PSU Profiles
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Last Name
Institution

Mary Jane De Souza

TitleProfessor
InstitutionCollege of Health and Human Development
DepartmentKinesiology
Address104 Noll Lab
University Park, PA 16802
Phone8148630045
Other Positions
InstitutionHuck Institutes of the Life Sciences

InstitutionCenter for Reproductive Biology and Health


 Overview 
 overview
PREFERRED TITLE/ROLE:

Professor of Kinesiology

GRADUATE PROGRAM AFFILIATIONS:

Interdepartmental Graduate Program in Physiology

EDUCATION:

Ph.D., Exercise Physiology, University of Connecticut, 1988
Post-Doctoral Fellowship in Reproductive Physiology, University of Connecticut School of Medicine 1988-1990

NARRATIVE:

Dr De Souza is a Professor of Kinesiology and Physiology at Penn State University and the Director of the Women’s Health and Exercise Laboratories (WHEL). Her expertise is in the field of women’s health and exercise, specifically reproductive and skeletal physiology. Dr De Souza is a renowned expert on the physiology of the Female Athlete Triad, particularly factors related to energy deficiency, eating behaviors, food intake, exercise and menstrual abnormalities, and bone health and osteoporosis in female athletes and exercising women. Dr De Souza is also doing research on the role of combined hormonal contraceptives in the skeletal integrity of young women. Dr De Souza has published extensively on these topics for 30 years. Dr De Souza’s WHEL laboratory is an active lab with expertise in running assays for endocrine related projects, including reproductive and bone-related assays in serum, urine and saliva. Dr De Souza’s lab is also experienced in the imaging of bone by both 2 and 3 dimensional strategies, to include DXA and pQCT. Her laboratory has a long and successful track record of enrolling young women aged 18-30 in both intervention and non-intervention studies and Dr. De Souza has a successful track record with the development, design and execution of clinical trials utilizing contraceptives, diet and exercise interventions.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Reed JL, De Souza MJ, Mallinson RJ, Scheid JL, Williams NI. Energy availability discriminates clinical menstrual status in exercising women. J Int Soc Sports Nutr. 2015; 12:11.
    View in: PubMed
  2. De Souza MJ, Williams NI, Nattiv A, Joy E, Misra M, Loucks AB, Matheson G, Olmsted MP, Barrack M, Mallinson RJ, Gibbs JC, Goolsby M, Nichols JF, Drinkwater B, Sanborn C, Agostini R, Otis CL, Johnson MD, Hoch AZ, Alleyne JM, Wadsworth LT, Koehler K, VanHeest J, Harvey P, Kelly AK, Fredericson M, Brooks GA, O'Donnell E, Callahan LR, Putukian M, Costello L, Hecht S, Rauh MJ, McComb J. Misunderstanding the female athlete triad: refuting the IOC consensus statement on Relative Energy Deficiency in Sport (RED-S). Br J Sports Med. 2014 Oct; 48(20):1461-5.
    View in: PubMed
  3. Joy E, De Souza MJ, Nattiv A, Misra M, Williams NI, Mallinson RJ, Gibbs JC, Olmsted M, Goolsby M, Matheson G, Barrack M, Burke L, Drinkwater B, Lebrun C, Loucks AB, Mountjoy M, Nichols J, Borgen JS. 2014 female athlete triad coalition consensus statement on treatment and return to play of the female athlete triad. Curr Sports Med Rep. 2014 Jul-Aug; 13(4):219-32.
    View in: PubMed
  4. Mallinson RJ, De Souza MJ. Current perspectives on the etiology and manifestation of the "silent" component of the Female Athlete Triad. Int J Womens Health. 2014; 6:451-67.
    View in: PubMed
  5. Reed JL, De Souza MJ, Kindler JM, Williams NI. Nutritional practices associated with low energy availability in Division I female soccer players. J Sports Sci. 2014; 32(16):1499-509.
    View in: PubMed
  6. De Souza MJ, Nattiv A, Joy E, Misra M, Williams NI, Mallinson RJ, Gibbs JC, Olmsted M, Goolsby M, Matheson G. 2014 Female Athlete Triad Coalition consensus statement on treatment and return to play of the female athlete triad: 1st International Conference held in San Francisco, CA, May 2012, and 2nd International Conference held in Indianapolis, IN, May 2013. Clin J Sport Med. 2014 Mar; 24(2):96-119.
    View in: PubMed
  7. Barrack MT, Gibbs JC, De Souza MJ, Williams NI, Nichols JF, Rauh MJ, Nattiv A. Higher incidence of bone stress injuries with increasing female athlete triad-related risk factors: a prospective multisite study of exercising girls and women. Am J Sports Med. 2014 Apr; 42(4):949-58.
    View in: PubMed
  8. De Souza MJ, Nattiv A, Joy E, Misra M, Williams NI, Mallinson RJ, Gibbs JC, Olmsted M, Goolsby M, Matheson G. 2014 Female Athlete Triad Coalition Consensus Statement on Treatment and Return to Play of the Female Athlete Triad: 1st International Conference held in San Francisco, California, May 2012 and 2nd International Conference held in Indianapolis, Indiana, May 2013. Br J Sports Med. 2014 Feb; 48(4):289.
    View in: PubMed
  9. Gibbs JC, Nattiv A, Barrack MT, Williams NI, Rauh MJ, Nichols JF, De Souza MJ. Low bone density risk is higher in exercising women with multiple triad risk factors. Med Sci Sports Exerc. 2014 Jan; 46(1):167-76.
    View in: PubMed
  10. Vanheest JL, Rodgers CD, Mahoney CE, De Souza MJ. Ovarian suppression impairs sport performance in junior elite female swimmers. Med Sci Sports Exerc. 2014 Jan; 46(1):156-66.
    View in: PubMed
  11. Hill BR, Rolls BJ, Roe LS, De Souza MJ, Williams NI. Ghrelin and peptide YY increase with weight loss during a 12-month intervention to reduce dietary energy density in obese women. Peptides. 2013 Nov; 49:138-44.
    View in: PubMed
  12. Hill BR, De Souza MJ, Wagstaff DA, Williams NI. The impact of weight loss on the 24-h profile of circulating peptide YY and its association with 24-h ghrelin in normal weight premenopausal women. Peptides. 2013 Nov; 49:81-90.
    View in: PubMed
  13. Gibbs JC, Williams NI, Mallinson RJ, Reed JL, Rickard AD, De Souza MJ. Effect of high dietary restraint on energy availability and menstrual status. Med Sci Sports Exerc. 2013 Sep; 45(9):1790-7.
    View in: PubMed
  14. Mallinson RJ, Williams NI, Olmsted MP, Scheid JL, Riddle ES, De Souza MJ. A case report of recovery of menstrual function following a nutritional intervention in two exercising women with amenorrhea of varying duration. J Int Soc Sports Nutr. 2013; 10:34.
    View in: PubMed
  15. Scheid JL, Birch LL, Williams NI, Rolls BJ, De Souza MJ. Postprandial peptide YY is lower in young college-aged women with high dietary cognitive restraint. Physiol Behav. 2013 Aug 15; 120:26-33.
    View in: PubMed
  16. Mallinson RJ, Williams NI, Hill BR, De Souza MJ. Body composition and reproductive function exert unique influences on indices of bone health in exercising women. Bone. 2013 Sep; 56(1):91-100.
    View in: PubMed
  17. Gibbs JC, Williams NI, De Souza MJ. Prevalence of individual and combined components of the female athlete triad. Med Sci Sports Exerc. 2013 May; 45(5):985-96.
    View in: PubMed
  18. Scheid JL, De Souza MJ, Hill BR, Leidy HJ, Williams NI. Decreased luteinizing hormone pulse frequency is associated with elevated 24-hour ghrelin after calorie restriction and exercise in premenopausal women. Am J Physiol Endocrinol Metab. 2013 Jan 1; 304(1):E109-16.
    View in: PubMed
  19. Reed JL, De Souza MJ, Williams NI. Changes in energy availability across the season in Division I female soccer players. J Sports Sci. 2013; 31(3):314-24.
    View in: PubMed
  20. Hill BR, De Souza MJ, Wagstaff DA, Sato R, Williams NI. 24-hour profiles of circulating ghrelin and peptide YY are inversely associated in normal weight premenopausal women. Peptides. 2012 Nov; 38(1):159-62.
    View in: PubMed
  21. Schwartz DH, Romans SE, Meiyappan S, De Souza MJ, Einstein G. The role of ovarian steroid hormones in mood. Horm Behav. 2012 Sep; 62(4):448-54.
    View in: PubMed
  22. Macnutt MJ, De Souza MJ, Tomczak SE, Homer JL, Sheel AW. Resting and exercise ventilatory chemosensitivity across the menstrual cycle. J Appl Physiol (1985). 2012 Mar; 112(5):737-47.
    View in: PubMed
  23. Scheid JL, De Souza MJ, Leidy HJ, Williams NI. Ghrelin but not peptide YY is related to change in body weight and energy availability. Med Sci Sports Exerc. 2011 Nov; 43(11):2063-71.
    View in: PubMed
  24. Gibbs JC, Williams NI, Scheid JL, Toombs RJ, De Souza MJ. The association of a high drive for thinness with energy deficiency and severe menstrual disturbances: confirmation in a large population of exercising women. Int J Sport Nutr Exerc Metab. 2011 Aug; 21(4):280-90.
    View in: PubMed
  25. Toombs RJ, Ducher G, Shepherd JA, De Souza MJ. The impact of recent technological advances on the trueness and precision of DXA to assess body composition. Obesity (Silver Spring). 2012 Jan; 20(1):30-9.
    View in: PubMed
  26. Ducher G, Turner AI, Kukuljan S, Pantano KJ, Carlson JL, Williams NI, De Souza MJ. Obstacles in the optimization of bone health outcomes in the female athlete triad. Sports Med. 2011 Jul 1; 41(7):587-607.
    View in: PubMed
  27. Hill BR, De Souza MJ, Williams NI. Characterization of the diurnal rhythm of peptide YY and its association with energy balance parameters in normal-weight premenopausal women. Am J Physiol Endocrinol Metab. 2011 Aug; 301(2):E409-15.
    View in: PubMed
  28. Reed JL, Bowell JL, Hill BR, Williams BA, De Souza MJ, Williams NI. Exercising women with menstrual disturbances consume low energy dense foods and beverages. Appl Physiol Nutr Metab. 2011 Jun; 36(3):382-94.
    View in: PubMed
  29. Scheid JL, Toombs RJ, Ducher G, Gibbs JC, Williams NI, De Souza MJ. Estrogen and peptide YY are associated with bone mineral density in premenopausal exercising women. Bone. 2011 Aug; 49(2):194-201.
    View in: PubMed
  30. Corr M, De Souza MJ, Toombs RJ, Williams NI. Circulating leptin concentrations do not distinguish menstrual status in exercising women. Hum Reprod. 2011 Mar; 26(3):685-94.
    View in: PubMed
  31. O'Donnell E, De Souza MJ. Increased serum adiponectin concentrations in amenorrheic physically active women are associated with impaired bone health but not with estrogen exposure. Bone. 2011 Apr 1; 48(4):760-7.
    View in: PubMed
  32. Scheid JL, De Souza MJ. Menstrual irregularities and energy deficiency in physically active women: the role of ghrelin, PYY and adipocytokines. Med Sport Sci. 2010; 55:82-102.
    View in: PubMed
  33. Reed JL, De Souza MJ, Williams NI. Effects of exercise combined with caloric restriction on inflammatory cytokines. Appl Physiol Nutr Metab. 2010 Oct; 35(5):573-82.
    View in: PubMed
  34. Williams NI, Reed JL, Leidy HJ, Legro RS, De Souza MJ. Estrogen and progesterone exposure is reduced in response to energy deficiency in women aged 25-40 years. Hum Reprod. 2010 Sep; 25(9):2328-39.
    View in: PubMed
  35. De Souza MJ, Toombs RJ, Scheid JL, O'Donnell E, West SL, Williams NI. High prevalence of subtle and severe menstrual disturbances in exercising women: confirmation using daily hormone measures. Hum Reprod. 2010 Feb; 25(2):491-503.
    View in: PubMed
  36. Awdishu S, Williams NI, Laredo SE, De Souza MJ. Oligomenorrhoea in exercising women: a polycystic ovarian syndrome phenotype or distinct entity? Sports Med. 2009; 39(12):1055-69.
    View in: PubMed
  37. West SL, Scheid JL, De Souza MJ. The effect of exercise and estrogen on osteoprotegerin in premenopausal women. Bone. 2009 Jan; 44(1):137-44.
    View in: PubMed
  38. Scheid JL, Williams NI, West SL, VanHeest JL, De Souza MJ. Elevated PYY is associated with energy deficiency and indices of subclinical disordered eating in exercising women with hypothalamic amenorrhea. Appetite. 2009 Feb; 52(1):184-92.
    View in: PubMed
  39. O'Donnell E, Harvey PJ, De Souza MJ. Relationships between vascular resistance and energy deficiency, nutritional status and oxidative stress in oestrogen deficient physically active women. Clin Endocrinol (Oxf). 2009 Feb; 70(2):294-302.
    View in: PubMed
  40. Vescovi JD, Scheid JL, Hontscharuk R, De Souza MJ. Cognitive dietary restraint: impact on bone, menstrual and metabolic status in young women. Physiol Behav. 2008 Sep 3; 95(1-2):48-55.
    View in: PubMed
  41. De Souza MJ, West SL, Jamal SA, Hawker GA, Gundberg CM, Williams NI. The presence of both an energy deficiency and estrogen deficiency exacerbate alterations of bone metabolism in exercising women. Bone. 2008 Jul; 43(1):140-8.
    View in: PubMed
  42. Vescovi JD, Jamal SA, De Souza MJ. Strategies to reverse bone loss in women with functional hypothalamic amenorrhea: a systematic review of the literature. Osteoporos Int. 2008 Apr; 19(4):465-78.
    View in: PubMed
  43. Vescovi JD, VanHeest JL, De Souza MJ. Short-term response of bone turnover to low-dose oral contraceptives in exercising women with hypothalamic amenorrhea. Contraception. 2008 Feb; 77(2):97-104.
    View in: PubMed
  44. Kontos PC, Miller KL, Brooks D, Jassal SV, Spanjevic L, Devins GM, De Souza MJ, Heck C, Laprade J, Naglie G. Factors influencing exercise participation by older adults requiring chronic hemodialysis: a qualitative study. Int Urol Nephrol. 2007; 39(4):1303-11.
    View in: PubMed
  45. De Souza MJ, Lee DK, VanHeest JL, Scheid JL, West SL, Williams NI. Severity of energy-related menstrual disturbances increases in proportion to indices of energy conservation in exercising women. Fertil Steril. 2007 Oct; 88(4):971-5.
    View in: PubMed
  46. Loucks AB, De Souza MJ, Williams NI. Effects of lifetime exercise on the outcome of in vitro fertilization. Obstet Gynecol. 2007 Feb; 109(2 Pt 1):456-7.
    View in: PubMed
  47. O'Donnell E, Harvey PJ, Goodman JM, De Souza MJ. Long-term estrogen deficiency lowers regional blood flow, resting systolic blood pressure, and heart rate in exercising premenopausal women. Am J Physiol Endocrinol Metab. 2007 May; 292(5):E1401-9.
    View in: PubMed
  48. De Souza MJ, Alleyne J, Vescovi JD, Williams NI, VanHeest JL, Warren MP. Correction of misinterpretations and misrepresentations of the female athlete triad. Br J Sports Med. 2007 Jan; 41(1):58-9.
    View in: PubMed
  49. De Souza MJ, Hontscharuk R, Olmsted M, Kerr G, Williams NI. Drive for thinness score is a proxy indicator of energy deficiency in exercising women. Appetite. 2007 May; 48(3):359-67.
    View in: PubMed
  50. Williams NI, De Souza MJ. Female athlete triad errors and misunderstandings. Med Sci Sports Exerc. 2006 May; 38(5):1021; author reply 1022.
    View in: PubMed
  51. Thompson HS, Scordilis SP, De Souza MJ. Serum creatine kinase activity varies with ovulatory status in regularly exercising, premenopausal women. Horm Res. 2006; 65(3):151-8.
    View in: PubMed
  52. De Souza MJ, Williams NI. Beyond hypoestrogenism in amenorrheic athletes: energy deficiency as a contributing factor for bone loss. Curr Sports Med Rep. 2005 Feb; 4(1):38-44.
    View in: PubMed
  53. Armstrong LE, Maresh CM, Keith NR, Elliott TA, Vanheest JL, Scheett TP, Stoppani J, Judelson DA, De Souza MJ. Heat acclimation and physical training adaptations of young women using different contraceptive hormones. Am J Physiol Endocrinol Metab. 2005 May; 288(5):E868-75.
    View in: PubMed
  54. De Souza MJ, Leidy HJ, O'Donnell E, Lasley B, Williams NI. Fasting ghrelin levels in physically active women: relationship with menstrual disturbances and metabolic hormones. J Clin Endocrinol Metab. 2004 Jul; 89(7):3536-42.
    View in: PubMed
  55. De Souza MJ, Williams NI. Physiological aspects and clinical sequelae of energy deficiency and hypoestrogenism in exercising women. Hum Reprod Update. 2004 Sep-Oct; 10(5):433-48.
    View in: PubMed
  56. O'Donnell E, De Souza MJ. The cardiovascular effects of chronic hypoestrogenism in amenorrhoeic athletes: a critical review. Sports Med. 2004; 34(9):601-27.
    View in: PubMed
  57. Klentrou P, Cunliffe M, Slack J, Wilk B, Bar-Or O, De Souza MJ, Plyley M. Temperature regulation during rest and exercise in the cold in premenarcheal and menarcheal girls. J Appl Physiol (1985). 2004 Apr; 96(4):1393-8.
    View in: PubMed
  58. De Souza MJ. Menstrual disturbances in athletes: a focus on luteal phase defects. Med Sci Sports Exerc. 2003 Sep; 35(9):1553-63.
    View in: PubMed
  59. De Souza MJ, Van Heest J, Demers LM, Lasley BL. Luteal phase deficiency in recreational runners: evidence for a hypometabolic state. J Clin Endocrinol Metab. 2003 Jan; 88(1):337-46.
    View in: PubMed
  60. Pescatello LS, Murphy DM, Anderson D, Costanzo D, Dulipsingh L, De Souza MJ. Daily physical movement and bone mineral density among a mixed racial cohort of women. Med Sci Sports Exerc. 2002 Dec; 34(12):1966-70.
    View in: PubMed
  61. Miller BE, De Souza MJ, Slade K, Luciano AA. Sublingual administration of micronized estradiol and progesterone, with and without micronized testosterone: effect on biochemical markers of bone metabolism and bone mineral density. Menopause. 2000 Sep-Oct; 7(5):318-26.
    View in: PubMed
  62. De Souza MJ, Miller BE, Loucks AB, Luciano AA, Pescatello LS, Campbell CG, Lasley BL. High frequency of luteal phase deficiency and anovulation in recreational women runners: blunted elevation in follicle-stimulating hormone observed during luteal-follicular transition. J Clin Endocrinol Metab. 1998 Dec; 83(12):4220-32.
    View in: PubMed
  63. De Souza MJ, Miller BE, Sequenzia LC, Luciano AA, Ulreich S, Stier S, Prestwood K, Lasley BL. Bone health is not affected by luteal phase abnormalities and decreased ovarian progesterone production in female runners. J Clin Endocrinol Metab. 1997 Sep; 82(9):2867-76.
    View in: PubMed
  64. Thompson HS, Hyatt JP, De Souza MJ, Clarkson PM. The effects of oral contraceptives on delayed onset muscle soreness following exercise. Contraception. 1997 Aug; 56(2):59-65.
    View in: PubMed
  65. Kassam A, Overstreet JW, Snow-Harter C, De Souza MJ, Gold EB, Lasley BL. Identification of anovulation and transient luteal function using a urinary pregnanediol-3-glucuronide ratio algorithm. Environ Health Perspect. 1996 Apr; 104(4):408-13.
    View in: PubMed
  66. De Souza MJ, Arce JC, Pescatello LS, Scherzer HS, Luciano AA. Gonadal hormones and semen quality in male runners. A volume threshold effect of endurance training. Int J Sports Med. 1994 Oct; 15(7):383-91.
    View in: PubMed
  67. De Souza MJ, Luciano AA, Arce JC, Demers LM, Loucks AB. Clinical tests explain blunted cortisol responsiveness but not mild hypercortisolism in amenorrheic runners. J Appl Physiol (1985). 1994 Mar; 76(3):1302-9.
    View in: PubMed
  68. Loucks AB, Cameron JL, De Souza MJ. Subject assignment may have biased exercise results. J Appl Physiol (1985). 1993 Apr; 74(4):2045-7.
    View in: PubMed
  69. De Souza MJ, Metzger DA. Reproductive dysfunction in amenorrheic athletes and anorexic patients: a review. Med Sci Sports Exerc. 1991 Sep; 23(9):995-1007.
    View in: PubMed
  70. De Souza MJ, Maguire MS, Maresh CM, Kraemer WJ, Rubin KR, Loucks AB. Adrenal activation and the prolactin response to exercise in eumenorrheic and amenorrheic runners. J Appl Physiol (1985). 1991 Jun; 70(6):2378-87.
    View in: PubMed
  71. De Souza MJ, Maguire MS, Rubin KR, Maresh CM. Effects of menstrual phase and amenorrhea on exercise performance in runners. Med Sci Sports Exerc. 1990 Oct; 22(5):575-80.
    View in: PubMed
  72. De Souza MJ, Maresh CM, Maguire MS, Kraemer WJ, Flora-Ginter G, Goetz KL. Menstrual status and plasma vasopressin, renin activity, and aldosterone exercise responses. J Appl Physiol (1985). 1989 Aug; 67(2):736-43.
    View in: PubMed
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