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Charles Lang

TitleProfessor
InstitutionCollege of Medicine
DepartmentCellular and Molecular Physiology
Address500 University Drive Hershey PA 17033
Mailbox: H166
Phone7175315538

 Overview 
 overview
PREFERRED TITLE/ROLE:

Distinguished Professor of Cellular and Molecular Physiology, and Surgery

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Surgery

GRADUATE PROGRAM AFFILIATIONS:

Cell and Molecular Biology, MD/PhD Degree Program, Physiology, Integrative Biosciences, Anatomy, Molecular Medicine

EDUCATION:

Ph.D., Hahnemann Medical College, 1981
Postdoctoral Training, LSU Medical Center, 1981-1984

NARRATIVE:

The mechanisms responsible for the muscle wasting that accompanies infection are poorly defined. Although inflammatory cytokines, such as TNF, IL-1 and IL-6, have been suggested as mediators of the enhanced muscle catabolism, it is unlikely that these cytokines act directly at the tissue level. Insulin-like growth factor (IGF)-I is a key endogenous anabolic hormone which can directly reduce proteolysis and enhance protein synthesis. Studies from our laboratory indicate that trauma, infection and endotoxin as well as exogenous administration of either TNF or IL-1 are capable of modulating various elements of the IGF system in the circulation and in muscle. Studies in the laboratory attempt to integrate mechanisms of action from the cellular level to the whole animal or person. In vivo studies are conducted to determine the role of cytokines and hormonal mediators in mediating the sepsis-induced changes in the growth hormone (GH)-IGF axis. In addition, in vitro studies are on-going that examine the potency of TNF, IL-1 and IL-6 on gene expression and secretion of IGF-I and IGF binding proteins in cultured hepatocytes and Kupffer cells. Moreover, the ability of cytokines to antagonize the anabolic actions of IGF-I on skeletal muscle protein synthesis and protein breakdown in cell culture is also being examined.

The second line of investigation in the laboratory involves elucidating the mechanism by which alcohol alters both the hepatic production of IGF-I and IGF binding protein-1, and how these changes work in concert to contribute to the muscle wasting associated with chronic alcohol consumption. These studies involve the use of rodent models of acute and chronic alcoholism, and the study of the GH-IGF axis using both in vivo and in vitro techniques. Our long-term goal in these studies is to better understand the mechanism for the alterations in muscle protein balance that remains a major cause of morbidity and mortality in patients with a history of chronic alcohol abuse.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Steiner JL, Lang CH. Sepsis attenuates the anabolic response to skeletal muscle contraction. Shock. 2015 Apr; 43(4):344-51.
    View in: PubMed
  2. Steiner JL, Gordon BS, Lang CH. Moderate alcohol consumption does not impair overload-induced muscle hypertrophy and protein synthesis. Physiol Rep. 2015 Mar; 3(3).
    View in: PubMed
  3. Gordon BS, Williamson DL, Lang CH, Jefferson LS, Kimball SR. Nutrient-Induced Stimulation of Protein Synthesis in Mouse Skeletal Muscle Is Limited by the mTORC1 Repressor REDD1. J Nutr. 2015 Apr; 145(4):708-13.
    View in: PubMed
  4. Hong-Brown LQ, Brown CR, Navaratnarajah M, Lang CH. Adamts1 mediates ethanol-induced alterations in collagen and elastin via a FoxO1-sestrin3-AMPK signaling cascade in myocytes. J Cell Biochem. 2015 Jan; 116(1):91-101.
    View in: PubMed
  5. Steiner JL, Lang CH. Alcohol Intoxication Following Muscle Contraction in Mice Decreases Muscle Protein Synthesis But Not mTOR Signal Transduction. Alcohol Clin Exp Res. 2015 Jan; 39(1):1-10.
    View in: PubMed
  6. Romero F, Shah D, Duong M, Stafstrom W, Hoek JB, Kallen CB, Lang CH, Summer R. Chronic alcohol ingestion in rats alters lung metabolism, promotes lipid accumulation, and impairs alveolar macrophage functions. Am J Respir Cell Mol Biol. 2014 Dec; 51(6):840-9.
    View in: PubMed
  7. Steiner JL, Lang CH. Alcohol impairs skeletal muscle protein synthesis and mTOR signaling in a time-dependent manner following electrically stimulated muscle contraction. J Appl Physiol (1985). 2014 Nov 15; 117(10):1170-9.
    View in: PubMed
  8. Laufenberg LJ, Pruznak AM, Navaratnarajah M, Lang CH. Sepsis-induced changes in amino acid transporters and leucine signaling via mTOR in skeletal muscle. Amino Acids. 2014 Dec; 46(12):2787-98.
    View in: PubMed
  9. Steiner JL, Bardgett ME, Wolfgang L, Lang CH, Stocker SD. Glucocorticoids attenuate the central sympathoexcitatory actions of insulin. J Neurophysiol. 2014 Nov 15; 112(10):2597-604.
    View in: PubMed
  10. Gordon BS, Steiner JL, Lang CH, Jefferson LS, Kimball SR. Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction. Am J Physiol Endocrinol Metab. 2014 Oct 15; 307(8):E703-11.
    View in: PubMed
  11. Steiner JL, Pruznak AM, Deiter G, Navaratnarajah M, Kutzler L, Kimball SR, Lang CH. Disruption of genes encoding eIF4E binding proteins-1 and -2 does not alter basal or sepsis-induced changes in skeletal muscle protein synthesis in male or female mice. PLoS One. 2014; 9(6):e99582.
    View in: PubMed
  12. Osuchowski MF, Remick DG, Lederer JA, Lang CH, Aasen AO, Aibiki M, Azevedo LC, Bahrami S, Boros M, Cooney R, Cuzzocrea S, Jiang Y, Junger WG, Hirasawa H, Hotchkiss RS, Li XA, Radermacher P, Redl H, Salomao R, Soebandrio A, Thiemermann C, Vincent JL, Ward P, Yao YM, Yu HP, Zingarelli B, Chaudry IH. Abandon the mouse research ship? Not just yet! Shock. 2014 Jun; 41(6):463-75.
    View in: PubMed
  13. Laufenberg LJ, Kazi AA, Lang CH. Salutary effect of aurintricarboxylic acid on endotoxin- and sepsis-induced changes in muscle protein synthesis and inflammation. Shock. 2014 May; 41(5):420-8.
    View in: PubMed
  14. Lang CH, Derdak Z, Wands JR. Strain-dependent differences for suppression of insulin-stimulated glucose uptake in skeletal and cardiac muscle by ethanol. Alcohol Clin Exp Res. 2014 Apr; 38(4):897-910.
    View in: PubMed
  15. Lloyd SA, Lang CH, Zhang Y, Paul EM, Laufenberg LJ, Lewis GS, Donahue HJ. Interdependence of muscle atrophy and bone loss induced by mechanical unloading. J Bone Miner Res. 2014; 29(5):1118-30.
    View in: PubMed
  16. Lang CH, Korzick DH. Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats. Am J Physiol Regul Integr Comp Physiol. 2014 Jan 1; 306(1):R23-33.
    View in: PubMed
  17. Hong-Brown LQ, Brown CR, Navaratnarajah M, Lang CH. Activation of AMPK/TSC2/PLD by alcohol regulates mTORC1 and mTORC2 assembly in C2C12 myocytes. Alcohol Clin Exp Res. 2013 Nov; 37(11):1849-61.
    View in: PubMed
  18. Lang CH, Pruznak A, Navaratnarajah M, Rankine KA, Deiter G, Magne H, Offord EA, Breuillé D. Chronic a-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy. Am J Physiol Endocrinol Metab. 2013 Aug 1; 305(3):E416-28.
    View in: PubMed
  19. Crossland H, Kazi AA, Lang CH, Timmons JA, Pierre P, Wilkinson DJ, Smith K, Szewczyk NJ, Atherton PJ. Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway. Am J Physiol Endocrinol Metab. 2013 Jul 15; 305(2):E183-93.
    View in: PubMed
  20. Laufenberg LJ, Weller GE, Lang CH, Ruiz-Velasco V. Nociceptin receptor signaling in sympathetic neurons from septic rats. J Surg Res. 2013 Oct; 184(2):973-80.
    View in: PubMed
  21. Korzick DH, Sharda DR, Pruznak AM, Lang CH. Aging accentuates alcohol-induced decrease in protein synthesis in gastrocnemius. Am J Physiol Regul Integr Comp Physiol. 2013 May 15; 304(10):R887-98.
    View in: PubMed
  22. She P, Olson KC, Kadota Y, Inukai A, Shimomura Y, Hoppel CL, Adams SH, Kawamata Y, Matsumoto H, Sakai R, Lang CH, Lynch CJ. Leucine and protein metabolism in obese Zucker rats. PLoS One. 2013; 8(3):e59443.
    View in: PubMed
  23. Pruznak AM, Nystrom J, Lang CH. Direct central nervous system effect of alcohol alters synthesis and degradation of skeletal muscle protein. Alcohol Alcohol. 2013 Mar-Apr; 48(2):138-45.
    View in: PubMed
  24. Sharda DR, Miller-Lee JL, Kanski GM, Hunter JC, Lang CH, Kennett MJ, Korzick DH. Comparison of the agar block and Lieber-DeCarli diets to study chronic alcohol consumption in an aging model of Fischer 344 female rats. J Pharmacol Toxicol Methods. 2012 Nov-Dec; 66(3):257-63.
    View in: PubMed
  25. Reynolds P, Wall P, van Griensven M, McConnell K, Lang C, Buchman T. Shock supports the use of animal research reporting guidelines. Shock. 2012 Jul; 38(1):1-3.
    View in: PubMed
  26. Hong-Brown LQ, Kazi AA, Lang CH. Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on mTORC1, mTORC2 and protein synthesis in myocytes. World J Biol Chem. 2012 Jun 26; 3(6):110-20.
    View in: PubMed
  27. Lang SM, Kazi AA, Hong-Brown L, Lang CH. Delayed recovery of skeletal muscle mass following hindlimb immobilization in mTOR heterozygous mice. PLoS One. 2012; 7(6):e38910.
    View in: PubMed
  28. Frost RA, Lang CH. Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle. Endocrinol Metab Clin North Am. 2012 Jun; 41(2):297-322, vi.
    View in: PubMed
  29. Hong-Brown LQ, Brown CR, Kazi AA, Navaratnarajah M, Lang CH. Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine. Am J Physiol Cell Physiol. 2012 May 15; 302(10):C1557-65.
    View in: PubMed
  30. Kazi AA, Hong-Brown L, Lang SM, Lang CH. Deptor knockdown enhances mTOR Activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy. Mol Med. 2011 Sep-Oct; 17(9-10):925-36.
    View in: PubMed
  31. She P, Zhang Z, Marchionini D, Diaz WC, Jetton TJ, Kimball SR, Vary TC, Lang CH, Lynch CJ. Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease. Am J Physiol Endocrinol Metab. 2011 Jul; 301(1):E49-61.
    View in: PubMed
  32. Frost RA, Lang CH. mTor signaling in skeletal muscle during sepsis and inflammation: where does it all go wrong? Physiology (Bethesda). 2011 Apr; 26(2):83-96.
    View in: PubMed
  33. Hong-Brown LQ, Brown CR, Navaratnarajah M, Huber DS, Lang CH. Alcohol-induced modulation of rictor and mTORC2 activity in C2C12 myoblasts. Alcohol Clin Exp Res. 2011 Aug; 35(8):1445-53.
    View in: PubMed
  34. Bertsch S, Lang CH, Vary TC. Inhibition of glycogen synthase kinase 3[beta] activity with lithium in vitro attenuates sepsis-induced changes in muscle protein turnover. Shock. 2011 Mar; 35(3):266-74.
    View in: PubMed
  35. Kazi AA, Pruznak AM, Frost RA, Lang CH. Sepsis-induced alterations in protein-protein interactions within mTOR complex 1 and the modulating effect of leucine on muscle protein synthesis. Shock. 2011 Feb; 35(2):117-25.
    View in: PubMed
  36. Frost RA, Pereyra E, Lang CH. Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes. Endocrinology. 2011 Jan; 152(1):151-63.
    View in: PubMed
  37. Lang CH. Potential therapeutic role of resistance training in diabetes: a contribution by the 2009 recipient of the APS New Investigator Award. Am J Physiol Endocrinol Metab. 2011 Jan; 300(1):E1-2.
    View in: PubMed
  38. Derdak Z, Lang CH, Villegas KA, Tong M, Mark NM, de la Monte SM, Wands JR. Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. J Hepatol. 2011 Jan; 54(1):164-72.
    View in: PubMed
  39. Culnan DM, Albaugh V, Sun M, Lynch CJ, Lang CH, Cooney RN. Ileal interposition improves glucose tolerance and insulin sensitivity in the obese Zucker rat. Am J Physiol Gastrointest Liver Physiol. 2010 Sep; 299(3):G751-60.
    View in: PubMed
  40. Lang CH. On the shoulders of giants. Am J Physiol Endocrinol Metab. 2010 Jul; 299(1):E1-2.
    View in: PubMed
  41. Lang CH, Lynch CJ, Vary TC. BCATm deficiency ameliorates endotoxin-induced decrease in muscle protein synthesis and improves survival in septic mice. Am J Physiol Regul Integr Comp Physiol. 2010 Sep; 299(3):R935-44.
    View in: PubMed
  42. Puleo F, Meirelles K, Navaratnarajah M, Fitzpatrick L, Shumate ML, Cooney RN, Lang CH. Skeletal muscle catabolism in trinitrobenzene sulfonic acid-induced murine colitis. Metabolism. 2010 Nov; 59(11):1680-90.
    View in: PubMed
  43. Albaugh VL, Vary TC, Ilkayeva O, Wenner BR, Maresca KP, Joyal JL, Breazeale S, Elich TD, Lang CH, Lynch CJ. Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents. Schizophr Bull. 2012 Jan; 38(1):153-66.
    View in: PubMed
  44. Kazi AA, Lang CH. PRAS40 regulates protein synthesis and cell cycle in C2C12 myoblasts. Mol Med. 2010 Sep-Oct; 16(9-10):359-71.
    View in: PubMed
  45. Hong-Brown LQ, Brown CR, Kazi AA, Huber DS, Pruznak AM, Lang CH. Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction. J Cell Biochem. 2010 Apr 15; 109(6):1172-84.
    View in: PubMed
  46. Lang CH, Frost RA, Bronson SK, Lynch CJ, Vary TC. Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. Am J Physiol Endocrinol Metab. 2010 Jun; 298(6):E1283-94.
    View in: PubMed
  47. Albaugh VL, Judson JG, She P, Lang CH, Maresca KP, Joyal JL, Lynch CJ. Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis. Mol Psychiatry. 2011 May; 16(5):569-81.
    View in: PubMed
  48. Lang CH, Lynch CJ, Vary TC. Alcohol-induced IGF-I resistance is ameliorated in mice deficient for mitochondrial branched-chain aminotransferase. J Nutr. 2010 May; 140(5):932-8.
    View in: PubMed
  49. Frost RA, Huber D, Pruznak A, Lang CH. Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubes. J Cell Biochem. 2009 Dec 1; 108(5):1192-202.
    View in: PubMed
  50. Frost RA, Nystrom GJ, Lang CH. Endotoxin and interferon-gamma inhibit translation in skeletal muscle cells by stimulating nitric oxide synthase activity. Shock. 2009 Oct; 32(4):416-26.
    View in: PubMed
  51. Jiao Q, Pruznak AM, Huber D, Vary TC, Lang CH. Castration differentially alters basal and leucine-stimulated tissue protein synthesis in skeletal muscle and adipose tissue. Am J Physiol Endocrinol Metab. 2009 Nov; 297(5):E1222-32.
    View in: PubMed
  52. Venardos K, Zhang WZ, Lang C, Kaye DM. Effect of peroxynitrite on endothelial L-arginine transport and metabolism. Int J Biochem Cell Biol. 2009 Dec; 41(12):2522-7.
    View in: PubMed
  53. Nystrom G, Pruznak A, Huber D, Frost RA, Lang CH. Local insulin-like growth factor I prevents sepsis-induced muscle atrophy. Metabolism. 2009 Jun; 58(6):787-97.
    View in: PubMed
  54. Meirelles K, Ahmed T, Culnan DM, Lynch CJ, Lang CH, Cooney RN. Mechanisms of glucose homeostasis after Roux-en-Y gastric bypass surgery in the obese, insulin-resistant Zucker rat. Ann Surg. 2009 Feb; 249(2):277-85.
    View in: PubMed
  55. Lang CH, Pruznak AM, Nystrom GJ, Vary TC. Alcohol-induced decrease in muscle protein synthesis associated with increased binding of mTOR and raptor: Comparable effects in young and mature rats. Nutr Metab (Lond). 2009; 6:4.
    View in: PubMed
  56. Nandate K, Abola R, Murray WB, Whitfield C, Lang C, Sinz E. Simulation of diabetic ketoacidosis for cellular and molecular basics of medical practice. Simul Healthc. 2009; 4(4):232-6.
    View in: PubMed
  57. Hong-Brown LQ, Brown CR, Huber DS, Lang CH. Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase. J Cell Biochem. 2008 Oct 15; 105(3):814-23.
    View in: PubMed
  58. Pruznak AM, Kazi AA, Frost RA, Vary TC, Lang CH. Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle. J Nutr. 2008 Oct; 138(10):1887-94.
    View in: PubMed
  59. Buzzelli MD, Nagarajan M, Radtka JF, Shumate ML, Navaratnarajah M, Lang CH, Cooney RN. Nuclear factor-kappaB mediates the inhibitory effects of tumor necrosis factor-alpha on growth hormone-inducible gene expression in liver. Endocrinology. 2008 Dec; 149(12):6378-88.
    View in: PubMed
  60. Pruznak AM, Hong-Brown L, Lantry R, She P, Frost RA, Vary TC, Lang CH. Skeletal and cardiac myopathy in HIV-1 transgenic rats. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E964-73.
    View in: PubMed
  61. Yuling H, Ruijing X, Xiang J, Luokun X, Wenjun Y, Feng C, Baojun H, Hui Y, Guang Y, Chunlei Y, Jixin Z, Lang C, Li Q, Chang A, Zhuan B, Youxin J, Feili G, Jinquan T. Essential role of sphingosine-1-phosphate receptor 1-bearing CD8+CD44+CCR7+ T cells in acute skin allograft rejection. Am J Transplant. 2008 Jul; 8(7):1401-12.
    View in: PubMed
  62. Buzzelli MD, Navaratnarajah M, Ahmed T, Nagarajan M, Shumate ML, Lang CH, Cooney RN. Nuclear factor kappaB mediates the inhibitory effects of interleukin-1 on growth hormone-inducible gene expression. J Trauma. 2008 Jun; 64(6):1427-35; discussion 1435-6.
    View in: PubMed
  63. Vary TC, Frost RA, Lang CH. Acute alcohol intoxication increases atrogin-1 and MuRF1 mRNA without increasing proteolysis in skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2008 Jun; 294(6):R1777-89.
    View in: PubMed
  64. Crozier SJ, Sans MD, Lang CH, D'Alecy LG, Ernst SA, Williams JA. CCK-induced pancreatic growth is not limited by mitogenic capacity in mice. Am J Physiol Gastrointest Liver Physiol. 2008 May; 294(5):G1148-57.
    View in: PubMed
  65. Lang CH, Frost RA, Vary TC. Acute alcohol intoxication increases REDD1 in skeletal muscle. Alcohol Clin Exp Res. 2008 May; 32(5):796-805.
    View in: PubMed
  66. Tao S, Liu YN, Lang C, Wang WT, Yuan HS, Zhang DY, Qiu WX, Liu JM, Liu ZG, Liu SZ, Yi R, Ji M, Liu XX. A directional passive air sampler for monitoring polycyclic aromatic hydrocarbons (PAHs) in air mass. Environ Pollut. 2008 Nov; 156(2):435-41.
    View in: PubMed
  67. Vary TC, Lang CH. Differential phosphorylation of translation initiation regulators 4EBP1, S6k1, and Erk 1/2 following inhibition of alcohol metabolism in mouse heart. Cardiovasc Toxicol. 2008 Mar; 8(1):23-32.
    View in: PubMed
  68. Lang CH, Nystrom G, Frost RA. Beta-adrenergic blockade exacerbates sepsis-induced changes in tumor necrosis factor alpha and interleukin-6 in skeletal muscle and is associated with impaired translation initiation. J Trauma. 2008 Feb; 64(2):477-86.
    View in: PubMed
  69. Nystrom GJ, Lang CH. Sepsis and AMPK Activation by AICAR Differentially Regulate FoxO-1, -3 and -4 mRNA in Striated Muscle. Int J Clin Exp Med. 2008; 1(1):50-63.
    View in: PubMed
  70. Frost RA, Lang CH. Regulation of muscle growth by pathogen-associated molecules. J Anim Sci. 2008 Apr; 86(14 Suppl):E84-93.
    View in: PubMed
  71. Vary TC, Lang CH. Assessing effects of alcohol consumption on protein synthesis in striated muscles. Methods Mol Biol. 2008; 447:343-55.
    View in: PubMed
  72. Fernandez-Solà J, Preedy VR, Lang CH, Gonzalez-Reimers E, Arno M, Lin JC, Wiseman H, Zhou S, Emery PW, Nakahara T, Hashimoto K, Hirano M, Santolaria-Fernández F, González-Hernández T, Fatjó F, Sacanella E, Estruch R, Nicolás JM, Urbano-Márquez A. Molecular and cellular events in alcohol-induced muscle disease. Alcohol Clin Exp Res. 2007 Dec; 31(12):1953-62.
    View in: PubMed
  73. Vargas R, Lang CH. Alcohol accelerates loss of muscle and impairs recovery of muscle mass resulting from disuse atrophy. Alcohol Clin Exp Res. 2008 Jan; 32(1):128-37.
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  74. Molina PE, Lang CH, McNurlan M, Bagby GJ, Nelson S. Chronic alcohol accentuates simian acquired immunodeficiency syndrome-associated wasting. Alcohol Clin Exp Res. 2008 Jan; 32(1):138-47.
    View in: PubMed
  75. Avramidou A, Kroczek C, Lang C, Schuh W, Jäck HM, Mielenz D. The novel adaptor protein Swiprosin-1 enhances BCR signals and contributes to BCR-induced apoptosis. Cell Death Differ. 2007 Nov; 14(11):1936-47.
    View in: PubMed
  76. Ronis MJ, Wands JR, Badger TM, de la Monte SM, Lang CH, Calissendorff J. Alcohol-induced disruption of endocrine signaling. Alcohol Clin Exp Res. 2007 Aug; 31(8):1269-85.
    View in: PubMed
  77. Lang CH, Frost RA, Vary TC. Regulation of muscle protein synthesis during sepsis and inflammation. Am J Physiol Endocrinol Metab. 2007 Aug; 293(2):E453-9.
    View in: PubMed
  78. Ahmed TA, Buzzelli MD, Lang CH, Capen JB, Shumate ML, Navaratnarajah M, Nagarajan M, Cooney RN. Interleukin-6 inhibits growth hormone-mediated gene expression in hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1793-803.
    View in: PubMed
  79. Jie X, Lang C, Jian Q, Chaoqun L, Dehua Y, Yi S, Yanping J, Luokun X, Qiuping Z, Hui W, Feili G, Boquan J, Youxin J, Jinquan T. Androgen activates PEG10 to promote carcinogenesis in hepatic cancer cells. Oncogene. 2007 Aug 23; 26(39):5741-51.
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  80. Frost RA, Lang CH. Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle mass. J Appl Physiol (1985). 2007 Jul; 103(1):378-87.
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  81. Krawiec BJ, Nystrom GJ, Frost RA, Jefferson LS, Lang CH. AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells. Am J Physiol Endocrinol Metab. 2007 Jun; 292(6):E1555-67.
    View in: PubMed
  82. Lang CH, Frost RA, Vary TC. Skeletal muscle protein synthesis and degradation exhibit sexual dimorphism after chronic alcohol consumption but not acute intoxication. Am J Physiol Endocrinol Metab. 2007 Jun; 292(6):E1497-506.
    View in: PubMed
  83. Lang CH, Frost RA. Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alpha. Metabolism. 2007 Jan; 56(1):49-57.
    View in: PubMed
  84. Hong-Brown LQ, Brown CR, Huber DS, Lang CH. Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinase-dependent mechanism in C2C12 skeletal myocytes. J Biol Chem. 2007 Feb 9; 282(6):3702-12.
    View in: PubMed
  85. Vary TC, Deiter G, Lang CH. Cytokine-triggered decreases in levels of phosphorylated eukaryotic initiation factor 4G in skeletal muscle during sepsis. Shock. 2006 Dec; 26(6):631-6.
    View in: PubMed
  86. Molina PE, McNurlan M, Rathmacher J, Lang CH, Zambell KL, Purcell J, Bohm RP, Zhang P, Bagby GJ, Nelson S. Chronic alcohol accentuates nutritional, metabolic, and immune alterations during asymptomatic simian immunodeficiency virus infection. Alcohol Clin Exp Res. 2006 Dec; 30(12):2065-78.
    View in: PubMed
  87. Lang CH, Frost RA. Glucocorticoids and TNFalpha interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscle. Mol Med. 2006 Nov-Dec; 12(11-12):291-9.
    View in: PubMed
  88. Frost RA, Nystrom GJ, Jefferson LS, Lang CH. Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle. Am J Physiol Endocrinol Metab. 2007 Feb; 292(2):E501-12.
    View in: PubMed
  89. Lang CH, Huber D, Frost RA. Burn-induced increase in atrogin-1 and MuRF-1 in skeletal muscle is glucocorticoid independent but downregulated by IGF-I. Am J Physiol Regul Integr Comp Physiol. 2007 Jan; 292(1):R328-36.
    View in: PubMed
  90. Hong-Brown LQ, Brown CR, Huber DS, Lang CH. Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes. Alcohol Clin Exp Res. 2006 Aug; 30(8):1297-307.
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  91. Lang CH. Elevated plasma free fatty acids decrease basal protein synthesis, but not the anabolic effect of leucine, in skeletal muscle. Am J Physiol Endocrinol Metab. 2006 Sep; 291(3):E666-74.
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  92. Yumet G, Shumate ML, Bryant DP, Lang CH, Cooney RN. Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signaling. Crit Care Med. 2006 May; 34(5):1420-7.
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  93. Ahmed T, Yumet G, Shumate M, Lang CH, Rotwein P, Cooney RN. Tumor necrosis factor inhibits growth hormone-mediated gene expression in hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G35-44.
    View in: PubMed
  94. Lang CH, Krawiec BJ, Huber D, McCoy JM, Frost RA. Sepsis and inflammatory insults downregulate IGFBP-5, but not IGFBP-4, in skeletal muscle via a TNF-dependent mechanism. Am J Physiol Regul Integr Comp Physiol. 2006 Apr; 290(4):R963-72.
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  95. Frost RA, Nystrom GJ, Lang CH. Multiple Toll-like receptor ligands induce an IL-6 transcriptional response in skeletal myocytes. Am J Physiol Regul Integr Comp Physiol. 2006 Mar; 290(3):R773-84.
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  96. Hong-Brown LQ, Brown CR, Lang CH. HIV antiretroviral agents inhibit protein synthesis and decrease ribosomal protein S6 and 4EBP1 phosphorylation in C2C12 myocytes. AIDS Res Hum Retroviruses. 2005 Oct; 21(10):854-62.
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  97. Lang CH, Frost RA, Summer AD, Vary TC. Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart. Int J Biochem Cell Biol. 2005 Oct; 37(10):2180-95.
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  98. Krawiec BJ, Frost RA, Vary TC, Jefferson LS, Lang CH. Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis. Am J Physiol Endocrinol Metab. 2005 Dec; 289(6):E969-80.
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  99. Frost RA, Nystrom G, Burrows PV, Lang CH. Temporal differences in the ability of ethanol to modulate endotoxin-induced increases in inflammatory cytokines in muscle under in vivo conditions. Alcohol Clin Exp Res. 2005 Jul; 29(7):1247-56.
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  100. Frost RA, Lang CH. Skeletal muscle cytokines: regulation by pathogen-associated molecules and catabolic hormones. Curr Opin Clin Nutr Metab Care. 2005 May; 8(3):255-63.
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  101. Hong-Brown LQ, Pruznak AM, Frost RA, Vary TC, Lang CH. Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. Am J Physiol Endocrinol Metab. 2005 Sep; 289(3):E382-90.
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  102. Vary TC, Lang CH. IGF-I activates the eIF4F system in cardiac muscle in vivo. Mol Cell Biochem. 2005 Apr; 272(1-2):209-20.
    View in: PubMed
  103. Lang CH, Frost RA. Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle. J Cell Physiol. 2005 Apr; 203(1):144-55.
    View in: PubMed
  104. Lang Ch, Sipos W, Schuh M, Schmoll F. Analysis of theFusarium toxins Deoxynivalenol and Zearalenone in Austrian feeds of the crop years 2002 and 2003. Mycotoxin Res. 2005 Mar; 21(1):29-31.
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  105. Lang CH, Pruznak AM, Frost RA. TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscle. J Cell Biochem. 2005 Feb 1; 94(2):419-31.
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  106. Vary TC, Deiter G, Lang CH. Diminished ERK 1/2 and p38 MAPK phosphorylation in skeletal muscle during sepsis. Shock. 2004 Dec; 22(6):548-54.
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  107. Lang CH, Hong-Brown L, Frost RA. Cytokine inhibition of JAK-STAT signaling: a new mechanism of growth hormone resistance. Pediatr Nephrol. 2005 Mar; 20(3):306-12.
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  108. Lang CH, Pruznak AM, Deshpande N, Palopoli MM, Frost RA, Vary TC. Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism. Alcohol Clin Exp Res. 2004 Nov; 28(11):1758-67.
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  109. Lang CH, Deshpande N, Frost RA. Leucine acutely reverses burn-induced alterations in translation initiation in heart. Shock. 2004 Oct; 22(4):326-32.
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  110. Frost RA, Nystrom GJ, Lang CH. Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C(2)C(12) myoblasts via Toll-like receptor-4 and c-Jun NH(2)-terminal kinase pathways. Am J Physiol Cell Physiol. 2004 Dec; 287(6):C1605-15.
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  111. Hong-Brown LQ, Brown CR, Lang CH. Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C2C12 myocytes. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1482-92.
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  112. Lang CH, Frost RA. Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation. Am J Physiol Endocrinol Metab. 2004 Oct; 287(4):E721-30.
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  113. Vary TC, Nairn AC, Lang CH. Restoration of protein synthesis in heart and skeletal muscle after withdrawal of alcohol. Alcohol Clin Exp Res. 2004 Apr; 28(4):517-25.
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  114. Lang CH, Frost RA, Svanberg E, Vary TC. IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats. Am J Physiol Endocrinol Metab. 2004 Jun; 286(6):E916-26.
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  115. Frost RA, Nystrom GJ, Lang CH. Epinephrine stimulates IL-6 expression in skeletal muscle and C2C12 myoblasts: role of c-Jun NH2-terminal kinase and histone deacetylase activity. Am J Physiol Endocrinol Metab. 2004 May; 286(5):E809-17.
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  116. Frost RA, Lang CH. Alteration of somatotropic function by proinflammatory cytokines. J Anim Sci. 2004; 82 E-Suppl:E100-109.
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  117. Lang CH, Frost RA, Vary TC. Thermal injury impairs cardiac protein synthesis and is associated with alterations in translation initiation. Am J Physiol Regul Integr Comp Physiol. 2004 Apr; 286(4):R740-50.
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  118. Lang CH, Vary TC, Frost RA. Acute in vivo elevation of insulin-like growth factor (IGF) binding protein-1 decreases plasma free IGF-I and muscle protein synthesis. Endocrinology. 2003 Sep; 144(9):3922-33.
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  119. Lang CH, Frost RA, Deshpande N, Kumar V, Vary TC, Jefferson LS, Kimball SR. Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle. Am J Physiol Endocrinol Metab. 2003 Dec; 285(6):E1205-15.
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  120. Frost RA, Nystrom GJ, Lang CH. Lipopolysaccharide and proinflammatory cytokines stimulate interleukin-6 expression in C2C12 myoblasts: role of the Jun NH2-terminal kinase. Am J Physiol Regul Integr Comp Physiol. 2003 Nov; 285(5):R1153-64.
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  121. Bryant P, Shumate M, Yumet G, Lang CH, Vary TC, Cooney RN. Capsaicin-sensitive nerves regulate the metabolic response to abdominal sepsis. J Surg Res. 2003 Jun 15; 112(2):152-61.
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  122. Lang CH, Silvis C, Deshpande N, Nystrom G, Frost RA. Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle. Shock. 2003 Jun; 19(6):538-46.
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  123. Frost RA, Nystrom GJ, Lang CH. Tumor necrosis factor-alpha decreases insulin-like growth factor-I messenger ribonucleic acid expression in C2C12 myoblasts via a Jun N-terminal kinase pathway. Endocrinology. 2003 May; 144(5):1770-9.
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  124. Hong-Brown LQ, Brown CR, Cooney RN, Frost RA, Lang CH. Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Am J Physiol Endocrinol Metab. 2003 Jul; 285(1):E63-72.
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  125. Molina PE, Hoek JB, Nelson S, Guidot DM, Lang CH, Wands JR, Crawford JM. Mechanisms of alcohol-induced tissue injury. Alcohol Clin Exp Res. 2003 Mar; 27(3):563-75.
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  126. Lang CH, Kumar V, Liu X, Frost RA, Vary TC. IGF-I induced phosphorylation of S6K1 and 4E-BP1 in heart is impaired by acute alcohol intoxication. Alcohol Clin Exp Res. 2003 Mar; 27(3):485-94.
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  127. Frost RA, Lang CH. Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells. Minerva Endocrinol. 2003 Mar; 28(1):53-73.
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  128. Vary TC, Nairn AC, Deiter G, Lang CH. Differential effects of alcohol consumption on eukaryotic elongation factors in heart, skeletal muscle, and liver. Alcohol Clin Exp Res. 2002 Dec; 26(12):1794-802.
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  129. Kumar V, Frost RA, Lang CH. Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle. Am J Physiol Endocrinol Metab. 2002 Nov; 283(5):E917-28.
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  130. Kumar V, Silvis C, Nystrom G, Deshpande N, Vary TC, Frost RA, Lang CH. Alcohol-induced increases in insulin-like growth factor binding protein-1 are partially mediated by TNF. Alcohol Clin Exp Res. 2002 Oct; 26(10):1574-83.
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  131. Frost RA, Nystrom GJ, Lang CH. Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2002 Sep; 283(3):R698-709.
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  132. Yumet G, Shumate ML, Bryant P, Lin CM, Lang CH, Cooney RN. Tumor necrosis factor mediates hepatic growth hormone resistance during sepsis. Am J Physiol Endocrinol Metab. 2002 Sep; 283(3):E472-81.
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  133. Lang CH, Frost RA. Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection. Curr Opin Clin Nutr Metab Care. 2002 May; 5(3):271-9.
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  134. Anthony JC, Lang CH, Crozier SJ, Anthony TG, MacLean DA, Kimball SR, Jefferson LS. Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. Am J Physiol Endocrinol Metab. 2002 May; 282(5):E1092-101.
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  135. Anthony JC, Reiter AK, Anthony TG, Crozier SJ, Lang CH, MacLean DA, Kimball SR, Jefferson LS. Orally administered leucine enhances protein synthesis in skeletal muscle of diabetic rats in the absence of increases in 4E-BP1 or S6K1 phosphorylation. Diabetes. 2002 Apr; 51(4):928-36.
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  136. Lang CH, Frost RA, Nairn AC, MacLean DA, Vary TC. TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E336-47.
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  137. Frost RA, Nystrom GJ, Lang CH. Regulation of IGF-I mRNA and signal transducers and activators of transcription-3 and -5 (Stat-3 and -5) by GH in C2C12 myoblasts. Endocrinology. 2002 Feb; 143(2):492-503.
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  138. Feldman KS, Wilson SL, Lawlor MD, Lang CH, Scheuchenzuber WJ. In vitro and in vivo inhibition of LPS-induced tumor necrosis factor-alpha production by dimeric gallotannin analogues. Bioorg Med Chem. 2002 Jan; 10(1):47-55.
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  139. Lang CH, Nystrom GJ, Frost RA. Burn-induced changes in IGF-I and IGF-binding proteins are partially glucocorticoid dependent. Am J Physiol Regul Integr Comp Physiol. 2002 Jan; 282(1):R207-15.
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  140. Molina PE, McClain C, Valla D, Guidot D, Diehl AM, Lang CH, Neuman M. Molecular pathology and clinical aspects of alcohol-induced tissue injury. Alcohol Clin Exp Res. 2002 Jan; 26(1):120-8.
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  141. Vary TC, Lynch CJ, Lang CH. Effects of chronic alcohol consumption on regulation of myocardial protein synthesis. Am J Physiol Heart Circ Physiol. 2001 Sep; 281(3):H1242-51.
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  142. Hong-Brown LQ, Frost RA, Lang CH. Alcohol impairs protein synthesis and degradation in cultured skeletal muscle cells. Alcohol Clin Exp Res. 2001 Sep; 25(9):1373-82.
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  143. Lang CH, Silvis C, Nystrom G, Frost RA. Regulation of myostatin by glucocorticoids after thermal injury. FASEB J. 2001 Aug; 15(10):1807-9.
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  144. Lang CH, Nystrom GJ, Frost RA. Tissue-specific regulation of IGF-I and IGF-binding proteins in response to TNFalpha. Growth Horm IGF Res. 2001 Aug; 11(4):250-60.
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  145. Feldman KS, Sahasrabudhe K, Lawlor MD, Wilson SL, Lang CH, Scheuchenzuber WJ. In vitro and In vivo inhibition of LPS-stimulated tumor necrosis factor-alpha secretion by the gallotannin beta-D-pentagalloylglucose. Bioorg Med Chem Lett. 2001 Jul 23; 11(14):1813-5.
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  146. Fedele MJ, Lang CH, Farrell PA. Immunization against IGF-I prevents increases in protein synthesis in diabetic rats after resistance exercise. Am J Physiol Endocrinol Metab. 2001 Jun; 280(6):E877-85.
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  147. Lang CH, Kimball SR, Frost RA, Vary TC. Alcohol myopathy: impairment of protein synthesis and translation initiation. Int J Biochem Cell Biol. 2001 May; 33(5):457-73.
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  148. Lang C, Schäfer M, Serra D, Hegardt F, Krähenbühl L, Krähenbühl S. Impaired hepatic fatty acid oxidation in rats with short-term cholestasis: characterization and mechanism. J Lipid Res. 2001 Jan; 42(1):22-30.
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  149. Svanberg E, Frost RA, Lang CH, Isgaard J, Jefferson LS, Kimball SR, Vary TC. IGF-I/IGFBP-3 binary complex modulates sepsis-induced inhibition of protein synthesis in skeletal muscle. Am J Physiol Endocrinol Metab. 2000 Nov; 279(5):E1145-58.
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  150. Lang CH, Frost RA, Kumar V, Vary TC. Impaired myocardial protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4F. Am J Physiol Endocrinol Metab. 2000 Nov; 279(5):E1029-38.
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  151. Frost RA, Nystrom GJ, Lang CH. Stimulation of insulin-like growth factor binding protein-1 synthesis by interleukin-1beta: requirement of the mitogen-activated protein kinase pathway. Endocrinology. 2000 Sep; 141(9):3156-64.
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  152. Co Ng LL, Lang CH, Bereket A, Purandare A, Smaldone A, Wilson TA. Effect of hyperthyroidism on insulin-like growth factor-I (IGF-I) and IGF-binding proteins in adolescent children. J Pediatr Endocrinol Metab. 2000 Sep-Oct; 13(8):1073-80.
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  153. Del Aguila LF, Krishnan RK, Ulbrecht JS, Farrell PA, Correll PH, Lang CH, Zierath JR, Kirwan JP. Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle. Am J Physiol Endocrinol Metab. 2000 Jul; 279(1):E206-12.
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  154. Lang CH, Frost RA, Jefferson LS, Kimball SR, Vary TC. Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-I. Am J Physiol Endocrinol Metab. 2000 Jun; 278(6):E1133-43.
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  155. Lang CH, Liu X, Nystrom GJ, Frost RA. Acute response of IGF-I and IGF binding proteins induced by thermal injury. Am J Physiol Endocrinol Metab. 2000 Jun; 278(6):E1087-96.
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  156. Maitra SR, Wojnar MM, Lang CH. Alterations in tissue glucose uptake during the hyperglycemic and hypoglycemic phases of sepsis. Shock. 2000 May; 13(5):379-85.
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  157. Lang CH, Liu X, Nystrom G, Wu D, Cooney RN, Frost RA. Acute effects of growth hormone in alcohol-fed rats. Alcohol Alcohol. 2000 Mar-Apr; 35(2):148-58.
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  158. Stamm J, Cooney RN, Maish GO, Shumate ML, Lang CH, Ehrlich HP, Vary TC. Growth hormone does not attenuate the inhibitory effects of sepsis on wound healing. Wound Repair Regen. 2000 Mar-Apr; 8(2):103-9.
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  159. Lang CH, Frost RA, Kumar V, Wu D, Vary TC. Impaired protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4E in muscle and eIF2B in liver. Alcohol Clin Exp Res. 2000 Mar; 24(3):322-31.
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  160. Fedele MJ, Hernandez JM, Lang CH, Vary TC, Kimball SR, Jefferson LS, Farrell PA. Severe diabetes prohibits elevations in muscle protein synthesis after acute resistance exercise in rats. J Appl Physiol (1985). 2000 Jan; 88(1):102-8.
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  161. Lang CH, Wu D, Frost RA, Jefferson LS, Vary TC, Kimball SR. Chronic alcohol feeding impairs hepatic translation initiation by modulating eIF2 and eIF4E. Am J Physiol. 1999 Nov; 277(5 Pt 1):E805-14.
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  162. Mynarcik DC, Frost RA, Lang CH, DeCristofaro K, McNurlan MA, Garlick PJ, Steigbigel RT, Fuhrer J, Ahnn S, Gelato MC. Insulin-like growth factor system in patients with HIV infection: effect of exogenous growth hormone administration. J Acquir Immune Defic Syndr. 1999 Sep 1; 22(1):49-55.
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  163. Frost RA, Lang CH. Differential effects of insulin-like growth factor I (IGF-I) and IGF-binding protein-1 on protein metabolism in human skeletal muscle cells. Endocrinology. 1999 Sep; 140(9):3962-70.
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  164. Farrell PA, Fedele MJ, Hernandez J, Fluckey JD, Miller JL, Lang CH, Vary TC, Kimball SR, Jefferson LS. Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exercise. J Appl Physiol (1985). 1999 Sep; 87(3):1075-82.
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  165. Lang CH, Wu D, Frost RA, Jefferson LS, Kimball SR, Vary TC. Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E. Am J Physiol. 1999 Aug; 277(2 Pt 1):E268-76.
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  166. Maitra SR, Gestring ML, El-Maghrabi MR, Lang CH, Henry MC. Endotoxin-induced alterations in hepatic glucose-6-phosphatase activity and gene expression. Mol Cell Biochem. 1999 Jun; 196(1-2):79-83.
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  167. Cooney RN, Maish GO, Gilpin T, Shumate ML, Lang CH, Vary TC. Mechanism of IL-1 induced inhibition of protein synthesis in skeletal muscle. Shock. 1999 Apr; 11(4):235-41.
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  168. Farrell PA, Fedele MJ, Vary TC, Kimball SR, Lang CH, Jefferson LS. Regulation of protein synthesis after acute resistance exercise in diabetic rats. Am J Physiol. 1999 Apr; 276(4 Pt 1):E721-7.
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  169. Lang C, Paulin-Levasseur M, Gajewski A, Alsheimer M, Benavente R, Krohne G. Molecular characterization and developmentally regulated expression of Xenopus lamina-associated polypeptide 2 (XLAP2). J Cell Sci. 1999 Mar; 112 ( Pt 5):749-59.
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  170. Wojnar MM, Fan J, Li YH, Lang CH. Endotoxin-induced changes in IGF-I differ in rats provided enteral vs. parenteral nutrition. Am J Physiol. 1999 Mar; 276(3 Pt 1):E455-64.
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  171. Lang CH, Nystrom GJ, Frost RA. Regulation of IGF binding protein-1 in hep G2 cells by cytokines and reactive oxygen species. Am J Physiol. 1999 Mar; 276(3 Pt 1):G719-27.
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  172. Bereket A, Lang CH, Wilson TA. Alterations in the growth hormone-insulin-like growth factor axis in insulin dependent diabetes mellitus. Horm Metab Res. 1999 Feb-Mar; 31(2-3):172-81.
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  173. Lang CH, Frost RA, Ejiofor J, Lacy DB, McGuinness OP. Hepatic production and intestinal uptake of IGF-I: response to infection. Am J Physiol. 1998 Dec; 275(6 Pt 1):G1291-8.
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  174. Crist GH, Xu B, Lanoue KF, Lang CH. Tissue-specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats. FASEB J. 1998 Oct; 12(13):1301-8.
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  175. McNurlan MA, Garlick PJ, Frost RA, Decristofaro KA, Lang CH, Steigbigel RT, Fuhrer J, Gelato M. Albumin synthesis and bone collagen formation in human immunodeficiency virus-positive subjects: differential effects of growth hormone administration. J Clin Endocrinol Metab. 1998 Sep; 83(9):3050-5.
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  176. Bereket G, Lin JJ, Bereket A, Lang CH, Kaskel FJ. Peritoneal loss of insulin-like growth factor-I and binding proteins in end-stage renal disease. Pediatr Nephrol. 1998 Sep; 12(7):581-8.
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  177. Haglind E, Malmlof K, Fan J, Lang CH. Insulin-like growth factor-I and growth hormone administration in intestinal ischemia shock in the rat. Shock. 1998 Jul; 10(1):62-8.
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  178. Bark TH, McNurlan MA, Lang CH, Garlick PJ. Increased protein synthesis after acute IGF-I or insulin infusion is localized to muscle in mice. Am J Physiol. 1998 Jul; 275(1 Pt 1):E118-23.
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  179. Vasques M, Lang C, Grindeland RE, Roy RR, Daunton N, Bigbee AJ, Wade CE. Comparison of hyper- and microgravity on rat muscle, organ weights and selected plasma constituents. Aviat Space Environ Med. 1998 Jun; 69(6 Suppl):A2-8.
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  180. Lang CH, Fan J, Lipton BP, Potter BJ, McDonough KH. Modulation of the insulin-like growth factor system by chronic alcohol feeding. Alcohol Clin Exp Res. 1998 Jun; 22(4):823-9.
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  181. Lang CH, Fan J, Wojnar MM, Vary TC, Cooney R. Role of central IL-1 in regulating peripheral IGF-I during endotoxemia and sepsis. Am J Physiol. 1998 Apr; 274(4 Pt 2):R956-62.
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  182. Frost RA, Lang CH. Growth factors in critical illness: regulation and therapeutic aspects. Curr Opin Clin Nutr Metab Care. 1998 Mar; 1(2):195-204.
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  183. Garlick PJ, McNurlan MA, Bark T, Lang CH, Gelato MC. Hormonal regulation of protein metabolism in relation to nutrition and disease. J Nutr. 1998 Feb; 128(2 Suppl):356S-359S.
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  184. Bereket A, Lang CH, Geffner ME, Wilson TA. Normal growth in a patient with septo-optic dysplasia despite both growth hormone and IGF-I deficiency. J Pediatr Endocrinol Metab. 1998 Jan-Feb; 11(1):69-75.
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  185. Rosato EF, Vemulapalli P, Lang CH, Lanza-Jacoby S. Insulin stimulates lipoprotein lipase activity and synthesis in adipocytes from septic rats. J Surg Res. 1997 Nov; 73(1):73-9.
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  186. McNurlan MA, Garlick PJ, Steigbigel RT, DeCristofaro KA, Frost RA, Lang CH, Johnson RW, Santasier AM, Cabahug CJ, Fuhrer J, Gelato MC. Responsiveness of muscle protein synthesis to growth hormone administration in HIV-infected individuals declines with severity of disease. J Clin Invest. 1997 Oct 15; 100(8):2125-32.
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  187. Frost RA, Lang CH, Gelato MC. Transient exposure of human myoblasts to tumor necrosis factor-alpha inhibits serum and insulin-like growth factor-I stimulated protein synthesis. Endocrinology. 1997 Oct; 138(10):4153-9.
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  188. Morgan AE, Lang CH. Involvement of capsaicin-sensitive nerves in regulating the hormone and glucose metabolic response to endotoxin. Am J Physiol. 1997 Aug; 273(2 Pt 1):E328-35.
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  189. Lang CH, Pollard V, Fan J, Traber LD, Traber DL, Frost RA, Gelato MC, Prough DS. Acute alterations in growth hormone-insulin-like growth factor axis in humans injected with endotoxin. Am J Physiol. 1997 Jul; 273(1 Pt 2):R371-8.
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  190. Li YH, Fan J, Lang CH. Differential role of glucocorticoids in mediating endotoxin-induced changes in IGF-I and IGFBP-1. Am J Physiol. 1997 Jun; 272(6 Pt 2):R1990-7.
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  191. Lynch JP, Wojnar MM, Lang CH. Ventromedial hypothalamic lesions impair glucoregulation in response to endotoxin. Am J Physiol. 1997 May; 272(5 Pt 2):R1525-31.
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  192. Bereket A, Lang CH, Blethen SL, Kaskel FJ, Stewart C, Wilson TA. Growth hormone treatment in growth retarded children with end stage renal failure: effect on free/dissociable IGF-I levels. J Pediatr Endocrinol Metab. 1997 Mar-Apr; 10(2):197-202.
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  193. Molina PE, Malek S, Lang CH, Qian L, Naukam R, Abumrad NN. Early organ-specific hemorrhage-induced increases in tissue cytokine content: associated neurohormonal and opioid alterations. Neuroimmunomodulation. 1997 Jan-Feb; 4(1):28-36.
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  194. Bereket A, Wilson TA, Blethen SL, Fan J, Frost RA, Gelato MC, Lang CH. Effect of short-term fasting on free/dissociable insulin-like growth factor I concentrations in normal human serum. J Clin Endocrinol Metab. 1996 Dec; 81(12):4379-84.
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  195. Samstein B, Hoimes ML, Fan J, Frost RA, Gelato MC, Lang CH. IL-6 stimulation of insulin-like growth factor binding protein (IGFBP)-1 production. Biochem Biophys Res Commun. 1996 Nov 12; 228(2):611-5.
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  196. Bereket A, Lang CH, Blethen SL, Ng LC, Wilson TA. Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children. Clin Endocrinol (Oxf). 1996 Sep; 45(3):321-6.
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  197. Fan J, Li YH, Wojnar MM, Lang CH. Endotoxin-induced alterations in insulin-stimulated phosphorylation of insulin receptor, IRS-1, and MAP kinase in skeletal muscle. Shock. 1996 Sep; 6(3):164-70.
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  198. Frost RA, Nachman SA, Lang CH, Gelato MC. Proteolysis of insulin-like growth factor-binding protein-3 in human immunodeficiency virus-positive children who fail to thrive. J Clin Endocrinol Metab. 1996 Aug; 81(8):2957-62.
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  199. Lang CH, Cooney R, Vary TC. Central interleukin-1 partially mediates endotoxin-induced changes in glucose metabolism. Am J Physiol. 1996 Aug; 271(2 Pt 1):E309-16.
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  200. Lang CH, Fan J, Frost RA, Gelato MC, Sakurai Y, Herndon DN, Wolfe RR. Regulation of the insulin-like growth factor system by insulin in burn patients. J Clin Endocrinol Metab. 1996 Jul; 81(7):2474-80.
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  201. Bereket A, Wilson TA, Kolasa AJ, Fan J, Lang CH. Regulation of the insulin-like growth factor system by acute acidosis. Endocrinology. 1996 Jun; 137(6):2238-45.
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  202. Frost RA, Fuhrer J, Steigbigel R, Mariuz P, Lang CH, Gelato MC. Wasting in the acquired immune deficiency syndrome is associated with multiple defects in the serum insulin-like growth factor system. Clin Endocrinol (Oxf). 1996 May; 44(5):501-14.
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  203. Bereket A, Wilson TA, Blethen SL, Sakurai Y, Herndon DN, Wolfe RR, Lang CH. Regulation of the acid-labile subunit of the insulin-like growth factor ternary complex in patients with insulin-dependent diabetes mellitus and severe burns. Clin Endocrinol (Oxf). 1996 May; 44(5):525-32.
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  204. Delman K, Malek SK, Bundz S, Abumrad NN, Lang CH, Molina PE. Resuscitation with lactated Ringer's solution after hemorrhage: lack of cardiac toxicity. Shock. 1996 Apr; 5(4):298-303.
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  205. Shangraw RE, Jahoor F, Wolfe RR, Lang CH. Pyruvate dehydrogenase inactivity is not responsible for sepsis-induced insulin resistance. Crit Care Med. 1996 Apr; 24(4):566-74.
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  206. Fan J, Wojnar MM, Theodorakis M, Lang CH. Regulation of insulin-like growth factor (IGF)-I mRNA and peptide and IGF-binding proteins by interleukin-1. Am J Physiol. 1996 Mar; 270(3 Pt 2):R621-9.
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  207. Lang CH, Fan J, Cooney R, Vary TC. IL-1 receptor antagonist attenuates sepsis-induced alterations in the IGF system and protein synthesis. Am J Physiol. 1996 Mar; 270(3 Pt 1):E430-7.
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  208. Meijerink WJ, Molina PE, Lang CH, Abumrad NN. Contribution of excitatory amino acids to morphine-induced metabolic alterations. Brain Res. 1996 Jan 8; 706(1):123-8.
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  209. Hashiguchi Y, Molina PE, Fan J, Lang CH, Abumrad NN. Central opiate modulation of growth hormone and insulin-like growth factor-I. Brain Res Bull. 1996; 40(2):99-104.
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  210. Lang CH. IGF-I stimulates muscle glucose uptake during sepsis. Shock. 1996 Jan; 5(1):22-7.
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  211. Bundz S, Molina PE, Lang CH, Abumrad NN. Endogenous opiates do not modulate LPS-induced alterations in carbohydrate metabolism. Shock. 1995 Dec; 4(6):397-402.
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  212. Bereket A, Lang CH, Blethen SL, Wilson TA. Insulin-like growth factor-binding protein-2 and insulin: studies in children with type 1 diabetes mellitus and maturity-onset diabetes of the young. J Clin Endocrinol Metab. 1995 Dec; 80(12):3647-52.
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  213. Fan J, Char D, Bagby GJ, Gelato MC, Lang CH. Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding proteins by tumor necrosis factor. Am J Physiol. 1995 Nov; 269(5 Pt 2):R1204-12.
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  214. Lang CH. Neural regulation of the enhanced uptake of glucose in skeletal muscle after endotoxin. Am J Physiol. 1995 Aug; 269(2 Pt 2):R437-44.
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  215. Bereket A, Lang CH, Blethen SL, Fan J, Frost RA, Wilson TA. Insulin-like growth factor binding protein-3 proteolysis in children with insulin-dependent diabetes mellitus: a possible role for insulin in the regulation of IGFBP-3 protease activity. J Clin Endocrinol Metab. 1995 Aug; 80(8):2282-8.
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  216. Fan J, Li YH, Bagby GJ, Lang CH. Modulation of inflammation-induced changes in insulin-like growth factor (IGF)-I and IGF binding protein-1 by anti-TNF antibody. Shock. 1995 Jul; 4(1):21-6.
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  217. Wojnar MM, Hawkins WG, Lang CH. Nutritional support of the septic patient. Crit Care Clin. 1995 Jul; 11(3):717-33.
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  218. Fan J, Char D, Kolasa AJ, Pan W, Maitra SR, Patlak CS, Spolarics Z, Gelato MC, Lang CH. Alterations in hepatic production and peripheral clearance of IGF-I after endotoxin. Am J Physiol. 1995 Jul; 269(1 Pt 1):E33-42.
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  219. Wojnar MM, Fan J, Frost RA, Gelato MC, Lang CH. Alterations in the insulin-like growth factor system in trauma patients. Am J Physiol. 1995 Apr; 268(4 Pt 2):R970-7.
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  220. Bereket A, Lang CH, Blethen SL, Gelato MC, Fan J, Frost RA, Wilson TA. Effect of insulin on the insulin-like growth factor system in children with new-onset insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1995 Apr; 80(4):1312-7.
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  221. Lang CH, Ajmal M. Metabolic, hormonal, and hemodynamic changes induced by metabotropic excitatory amino acid agonist (1S,3R)-ACPD. Am J Physiol. 1995 Apr; 268(4 Pt 2):R1026-33.
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  222. Lang CH, Ajmal M, Baillie AG. Neural control of glucose uptake by skeletal muscle after central administration of NMDA. Am J Physiol. 1995 Feb; 268(2 Pt 2):R492-7.
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  223. Petit F, Bagby GJ, Lang CH. Tumor necrosis factor mediates zymosan-induced increase in glucose flux and insulin resistance. Am J Physiol. 1995 Feb; 268(2 Pt 1):E219-28.
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  224. Lang CH. Inhibition of central GABAA receptors enhances hepatic glucose production and peripheral glucose uptake. Brain Res Bull. 1995; 37(6):611-6.
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  225. Jarrous A, Lang CH. Central administration of IL-1 alpha increases glucose uptake by muscle. Cytokine. 1995 Jan; 7(1):57-63.
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  226. Petit F, Jarrous A, Dickinson RD, Molina PE, Abumrad NN, Lang CH. Contribution of central and peripheral adrenergic stimulation to IL-1 alpha-mediated glucoregulation. Am J Physiol. 1994 Jul; 267(1 Pt 1):E49-56.
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  227. Lang CH, Molina PE, Skrepnick N, Bagby GJ, Spitzer JJ. Epinephrine-induced changes in hepatic glucose production after ethanol. Am J Physiol. 1994 Jun; 266(6 Pt 1):E863-9.
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  228. Frost RA, Bereket A, Wilson TA, Wojnar MM, Lang CH, Gelato MC. Phosphorylation of insulin-like growth factor binding protein-1 in patients with insulin-dependent diabetes mellitus and severe trauma. J Clin Endocrinol Metab. 1994 Jun; 78(6):1533-5.
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  229. Molina PE, Yousef KA, Smith RM, Tepper PG, Lang CH, Abumrad NN. Thiamin deficiency impairs endotoxin-induced increases in hepatic glucose output. Am J Clin Nutr. 1994 May; 59(5):1045-9.
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  230. Yousef KA, Lang CH. Modulation of endotoxin-induced changes in hemodynamics and glucose metabolism by an N-methyl-D-aspartate receptor antagonist. Shock. 1994 May; 1(5):335-42.
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  231. Fan J, Molina PE, Gelato MC, Lang CH. Differential tissue regulation of insulin-like growth factor-I content and binding proteins after endotoxin. Endocrinology. 1994 Apr; 134(4):1685-92.
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  232. Molina PE, Myers N, Smith RM, Lang CH, Yousef KA, Tepper PG, Abumrad NN. Nutritional and metabolic characterization of a thiamine-deficient rat model. JPEN J Parenter Enteral Nutr. 1994 Mar-Apr; 18(2):104-11.
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  233. Molina PE, Tepper PG, Yousef KA, Abumrad NN, Lang CH. Central NMDA enhances hepatic glucose output and non-insulin-mediated glucose uptake by a nonadrenergic mechanism. Brain Res. 1994 Jan 14; 634(1):41-8.
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  234. Yousef KA, Tepper PG, Molina PE, Abumrad NN, Lang CH. Differential control of glucoregulatory hormone response and glucose metabolism by NMDA and kainate. Brain Res. 1994 Jan 14; 634(1):131-40.
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  235. Lang CH. Stress induced by central cholinergic stimulation alters regional distribution of glucose uptake. Shock. 1994 Jan; 1(1):36-42.
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  236. Broussard HJ, Lang C, Burns AH. Myocardial effects of experimental neoplastic disease. Life Sci. 1994; 54(4):287-93.
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  237. Lang CH, Molina PE, Abumrad NN. Granulocyte colony-stimulating factor prevents ethanol-induced impairment in host defense in septic rats. Alcohol Clin Exp Res. 1993 Dec; 17(6):1268-74.
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  238. Lang CH, Molina PE, Yousef KA, Tepper PG, Abumrad NN. Role of IL-1 alpha in central nervous system immunomodulation of glucoregulation. Brain Res. 1993 Oct 8; 624(1-2):53-60.
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  239. Deaciuc IV, Lang CH, Bagby GJ, Spitzer JJ. Effect of subcutaneous Escherichia coli-induced hypermetabolic sepsis on hepatic gluconeogenesis and its hormonal responsiveness in the rat. Circ Shock. 1993 Oct; 41(2):82-7.
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  240. Lang CH, Spolarics Z, Ottlakan A, Spitzer JJ. Effect of high-dose endotoxin on glucose production and utilization. Metabolism. 1993 Oct; 42(10):1351-8.
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  241. Lang CH, Skrepnik N, Dobrescu C, Burns AH. Impairment of insulin action on peripheral glucose uptake and hepatic glucose production in tumor-bearing rats. Am J Physiol. 1993 Aug; 265(2 Pt 2):R356-64.
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  242. Deaciuc IV, Bagby GJ, Lang CH, Skrepnik N, Spitzer JJ. Gram-negative bacterial lipopolysaccharide impairs hyaluronan clearance in vivo and its uptake by the isolated, perfused rat liver. Hepatology. 1993 Jul; 18(1):173-8.
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  243. Lang CH. Beta-adrenergic blockade attenuates insulin resistance induced by tumor necrosis factor. Am J Physiol. 1993 May; 264(5 Pt 2):R984-91.
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  244. Bagby GJ, Lang CH, Skrepnik N, Golightly G, Spitzer JJ. Regulation of glucose metabolism after endotoxin and during infection is largely independent of endogenous tumor necrosis factor. Circ Shock. 1993 Mar; 39(3):211-9.
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  245. Deaciuc IV, Bagby GJ, Lang CH, Spitzer JJ. Hyaluronic acid uptake by the isolated, perfused rat liver: an index of hepatic sinusoidal endothelial cell function. Hepatology. 1993 Feb; 17(2):266-72.
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  246. D'Souza NB, Bagby GJ, Lang CH, Deaciuc IV, Spitzer JJ. Ethanol alters the metabolic response of isolated perfused rat liver to a phagocytic stimulus. Alcohol Clin Exp Res. 1993 Feb; 17(1):147-54.
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  247. Ottlakán A, Spolarics Z, Lang CH, Spitzer JJ. Adrenergic blockade attenuates endotoxin-induced hepatic glucose uptake. Circ Shock. 1993 Jan; 39(1):74-9.
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  248. Lang CH, Bagby GJ, Dobrescu C, Ottlakan A, Spitzer JJ. Sepsis- and endotoxin-induced increase in organ glucose uptake in leukocyte-depleted rats. Am J Physiol. 1992 Dec; 263(6 Pt 2):R1324-32.
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  249. Lang CH, Bagby GJ, Dobrescu C, Nelson S, Spitzer JJ. Modulation of glucose metabolic response to endotoxin by granulocyte colony-stimulating factor. Am J Physiol. 1992 Nov; 263(5 Pt 2):R1122-9.
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  250. Deaciuc IV, D'Souza NB, Lang CH, Spitzer JJ. Effects of acute alcohol intoxication on gluconeogenesis and its hormonal responsiveness in isolated, perfused rat liver. Biochem Pharmacol. 1992 Oct 20; 44(8):1617-24.
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  251. Lang CH. Sepsis-induced insulin resistance in rats is mediated by a beta-adrenergic mechanism. Am J Physiol. 1992 Oct; 263(4 Pt 1):E703-11.
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  252. Lang CH, Dobrescu C. Regulation of glucose metabolism by free fatty acid availability in septic and nonseptic rats. Circ Shock. 1992 Oct; 38(2):91-102.
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  253. Lang CH, Bagby GJ, Dobrescu C, Nelson S, Spitzer JJ. Effect of granulocyte colony-stimulating factor on sepsis-induced changes in neutrophil accumulation and organ glucose uptake. J Infect Dis. 1992 Aug; 166(2):336-43.
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  254. Bautista AP, D'Souza NB, Lang CH, Spitzer JJ. Modulation of f-met-leu-phe induced chemotactic activity and superoxide production by neutrophils during chronic ethanol intoxication. Alcohol Clin Exp Res. 1992 Aug; 16(4):788-94.
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  255. Spolarics Z, Ottlakán A, Lang CH, Spitzer JJ. Kupffer cells play a major role in insulin-mediated hepatic glucose uptake in vivo. Biochem Biophys Res Commun. 1992 Jul 15; 186(1):455-60.
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  256. Deaciuc IV, D'Souza NB, Bagby GJ, Lang CH, Spitzer JJ. Effect of acute alcohol administration on TNF-alpha binding to neutrophils and isolated liver plasma membranes. Alcohol Clin Exp Res. 1992 Jun; 16(3):533-8.
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  257. Spolarics Z, Schuler A, Bagby GJ, Lang CH, Nelson S, Spitzer JJ. In vivo metabolic response of hepatic nonparenchymal cells and leukocytes to granulocyte-macrophage colony-stimulating factor. J Leukoc Biol. 1992 Apr; 51(4):360-5.
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  258. Bagby GJ, Lang CH, Skrepnik N, Spitzer JJ. Attenuation of glucose metabolic changes resulting from TNF-alpha administration by adrenergic blockade. Am J Physiol. 1992 Apr; 262(4 Pt 2):R628-35.
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  259. Stephens JM, Bagby GJ, Pekala PH, Shepherd RE, Spitzer JJ, Lang CH. Differential regulation of glucose transporter gene expression in adipose tissue or septic rats. Biochem Biophys Res Commun. 1992 Mar 16; 183(2):417-22.
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  260. D'Souza NB, Bautista AP, Lang CH, Spitzer JJ. Acute ethanol intoxication prevents lipopolysaccharide-induced down regulation of protein kinase C in rat Kupffer cells. Alcohol Clin Exp Res. 1992 Feb; 16(1):64-7.
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  261. Lang CH, Dobrescu C, Bagby GJ. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology. 1992 Jan; 130(1):43-52.
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  262. Lang CH. Rates and tissue sites of noninsulin- and insulin-mediated glucose uptake in diabetic rats. Proc Soc Exp Biol Med. 1992 Jan; 199(1):81-7.
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  263. Spolarics Z, Bagby GJ, Lang CH, Spitzer JJ. Up-regulation of glucose metabolism in Kupffer cells following infusion of tumour necrosis factor. Biochem J. 1991 Sep 1; 278 ( Pt 2):515-9.
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  264. Spolarics Z, Lang CH, Bagby GJ, Spitzer JJ. Glutamine and fatty acid oxidation are the main sources of energy for Kupffer and endothelial cells. Am J Physiol. 1991 Aug; 261(2 Pt 1):G185-90.
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  265. Lang CH, Obih JC, Bagby GJ, Bagwell JN, Spitzer JJ. Increased glucose uptake by intestinal mucosa and muscularis in hypermetabolic sepsis. Am J Physiol. 1991 Aug; 261(2 Pt 1):G287-94.
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  266. Lang CH, Dobrescu C. Sepsis-induced increases in glucose uptake by macrophage-rich tissues persist during hypoglycemia. Metabolism. 1991 Jun; 40(6):585-93.
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  267. Molina PE, Lang CH, Bagby GJ, Spitzer JJ. Ethanol oxidation is not required to attenuate endotoxin-enhanced glucose metabolism. Am J Physiol. 1991 Jun; 260(6 Pt 2):R1058-65.
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  268. Bautista AP, D'Souza NB, Lang CH, Bagwell J, Spitzer JJ. Alcohol-induced downregulation of superoxide anion release by hepatic phagocytes in endotoxemic rats. Am J Physiol. 1991 May; 260(5 Pt 2):R969-76.
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  269. Lang CH, Obih JA, Bagby GJ, Bagwell JN, Spitzer JJ. Endotoxin-induced increases in regional glucose utilization by small intestine: a TNF-independent effect. Am J Physiol. 1991 Apr; 260(4 Pt 1):G548-55.
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  270. D'Souza NB, Bautista AP, Bagby GJ, Lang CH, Spitzer JJ. Acute ethanol intoxication suppresses E. coli lipopolysaccharide enhanced glucose utilization by hepatic nonparenchymal cells. Alcohol Clin Exp Res. 1991 Mar; 15(2):249-54.
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  271. Spolarics Z, Schuler A, Bagby GJ, Lang CH, Mészáros K, Spitzer JJ. Tumor necrosis factor increases in vivo glucose uptake in hepatic nonparenchymal cells. J Leukoc Biol. 1991 Mar; 49(3):309-12.
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  272. Lang CH, Dobrescu C. Gram-negative infection increases noninsulin-mediated glucose disposal. Endocrinology. 1991 Feb; 128(2):645-53.
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  273. Mészáros K, Bojta J, Bautista AP, Lang CH, Spitzer JJ. Glucose utilization by Kupffer cells, endothelial cells, and granulocytes in endotoxemic rat liver. Am J Physiol. 1991 Jan; 260(1 Pt 1):G7-12.
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  274. Ali M, Allen HR, Vedeckis WV, Lang CH. Depletion of rat liver glucocorticoid receptor hormone-binding and its mRNA in sepsis. Life Sci. 1991; 48(7):603-11.
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  275. Spitzer JJ, Bagby GJ, Bautista AP, D'Souza NB, Molina PE, Lang CH. Immunosuppressive effect of alcohol on hepatic parenchymal and nonparenchymal cell functions following endotoxin. Adv Exp Med Biol. 1991; 288:255-64.
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  276. Schuler A, Spolarics Z, Lang CH, Bagby GJ, Nelson S, Spitzer JJ. Upregulation of glucose metabolism by granulocyte-monocyte colony-stimulating factor. Life Sci. 1991; 49(12):899-906.
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  277. Hargrove DM, Skrepnik N, Lang CH, Bagby GJ, Spitzer JJ. Role of insulin in the blunted glucose metabolic response of septic rats to epinephrine. Metabolism. 1990 Nov; 39(11):1180-5.
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  278. Lang CH, Dobrescu C, Mészáros K. Insulin-mediated glucose uptake by individual tissues during sepsis. Metabolism. 1990 Oct; 39(10):1096-107.
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  279. D'Souza NB, Lang CH, Bagby GJ, Spitzer JJ. The effect of ethanol infusion on the altered glucose turnover during bacterial infection. Metabolism. 1990 Jun; 39(6):588-94.
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  280. Molina PE, Lang CH, Bagby GJ, Spitzer JJ. Ethanol attenuates endotoxin-enhanced glucose utilization. Am J Physiol. 1990 Apr; 258(4 Pt 2):R987-93.
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  281. Lang CH, Molina PE, Bagby GJ, Spitzer JJ. Chronic alcohol consumption prevents the sepsis-induced increases in gluconeogenesis and metabolic clearance rate. Prog Clin Biol Res. 1990; 325:373-82.
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  282. Lang CH, Bagby GJ, Blakesley HL, Spitzer JJ. Importance of hyperglucagonemia in eliciting the sepsis-induced increase in glucose production. Circ Shock. 1989 Nov; 29(3):181-91.
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  283. Hargrove DM, Lang CH, Bagby GJ, Spitzer JJ. Epinephrine-induced increase in glucose turnover is diminished during sepsis. Metabolism. 1989 Nov; 38(11):1070-6.
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  284. Mészáros K, Lang CH, Hargrove DM, Spitzer JJ. Tissue glucose utilization during epinephrine-induced hyperglycemia. J Appl Physiol (1985). 1989 Nov; 67(5):1770-5.
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  285. Mészáros K, Lang CH, Bojta J, Spitzer JJ. Early changes in glucose utilization of individual tissues after endotoxin administration. Circ Shock. 1989 Oct; 29(2):107-14.
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  286. Lang CH, Dobrescu C. Sepsis-induced changes in in vivo insulin action in diabetic rats. Am J Physiol. 1989 Sep; 257(3 Pt 1):E301-8.
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  287. Lang CH, Dobrescu C. In vivo insulin resistance during nonlethal hypermetabolic sepsis. Circ Shock. 1989 Jun; 28(2):165-78.
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  288. Molina PE, Lang CH, Bagby GJ, D'Souza NB, Spitzer JJ. Ethanol administration diminishes the endotoxin-induced increase in glucose metabolism. Alcohol Clin Exp Res. 1989 Jun; 13(3):407-12.
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  289. D'Souza NB, Bagby GJ, Nelson S, Lang CH, Spitzer JJ. Acute alcohol infusion suppresses endotoxin-induced serum tumor necrosis factor. Alcohol Clin Exp Res. 1989 Apr; 13(2):295-8.
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  290. Lang CH, Dobrescu C. Interleukin-1 induced increases in glucose utilization are insulin mediated. Life Sci. 1989; 45(22):2127-34.
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  291. Spitzer JJ, Bagby GJ, Hargrove DM, Lang CH, Mészáros K. Alterations in the metabolic control of carbohydrates in sepsis. Prog Clin Biol Res. 1989; 308:545-61.
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  292. Spitzer JJ, Bagby GJ, Meszaros K, Lang CH. Altered control of carbohydrate metabolism in endotoxemia. Prog Clin Biol Res. 1989; 286:145-65.
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  293. Mészáros K, Lang CH, Bagby GJ, Spitzer JJ. In vivo glucose utilization by individual tissues during nonlethal hypermetabolic sepsis. FASEB J. 1988 Dec; 2(15):3083-6.
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  294. Spitzer JJ, Bagby GJ, Mészáros K, Lang CH. Alterations in lipid and carbohydrate metabolism in sepsis. JPEN J Parenter Enteral Nutr. 1988 Nov-Dec; 12(6 Suppl):53S-58S.
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  295. Lang C, Dobrescu C. Attenuation of burn-induced changes in hemodynamics and glucose metabolism by the PAF antagonist SRI 63-675. Eur J Pharmacol. 1988 Nov 1; 156(2):207-14.
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  296. Hargrove DM, Bagby GJ, Lang CH, Spitzer JJ. Adrenergic blockade prevents endotoxin-induced increases in glucose metabolism. Am J Physiol. 1988 Nov; 255(5 Pt 1):E629-35.
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  297. Lang CH, Blakesley HL, Bagby GJ, Spitzer JJ. Lipoxygenase and cyclooxygenase blockade by BW755C prevents endotoxin-induced hypotension but not changes in glucose metabolism. Horm Metab Res. 1988 Sep; 20(9):551-4.
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  298. Bagby GJ, Lang CH, Hargrove DM, Thompson JJ, Wilson LA, Spitzer JJ. Glucose kinetics in rats infused with endotoxin-induced monokines or tumor necrosis factor. Circ Shock. 1988 Feb; 24(2):111-21.
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  299. Lang CH, Dobrescu C, Hargrove DM, Bagby GJ, Spitzer JJ. Platelet-activating factor-induced increases in glucose kinetics. Am J Physiol. 1988 Feb; 254(2 Pt 1):E193-200.
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  300. Hargrove DM, Bagby GJ, Lang CH, Spitzer JJ. Adrenergic blockade does not abolish elevated glucose turnover during bacterial infection. Am J Physiol. 1988 Jan; 254(1 Pt 1):E16-22.
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  301. Lang CH, Bagby GJ, Hargrove DM, Hyde PM, Spitzer JJ. Alterations in glucose kinetics induced by pentobarbital anesthesia. Am J Physiol. 1987 Dec; 253(6 Pt 1):E657-63.
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  302. Mészáros K, Lang CH, Bagby GJ, Spitzer JJ. Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues. Biochem Biophys Res Commun. 1987 Nov 30; 149(1):1-6.
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  303. Lang CH, Bagby GJ, Blakesley HL, Spitzer JJ. Fever is not responsible for the elevated glucose kinetics in sepsis. Proc Soc Exp Biol Med. 1987 Sep; 185(4):455-61.
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  304. Mészáros K, Lang CH, Bagby GJ, Spitzer JJ. Contribution of different organs to increased glucose consumption after endotoxin administration. J Biol Chem. 1987 Aug 15; 262(23):10965-70.
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  305. Lang CH, Dobrescu C, Bagby GJ, Spitzer JJ. Altered glucose kinetics in diabetic rats during gram-negative infection. Am J Physiol. 1987 Aug; 253(2 Pt 1):E123-9.
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  306. McDonough KH, Barbee RW, Dobrescu C, Lang CH, Spitzer JJ. Enhanced myocardial depression in diabetic rats during E. coli sepsis. Am J Physiol. 1987 Aug; 253(2 Pt 2):H276-82.
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  307. Mészáros K, Bagby GJ, Lang CH, Spitzer JJ. Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscles in endotoxin-treated rats. Am J Physiol. 1987 Jul; 253(1 Pt 1):E33-9.
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  308. Lang CH, Spitzer JA. Glucose kinetics and development of endotoxin tolerance during long-term continuous endotoxin infusion. Metabolism. 1987 May; 36(5):469-74.
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  309. Shepherd RE, Lang CH, McDonough KH. Myocardial adrenergic responsiveness after lethal and nonlethal doses of endotoxin. Am J Physiol. 1987 Feb; 252(2 Pt 2):H410-6.
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  310. Lang CH, Bagby GJ, Buday AZ, Spitzer JJ. The contribution of gluconeogenesis to glycogen repletion during glucose infusion in endotoxemia. Metabolism. 1987 Feb; 36(2):180-7.
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  311. Lang CH, Bagby GJ, Blakesley HL, Spitzer JJ. Glucose kinetics and pyruvate dehydrogenase activity in septic rats treated with dichloroacetate. Circ Shock. 1987; 23(2):131-41.
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  312. Lang CH, Dobrescu C, Hargrove DM, Bagby GJ, Spitzer JJ. Attenuation of endotoxin-induced increase in glucose metabolism by platelet-activating factor antagonist. Circ Shock. 1987; 23(3):179-88.
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  313. Lang CH, Bagby GJ, Blakesley HL, Spitzer JJ. Inhibition of eicosanoid production by BW755C does not attenuate sepsis-induced alterations in glucose kinetics. Circ Shock. 1987; 22(2):105-13.
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  314. Lang CH, Bagby GJ, Blakesley HL, Johnson JL, Spitzer JJ. Plasma glucose concentration determines direct versus indirect liver glycogen synthesis. Am J Physiol. 1986 Nov; 251(5 Pt 1):E584-90.
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  315. Lang CH, Alteveer RJ. Effects of glucose-insulin-potassium on intestinal hemodynamics and substrate utilization during endotoxemia. Am J Physiol. 1986 Sep; 251(3 Pt 1):G341-8.
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  316. McDonough KH, Brumfield BA, Lang CH. In vitro myocardial performance after lethal and nonlethal doses of endotoxin. Am J Physiol. 1986 Feb; 250(2 Pt 2):H240-6.
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  317. Bagby GJ, Lang CH, Giaimo ME, Spitzer JJ. Increased glucose metabolism by epitrochlearis muscle removed from endotoxin-treated rats. Circ Shock. 1986; 20(3):171-9.
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  318. Buday AZ, Lang CH, Bagby GJ, Spitzer JJ. Glycogen synthase and phosphorylase activities during glycogen repletion in endotoxemic rats. Circ Shock. 1986; 19(2):149-63.
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  319. Lang CH, Bagby GJ. Endotoxin tolerance diminishes endotoxin-induced alterations in carbohydrate kinetics. Circ Shock. 1986; 20(2):141-50.
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  320. Fish RE, Lang CH, Spitzer JA. Regional blood flow during continuous low-dose endotoxin infusion. Circ Shock. 1986; 18(4):267-75.
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  321. McDonough KH, Henry JJ, Lang CH, Spitzer JJ. Substrate utilization and high energy phosphate levels of hearts from hyperdynamic septic rats. Circ Shock. 1986; 18(3):161-70.
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  322. Lang CH, Bagby GJ, Spitzer JJ. Glucose kinetics and body temperature after lethal and nonlethal doses of endotoxin. Am J Physiol. 1985 Apr; 248(4 Pt 2):R471-8.
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  323. Fish RE, Burns AH, Lang CH, Spitzer JA. Myocardial dysfunction in a nonlethal, nonshock model of chronic endotoxemia. Circ Shock. 1985; 16(3):241-52.
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  324. Lang CH, Bagby GJ, Nowotny A, Spitzer JJ. Effects of toxic and nontoxic endotoxin derivatives on glucose kinetics. Circ Shock. 1985; 17(4):301-11.
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  325. McDonough KH, Lang CH, Spitzer JJ. Effect of cardiotropic agents on the myocardial dysfunction of hyperdynamic sepsis. Circ Shock. 1985; 17(1):1-19.
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  326. Scholl RA, Lang CH, Bagby GJ. Hypertriglyceridemia and its relation to tissue lipoprotein lipase activity in endotoxemic, Escherichia coli bacteremic, and polymicrobial septic rats. J Surg Res. 1984 Nov; 37(5):394-401.
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  327. Lang CH, Bagby GJ, Spitzer JJ. Carbohydrate dynamics in the hypermetabolic septic rat. Metabolism. 1984 Oct; 33(10):959-63.
    View in: PubMed
  328. Lang CH, Bagby GJ, Ferguson JL, Spitzer JJ. Cardiac output and redistribution of organ blood flow in hypermetabolic sepsis. Am J Physiol. 1984 Mar; 246(3 Pt 2):R331-7.
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  329. McDonough KH, Lang CH, Spitzer JJ. Depressed function of isolated hearts from hyperdynamic septic rats. Circ Shock. 1984; 12(4):241-51.
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  330. Lang CH, Bagby GJ, Bornside GH, Vial LJ, Spitzer JJ. Sustained hypermetabolic sepsis in rats: characterization of the model. J Surg Res. 1983 Sep; 35(3):201-10.
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