb 27; 421(6926):905-6.
    View in: PubMed
  25. Hinkle B, Slepchenko B, Rolls MM, Walther TC, Stein PA, Mehlmann LM, Ellenberg J, Terasaki M. Chromosomal association of Ran during meiotic and mitotic divisions. J Cell Sci. 2002 Dec 1; 115(Pt 23):4685-93.
    View in: PubMed
  26. Voeltz GK, Rolls MM, Rapoport TA. Structural organization of the endoplasmic reticulum. EMBO Rep. 2002 Oct; 3(10):944-50.
    View in: PubMed
  27. Stein PA, Toret CP, Salic AN, Rolls MM, Rapoport TA. A novel centrosome-associated protein with affinity for microtubules. J Cell Sci. 2002 Sep 1; 115(Pt 17):3389-402.
    View in: PubMed
  28. Rolls MM, Hall DH, Victor M, Stelzer EH, Rapoport TA. Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Mol Biol Cell. 2002 May; 13(5):1778-91.
    View in: PubMed
  29. Terasaki M, Campagnola P, Rolls MM, Stein PA, Ellenberg J, Hinkle B, Slepchenko B. A new model for nuclear envelope breakdown. Mol Biol Cell. 2001 Feb; 12(2):503-10.
    View in: PubMed
  30. Hinkle B, Rolls MM, Stein P, Rapoport T, Terasaki M. Ran is associated with chromosomes during starfish oocyte meiosis and embryonic mitoses. Zygote. 2000; 8 Suppl 1:S91.
    View in: PubMed
  31. Rolls MM, Stein PA, Taylor SS, Ha E, McKeon F, Rapoport TA. A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. J Cell Biol. 1999 Jul 12; 146(1):29-44.
    View in: PubMed
  32. Neuhof A, Rolls MM, Jungnickel B, Kalies KU, Rapoport TA. Binding of signal recognition particle gives ribosome/nascent chain complexes a competitive advantage in endoplasmic reticulum membrane interaction. Mol Biol Cell. 1998 Jan; 9(1):103-15.
    View in: PubMed
  33. Rolls MM, Marquardt MT, Kielian M, Machamer CE. Cholesterol-independent targeting of Golgi membrane proteins in insect cells. Mol Biol Cell. 1997 Nov; 8(11):2111-8.
    View in: PubMed
  34. Adkins HB, Brojatsch J, Naughton J, Rolls MM, Pesola JM, Young JA. Identification of a cellular receptor for subgroup E avian leukosis virus. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11617-22.
    View in: PubMed
  35. Brojatsch J, Naughton J, Rolls MM, Zingler K, Young JA. CAR1, a TNFR-related protein, is a cellular receptor for cytopathic avian leukosis-sarcoma viruses and mediates apoptosis. Cell. 1996 Nov 29; 87(5):845-55.
    View in: PubMed
  36. Rapoport TA, Rolls MM, Jungnickel B. Approaching the mechanism of protein transport across the ER membrane. Curr Opin Cell Biol. 1996 Aug; 8(4):499-504.
    View in: PubMed
  37. Rolls MM, Haglund K, Rose JK. Expression of additional genes in a vector derived from a minimal RNA virus. Virology. 1996 Apr 15; 218(2):406-11.
    View in: PubMed
  38. Rolls MM, Webster P, Balba NH, Rose JK. Novel infectious particles generated by expression of the vesicular stomatitis virus glycoprotein from a self-replicating RNA. Cell. 1994 Nov 4; 79(3):497-506.
    View in: PubMed
  39. Machamer CE, Grim MG, Esquela A, Chung SW, Rolls M, Ryan K, Swift AM. Retention of a cis Golgi protein requires polar residues on one face of a predicted alpha-helix in the transmembrane domain. Mol Biol Cell. 1993 Jul; 4(7):695-704.
    View in: PubMed
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